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단세포전기영동법(Single Cell Gel Electrophoresis Assay)을 이용한 농약 살포자의 DNA손상 평가
이연경(Yeon Kyeng Lee),이도영(Do Young Lee),이은일(Eunil Lee),이동배(Dong Bae Lee),류재천(Jae Chun Ryu),김해준(Hae-Joon Kim),설동근(Donggeun Sul) 한국환경성돌연변이발암원학회 2001 한국환경성돌연변이·발암원학회지 Vol.21 No.2
Single cell gel electrophoresis (SCGE) assay, also called comet assay, is a rapid and sensitive method to detect DNA damage in single cell level. To evaluate the DNA damage of lymphocytes of pesticides sprayers, SCGE assay was carried out for 50 pesticides sprayers and 58 control subjects. They were interviewed with structured questionnaire to get the information about the kinds and amount of pesticide. Insecticides and fungicides were predominant among pesticides. Major components of pesticides were organophosphorus, organosulfate, cartap, carbamates, and triazole. Sprayed pesticides were classified into two groups. Group I included organophosphorus, organoarsenic, organotin, tetrazine, triazole and gramoxone, which were known to cause DNA damages. Group II pesticide were carbamates, surfactants, organosulfates, etc., which were not found as DNA damaging agents in scientific documents. Olive tail moments of 100 lymphocytes were measured by<br/> KOMET 3.1 program for each person. The means of tail moments were compared between farmers exposed to pesticides and control subjects. Farmers showed higher tail moments than control subjects (2.07±1.40 vs 1.53±0.77, p<0.05). The means of tail moments also were compared among group I sprayers (n=36), group II sprayers (n=24) and, control subjects, and the means of tail moments were 3.45±3.20, 2.66±2.20 and 1.53±0.77 respectively. The difference between means of group I sprayers and controls was statistically significant (p<0.05). In conclusion, this study showed higher DNA damage in farmers exposed to pesticides than control subjects, and<br/> comet assay could be useful as a biological monitoring method of genotoxic pesticides for farmers.
Yu, Eui-Sang,Lee, Sin-Hyung,Bae, Young-Gyu,Choi, Jaebin,Lee, Donggeun,Kim, Chulki,Lee, Taikjin,Lee, Seung-Yeol,Lee, Sin-Doo,Ryu, Yong-Sang American Chemical Society 2018 ACS APPLIED MATERIALS & INTERFACES Vol.10 No.44
<P>A liquid-permeable concept in a metal-insulator-metal (MIM) structure is proposed to achieve highly sensitive color-tuning property through the change of the effective refractive index of the dielectric insulator layer. A semicontinuous top metal film with nanoapertures, adopted as a transreflective layer for MIM resonator, allows to tailor the nanomorphology of a dielectric layer through selective etching of the underneath insulator layer, resulting in nanopillars and hollow voids in the insulator layer. By allowing outer mediums to enter into the hollow voids of the dielectric layer, such liquid-permeable MIM architecture enables to achieve the wavelength shift as large as 323.5 nm/RIU in the visible range, which is the largest wavelength shift reported so far. Our liquid-permeable approaches indeed provide dramatic color tunablility, a real-time sensing scheme, long-term durability, and reproducibility in a simple and scalable manner.</P> [FIG OMISSION]</BR>
Highly efficient process capability indices under contaminated data
Donggeun Lee,Ryeji Jung 대한산업공학회 2017 대한산업공학회 추계학술대회논문집 Vol.2017 No.11
In order to improve manufacturing process, process capability indices have been popularly used. Process capability represents the performance of a process when condition is normal and in-control. This paper propose a new process capability indices based on the Hodge Lehmann and Shamos estimators. The new method performs well under the normal condition and outperforms the existing methods under the contamination.
Efficient Rolling Shutter Distortion Removal using Hierarchical Block-based Motion Estimation
Lee, Donggeun,Choi, Kang-Sun The Institute of Electronics and Information Engin 2014 IEIE Transactions on Smart Processing & Computing Vol.3 No.4
This paper reports an efficient algorithm for accurate rolling shutter distortion removal. A hierarchical global motion estimation approach for a group of blocks reduces the level of computation by three orders of magnitude. In addition, the motion of each scanline is determined accurately by averaging two candidates obtained through cubic spline interpolation. The experimental results show that the proposed method produces accurate motion information with significant computation reduction and corrects the rolling shutter distortion effectively.
Aerodynamic focusing of 5–50nm nanoparticles in air
Lee, Kwang-Sung,Kim, Songkil,Lee, Donggeun Elsevier 2009 Journal of aerosol science Vol.40 No.12
<P><B>Abstract</B></P><P>An aerodynamic lens consisting of several thin plate orifices has been widely used to focus 30–300nm nanoparticles. However, there is a big challenge in focusing sub-30nm particles in air mainly due to flow instability in the lens. Here, we propose a new design of the aerodynamic lens consisting of three converging–diverging orifices to resolve the challenge. Through a series of numerical simulation from single- to multi-lens, we determined a specific design for sub-optimal focusing of 5–100nm aerosol particles while keeping the air flow stable and free of shock formation. The final multi-lens assembly was revealed to be quite successful.</P>
Lee, Sang-Hun,Lee, Donggeun,Choi, Man Ho,Son, Joo-Hiuk,Seo, Minah American Chemical Society 2019 ANALYTICAL CHEMISTRY - Vol.91 No.10
<P>Discrimination and quantification of trace amounts of steroid hormones in biological specimens are needed to elucidate their changing expression because their biological functions are responsible for the development and prevention of endocrine disorders. Although mass-spectrometry-based assays are most commonly recommended, development of a new type of highly sensitive and selective detection methods in clinical practices is needed. Here, we introduce a label-free type of terahertz molecule sensor capable of sensing and identifying progesterone and 17α-OH-progesterone selectively. Nanoslot-array-based sensing chips were used as launching pads for absorption cross-section enhancement of molecules at a reliable terahertz frequency. With use of nanoslots with resonances at 1.17 THz corresponding to intrinsic THz absorption resonance mode for progesterone and at 1.51 THz for 17α-OH-progesterone, respectively, each steroid shows prominent transmittance change in terms of its amount. In particular, the sensing performance has been much improved by controlling evaporation speed, in turn resulting in an efficient, homogeneous distribution of the molecules onto a sensing hot spot.</P> [FIG OMISSION]</BR>
On the generalized mean square error and its applications
Lee Donggeun 대한산업공학회 2017 대한산업공학회 추계학술대회논문집 Vol.2017 No.11
There are several evaluation methods on whether estimates are centralized to true parameter or not. For example, mean squared error (MLE), Euclidean distance, Mahalanobis distance and etc. But when data has two or more parameter it is hard to evaluate whether it is good or bad estimates. In this paper we focus to define the generalized bias (GB) and generalized mean squared error (GMSE) related to generalized variance (GV) applying to MSE concept to evaluate the parameter estimated. Moreover we will prove this concept beyond the three-dimensional, hyper dimensional. Also we will check the applications of these terms.First, we will evaluate the Robust estimates such as MAD, Hodges-Lehmann estimator compared to other evaluation methods. Second, we will use nuclear area data and find efficient method to predict Weibull distribution in some condition.
Lee, Min,Kim, Byung-Jo,Lim, Eun Jeong,Back, Seung Keun,Lee, Ju-Han,Yu, Sung-Wook,Hong, Sung-Ha,Kim, Joo Han,Lee, Sang-Heon,Jung, Woon-Won,Sul, Donggeun,Na, Heung Sik Ovid Technologies (Wolters Kluwer) - AnesthesiaAna 2009 Anesthesia and analgesia Vol.109 No.4
<P>BACKGROUND: Although numerous animal models for low back pain associated with intervertebral disk (IVD) degeneration have been proposed, insufficient data have been provided to make any conclusions regarding pain. Our aim in this study was to determine the reliability of complete Freund's adjuvant (CFA) injection into the rat spine as an animal model representing human discogenic pain. METHODS: We studied IVD degenerative changes with pain development after a 10-microL CFA injection into the L5-6 IVD of adult rats using behavioral, histologic, and biochemical studies. Serial histologic changes were analyzed to detect degenerative changes. Expression of calcitonin gene-related peptide (CGRP), prostaglandin E (PGE), and inducible nitric oxide synthase (iNOS) were determined using immunohistochemistry or real-time polymerase chain reaction as support data for pain development. In addition, CGRP immunoreactivity (ir) at the IVD was considered indirect evidence of neural ingrowth into the IVD. RESULTS: There was a significant increase of the hindpaw withdrawal response in the CFA group until 7 wk postoperatively (P < 0.05). Histologic analyses revealed progressive degenerative changes of the disks without any damage in adjacent structures, including nerve roots. In the CGRP-ir staining study, the bilateral dorsal horns and IVD had positive ir after intradiscal CFA injection. CGRP mRNA expression was increased in the dorsal root ganglion (DRG) at 2 and 4 wk, whereas PGE and iNOS mRNAs were markedly increased at 2 wk. The increment of CGRP expression was higher in allodynic rats compared with nonallodynic rats. CONCLUSION: Intradiscal CFA injection led to chronic disk degeneration with allodynia, which was suggested by pain behavior and expression of pain-related mediators. The increment of CGRP, PGE, and iNOS also suggest pain-related signal processing between the IVD and the neural pathway in this animal model. This animal model may be useful for future research related to the pathophysiology and development of novel treatment for spine-related pain.</P>