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Salvatore Terrazzino,Letizia Deantonio,Sarah Cargnin,Laura Donis,Carla Pisani,Laura Masini,Giuseppina Gambaro,Pier Luigi Canonico,Armando A. Genazzani,Marco Krengli 대한암학회 2017 Cancer Research and Treatment Vol.49 No.2
Purpose This study was conducted to investigate the role of four polymorphic variants of DNA methyltransferase genes as risk factors for radiation-induced fibrosis in breast cancer patients. We also assessed their ability to improve prediction accuracy when combined with mitochondrial haplogroup H, which we previously found to be independently associated with a lower hazard of radiation-induced fibrosis. Materials and Methods DNMT1 rs2228611, DNMT3A rs1550117, DNMT3A rs7581217, and DNMT3B rs2424908 were genotyped by real-time polymerase chain reaction in 286 Italian breast cancer patients who received radiotherapy after breast conserving surgery. Subcutaneous fibrosis was scored according to the Late Effects of Normal Tissue–Subjective Objective Management Analytical (LENT-SOMA) scale. The discriminative accuracy of genetic models was assessed by the area under the receiver operating characteristic curves (AUC). Results Kaplan-Meier curves showed significant differences among DNMT1 rs2228611 genotypes in the cumulative incidence of grade 2 subcutaneous fibrosis (log-rank test p-value= 0.018). Multivariate Cox regression analysis revealed DNMT1 rs2228611 as an independent protective factor for moderate to severe radiation-induced fibrosis (GG vs. AA; hazard ratio, 0.26; 95% confidence interval [CI], 0.10 to 0.71; p=0.009). Adding DNMT1 rs2228611 to haplogroup H increased the discrimination accuracy (AUC) of the model from 0.595 (95% CI, 0.536 to 0.653) to 0.655 (95% CI, 0.597 to 0.710). Conclusion DNMT1 rs2228611 may represent a determinant of radiation-induced fibrosis in breast cancer patients with promise for clinical usefulness in genetic-based predictive models.
Song, J.M.,Kim, Y.C.,Barlow, P.G.,Hossain, M.J.,Park, K.M.,Donis, R.O.,Prausnitz, M.R.,Compans, R.W.,Kang, S.M. Elsevier/North-Holland 2010 Antiviral research Vol.88 No.2
To develop a more effective vaccination method against H5N1 virus, we investigated the immunogenicity and protective efficacy after skin vaccination using microneedles coated with influenza virus-like particles containing hemagglutinin derived from A/Vietnam/1203/04 H5N1 virus (H5 VLPs). A single microneedle vaccination of mice with H5 VLPs induced increased levels of antibodies and provided complete protection against lethal challenge without apparent disease symptoms. In contrast, intramuscular injection with the same vaccine dose showed low levels of antibodies and provided only partial protection accompanied by severe body weight loss. Post-challenge analysis suggested that improved protection was associated with lower lung viral titers and enhanced generation of recall antibody secreting cells by microneedle vaccination. Thus, this study provides evidence that skin delivery of H5 VLP vaccines using microneedles designed for self-administration induces improved protection compared to conventional intramuscular immunization.
Song, J.M.,Hossain, J.,Yoo, D.G.,Lipatov, A.S.,Davis, C.T.,Quan, F.S.,Chen, L.M.,Hogan, R.J.,Donis, R.O.,Compans, R.W.,Kang, S.M. Academic Press 2010 Virology Vol.405 No.1
We generated influenza virus-like particles (VLPs) containing the wild type (WT) H5 hemagglutinin (HA) from A/Viet Nam/1203/04 virus or a mutant H5 HA with a deletion of the multibasic cleavage motif. VLPs containing mutant H5 HA were found to be as immunogenic as VLPs containing WT HA. A single intramuscular vaccination with either type of H5 VLPs provided complete protection against lethal challenge. In contrast, the recombinant H5 HA vaccine was less immunogenic and vaccination even with a 5 fold higher dose did not induce protective immunity. VLP vaccines were superior to the recombinant HA in inducing T helper type 1 immune responses, hemagglutination inhibition titers, and antibody secreting cells, which significantly contribute to inducing protective immunity after a single dose vaccination. This study provides insights into the potential mechanisms of improved immunogenicity by H5 VLP vaccines as an approach to improve the protective efficacy against potential pandemic viruses.
Increase of Cardiometabolic Biomarkers Among Vehicle Inspectors Exposed to PM0.25 and Compositions
Ramdhan, Doni Hikmat,Kurniasari, Fitri,Tejamaya, Mila,Fitri, Aidila,Indriani, Aisyah,Kusumawardhani, Adinda,Santoso, Muhayatun Occupational Safety and Health Research Institute 2021 Safety and health at work Vol.12 No.1
Background: Exposure to particulate matter (PM) emitted from vehicle exhaust might disrupt systemic function and elevate the risk of cardiovascular disease. In this study, we examined the changes of cardiometabolic biomarkers among vehicle inspectors exposed daily to PM0.25 and components. Methods: This cross-sectional study was conducted at two vehicle inspection centers, Pulogadung and Ujung Menteng, located in East Jakarta, Indonesia. The exposed respondents were 43 workers from vehicle inspection centers, and the unexposed group consisted of 22 staff officers working in the same locations. Vehicle exhaust particulate matter was measured for eight hours using a Leland Legacy personal pump attached to a Sioutas Cascade Impactor. The used filters were 25 and 37-mm quartz filters. The particulate matter concentration was analyzed using a gravimetric method, whereas trace elements were analyzed using energy dispersive X-ray fluorescence. An EEL Smoke Stain Reflectometer analyzed black carbon. Results: The personal exposure concentrations of PM0.25 were 10.4-fold higher than those in unexposed groups. Calcium and sulfur were the major components in the obtained dust, and their levels were 3.3- and 7.2-fold higher, respectively, in the exposed group. Based on an independent-samples t-test, high-density lipoprotein, triglyceride, HbA1c, total immunoglobulin E, high-sensitivity C-reactive protein, tumor necrosis factor-alpha, and nitric oxide levels were significantly different between the groups. Conclusions: In summary, it was suggested that PM0.25 exposure from vehicle exhaust might affect cardiometabolic biomarkers change.
High strain-to-failure porous alumina ceramics with improved mechanical properties
D. Doni Jayaseelan,S. Ueno,T. Ohji,S. Kanzaki 한양대학교 세라믹연구소 2004 Journal of Ceramic Processing Research Vol.5 No.1
A pulse electric current sintering technique was employed to fabricate porous alumina from a commercially available powder. Porosity was controllable between 20 to 50% depending on the sintering temperature. The fracture strength was correlated exponentially as a function of porosity. A high strength of ~250 MPa was achieved for the specimens, which had porosity of 30 vol.%. The strain-to-failure of the porous Al2O3 ceramics increased considerably and this improves the reliability of the specimens.
Iryanti Fatyasari Nata,Doni Rahmat Wicakso,Agus Mirwan,Chairul Irawan,Rinna Juwita,Niken Anggraini Astuti,Rizka Tiara An-Nisa 한국화학공학회 2022 Korean Journal of Chemical Engineering Vol.39 No.7
Rice husk (RH) cellulose as a matrix was synthesized for amine rice husk magnetic biocomposite (RBNH2)by one-pot solvothermal method. The synergic effect of amine on magnetic nanoparticle will enhance the reactivityof material. Ethylene glycol as solvent was used for dissolved iron(III) chloride hexahydrate, Na-acetate anhydrate,and 1,6-hexanediamine, then RH was added, kept at ±200 oC for 6 h. The optimums of Fe contained and amineconcentrations on biocomposite were detected at 93% and 2.9mmol/g, respectively. The surface area of rice husk significantlyincreased from 1.309m2 g1 to 19.45m2 g1 when converted to biocomposite. The RB-NH2 has good capabilityto adsorb Cu(II) ion at 116.45mg g1 at pH 5 for 60min. Surprisingly, during adsorption, the RB-NH2 also workedon reducing the chemical oxygen demand (COD) number, total suspended solid (TSS) and dye for 22%, 54.37%, and33.74%, respectively. The reuse effectiveness for RB-NH2 showed a good result with four repetitions. The multipleeffects of amine rice husk magnetic biocomposite on wastewater contaminants leads to becoming a candidate materialto be developed and applied in a wide range of waste water treatment applications.
Shunkichi Ueno,D. Doni Jayaseelan,Tatsuki Ohji,Hua-Tay Lin 한양대학교 세라믹연구소 2005 Journal of Ceramic Processing Research Vol.6 No.1
The oxidation and water vapor corrosion behavior of sintered HfSiO4, ZrSiO4, TiSiO4 compacts and high density HfSiO4 coated silicon nitride ceramics were examined at 1500 oC in a static state water vapor environment. The bulk weights of HfSiO4 and ZrSiO4 decreased after the water vapor corrosion test with a weight loss rate of 7.080 × 10−6 and 1.333 × 10−6 g/cm2·h, respectively. The weight of TiSiO4 remained unchanged within the experimental error after the corrosion test. A trace of corrosion was observed on the surface of grains of corrosion-tested compacts. On the other hand, the weight of high density HfSiO4 layer (Environmental Barrier Coating, EBC layer) coated silicon nitride specimens increased with a weight gain rate 1.495 × 10−6 g/cm2·h, which is attributed by the oxidation of the silicon nitride substrate.
Comparison of water vapor corrosion behavior of silicon nitride with various EBC layers
Shunkichi Ueno,D. Doni Jayaseelan,Tatsuki Ohji 한양대학교 세라믹연구소 2004 Journal of Ceramic Processing Research Vol.5 No.4
The water vapor corrosion resistance of silicon nitride ceramics with Lu2Si2O7, Yb2Si2O7 and ZrSiO4 environmental barrier coating (EBC) layers prepared by a reaction sintering method were examined at 1500 oC in a static state water vapor environment. The weights of these samples slightly increased during the corrosion test. The weight gain rates for Lu, Yb and zircon EBC samples were 2.218 × 10−6, 4.688 × 10−6 and 2.989 × 10−6 g/cm2·h, respectively. In the corrosion mechanism of Lu and Yb cases, the gas path through channels in the EBC layer were generated by the elimination of the boundary silica phase and then, the silicon nitride substrate was slightly oxidized. On the other hand, in the case of ZrSiO4, many cracks were introduced in the EBC layer during the corrosion test due to the difference in thermal expansion coefficient between the EBC layer and the substrate. However, the adhesion between the substrate and the EBC layer of ZrSiO4 was better than that of Lu and/or Yb EBC samples.