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- 저자 : Dwi A. Suryandari (검색결과 2 건)
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Lindawati S. Kusdhany,Elza I. Auerkari,Dwi A. Suryandari,Tribudi W. Rahardjo,Eef Hogervoorst,Christopher Talbot 대한예방치과학회 2011 International Journal of Clinical Preventive Denti Vol.7 No.1
Objective: Osteoporosis is a disease of bone metabolism, characterized by reduced density of e.g. the jawbone, with decreasing stability of the denture. Polymorphism in the estrogen receptor β gene (ER-β) has been linked with susceptibility to osteoporosis in ageing persons. The present study aimed to evaluate the association between the ER-β gene polymorphism and osteoporosis in Indonesian postmenopausal women. Methods: The research was a cross-sectional study of 288 subjects that were 47-75 years old. Bone density was determined by an ultrasonic technique and the subjects were divided on this basis into normal, osteopenia and osteoporosis groups. Peripheral blood samples were used for DNA isolation, and the ER-β polymorphism status of the subjects was evaluated using the PCR-RFLP technique with Alu1 restriction enzyme for cutting. Chi-square testing was used to evaluate the relation between the polymorphism status and the observed bone density. Results: The results showed that the status of ER-β polymorphism is significantly associated with osteoporosis in Indonesian postmenopausal women. In particular, a high fraction (68%) of subjects with osteoporosis were of the AA genotype, while osteoporosis was less common (32%) in the Aa genotype and apparently rare in the aa genotype that was in case uncommon. Conclusion: The majority of subjects with osteoporosis were of the AA genotype in terms of ER-β polymorphisms in Indonesian postmenopausal women. As the majority of all subjects were of AA genotype, the results support the view that expression of ER-β would increase the risk to osteoporosis and fracture in ageing women.
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Jen Fuk Liem,Dwi A. Suryandari,Safarina G. Malik,Muchtaruddin Mansyur,Dewi S. Soemarko,Aria Kekalih,Imam Subekti,Franciscus D. Suyatna,Bertha Pangaribuan 대한예방의학회 2022 예방의학회지 Vol.55 No.3
Objectives: One of the most widely used pesticides today is chlorpyrifos (CPF). Cytochrome P450 (CYP)2B6, the most prominent catalyst in CPF bioactivation, is highly polymorphic. The objective of our study was to evaluate the role of CYP2B6*6, which contains both 516G>T and 785A>G polymorphisms, in CPF toxicity, as represented by the concentration of 3,5,6-trichloro-2-pyridinol (TCPy), among vegetable farmers in Central Java, Indonesia, where CPF has been commonly used. Methods: A cross-sectional study was conducted among 132 vegetable farmers. Individual socio-demographic and occupational characteristics, as determinants of TCPy levels, were obtained using a structured interviewer-administered questionnaire and subsequently used to estimate the cumulative exposure level (CEL). TCPy levels were detected with liquid chromatography-mass spectrometry. CYP2B6*6 gene polymorphisms were analyzed using a TaqMan® SNP Genotyping Assay and Sanger sequencing. Linear regression analysis was performed to analyze the association between TCPy, as a biomarker of CPF exposure, and its determinants. Results: The prevalence of CYP2B6*6 polymorphisms was 31% for *1/*1, 51% for *1/*6, and 18% for *6/*6. TCPy concentrations were higher among participants with CYP2B6*1/*1 than among those with *1/*6 or *6/*6 genotypes. CYP2B6*6 gene polymorphisms, smoking, CEL, body mass index, and spraying time were retained in the final linear regression model as determinants of TCPy. Conclusions: The results suggest that CYP2B6*6 gene polymorphisms may play an important role in influencing susceptibility to CPF exposure. CYP2B6*6 gene polymorphisms together with CEL, smoking habits, body mass index, and spraying time were the determinants of urinary TCPy concentrations, as a biomarker of CPF toxicity.
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