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홍동균 ( Dong Kyun Hong ),정남지 ( Nam Ji Jeong ),임명 ( Myung Im ),이영 ( Young Lee ),서영준 ( Young Joon Seo ),이증훈 ( Jeung Hoon Lee ) 대한피부과학회 2011 大韓皮膚科學會誌 Vol.49 No.12
Chronic graft-versus-host disease (GVHD) usually presents 100 days after allogenic bone marrow transplantation. Chronic GVHD cutaneous lesions are characterized by lichenoid or sclerodermoid variants. Vesicles, a common presentation in patients with acute GVHD, rarely appear in chronic GVHD. We report a case of a 49-year-old man who presented with bilateral vesicles on lower extremities. He was diagnosed with myelodysplastic syndrome 2 years before and was taking oral cyclosporine after the allogenic bone marrow transplantation. Six months post-transplantation, lichenoid and sclerodermoid lesions developed on his entire body and he was diagnosed with chronic GVHD and eosinophilic fasciitis. A biopsy of the vesicles revealed detached lower margins of the epidermis, necrotized keratinocytes, and infiltration of lymphocytic inflammatory cells. Administration of oral prednisolone alleviated the patient`s symptoms. This is an interesting case showing a new pattern of vesicle appearance after development of typical chronic GVHD lesions. (Korean J Dermatol 2011;49(12):1125~1127)
SLS로 자극한 간찰 부위 피부에 대한 파우더와 보습제의 효과
홍동균 ( Dong Kyun Hong ),김유진 ( Yu Jin Kim ),임명 ( Myung Im ),이영 ( Young Lee ),김창덕 ( Chang Deok Kim ),이증훈 ( Jeung Hoon Lee ),서영준 ( Young Joon Seo ) 대한피부과학회 2013 대한피부과학회지 Vol.51 No.9
Background: Intertrigo is a form of contact dermatitis of skin folds of the body, for which a large variety of topical medications may be recommended. Application of a suitable barrier preparation is the cornerstone for the prevention and treatment for the intertrigo. Objective: There is a notable absence of controlled trials to support and guide the use of barrier preparations for intertrigo. Methods: We evaluated the effect of powders and moisturizers with non-invasive measuring methods on irritated skin reactions induced by sodium lauryl sulphate in the sintertriginous skin of 21 healthy volunteers. After skin irritation for 24 hours with patch test of 1% sodium lauryl sulphate on both axilla, we applied a powder and a moisturizer respectively. Evaluation was done at 2 weeks by transepidermal water loss, electrical capacitance. Results: TEWL values of the moisturizer treated side were significantly lower than that of the powder treated side. Water holding capacity values of the moisturizer treated side were significantly higher than that of the powder treated side. Conclusion: These results suggest that topical application of a moisturizer might improve the disruption of permeability barrier function of intertrigo. We suggest this experimental model for further barrier preparation efficacy testing of intertrigo.
태경,홍동균,이형석,박철원,Tae, Kyung,Hong, Dong-Kyun,Lee, Hyung-Seok,Park, Chul-Won 대한기관식도과학회 2001 大韓氣管食道科學會誌 Vol.7 No.1
Management of laryngotracheal stenosis remains one of the most challenging problems facing the otolaryngologist. The key to success is to obtain adequate rigid circular support with normal mucosal lining. Four Patients with laryngotracheal stenosis were surgically treated in our institution in 2000. All the patients were male adults. The cause of stenosis were longterm or repeated endotracheal intubation and tracheostomy in our patients. All patients were successfully decannulated following segmental resection of the stenotic portion including the anterior arch of the cricoid cartilage and end-to-end anastomosis after suprahyoid laryngeal release. The time between treatment and decannulation was just one day in three patients. These results suggest the Possibility of early decannulation even if the cricoid cartilage was partially resected. It is better to prevent laryngotracheal stenosis rather than to treat it once it has occurred.
정남지 ( Nam Ji Jeong ),홍동균 ( Dong Kyun Hong ),이영 ( Young Lee ),서영준 ( Young Joon Seo ),이증훈 ( Jeung Hoon Lee ),임명 ( Myung Im ) 대한피부과학회 2012 대한피부과학회지 Vol.50 No.6
An apocrine hydrocystoma is a translucent cystic nodule that looks like adenomatous cystic proliferation of an apocrine gland, which originated from a hair germ. Dermoid cyst is a cystic teratoma that contains developmentally mature skin appendages, such as hair follicles, sweat glands, and other tissues derived from the ectoderm. Many investigators believe that dermoid cysts re originated from the ectoderm, specifically the hair germ cells. A 58-year-old woman was presented with a purple, asymptomatic, dome-shaped nodule on her right lower eyelid that had been slowly increasing in size for several years. Histopathological examination revealed two well-demarcated cysts: one was lined with stratified squamous epithelium with mature hair and sebaceous glands and the other contained large cystic spaces, which papillary projections extended. We report a rare case of a dermoid cyst, combined with an apocrine hydrocystoma, occurring in the right lower eyelid.
Immunohistochemical Study of O-GlcNAcylation in Human Skin Tumors
Young Lee(이영),Dong Kyun Hong(홍동균),Dae Kyoung Choi(최대경),Seul Ki Lim(임슬기),Kyung Cheol Sohn(손경철),Myung Im(임명),Young Joon Seo(서영준),Young Ho Lee(이영호),Jeung Hoon Lee(이증훈),Chang Deok Kim(김창덕) 대한체질인류학회 2014 해부·생물인류학 (Anat Biol Anthropol) Vol.27 No.2
단백질 전사 후 변형 (posttranslational modification)은 단백질 기능을 조절하는 기전의 하나로, 당화(gycosylation), 아세틸화 (acetylation), 메틸화 (methylation) 등을 포함한다. O-linked β-N-acetylglucosamine (OGlcNAc)에 의한 단백질 전사 후 변형은 많은 세포 반응에 관여하는 조절 기전으로 최근 연구가 많이 진행되고 있다. 특히, O-GlcNAc에 의한 단백질 전사 후 변형(O-GlcNAcylation)은 유방암, 폐암 및 대장암 등과 같은 암질환의 발병에 관여함이 보고되었다. 그러나 이러한 O-GlcNAcylation이 피부종양에 어떠한 영향을 미치는지 잘 밝혀져 있지 않다. 본 연구에서는 다양한 피부종양을 대상으로 하여 O-GlcNAcylation이 어떻게 일어나는지 면역조직화학을 통해 살펴보았다. 그 결과, 양성종양에 비해 암전구증 및 악성종양에서 전체적으로 O-GlcNAcylation이 증가해 있었다. 또한 O-GlcNAcylation을 담당하는 효소인 O-GlcNAc transferase (OGT) 및 O-GlcNAc을 제거하는 효소인 O-GlcNAcase (OGA) 발현 또한 양성종양에 비해 암전구증 및 악성종양에서 증가해 있었다. 이러한 연구 결과는 O-GlcNAcylation이 여러 피부종양의 발병에 관여함을 시사한다. O-linked β-N-acetylglucosamine modification is an important post-translational modification, emerging as a novel regulatory mechanism in various cellular events. Recently, several studies have shown that O-GlcNAcylation plays an essential role in human breast, lung, and colon cancers. With regard to skin cancers, the role of O-GlcNAcylation has yet to be elucidated. To investigate whether O-GlcNAcylation is linked to human skin tumor development, immunohistochemical analysis was performed to investigate the presence of OGlcNAcylation in various skin tumors. We evaluated the levels of O-GlcNAcylation, O-GlcNAc transferase, and O-GlcNAcase in 29 benign tumors, 12 premalignant tumors, and 26 malignant tumors in skin. Compared to the benign tumors, premalignant and malignant tumors had increased patterns of O-GlcNAcylation. In addition, the O-GlcNAc transferase and O-GlcNAcase levels were higher in premalignant and malignant tumors than in benign tumors. Interestingly, O-GlcNAcase levels were significantly increased in premalignant tumors compared to benign and malignant tumors. These results suggest that O-GlcNAcylation of proteins may play an important role in the development of human skin tumors.
정남지 ( Nam Ji Jeong ),홍동균 ( Dong Kyun Hong ),임명 ( Myung Im ),이영 ( Young Lee ),서영준 ( Young Joon Seo ),이증훈 ( Jeung Hoon Lee ) 대한피부과학회 2012 대한피부과학회지 Vol.50 No.11
Erosive adenomatosis of the nipple is a rare, benign neoplasm, currently thought to originate from the terminal lactiferous ducts and subareolar breast tissue. Clinically, erosive adenomatosis of the nipple is often indistinguishable from that of mammary Paget`s disease, and it could be misdiagnosed as intraductal carcinoma as it has a similar histological finding. We present the case of a 36-year-old woman who had a unilateral erythematous induration of the nipple that contained a palpable, firm nodule. It had first been noticed 2 years earlier. The surface was occasionally crusted, and there was a bloody discharge. Histopathological examination showed irregular, dilated tubular structures, which were lined by a peripheral layer of cuboidal cells and a luminal layer of the columnar cells that demonstrated decapitation secretion at their luminal border. (Korean J Dermatol 2012;50(11):991∼993)
원발병소의 외과적 절제 9년 후 경부 림프절에 전이된 경구개 선암종 1예
이형석(Hyung Seok Lee),전성하(Sung Ha Jeon),홍동균(Dong Kyun Hong),조석현(Seok Hyun Cho),태경(Kyung Tae) 대한두경부종양학회 2004 대한두경부 종양학회지 Vol.20 No.1
Primary malignancies of hard palate are rare, espicially adenocarcinoma of minor salivary gland in hard palate. The clinical stage of the tumor and its histologic grade at the time of treatment were significant predictors of survival. A 33-year-old woman was diagnosed with stage II, polymorphous low-grade adenocarcinoma of the hard palate and treated with surgery. We thougt that she would have excellent prognosis. After that, there was no definite evidence of recurrence during 3 months. Since then, the patient herself decided to discontunue follow-up. 9 years after that she came to the hospital due to both submandibular mass without any sign of local recurrence. CT scan and biopsy of the mass revealed multiple cervical metastatic adenocarcinoma without distant metastasis and the histologic findings were similar to that of the primary hard palate adenocarcinoma. So, we present this case with the review of literature.
Neurofibromatosis Type I 환자에서 부인두강에 발생한 거대 신경섬유종증 1례
이형석(Hyung Seok Lee),이승환(Seung Hwan Lee),허영돈(Young Don Huh),홍동균(Dong Kyun Hong),이윤서(Yoon Seo Lee) 대한두경부종양학회 2000 대한두경부 종양학회지 Vol.16 No.1
Neurofibromatosis type I or Von Recklinghausen's disease can occur at any site in the body. It is characterized by multiple spots on the skin-more than six spots greater than 1.5cm-, neurofibromas of the peripheral and centarl nervous system, and variety of other dysplastic abnormalities of the skin, bones, endocrine organs, nervous systems, and blood vessels. It is an autosomal dominant trait disease with a frequency of 1 of 3000. Neurofibromatosis is known to be complicated by malignancies. Neurofibromatosis is progressive disease and shows a marked variations in expression in affected individuals. In this report we describe a male patient with neurofibromatosis type I developed in the parapharyngeal space. The patient had huge mass at left parapharyngeal space and inguinal area. We successfully treated the patient with surgery without complication.
여성형탈모에서 두타스테리드의 임상적 치료 효과 및 작용 기전에 대한 연구
김수정 ( Soo Jung Kim ),황율례 ( Yul-lye Hwang ),임수혁 ( Su-hyuk Yim ),홍동균 ( Dong Kyun Hong ),최종원 ( Chong Won Choi ),정경은 ( Kyung Eun Jung ),서영준 ( Young-joon Seo ),김창덕 ( Chang-deok Kim ),신정민 ( Jung Min Shin ) 대한피부과학회 2020 대한피부과학회지 Vol.58 No.4
Background: Female-pattern hair loss (FPHL) is a common hair loss disorder in women. The various treatments include topical minoxidil and 17α-estradiol, as well as oral anti-androgens. However, the clinical efficacy of 5α -reductase inhibitors remains controversial. Objective: We evaluated the clinical utility of dutasteride in FPHL patients and how dutasteride promotes hair growth. Methods: We evaluated hair follicle density and thickness before and after oral dutasteride treatment in 24 patients with FPHL. We measured β-catenin activity in primary cultures of human dermal papilla cells (DPCs) using the TOP Flash reporter assay and Western blotting. The expression levels of genes promoting hair growth were quantitatively assessed using quantitative polymerase chain reaction (Q-PCR). Results: The mean vertex hair density increased significantly from 67±14 to 76±13/cm<sup>2</sup> (p=0.001) and the mean occipital hair density increased from 89±11 to 94±13/cm<sup>2</sup> (p=0.012) after dutasteride treatment. However, the mean hair thickness did not increase. When DPCs were treated with dutasteride, TOP Flash activity increased in a dose-dependent manner, and the protein level of non-phosphorylated (active) β-catenin also increased. The mRNA level of vascular endothelial growth factor increased, but the mRNA levels of the keratinocyte growth factor, insulin growth factor-1, and Noggin were not affected by dutasteride. Conclusion: This study shows a novel mechanism of dutasteride in promoting hair growth and provides support for the possible clinical application of 5α-reductase inhibitors for the treatment of FPHL. (Korean J Dermatol 2020;58(4):231∼238)