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도시경관에 있어서 높이기준유형별 건축물의 형태적 특징에 관한 연구
김도년,임희지 대한건축학회 2004 대한건축학회논문집 Vol.20 No.8
Height control is about providing light and air on the streets and managing urban cityscape In order to achieve these goals, major cities in foreign countries are administering various unique height control methods that are adaptable to the city And by examining the architectural characteristics of the cities with various height control methods the following conclusions have been made In most modern cities excluding European historical cities paris and Berlin height limits are eased and controlled by each lot based on the widths of the adjacent streets There is a tendency to lighten the height limits as the height is controlled improvement as it interrupts the continuity of streets results in excessive tall towers and produces abnormal form of buildings like slanted facets Cities like New York and Tokyo, which previously controlled the height by lot are now adopting height-controlling by district in order to create unified street landscapes Recently seoul has introduced block height limits a form of district height controlling methods but it seems that there is a need for various height limits in the areas of atypical urban tissue and of unique characteristics so that they can be applied to the whole city.
지역경제 활성화를 위한 환경정비형 지구단위계획의 시행평가 연구
배웅규,김도년 대한건축학회 2005 대한건축학회논문집 Vol.21 No.2
The purpose of this study is to propose new District Unit Plan approach to meet changes in social and urban circumstances; existing built-up areas and the need for business improvement in the process of urban development. The paper's significance lies in that it shows a new direction in urban design which has been made into a district unit plan through in support of the application to the pilot project compared with previous physical and business environment. The proposed urban design technique for the improvement of existing commercial areas, specially commercial streets have advantages. Local Government' initiation makes possible to make improvement and give administrative and financial support which is sensitive to the existing conditions of urban area for the better environment. Also it can maintain and improve the vitality of existing retail street by taking into account it's potentiality. This new application can maximize not only the effect of improvement of existing commercial district but also the build of community board can be mutual communication channer of public sector. Thus, this research suggests how district unit plan as a newly organized urban design system can cope with collaborating a community board and a local government.
Expression of Viral MicroRNAs in Epstein-Barr Virus-Associated Gastric Carcinoma
Kim, Do Nyun,Chae, Hiun-Suk,Oh, Sang Taek,Kang, Jin-Hyoung,Park, Cho Hyun,Park, Won Sang,Takada, Kenzo,Lee, Jae Myun,Lee, Won-Keun,Lee, Suk Kyeong American Society for Microbiology 2007 Journal of virology Vol.81 No.2
<B>ABSTRACT</B><P>Epstein-Barr virus (EBV) is associated with about 6 to 16% of gastric carcinoma cases worldwide. Expression of the EBV microRNAs (miRNAs) was observed in B cells and nasopharyngeal carcinoma cells infected with EBV. However, it is not clear if the EBV miRNAs are expressed in EBV-associated gastric carcinomas (EBVaGCs). We found that BART miRNAs but not BHRF1 miRNAs were expressed in EBV-infected gastric carcinoma cell lines and the tumor tissues from patients as well as the animal model. The expression of viral miRNAs in EBVaGCs suggests that these EBV miRNAs may play important roles in the tumorigenesis of EBVaGCs.</P>
The impact of steatosis on liver stiffness measurement in patients with chronic hepatitis B.
Kim, Seung Up,Kim, Do Young,Ahn, Sang Hoon,Kim, Hee Man,Lee, Jung Min,Chon, Chae Yoon,Park, Young Nyun,Han, Kwang-Hyub,Park, Jun Yong G. Thieme 2010 Hepato-gastroenterology Vol.57 No.101
<P>BACKGROUND/AIMS: Recently, several studies have indicated that liver stiffness measurement (LSM) using FibroScan accurately predicts liver fibrosis. This study investigated the impact of steatosis on LSM in patients with chronic hepatitis B (CHB). METHODOLOGY: The study prospectively enrolled 162 patients (106 men and 56 women) with CHB who underwent both a liver biopsy and LSM between January 2005 and June 2008. We examined the overall univariate correlation between steatosis and LSM value and also performed a multivariate regression analysis to identify independent variables influencing LSM values. RESULTS: The mean age of the patients was 44.4 years and the mean body mass index was 23.3 +/- 2.8kg/m2. The fibrosis stage ranged from F1 to F4 in 16 patients (9.9%), 37 (22.8%), 17 (10.5%) and 92 (56.8%), respectively. Steatosis was S0 in 128 patients (79.0%), S1 in 28 (17.3%), S2 in 6 (3.7%) and S3 in none. No overall significant correlation was noted between LSM value and steatosis (r = 0.023, p = 0.770). In the multivariate linear regression analysis, only fibrosis stage showed statistical significance (r = 0.268, p < 0.001), while steatosis did not (r = 0.013, p = 0.841). CONCLUSIONS: Our findings suggest that mild to moderate steatosis does not have a significant impact on LSM values in patients with CHB.</P>
Usefulness of FibroScan for Detection of Early Compensated Liver Cirrhosis in Chronic Hepatitis B
Kim, Do Young,Kim, Seung Up,Ahn, Sang Hoon,Park, Jun Yong,Lee, Jung Min,Park, Young Nyun,Yoon, Ki Tae,Paik, Yong Han,Lee, Kwan Sik,Chon, Chae Yoon,Han, Kwang-Hyub Springer-Verlag 2009 Digestive diseases and sciences Vol.54 No.8
Kim, Beom Kyung,Kim, Do Young,Park, Jun Yong,Ahn, Sang Hoon,Chon, Chae Yoon,Kim, Ja Kyung,Paik, Yong Han,Lee, Kwan Sik,Park, Young Nyun,Han, Kwang Hyub Blackwell Publishing Ltd 2010 Liver International Vol.30 No.4
<P>Abstract</P><P>Backgrounds</P><P>To optimize management and predict long-term clinical courses in patients with chronic hepatitis B (CHB), noninvasive tests to determine the degree of hepatic fibrosis have been developed.</P><P>Aims</P><P>This study aimed to validate a simple, noninvasive FIB-4 index, which was first derived from an HCV–HIV-co-infected population, in patients with CHB and to compare it with other noninvasive tests for predicting cirrhosis.</P><P>Methods</P><P>From 2006–2008, a total of 668 consecutive CHB patients who underwent liver biopsies were enrolled. The fibrosis stage was assessed according to the Batts and Ludwig system by a single pathologist blinded to patients' data.</P><P>Results</P><P>For prediction of significant (<I>F</I>≥2) and severe (<I>F</I>≥3) fibrosis, and cirrhosis (<I>F</I>=4), the area under the receiver-operating characteristic curves were 0.865, 0.910 and 0.926 respectively. In predicting cirrhosis, it demonstrated diagnostic values comparable to the age–spleen platelet ratio index (0.937, <I>P</I>=0.414) and age–platelet index (0.928, <I>P</I>=0.888), and better outcomes than spleen–platelet ratio index (0.882, <I>P</I>=0.007), aspartate aminotransferase (AST)–platelet ratio index (0.731, <I>P</I><0.001) and AST–alanine aminotransferase ratio index (0.730, <I>P</I><0.001). FIB-4 cut-offs of 1.6 and 3.6 provided 93.2% negative predictive value and 90.8% positive predictive value for detection of cirrhosis respectively. Based on these results, liver biopsy could be avoided in 70.5% of the study population. These cut-offs were validated internally using bootstrap resampling methods, showing good agreement.</P><P>Conclusions</P><P>FIB-4 is a simple, accurate and inexpensive method of predicting cirrhosis, with outcomes comparable to other noninvasive tests and may reduce the need for liver biopsy in the majority of CHB patients.</P>
Biogenesis of Epstein-Barr virus microRNAs.
Kim, Do Nyun,Lee, Suk Kyeong Dr. W. Junk B. V. Publishers ; Kluwer Academic Pub 2012 MOLECULAR AND CELLULAR BIOCHEMISTRY - Vol.365 No.1
<P>Epstein-Barr virus (EBV) is a ubiquitous human herpesvirus implicated in lymphomas, such as Burkitt's lymphoma, Hodgkin's lymphoma, and NK/T cell lymphoma. MicroRNAs (miRNAs) are 19-25 nucleotide long single-stranded RNAs involved in post-transcriptional gene regulation. miRNAs are mainly transcribed by RNA polymerase II (pol II) to have stem-loop structures and subsequently processed by Drosha and Dicer. EBV miRNAs are expressed in B cells, nasopharyngeal carcinoma cells, and gastric carcinoma cells infected with EBV. EBV miRNAs can be divided into two groups: BHRF1 miRNAs and BART miRNAs. In this study, we investigated the biogenesis of EBV miRNAs. Treatment of the SNU-719 EBV-positive gastric cancer cell line with 관-amanitin at a concentration that selectively inhibits RNA polymerase II activity decreased the expression levels of BART miRNAs. The expression levels of BART miRNAs were also reduced by RNA interference targeting Drosha and Dicer. Two of each C/EBP관 and c-Myc binding sites are located upstream of the proposed initiation sites for primary BART miRNA transcripts. Knockdown of C/EBP관 but not c-Myc using siRNAs reduced BART miRNA expression by 25-55% compared with the control. These results suggest that BART miRNAs are transcribed by pol II and undergo a similar biogenesis process with cellular miRNAs.</P>