Cancer Pain Prevalence and its Management

Arslan, Deniz,Koca, Timur,Akar, Emre,Tural, Deniz,Ozdogan, Mustafa Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.20

Pain is a public health problem affecting more than half of cancer patients. Despite the success of the protocols currently used, pain cannot still be reduced satisfactorily in the large majority of patients. In order to improve pain management, all healthcare professionals involved with pain should have sufficient knowledge on pain assessment and treatment, and should inform patients to prevent patient-related barriers. In this compilation, the prevalence values and the treatment methods of cancer pain, and the barriers to pain management have been assessed.

Survival Results and Prognostic Factors in T4 N0-3 Non-small Cell Lung Cancer Patients According to the AJCC 7^th Edition Staging System

Arslan, Deniz,Bozcuk, Hakan,Gunduz, Seyda,Tural, Deniz,Tattli, Ali Murat,Uysal, Mukremin,Goksu, Sema Sezgin,Bassorgun, Cumhur Ibrahim,Koral, Lokman,Coskun, Hasan Senol,Ozdogan, Mustafa,Savas, Burhan Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.6

Background: The American Joint Committee on Cancer (AJCC) published a new staging system ($7^{th}$ edition) in 2009. In our study, we evaluated the survival results and prognostic factors among T4 local advanced non-small cell lung cancer (LA-NSCLC) patients in a large heterogeneous group, in accordance with this new system. Materials and Methods: We retrospectively evaluated the files of 122 T4 N0-3 M0 LA-NSCLC patients, identified according to the new staging system, treated at two centers between November 2003 and June 2012. Variables correlating with univariate survival at p<0.20 were later included in multivariate Cox regression analysis. Here, selection of relevant predictors of survival was carried out in accordance with the likelihood ratio formula with p<0.05 regarded as significant. Results: The median age was 60 and the median follow-up period was 17.4 months. Median overall survival (OS) was 18.3 months, the 1 year overall survival (OS) rate was 72%, and the 5 year OS rate was 28%. Statistically significant predictors of survival were (p<0.20) ECOG-PS (Eastern Cooperative Oncology Group Performance Status), age, T4 factor subgroup, stage and primary treatment in OS univariate analysis. On multivariate analysis for OS ECOG-PS (p=0.001), diagnostic stage (p=0.021), and primary treatment (p=0.004) were significant. In the group receiving non-curative treatment, the median OS was 11.0 months, while it was 19.0 months in the definitive RT group and 26.6 months in the curative treatment group. There was a significant difference between the non-curative group and the groups which had definitive RT and curative operations (respectively p<0.001 and p=0.001) in terms of OS, but not between the groups which had definitive RT and curative operations. The median event free survival (EFS) rate was 9.9 months, with rates of 46% and 19% at 3 and 5 years, respectively. On univariate analysis of EFS rate with ECOG-PS, weight loss and staging, statistical significance was found only for thorax computerized tomography (CT)+18F-fluorodeoxy-glucose positron emission tomography-CT (PET-CT) use, stage and primary treatment (p<0.20). In multivariate analysis with EFS, only the primary treatment was statistically significant (p=0.001). In the group receiving non-curative treatment, the median EFS was 10.5 months while in the curative operation group it was 14.7 months. When all the primary treatment groups were taken into consideration, grade III/IV side effect swas observed in 57 patients (46.6%). Esophagitis was most prominent among those that received definitive radiotherapy. Conclusions: Independent prognostic factors among these 122 heterogeneous LA-NSCLC T4 N0-3 M0 patients were age at diagnosis, ECOG-PS, stage and primary treatment, the last also being a significant prognostic indicator of EFS. Our findings point to the importance of appropriate staging and a multidisciplinary approach with modern imaging methods in this patient group. In those with T4 lesions, treatment selection and the effective use of curative potential should be the most important goal of clinical care.

Increase in the Rate of HPV Positive Oropharyngeal Cancers During 1996-2011 in a Case Study in Turkey

Tural, Deniz,Elicin, Olgun,Batur, Sebnem,Arslan, Deniz,Oz, Buge,Serdengecti, Suheyla,Uzel, Omer Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.10

Background: Primary aim of this study is to assess whether or not there is an increase at rate of HPV positive oropharyngeal cancers during 1996-2011 in Turkey, for comparison with prior reports from Western countries. Materials and Methods: A total of 138 newly diagnosed patients with oropharyngeal cancer were identified, 39 of which had no primary tumor specimen available and 18 patients with invalid HPV status, therefore HPV status for remaining 81 patients was evaluated. The presence and type of HPV DNA were determined with formalin-fixed paraffin embedded specimens, using an HPV DNA-based multiplex PCR assay. Associations between HPV status and clinicopathological characteristics were evaluated using a two-sample t-test for the continuous variables and the categorical variables were compared by chi-square test. Overall survival (OS) periods were calculated with Kaplan-Meier method. Results: The proportion of HPV-positive cancer has continued to increase during 2004-2011 as compared with 1996-2003. Notably, 33% (6/18) of the cases were HPV-positive in 1996-1999, 43% (9/21) in 2000-2003, 55% (11/20) in 2004-2007 and 70% (16/23) in 2008-2011. Thus, when we compared the results obtained during the 2004-2011with results of 1996-2003 period, we found that increase at HPV-positivity ratio was statistically significant (38% vs 64% p=0.012). Conclusions: This study demonstrated that HPV positive oropharyngeal cancers are increasing in Turkish patients as in the Western world.

Seismic-Stratigraphic study of the northern East China Sea shelf basin : Basin structure and igneous activity

DENIZ CUKUR,GWANG HOON LEE,HYUN CHUL HAN,KANG MOO HEE,KYUNG O KIM 대한지질학회 2008 대한지질학회 학술대회 Vol.2008 No.

Midterm results of kissing stent reconstruction of the aortoiliac bifurcation

Deniz Serefli,Onur Saydam,A. Yaprak Engin,Mehmet Atay 대한외과학회 2021 Annals of Surgical Treatment and Research(ASRT) Vol.101 No.4

Purpose: One subset of peripheral arterial disease is aortoiliac occlusive diseases (AIOD). AIOD is the term for all arterial lesions between the infrarenal distal aorta and common femoral artery. Implantation of kissing stents (KS) with covered stents (CS), bare-metal stents (BMS) is one of the endovascular treatment (ET) modalities for AIOD involving aortic bifurcation. In this study, we report the outcomes of the KS technique in infrarenal AIOD. Methods: Between January 2014 and September 2017, 31 patients who underwent ET were treated with KS technique either with balloon-expandable BMS or balloon-expandable CS. Technical details, clinical success, complications, and patency at follow-up were documented. Results: The majority of patients were male (77.4%), and the median age was 62 years (range, 45–78 years). All patients were classified according to the TASC II criteria. Eight patients (25.8%) were classified as TASC B. Fifteen patients (48.4%) were classified as TASC C, and 8 patients (25.8%) were classified as TASC D. These 23 patients were classified as complex AIOD group. BMS was used in 17 patients (54.8%), and CS was used in 14 patients (45.2%). Technical and clinical success was achieved in 100% of treated cases. The median follow-up was 24 months (range, 24–34 months). Primary patency rates at 12, 18, and 24 months after ET were 100%, 96.8%, and 90.3%, respectively. Conclusion: We found that the KS technique has satisfying 24-month results, even in complex AIOD lesions, with high technical success and acceptable midterm patency.

Production of SrCO3 and (NH4)2SO4 by the dry mechanochemical processing of celestite

Deniz Bingol,Salih Aydogan,Seda Karayunlu Bozbas 한국공업화학회 2012 Journal of Industrial and Engineering Chemistry Vol.18 No.2

A SrCO3 formation starting from activated SrSO4–(NH4)2CO3mixtures as a result of dry mechanochemical treatment for 180 min in a planetary ball mill of celestite together with (NH4)2CO3 was studied. The phases that formed during milling were successfully characterized by X-ray diffraction measurement (XRD), Fourier transform infrared spectroscopy (FT-IR), scanning electron microscopy (SEM), and chemical analysis. A novel hydrometallurgical process to convert both SrCO3 (product) and (NH4)2SO4(by-product) from celestite via dry mechanochemical conversion with (NH4)2CO3 was developed for the first time in this work. Under optimum conditions, the conversion of SrCO3 was 98.1%. The (NH4)2SO4leach solution was crystallized.

GPR Image Recovery Effect on Faster R-CNNBased Buried Target Detection

Deniz Kumlu 한국전자파학회 2022 Journal of Electromagnetic Engineering and Science Vol.22 No.5

Measurements acquired through ground-penetrating radar (GPR) may contain missing information that needs to be recovered before the implementation of any post-processing method, such as target detection, since buried target detection methods fail and cannot produce desired results if the input GPR image contains missing information. This study proves that the recovery of missing information in a GPR image has a direct influence on the performance of subsequent target detection methods. Thus, state-of-the-art matrix completion methods are applied to the GPR image with missing information in both pixel- and column-wise cases with different missing rates, such as 30% and 50%. After the GPR image is successfully recovered, the faster region-based convolutional neural network (Faster R-CNN) target detection method is applied. The performance correlation between matrix completion accuracy and the target detection method’s confidence score is analyzed using both quantitative and visual results. The obtained results demonstrate the importance of GPR image recovery prior to any post-processing implementation, such as target detection.

Identifying Risk Management Locations for Synthetic Natural Gas Plant Using Pipe Stress Analysis and Finite Element Analysis

Deniz Taygun Erten(데니즈 타이군 엘텐),Jong Min Yu(유종민),Kee Bong Yoon(윤기봉),Ji Yoon Kim(김지윤) 한국에너지학회 2017 에너지공학 Vol.26 No.2

Antinociceptive Effect of Chlorogenic Acid in Rats with Painful Diabetic Neuropathy

Deniz Bagdas,Hasret Yucel Ozboluk,Nilufer Cinkilic,Mine Sibel Gurun 한국식품영양과학회 2014 Journal of medicinal food Vol.17 No.6

The present study aimed to evaluate possible antinociceptive effects of chlorogenic acid in streptozotocininduced diabetic neuropathic pain in rats. Chlorogenic acid (100 mg/kg) was administered daily for 14 days. Our study showed for the first time that both single and chronic chlorogenic acid treatments produced significant antinociceptive effects in diabetic rats. In contrast, single dose of chlorogenic acid showed no signs of an antinociceptive effect, but chronic treatment exerted antinociceptive potential in nondiabetic rats. Additionally, chronic treatment effectively reduced hyperglycemia that induced by diabetes. In conclusion, chlorogenic acid has beneficial effects for the management of diabetic neuropathic pain.

Methacryloylamidohistidine in Affinity Ligands for Immobilized Metal-ion Affinity Chromatography of Ferritin

Deniz Akta Uygun,Nevra Öztürk,Sinan Akgöl,Adil Denizli 한국생물공학회 2011 Biotechnology and Bioprocess Engineering Vol.16 No.1

A new metal-chelate adsorbent utilizing 2-methacryloylamidohistidine (MAH) was prepared as a metalchelating ligand. MAH was synthesized using methacryloly chloride and histidine. Monosize nanospheres with an average diameter of 450 nm were produced by emulsion polymerization of 2-hydroxyetylmethacrylate (HEMA) and MAH. Then, Fe^(3+) ions were chelated directly onto the monosize nanospheres. Mon-poly(HEMA-MAH) nanospheres were characterized by Fourier transform infrared spectroscopy,scanning electron microscopy, and elemental analysis. Fe^(3+) chelated monosize nanospheres were used in ferritin adsorption from an aqueous solution. The maximum ferritin adsorption capacity of Fe^(3+)-chelated mon-poly(HEMAMAH)nanospheres was 202 mg/g at pH 4.0 in acetate buffer. The non-specific ferritin adsorption on the monpoly(HEMA-MAH) nanospheres was 20 mg/g. The adsorption behavior of ferritin could be modeled using both Langmuir and Freundlich isotherms. The adsorption capacity decreased with increasing ionic strength of the binding buffer. High desorption ratios (> 95% of the adsorbed ferritin) were achieved with 1.0 M NaCl at pH 7.0. Ferritin could be repeatedly adsorbed and desorbed with the Fe^(3+)-chelated mon-poly(HEMA-MAH) nanospheres without significant loss of adsorption capacity.