Research of Online Reviews Deviation for Sales in B2C Plafform

Wenjun Liu,Lin Ding,Cuibo Wang 보안공학연구지원센터 2016 International Journal of Hybrid Information Techno Vol.9 No.8

This research focuses on online reviews deviation in B2C platform, and tries to analyze the phenomenon that shops which have large sales volume are lowly recommended compared with the average in Tmall. After verifying the validity of online reviews, we find out that the consumers' sensibility for negative comments become weaker. And the sellers’ sincerity that reflected by their replies to negative comments have little influence on sales. Only the number of total comments and positive comments can obviously influence on sales . Shops, in B2C platform, just concern about taking part in sales promotion to create hot products, instead of devoting to the quality of service. B2C platform whose primary business is selling entrance of users flow, prefers to protect large sellers, and the unreasonable rules in online reviews is the main reason for partial failure in the influence of reviews to sales.

Polymorphism of Growth Hormone Gene in 12 Pig Breeds and Its Relationship with Pig Growth and Carcass Traits

Wang, Wenjun,Huang, Lusheng,Gao, Jun,Ding, NengShui,Chen, Kefei,Ren, Jun,Luo, Ming Asian Australasian Association of Animal Productio 2003 Animal Bioscience Vol.16 No.2

The polymorphism of the growth hormone gene in 12 pig breeds (total n=475) was detected by PCR-Apa I-RFLP, and allele A (449 bp, 101 bp and 55 bp) or allele B (316 bp, 133 bp, 101 bp and 55 bp) were observed. In these pig breeds, we found that European pig breeds had high frequencies of allele B, while Chinese native pig breeds had high frequencies of allele A. In addition, the role of porcine GH was investigated in 117 Nanchang White pigs and 361 Large Yorkshire pigs. Eight traits about growth and carcass were recorded for analyzing associations between GH gene polymorphism and performance quantitative traits. In the Nanchang White pigs, no significant difference was observed between different genotypes and different growth and carcass traits. In Large Yorkshire pigs, those with BB genotype had more lean percentage than pigs with AA genotype (p<0.05). Based on these results, we conclude that the GH locus should be further investigated in commercial breeds to determine its suitability for use in marker-assisted selection programmes.

Progranulin Controls Sepsis via C/EBPα-Regulated <i>Il10</i> Transcription and Ubiquitin Ligase/Proteasome-Mediated Protein Degradation

Yan, Wenjun,Ding, Aihao,Kim, Ha-Jeong,Zheng, Hua,Wei, Fang,Ma, Xiaojing American Association of Immunologists 2016 Journal of Immunology Vol. No.

<P>Progranulin (PGRN) is a widely expressed, pleiotropic protein that is involved in diverse biological processes, including cellular proliferation, neuron development, and wound healing. However, the role of PGRN in the regulation of pathogen-induced systemic inflammation and the mechanisms involved have not been established. In this study, we show that PGRN-deficient mice display heightened mortality in models of polymicrobial sepsis and endotoxinemia, with increased tissue levels of inflammatory cytokines and reduced IL-10 production. Conversely, administration of rPGRN decreases the susceptibility of PGRN-deficient mice to LPS-induced endotoxemic shock and augments IL-10 production by LPS-activated macrophages in a TNFR-dependent manner. Molecular analysis reveals a direct role of the transcription factor C/EBP alpha in PGRN-regulated IL-10 expression. C/EBP alpha-deficient macrophages produce less IL-10 in response to LPS. Furthermore, mice deficient in C/EBP alpha in hematopoietic cells are highly vulnerable to LPS-induced septic shock. Lastly, the defective IL-10 production by PGRN-deficient cells is primarily due to reduced C/EBP alpha protein stability via the E3 ubiquitin-conjugating enzyme E6AP and proteasome-mediated degradation. To our knowledge, this study provides the first evidence that PGRN is a nonredundant regulator of systemic inflammation via modulating the levels and activity of C/EBP alpha, IL-10, and the ubiquitin-proteasome proteolysis pathway. The results bear strong and profound implications for PGRN insufficiency and its mutation-associated systemic and organ-specific inflammatory human diseases.</P>

Ecosystem Services Provided by Heavy Metal Contaminated Soils in China

Kengbo Ding,Qing Wu,Hang Wei,Wenjun Yang,Geoffroy Sere,Shizhong Wang,Guillaume Echevarria,Yetao Tang,Juan Tao,Jean Louis Morel,Rongliang Qiu 한국토양비료학회 2016 한국토양비료학회 학술발표회 초록집 Vol.2016 No.10

Risk Factors of Colorectal Stricture Associated with Developing High-Grade Dysplasia or Cancer in Ulcerative Colitis: A Multicenter Long-term Follow-up Study

Weimin Xu,Wenjun Ding,Yubei Gu,Long Cui,Jie Zhong,Peng Du 거트앤리버 소화기연관학회협의회 2020 Gut and Liver Vol.14 No.5

Background/Aims: The risk factors of colorectal stricture associated with ulcerative colitis (UC) carcinogenesis in the long-term disease duration remain unclear. Methods: This study included all UC patients registered from a prospectively maintained database between June 1986 to July 2018. The demographic data, clinical features, and outcomes in patients with dysplasia and stricture were assessed using univariable analysis and multivariate logistic regression models. Results: A total of 246 eligible patients were included in the analysis. The median follow-up time was 13.0 years (interquartile range [IQR], 9.0 to 16.0). There were 35 cases (14.2%) of colorectal stricture. Patients with stricture had worse clinical outcomes. Stricture formation (odds ratio [OR], 9.350; 95% confidence interval [CI], 2.842 to 30.762), inflammatory polyps (OR, 5.464; 95% CI, 1.692 to 17.638), disease duration of more than 10 years (OR, 3.223; 95% CI, 1.040 to 9.985), and age >40 years at diagnosis (OR, 8.499; 95% CI, 1.903 to 37.956) were significantly associated with high-grade dysplasia or colorectal cancer. In addition, disease duration of more than 5 years (OR, 3.211; 95% CI, 1.168 to 8.881), moderated anemia (OR, 3.373; 95% CI, 1.472 to 7.731), and primary sclerosing cholangitis (OR, 5,842; 95% CI, 1.395 to 24.468) were contributing factors for the development of colorectal stricture. Conclusions: Colorectal stricture had the highest risk for malignant transformation. Earlier initiation of colonoscopic surveillance in UC patients with risk factors for stricture should be considered to prevent stricture formation and further malignant transformation.

Mechanical behavior of outer square inner circular concrete-filled dual steel tubular stub columns

Fa-Xing Ding,Wenjun Wang,Xue-mei Liu,Liping Wang,Yi Sun 국제구조공학회 2021 Steel and Composite Structures, An International J Vol.38 No.3

The mechanical behavior of the outer square inner circular concrete-filled dual steel tubular (SCCFT) stub columns under axial compression is investigated by means of experimental research, numerical analysis and theoretical investigation. Parameters such as diameter ratio, concrete strength and steel ratio were discussed to identify their influence on the mechanical properties of SCCFT short columns on the basis of the experimental investigation of seven SCCFT short columns. By establishing a finite element model, nonlinear analysis was performed to discuss the longitudinal and transverse stress of the dual steel tubes. The longitudinal stress characteristics of the core and sandwich concrete were also analyzed. Furthermore, the failure sequence was illustrated and the reasonable cross-section composition of SCCFT stub column was proposed. A formula to predict the axial load capacity of SCCFT stub column was advanced and verified by the results from experiment and the finite element.

Integrated omics approaches to characterize a nuclear receptor corepressor-associated histone deacetylase in mouse skeletal muscle

Gong, Yingyun,Cao, Rui,Ding, Guolian,Hong, Sungguan,Zhou, Wenjun,Lu, Wenyun,Damle, Manashree,Fang, Bin,Wang, Chuhan C.,Qian, Justin,Lie, Natasha,Lanzillotta, Cristina,Rabinowitz, Joshua D.,Sun, Zheng Elsevier 2018 Molecular and cellular endocrinology Vol.471 No.-

<P><B>Abstract</B></P> <P>Nuclear receptors regulate gene expression by differentially binding to coactivators or corepressors in a ligand-dependent manner, which further recruits a set of epigenome-modifying enzymes that remodel chromatin conformation. Histone acetylation is a major epigenomic change controlled by histone acetyltransferases (HATs) and histone deacetylases (HDACs). HDAC3 is the only HDAC that confers the enzymatic activity to the complexes nucleated by nuclear receptor corepressors NCoR and SMRT. To address the metabolic function of HDAC3, we have deleted it specifically in mouse skeletal muscles. We have performed the following omics profiling in skeletal muscles of these mice: (1) RNA-seq profiling of total RNA; (2) Global nuclear run-on (GRO-seq) analysis of nascent RNAs; (3) Chromatin immuno-precipitation (ChIP-seq) of HDAC3 at both early evening and early morning; (4) proteomics profiling with mass spectrometry; (5) snap-shot metabolomics profiling of water-soluble metabolites at the basal condition; (6) snap-shot metabolomics profiling of lipid species at the basal condition; (7) kinetic fluxomics analysis of glucose utilization using <SUP>13</SUP>C<SUB>6</SUB>-glucose <I>In vivo</I> during treadmill running exercise. These approaches have provided several novel insights into how nuclear receptors regulate circadian rhythm of skeletal muscle fuel metabolism, which has been published elsewhere. Here we present the original datasets and technical details during the execution, analysis, and interpretation of these omics studies.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A mouse model with skeletal muscle-specific KO of HDAC3. </LI> <LI> <I>in vivo</I> RNA-seq, GRO-seq, and ChIP-seq identified relevance to circadian clock. </LI> <LI> Total proteome profiling in muscle samples. </LI> <LI> Metabolomics profiling identified disruption of BCAAs metabolism. </LI> <LI> Fluxomics with <SUP>13</SUP>C-glucose <I>in vivo</I> during treadmill running. </LI> </UL> </P>

Surgical Options for Appropriate Length of J-Pouch Construction for Better Outcomes and Long-term Quality of Life in Patients with Ulcerative Colitis after Ileal Pouch-Anal Anastomosis

Xu Weimin,Tang Wenbo,Ding Wenjun,Hua Zhebin,Wang Yaosheng,Ge Xiaolong,Cui Long,Wu Xiaojian,Zhou Wei,Ding Zhao,Du Peng 거트앤리버 소화기연관학회협의회 2024 Gut and Liver Vol.18 No.1

Background/Aims: Total proctocolectomy with ileal pouch-anal anastomosis (IPAA) is widely accepted as a radical surgery for refractory ulcerative colitis (UC). Definite results on the appropriate pouch length for an evaluation of the risk-to-benefit ratio regarding technical complications and long-term quality of life (QOL) are still scarce. Methods: Data on UC patients who underwent IPAA from 2008 to 2022 in four well-established pouch centers affiliated to China UC Pouch Center Union were collected. Results: A total of 208 patients with a median follow-up time of 6.0 years (interquartile range, 2.3 to 9.0 years) were enrolled. The median lengths of the patients’ short and long pouches were 14.0 cm (interquartile range, 14.0 to 15.0 cm) and 22.0 cm (interquartile range, 20.0 to 24.0 cm), respectively. Patients with a short J pouch configuration were less likely to achieve significantly improved long-term QOL (p=0.015) and were prone to develop late postoperative complications (p=0.042), such as increased defecation frequency (p=0.003) and pouchitis (p=0.035). A short ileal pouch was an independent risk factor for the development of late postoperative complications (odds ratio, 3.100; 95% confidence interval, 1.519 to 6.329; p=0.002) and impaired long-term QOL improvement (odds ratio, 2.221; 95% confidence interval, 1.218 to 4.050, p=0.009). Conclusions: The length of the J pouch was associated with the improvement in long-term QOL and the development of late post-IPAA complications. A long J pouch configuration could be a considerable surgical option for pouch construction.

Ultralarge elastic deformation of nanoscale diamond

Banerjee, Amit,Bernoulli, Daniel,Zhang, Hongti,Yuen, Muk-Fung,Liu, Jiabin,Dong, Jichen,Ding, Feng,Lu, Jian,Dao, Ming,Zhang, Wenjun,Lu, Yang,Suresh, Subra American Association for the Advancement of Scienc 2018 Science Vol.360 No.6386

<P>Diamonds have substantial hardness and durability, but attempting to deform diamonds usually results in brittle fracture. We demonstrate ultralarge, fully reversible elastic deformation of nanoscale (similar to 300 nanometers) single-crystalline and polycrystalline diamond needles. For single-crystalline diamond, the maximum tensile strains (up to 9%) approached the theoretical elastic limit, and the corresponding maximum tensile stress reached similar to 89 to 98 gigapascals. After combining systematic computational simulations and characterization of pre- and postdeformation structural features, we ascribe the concurrent high strength and large elastic strain to the paucity of defects in the small-volume diamond nanoneedles and to the relatively smooth surfaces compared with those of microscale and larger specimens. The discovery offers the potential for new applications through optimized design of diamond nanostructure, geometry, elastic strains, and physical properties.</P>