Involvement of Nrf2-Mediated Upregulation of Heme Oxygenase-1 in Mollugin-Induced Growth Inhibition and Apoptosis in Human Oral Cancer Cells

Lee, Young-Man,Auh, Q-Schick,Lee, Deok-Won,Kim, Jun-Yeol,Jung, Ha-Jin,Lee, Seung-Ho,Kim, Eun-Cheol Hindawi Publishing Corporation 2013 BioMed research international Vol.2013 No.-

<P>Although previous studies have shown that mollugin, a bioactive phytochemical isolated from <I>Rubia cordifolia</I> L. (Rubiaceae), exhibits antitumor effects, its biological activity in oral cancer has not been reported. We thus investigated the effects and putative mechanism of apoptosis induced by mollugin in human oral squamous cell carcinoma cells (OSCCs). Results show that mollugin induces cell death in a dose-dependent manner in primary and metastatic OSCCs. Mollugin-induced cell death involved apoptosis, characterized by the appearance of nuclear shrinkage, flow cytometric analysis of sub-G<SUB>1</SUB> phase arrest, and annexin V-FITC and propidium iodide staining. Western blot analysis and RT-PCR revealed that mollugin suppressed activation of NF-<I><I>κ</I></I>B and NF-<I><I>κ</I></I>B-dependent gene products involved in antiapoptosis (Bcl-2 and Bcl-xl), invasion (MMP-9 and ICAM-1), and angiogenesis (FGF-2 and VEGF). Furthermore, mollugin induced the activation of p38, ERK, and JNK and the expression of heme oxygenase-1 (HO-1) and nuclear factor E2–related factor 2 (Nrf2). Mollugin-induced growth inhibition and apoptosis of HO-1 were reversed by an HO-1 inhibitor and Nrf2 siRNA. Collectively, this is the first report to demonstrate the effectiveness of mollugin as a candidate for a chemotherapeutic agent in OSCCs via the upregulation of the HO-1 and Nrf2 pathways and the downregulation of NF-<I><I>κ</I></I>B.</P>

수학수업의 흥미유발을 위한 수학사 및 예화자료 연구 : 수학Ⅰ을 중심으로

이덕호,이만희 한국학교수학회 2000 韓國學校數學會論文集 Vol.3 No.1

This study has been done to help teach mathematics on the spot of education by providing the history of mathematics and illustrations concerning mathematics, which were rearranged for the level of the second grade students in highschool and intented to interest students in mathematics classes. The contents of teaching, according to each unit (Matrix, Sequence, Limit, Differentiation, Integration, Probability, Statistics) include the life of the representative mathematician, the historical background centered on episodes, questions linked with reality, questions making sensations in history and something for maxim in mathematics. If such contents are properly used, they are expected to be able to stimulate students' curiosity, and to be effective in improving students' learning ability in mathematics by causing them to show their active attitudes toward learning mathematics.

일반화된 적분의 Fubini 정리

이덕호 공주대학교 사범대학 과학교육연구소 1998 과학교육연구 Vol.29 No.1

In this paper, we generalize Riemann, Lebesgue, Mcshane and Henstock integral and define integral structure. Given integral structure ??, we defined an outer measure ??. We prove that if ?? and ?? are integral structure of λ and μ and ?? is countably subadditive then for any absolutely ?? -integrable function f the following equality holds. ?? 이 논문에서는 종래의 Riemann, Lebesgue, Mcshane, Henstock 적분 등을 일반화하여 적분구조를 정의하고 주어진 적분구조 ??에 대하여 외측도??를 정의하였으며 주어진 두 적분구조 ??, ?? 에 대하여 외측도 ??가 가산 준가법성을 만족하면 함수 f가 ??-적분 가능할 때 Fubini정리 ?? 가 성립함을 증명하였다.

라이만합을 이용한 Fuzzy 적분의 정의

이덕호 공주대학교 사범대학 과학교육연구소 2000 과학교육연구 Vol.31 No.1

Fuzzy 측도공간에서의 함수에 대하여 논리합과 논리곱에 대한 Riemann 합을 만들어 그 극한을 적분으로 정의할 때 함수가 가측이고 유계이면 적분가능하고 이 적분값은 Fuzzy 적분과 일치한다는 것을 증명하였다. In this note we introduce a new type of integration of functions with respect to a fuzzy measure. In the definition of the new integral, we use the Riemann type sum. We investigate the relation between the new integral and the classical fuzzy integral.

궤적 정보를 이용한 냉동 컨테이너 모니터링 시스템

이명진,이응재,하덕천,류근호,백승재 한국지리정보학회 2005 한국지리정보학회지 Vol.8 No.1

위성 통신 기술의 발달로 국부적으로 수행리던 위치 추적의 범위가 선 세계로 3~4간되었다 하지만 기존의 물류 관제 시스템들은 관제 서버와 물류간의 통신을 위하여 휴대폰 통신망을 이용하기 때문에 일부 지역 내에서 이동하는 물류에 대해서만 관제가 가능하다. 이 논문에서는 위성 통신을 이용하여 전 세계를 이동하는 물류 매체인 냉동 컨테이너의 위치 및 상태 정보를 관리하기 위한시스템을 제안하였다. 제안 시스템은 냉동 컨테이너의 상태를 직절 관제하는 데이터 수집부, 관제서버와의 통신을 담당하는 위성 통신부, 냉동 컨테이너 정보를 판리하는 관제부로 구성된다. 시스템의 관제부에서는 냉동 컨테이너의 위치 주적 및 관제를 효과적으로 수행하기 위하여 기존의 TB 트리를 기반으로 하는 다중 버전 이동 객체 색인을 사용하였다. 제안된 냉동 컨테이너 관제시스템은 화주, 운송회사 등 육해상 물류관련 기관에서 냉동컨테이너 및 선박 위치추적, 컨테이너 통제, 컨테이너 통계 등 다양한 용도로 사용될 수 있어 화주에게는 컨테이너 운송에 대한 서비스를 제공하며, 선사에게는 선박안전경보시스템, 선박 관리, 냉동컨테이너를 효율적인 관리 기능을 제공하게 한다. As developing satellite communication, the tracking range of the moving objects which move in local area is expanded to the whole world. However previous logistics management system is able to monitor freight which transporting in local area using mobile communication system. In this paper, we propose the reefer container management system that manages the location information and other related information such as temperature, humidity of container using the satellite system. The proposed system consists of three parts; data collector, satellite communication manager, reefer container information manager. And the proposed system uses the moving object index for managing the trajectory of container and tracing the location of container or vessel that is transporting the container, and supports various services such as reefer container and vessel tracking, container control and container statistics to logistic companies like shipper and forwarding agent. And the system can be increasing the quality of container transportation service to the shipper, and it makes the efficient management of reefer container to the shipping company.

횡성댐건설사업

이정호,장덕제 慶熙大學校 社會科學硏究院 行政硏究所 1993 行政問題硏究 Vol.1 No.1

변수에 의한 함수 지도가 함수개념의 형성에 미치는 효과

이덕호,길영순 한국학교수학회 2001 韓國學校數學會論文集 Vol.4 No.1

The purpose of this study is to develop learning materials for functional concept on variable and to verify the effect of how well students could learn functional concept after they studied with those materials. To accomplish the purpose of this study, I developed learning materials and after teaching students with them. I have concluded the followings : First, there was little effect in teaching functional concept on variable between two experimental groups, whereas teaching functional concept had greater effect on forming functional concept in high level groups in those two experimental groups. Second, teaching functional concept on variable had little effect on students' understanding of functional concept and perfecting tables in Black box, graph, and mathematical problems, whereas there was much effect in students' understanding functional concept and solving relation formula, in age, and range problems related to everyday life or general things. On the basis of the problems which appeared in the process of this study, the following can be suggested : First, we should develop learning materials fit for low level students so that they could understand functional concept. Second, we should continue to teach the basic problems like solving relation formula, image, and range, and understanding functional concept in graph until students are able to understand them exactly. Third, since the goals of Unit Function in a middle school textbook is to solve problems related to everyday life through functional thinking, there should be change in constructing systematic contents of Unit Function in a middle school textbook.

Fuzzy Difuntional Relation의 특성화

노영순,이덕호,성열욱 공주대학교 사범대학 과학교육연구소 2000 과학교육연구 Vol.31 No.1

본 눈문에서는 fuzzy difunctional relation 동치조건들을 소개하였고 이를 이용하여 fuzzy difunctional relation과 관련된 일부 결과를 제시하였으며 또한 반군에서의 퍼지합동관계를 α-cut로 특성화 하였다. In this paper, we shall introduce equivalent conditions of the fuzzy difunctional relation, give some results in connection with fuzzy difunctional relations and characterize the fuzzy congruence relation on a semigroup in terms of its α-cut. Also, closed relationship between fuzzy difunctional relations and fuzzy congruence relations will be revealed.

Polylysine을 입힌 배양면이 GH₃ 뇌하수체 종양 세포에 미치는 영향에 관한 연구

김정진,백상호,황덕호,황영일,이왕재,이병란 대한해부학회 1998 Anatomy & Cell Biology Vol.31 No.3

논리회로를 이용한 추론지도

박기석,이덕호 한국학교수학회 1998 韓國學校數學會論文集 Vol.1 No.1

We proposed the teaching method about the logical inference in highschool using Logic Network. This method that we proposed is better than Vendiagram method because that is able to represent the more conditions in plane. The contents of this paper explained the method that conclusion is drived from given conditions using Logic Network. And we gave some examples of the process of logical inference.