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RISS 인기검색어
- 검색키워드
- 저자 : Dowsett, S.A. (검색결과 2 건)
- 무료
- 기관 내 무료
- 유료
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Effect of GnRH Immunization on Testicular Function in Colts
Tshewang, U.,Dowsett, K.F.,Knott, L.,Jackson, A. Asian Australasian Association of Animal Productio 1999 Animal Bioscience Vol.12 No.3
Ten Australian Stock Horses colts (five yearling and five 3-year old colts) of which 2 yearlings and 2 three year old colts served as control animals while 3 yearlings and 3 three year old colts received two GnRH immunizations within 4 weeks interval were used in this study. By the 5th to 6th week after immunization, the GnRH antibody titres in the plasma rose above 1:1000 and attained peak levels of 1:6500 by the 8th week and gradually declined to about 1:3000 by the 10th week in both the age groups. The testosterone and androstenedione concentrations of the control colts in both age groups were significantly greater (p<0.05) than that of the vaccinated groups. During the immunosuppression period, the vaccinated colts behaved like geldings. Semen could not be collected from 2 of the 3 three-year old vaccinated colts. The testicular dimensions, testicular weight, parenchymal weight, seminiferous tubule volumes, interstitial space volumes, Leydig cell volume, seminiferous tubule % of the control colts were significantly greater than those of the vaccinated colts in both the age groups. The 3-year old control colts had a significantly (p<0.05) greater % of Leydig cells than the control and vaccinated 1-year old colts. There was arrest of spermatogenesis with complete absence of sperm in the testes of the vaccinated colts while there was various stages of spermatogenesis in those of the control colts. Morphometric analysis demonstrated that the 3-year old colts had significantly (p<0.05) greater DSP/gm of testis and DSP/testis than those of the 1-year old control colts. This study elucidated that the GnRH immunization could suppress the testicular function of the 3-year old and yearling colts.
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Brock, G.,Heiselman, D.,Maggi, M.,Kim, S.W.,Rodriguez Vallejo, J.M.,Behre, H.M.,McGettigan, J.,Dowsett, S.A.,Hayes, R.P.,Knorr, J.,Ni, X.,Kinchen, K. Williams and Wilkins Co 2016 The Journal of urology Vol.195 No.3
<P>Purpose: We determined the effect of testosterone solution 2% on total testosterone level and the 2 symptoms of hypogonadism, sex drive and energy level. Materials and Methods: This was a randomized, multicenter, double-blind, placebo controlled, 16-week study to compare the effect of testosterone and placebo on the proportion of men with a testosterone level within the normal range (300 to 1,050 ng/dl) upon treatment completion. We also assessed the impact of testosterone on sex drive and energy level measured using SAID (Sexual Arousal, Interest and Drive scale) and HED (Hypogonadism Energy Diary), respectively. A total of 715 males 18 years old or older with total testosterone less than 300 ng/dl and at least 1 symptom of testosterone deficiency (decreased energy and/or decreased sexual drive) were randomized to 60 mg topical testosterone solution 2% or placebo once daily. Results: Of study completers 73% in the testosterone vs 15% in the placebo group had a testosterone level within the normal range at study end point (p < 0.001). Participants assigned to testosterone showed greater baseline to end point improvement in SAID scores (low sex drive subset p < 0.001 vs placebo) and HED scores (low energy subset p = 0.02 vs placebo, not significant at prespecified p < 0.01). No major adverse cardiovascular or venous thrombotic events were reported in the testosterone group. The incidence of increased hematocrit was higher with testosterone vs placebo (p = 0.04). Conclusions: Once daily testosterone solution 2% for 12 weeks was efficacious in restoring normal testosterone levels and improving sexual drive in hypogonadal men. Improvement was also seen in energy levels on HED though not at the prespecified p < 0.01. No new safety signals were identified.</P>
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