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RISS 인기검색어
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- 저자 : Delong KONG (검색결과 2 건)
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Fanyun Kong,Yukai Tao,Dongchen Yuan,Ning Zhang,Qi Li,Tong Yu,Xiaoying Yang,Delong Kong,Xiaohui Ding,Xiangye Liu,Hongjuan You,Kuiyang Zheng,Renxian Tang 대한암학회 2021 Cancer Research and Treatment Vol.53 No.2
Purpose C5α receptor 1 (C5ΑR1) is associated with the development of various human cancers. However, whether it is involved in the development of hepatitis B virus (HBV)–related hepatocellular carcinoma (HCC) is poorly understood. We explored the expression, biological role, and associated mechanisms of C5AR1 in HBV-related hepatoma cells. Materials and Methods The expression of C5ΑR1 mediated by HBV and HBV core protein (HBc) was detected in hepatoma cells. The function of nuclear factor кB (NF-κB) pathway in HBc-induced C5AR1 expression was assessed. The roles of C5ΑR1 in the activation of intracellular signal pathways, the upregulation of inflammatory cytokines, and the growth and migration of hepatoma cells mediated by HBc, were investigated. The effect of C5α in the development of HCC mediated by C5AR1 was also measured. Results C5ΑR1 expression was increased in HBV-positive hepatoma cells. Dependent on HBc, HBV enhanced the expression of C5ΑR1 at the mRNA and protein levels. Besides, HBc could promote C5ΑR1 expression via the NF-κB pathway. Based on the C5ΑR1, HBc facilitated the activation of JNK and ERK pathways and the expression and secretion of interleukin-6 in hepatoma cells. Furthermore, C5ΑR1 was responsible for enhancing the growth and migration of hepatoma cells mediated by HBc. Except these, C5α could promote the malignant development of HBc-positive HCC via C5AR1. Conclusion We provide new insight into the mechanisms of hepatocarcinogenesis mediated by HBc. C5ΑR1 has a significant role in the functional abnormality of hepatoma cells mediated by HBc, and might be utilized as a potential therapeutic target for HBV-related HCC.
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Zi-Hao LYU,Delong KONG,Jie CHENG,Tong Lin 한국곤충학회 2020 Entomological Research Vol.50 No.2
Cytochrome P450 monooxygenases (CYPs) play an important role in the decomposition of insecticides. Plecoptera oculata Moore is a lepidopteran forestry pest that severely affects Dalbergia odorifera T. Chen. In this study, 27 putative CYP genes were identified in the transcriptome of larval P. oculata. Phylogenetic analysis showed that these genes are grouped into four clans, 15 families, and 22 subfamilies. The tissue-specific expression profile for each gene was determined using real-time reverse transcription-quantitative PCR (RT-qPCR), and the 27 genes were found to be ubiquitously expressed, mainly in the midgut, Malpighian tubules, and fat body. The expression profiles of all 27 PoCYP genes exposed to half the lethal concentration (LC50) of sendebao and lambda-cyhalothrin were determined using RT-qPCR. The results showed that six and twelve PoCYP genes were significantly down- and up-regulated, respectively, by exposure to sendebao, and three and twelve PoCYP genes were significantly down- and up-regulated, respectively, by exposure to lambda-cyhalothrin. To the best of our knowledge, this study is the first to show the expression of CYP genes in P. oculata. Our results provide a basis for further investigation of the roles of PoCYP genes in insecticide detoxification and as potential targets for novel pesticides.
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