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Won, Ki-Bum,Nam, Chang-Wook,Cho, Yun-Kyeong,Yoon, Hyuck-Jun,Park, Hyoung-Seob,Kim, Hyungseop,Han, Seongwook,Hur, Seung-Ho,Kim, Yoon-Nyun,Park, Sang-Hyun,Han, Jung-Kyu,Koo, Bon-Kwon,Kim, Hyo-Soo,Doh, J The Korean Academy of Medical Sciences 2016 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.31 No.12
<P>Data on the clinical outcomes in deferred coronary lesions according to functional severity have been limited. This study evaluated the clinical outcomes of deferred lesions according to fractional flow reserve (FFR) grade using Korean FFR registry data. Among 1,294 patients and 1,628 lesions in Korean FFR registry, 665 patients with 781 deferred lesions were included in this study. All participants were consecutively categorized into 4 groups according to FFR; group 1: ≥ 0.96 (n = 56), group 2: 0.86–0.95 (n = 330), group 3: 0.81–0.85 (n = 170), and group 4: ≤ 0.80 (n = 99). Primary endpoint was major adverse cardiac events (MACE), a composite of all-cause death, myocardial infarction, and target vessel revascularization. The median follow-up period was 2.1 years. During follow-up, the incidence of MACE in groups 1–4 was 1.8%, 7.6%, 8.8%, and 13.1%, respectively. Compared to group 1, the cumulative rate by Kaplan-Meier analysis of MACE was not different for groups 2 and 3. However, group 4 had higher cumulative rate of MACE compared to group 1 (log-rank <I>P</I> = 0.013). In the multivariate Cox hazard models, only FFR (hazard ratio [HR], 0.95; <I>P</I> = 0.005) was independently associated with MACE among all participants. In contrast, previous history of percutaneous coronary intervention (HR, 2.37; <I>P</I> = 0.023) and diagnosis of acute coronary syndrome (ACS) (HR, 2.35; <I>P</I> = 0.015), but not FFR, were independent predictors for MACE in subjects with non-ischemic (FFR ≥ 0.81) deferred coronary lesions. Compared to subjects with ischemic deferred lesions, clinical outcomes in subjects with non-ischemic deferred lesions according to functional severity are favorable. However, longer-term follow-up may be necessary.</P>
( Won Ho Choi ),( Sung Uk Kwon ),( Yoon Jung Jwa ),( Jung A Kim ),( Yun Ho Choi ),( Je Ho Chang ),( Hoon Jung ),( Joon Hyung Doh ),( June Namgung ),( Sung Yun Lee ),( Won Ro Lee ) 대한내과학회 2009 The Korean Journal of Internal Medicine Vol.24 No.2
Background/Aims: Many prognostic models have been developed to help physicians make medical decisions on treating patients with pulmonary embolism. Among these models, the Pulmonary Embolism Severity Index (PESI) has been shown to be a successful risk stratification tool for patients with acute pulmonary embolism. The PESI, however, had not been applied to patients with pulmonary embolism in Korea. Methods: The patients included in this study were diagnosed by computed tomography at Inje University`s Ilsan Paik Hospital between December 1999 and March 2007. Risk stratification for the patients was performed using the PESI. The mortality rate was calculated according to each PESI risk class. Results: Of the 90 patients enrolled in this study, ten were assigned to PESI class I, 29 to PESI class II, 22 to PESI class III, eight to PESI class IV, and ten to PESI class V. The mortality rate after 30 days in each class was 0, 10.3, 9.1, 0, and 50% (p=0.0016), respectively, whereas the respective hospital mortality rate was 4.8, 13.8, 13.6, 12.5, and 50% (p=0.0065). The overall mortality was 9.5, 27.6, 31.8, 50.0, and 60%, respectively (p=0.0019). The mortality rate was significantly associated with the PESI class. Conclusions: The PESI class was found to be significantly correlated with the 30-day mortality rate, hospital mortality, and overall mortality. Our data indicate that the PESI can be used to predict the prognosis of patients with pulmonary embolism and in making medical decisions regarding the treatment of patients with pulmonary embolism. (Korean J Intern Med 2009;24:123-127)
Symmetry Transitions of Polymer-Grafted Nanoparticles: Grafting Density Effect
Yun, Hongseok,Yu, Ji Woong,Lee, Young Jun,Kim, Jin-Seong,Park, Chan Ho,Nam, Chongyong,Han, Junghun,Heo, Tae-Young,Choi, Soo-Hyung,Lee, Doh C.,Lee, Won Bo,Stein, Gila E.,Kim, Bumjoon J. American Chemical Society 2019 Chemistry of materials Vol.31 No.14
<P>We examined the packing structure of polystyrene-coated gold nanoparticles (Au@PS) as a function of grafting density. A series of Au@PS nanoparticles with grafting densities in the range of 0.51-1.94 chains nm<SUP>-2</SUP> were prepared by a ligand exchange process using thiol-terminated PS and then self-assembled at a liquid-air interface. We observed a transition from disordered to body-centered cubic (bcc) to face-centered cubic (fcc) arrangements with increasing grafting density, even though the ligand length-to-core radius ratio (λ) was as high as 3.0, a condition that typically favors nonclose-packed bcc symmetry in the self-assembly of hard nanoparticles. To explain this phenomenon, we define λ<SUB>eff</SUB> to include the concentrated polymer brush regime as part of the “hard core”, which predicts that the softness of Au@PS nanoparticles is reduced from 1.53 to 0.14 in a theta solvent as the grafting density increases from 0.51 to 1.94 chains nm<SUP>-2</SUP>. This new definition of λ can also predict the effective radii of nanoparticles using the established optimal packing model. The experimental findings are supported by a combination of coarse-grained molecular dynamics simulation and adaptive common neighbor analysis, which show that changes in grafting density can drive the observed transitions in nanoparticle packing. These studies provide new insights for controlling the self-assembled symmetries of polymer-coated nanocrystals using a simple ligand exchange process to tune particle softness.</P> [FIG OMISSION]</BR>
원심 오일 정화기의 유동 특성 및 여과효율 증대를 위한 개선연구
정호윤(Ho-Yun Jung),최윤환(Yoon-Hwan Choi),이연원(Yeon-Won Lee),도덕희(Deog-Hee Doh) 한국마린엔지니어링학회 2010 한국마린엔지니어링학회 학술대회 논문집 Vol.2010 No.4
The centrifugal oil purifier is used in ships for purifying the engine lubrication oil. The momentum needed for the rotation of the cylindrical chamber is obtained by jet injections. The dust particles in the oil are separated by the centrifugal forces moving to the inner wall of the rotating cylindrical chamber body. The dust particles are eliminated when the particles are adsorbed onto the surface of the inner wall of the chamber body. the flow characteristics and the physical behaviours of particles in this centrifugal oil purifier have been investigated numerically and the filtration efficiencies have been evaluated. For the calculations, a commercial code has been used and the SST k-ω turbulence model has been adopted. the MRF(Multiple Reference Frame) method has been introduced to consider the rotating effect of the flows.
건강진단자에서 복부초음파검사상 나타난 공간점유간병소에 대한 임상적 고찰
김기윤(Ki Yun Kim),이헌주(Heon Ju Lee),서정일(Jeong Ill Suh),박찬원(Chan Won Back),이동준(Dong Jun Lee),송영두(Young Doo Song),도갑석(Gab Suk Doh),전경진(Kweong Jin Jeon),김준환(Jun Hawn Kim) 대한내과학회 1996 대한내과학회지 Vol.51 No.2
N/A Objectives: Ultrasonography(USG) is widely used for the screening and detection of liver SOL in pa- tients with acute and chronic hepatopathy, but the prevalence of liver SOL on a nonselected population by ultrasonographic screening examination is not well know. We experienced some patients with liver SOL in a automated med-screening center visitor by USG and reviewed the prevalence and clinical aspects of liver SOL detected by USG in a view of dynamic relation to hepatoma. Methods: Form March 1983 to April 1994, USG was performed on 27,140 visitors from a urban and suburban area of Taegu city. Initial USG of the liver was followed by follow up USG and other imaging modalities in case it was necessary. Results: 1) Liver SOL was detected in 337 cases(1.24%) of 27140 examinees by initial screening USG. 2) Among 337 cases of liver SOL 226(67.1%) of cyst, 19(5.7%) of hepatoma, 15(4.5%) of hemangioma, 12(3.6%) of polycystic kidney, 2(0.6%) of metastatic cancer, 1(0.3%) of abscess, 22(6.5%) of false positive finding without SOL and 40 cases(11.9%) of nonspecific questionable SOL without confirmation were noted at the end. 3) The sensitivity of USG detecting liver SOL was 93.5% and 100.0%, 93.3% and 94.7 in cyst, hemangioma and hepatoma respectively. False positivity of USG was 6.5%. 4) The incidence rate of hepatoma is presumed to be 8.1 and 3.5 per 100,000 in male nad female, respectively. Coclusion: The prevalence of liver SOL in general population by USG screening was presumed to be 1.24%. USG screening and follow up examination might be needed for the detection of benign and
신축공동주택의 설내공기오염 평가를 위한 간이프로그램 개발
이윤규(Lee. Yun-Gyu),한길원(Han Kil-Won),도주희(Doh Joo-Hee) 대한건축학회 2004 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.24 No.1
The quantity and harmfulness of pollutants that originate in architectural materials increase more and more. At present, we need ventilation system that can effectively remove extremely small quantities of noxious pollutant and basic research that institutes guidelines to prevent accumulation pollutants indoors.<br/> It is time to request "the Healthy Buildings" for agreeable residential environment. So, the aims of this study are to establish developing synthetic design supporting program relation to ventilation system and coordinating information of indoor air.