영동 국악체험촌 조경기본계획

"이시영", "박진아", "련등", "김대수" 배재대학교 자연과학연구소 2015 自然科學論文集 Vol.26 No.1

21세기는 지식 정보화와 병행하여 문화의 세기가 될 것으로 예견된다. 문화상품의 고부가가치를 창출하기 위하여 영동군이 보유하고 있는 국악 인프라와 연계하여 국가 문화산업의 전략적 우위를 도모하고 전통문화의 전승과 발전에 일익을 담당코저 한다. 난계 박연 선생의 탄생지인 심천면 고당리 일원에 국악을 테마로 하는 체험촌 조성이 필요하였다. 영동군에서는 한국의 정신세계를 재조명하고 전통문화에 대한 이해와 접근이 용이한 관광자원으로 국악체험촌을 건립하여 관광명소를 육성하고자 한다. The 21st century is predicted to be the century of knowledge and information and culture. To create high value of cultural goods, in conjunction with Korean Classical Music infrastructures which Yeongdong County has, this proposal was planning to be contributed to the development of traditional culture and folklore. Yeongdong County revisited in the spirit world and build an understanding of Korea and Experience Music Village with easy access to the traditional culture and tourist resources and to foster the attractions.

Age-dependent gait abnormalities in mice lacking the <i>Rnf170</i> gene linked to human autosomal-dominant sensory ataxia

Kim, Youngsoo,Kim, Seong Hun,Kim, Kook Hwan,Chae, Sujin,Kim, Chanki,Kim, Jeongjin,Shin, Hee-Sup,Lee, Myung-Shik,Kim, Daesoo IRL Press 2015 Human molecular genetics Vol.24 No.25

<P>Really interesting new gene (RING) finger protein 170 (RNF170) is an E3 ubiquitin ligase known to mediate ubiquitination-dependent degradation of type-I inositol 1,4,5-trisphosphate receptors (ITPR1). It has recently been demonstrated that a point mutation of <I>RNF170</I> gene is linked with autosomal-dominant sensory ataxia (ADSA), which is characterized by an age-dependent increase of walking abnormalities, a rare genetic disorder reported in only two families. Although this mutant allele is known to be dominant, the functional identity thereof has not been clearly established. Here, we generated mice lacking <I>Rnf170</I> (<I>Rnf170<SUP>−/−</SUP></I>) to evaluate the effect of its loss of function <I>in vivo</I>. Remarkably, <I>Rnf170<SUP>−/−</SUP></I> mice began to develop gait abnormalities in old age (12 months) in the form of asynchronous stepping between diagonal limb pairs with a fixed step sequence during locomotion, while age-matched wild-type mice showed stable gait patterns using several step sequence repertoires. As reported in ADSA patients, they also showed a reduced sensitivity for proprioception and thermal nociception. Protein blot analysis revealed that the amount of Itpr1 protein was significantly elevated in the cerebellum and spinal cord but intact in the cerebral cortex in <I>Rnf170<SUP>−/−</SUP></I> mice. These results suggest that the loss of <I>Rnf170</I> gene function mediates ADSA-associated phenotypes and this gives insights on the cure of patients with ADSA and other age-dependent walking abnormalities.</P>

Effects of the 2018 heat wave on health in the elderly: implications for adaptation strategies to climate change

Soyeon Kim,Sang-Yub Kim,Jongmin Oh,Yeora Chae,Jongchul Park,Daesoo Kim,Young-Min Kim 환경독성보건학회 2020 환경독성보건학회지 Vol.35 No.4

There has been growing concern over the effects of heat waves on health. However, the effects of heat waves on the health of individuals in vulnerable groups have rarely been examined. We aimed to investigate the acute health effects of heat waves in elderly individuals living in rural areas and to survey their adaptation capacity. Repeated measurements of body temperature (BT), blood pressure, sleep disturbance, and indoor temperature were conducted up to six times for each of 104 elderly individuals living in rural areas of South Korea during the 2018 heat wave. Changes in BT, systolic blood pressure (SBP), and diastolic blood pressure (DBP) according to variations in indoor and outdoor temperature were analyzed using linear mixed effect models controlling for age, sex, smoking, and drug use. We also surveyed heat wave adaptation capacity, heat wave shelters, and self-reported health problems. The average indoor temperature measured during the study period was 30.5℃ (range: 22.9–38.3℃) and that of ambient temperature was 30.6℃ (range: 24.6–36.3℃). BT significantly increased with indoor and outdoor temperatures. The effect on BT was greater in elderly women and the elderly with hypertension. DBP generally decreased with increasing indoor temperature, though the correlation was only statistically significant among the elderly with hypertension. Only 22 (21.2%) individuals used air conditioners during the heat wave. Most did not use an air conditioner mainly to avoid high electricity costs. Of the participants, 58.7% reported experiencing sleep disturbance, which was the most frequent self-reported health problem. Elderly individuals living in rural areas are directly exposed to high temperatures during heat waves, and their vital signs are sensitive to increases in indoor temperature due to poor adaptation capacity. Well-designed strategies for alleviating health-related stress during heat waves are necessary.

Medial septal GABAergic projection neurons promote object exploration behavior and type 2 theta rhythm

Gangadharan, Gireesh,Shin, Jonghan,Kim, Seong-Wook,Kim, Angela,Paydar, Afshin,Kim, Duk-Soo,Miyazaki, Taisuke,Watanabe, Masahiko,Yanagawa, Yuchio,Kim, Jinhyun,Kim, Yeon-Soo,Kim, Daesoo,Shin, Hee-Sup National Academy of Sciences 2016 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.113 No.23

<P>Exploratory drive is one of the most fundamental emotions, of all organisms, that are evoked by novelty stimulation. Exploratory behavior plays a fundamental role in motivation, learning, and well-being of organisms. Diverse exploratory behaviors have been described, although their heterogeneity is not certain because of the lack of solid experimental evidence for their distinction. Here we present results demonstrating that different neural mechanisms underlie different exploratory behaviors. Localized Ca(v)3.1 knockdown in the medial septum (MS) selectively enhanced object exploration, whereas the null mutant (KO) mice showed enhanced-object exploration as well as open-field exploration. In MS knockdown mice, only type 2 hippocampal theta rhythm was enhanced, whereas both type 1 and type 2 theta rhythm were enhanced in KO mice. This selective effect was accompanied by markedly increased excitability of septo-hippocampal GABAergic projection neurons in the MS lacking T-type Ca2+ channels. Furthermore, optogenetic activation of the septo-hippocampal GABAergic pathway in WT mice also selectively enhanced object exploration behavior and type 2 theta rhythm, whereas inhibition of the same pathway decreased the behavior and the rhythm. These findings define object exploration distinguished from open-field exploration and reveal a critical role of T-type Ca2+ channels in the medial septal GABAergic projection neurons in this behavior.</P>

Optogenetic control of stress and mood disorders

Daesoo Kim 한국실험동물학회 2016 한국실험동물학회 학술발표대회 논문집 Vol.2016 No.08

Organizational culture and innovation

DaeSoo, Kim(김대수),EuiBeom, Jeong(정의범),Jebum, Pyun(편제범) 한국경영학회 2016 한국경영학회 통합학술발표논문집 Vol.2016 No.8

Innovation is especially recognized as a key driver in achieving sustainable competitive advantage in our field. The generation and refinement of creative ideas by organization members are in turn influenced by organizational culture (Cannon et al., 2010; Grand and Berry, 2011). Thus organizational culture, often shaped by national culture, has become a crucial factor for achieving the success of innovation (Huang et al., 2011). This study intends to empirically investigate the effect of organizational culture on product and process innovation performance, with a focus on the moderating effect of national culture.

Overcoming Depression by Inhibition of Neural Burst Firing

Kim, Daesoo,Cheong, Eunji,Shin, Hee-Sup Elsevier 2018 Neuron Vol.98 No.5

<P>The N-methyl-D-aspartate receptor (NMDAR) antagonist ketamine has been found to have rapid and long-lasting antidepressive effects. Two elegant studies from Hailan Hu’s laboratory () showed that ketamine blocks burst firing of neurons in the lateral habenula (LHb), rapidly relieving symptoms of depression.</P>

Re-Deposition of Aluminum Species after Dissolution to Improve Electrode Performances of Lithium Manganese Oxide

Kim, Daesoo,Yoon, Taeho,Park, Sangjin,Shin, Soyoung,Ryu, Ji Heon,Oh, Seung M. The Electrochemical Society 2014 Journal of the Electrochemical Society Vol.161 No.14

<P>In order to address the role of aluminum dopant in spinel-structured lithium manganese oxide (Li<SUB>1.08</SUB>Mn<SUB>1.84</SUB>Al<SUB>0.08</SUB>O<SUB>3.96</SUB>, Al-doped LMO) electrode, high-temperature (60°C) charge/discharge cycling and storage experiments are carried out. The Al-doped LMO outperforms the un-doped counterpart with respect to capacity fading and Mn dissolution. However, the electrode polarization becomes substantial for the Al-doped LMO after the high-temperature storage. As the resistive component to be responsible for the electrode polarization, Al<SUB>2</SUB>O<SUB>3</SUB> and Al(OH)<SUB>x</SUB>F<SUB>3-x</SUB> are identified on the Al-doped LMO surface from X-ray photoelectron spectroscopy study. It is very likely that the doped Al ions dissolve into the electrolyte during the high-temperature storage but re-deposit as a form of Al<SUB>2</SUB>O<SUB>3</SUB> and Al(OH)<SUB>x</SUB>F<SUB>3-x</SUB> on the LMO surface. Due to a scavenging action of these Al species for hydrogen fluoride, Mn dissolution is suppressed to give an improved cycle and storage performance at elevated temperature.</P>

Re-Deposition of Manganese Species on Spinel LiMn₂O₄ Electrode after Mn Dissolution

Kim, Daesoo,Park, Sangjin,Chae, Oh B.,Ryu, Ji Heon,Kim, Young-Ugk,Yin, Ri-Zhu,Oh, Seung M. The Electrochemical Society 2012 Journal of the Electrochemical Society Vol.159 No.3

<P>Re-deposition of manganese compounds on LiMn<SUB>2</SUB>O<SUB>4</SUB> electrode after Mn dissolution and its impact on the positive electrode performances are studied by a control experiment, in which the spinel electrode is stored in its charged state at elevated temperature (60°C) to accelerate Mn dissolution. Upon storage with Li foil, the re-deposition of manganese species is marginal since the dissolved Mn<SUP>2+</SUP> ions move to the Li foil to be deposited. When stored without Li foil, however, under which the chance for re-deposition of Mn species on the spinel electrode is rather high, the dissolved Mn<SUP>2+</SUP> ions are deposited as oxide and fluoride. The depth-profiling X-ray photoelectron spectroscopy and transmission electron microscope studies illustrate that Mn-O species are deposited in the earlier period of storage, whereas the Mn-F compounds (MnF<SUB>2</SUB>) in the later stage. Due to the deposition of highly resistive MnF<SUB>2</SUB> phase, the electrode stored for a longer period of time shows a severe cell polarization and capacity loss.</P>

Thalamic T-Type Ca2+ Channels Mediate Frontal Lobe Dysfunctions Caused by a Hypoxia-Like Damage in the Prefrontal Cortex.

Kim, Jeongjin,Woo, Jeonghoon,Park, Young-Gyun,Chae, Sujin,Jo, Seonmi,Choi, Jeong Woo,Jun, Hong Young,Yeom, Young Il,Park, Seong Hoon,Kim, Kyung Hwan,Shin, Hee-Sup,Kim, Daesoo The Society 2011 The Journal of neuroscience Vol.31 No.11

<P>Hypoxic damage to the prefrontal cortex (PFC) has been implicated in the frontal lobe dysfunction found in various neuropsychiatric disorders. The underlying subcortical mechanisms, however, have not been well explored. In this study, we induced a PFC-specific hypoxia-like damage by cobalt-wire implantation to demonstrate that the role of the mediodorsal thalamus (MD) is critical for the development of frontal lobe dysfunction, including frontal lobe-specific seizures and abnormal hyperactivity. Before the onset of these abnormalities, the cross talk between the MD and PFC nuclei at theta frequencies was enhanced. During the theta frequency interactions, burst spikes, known to depend on T-type Ca(2+) channels, were increased in MD neurons. In vivo knockout or knockdown of the T-type Ca(2+) channel gene (Ca(V)3.1) in the MD substantially reduced the theta frequency MD-PFC cross talk, frontal lobe-specific seizures, and locomotor hyperactivity in this model. These results suggest a two-step model of prefrontal dysfunction in which the response to a hypoxic lesion in the PFC results in abnormal thalamocortical feedback driven by thalamic T-type Ca(2+) channels, which, in turn, leads to the onset of neurological and behavioral abnormalities. This study provides valuable insights into preventing the development of neuropsychiatric disorders arising from irreversible PFC damage.</P>