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S-276 Immediate and late outcomes of percutaneous transluminal angioplasty in Buerger``s disease
( Daehoon Kim ),( Young-guk Ko ),( Chul-min Ahn ),( Dong-ho Shin ),( Jung-sun Kim ),( Byeong-keuk Kim ),( Donghoon Choi ),( Myeong-ki Hong ),( Yangsoo Jang ) 대한내과학회 2016 대한내과학회 추계학술대회 Vol.2016 No.1
Objectives: The aim of this study was to appraise clinical outcomes after percutaneous transluminal angioplasty (PTA) for Buerger's disease patients with lower extremity artery disease. Methods: Between January 2006 and May 2015, 43 consecutive Buerger's disease patients with 48 target limbs were treated by PTA. The primary endpoint was clinically driven target lesion revascularization (TLR) at 24 months. Secondary endpoints included limb salvage rate, survival free from unexpected amputation, and changes in Rutherford class, ankle-brachial index (ABI). Results: Technical success using PTA was achieved in 35 (72.9%) of 48 limbs. The mean treated lesion length was 201±14 mm, including 39.6% multi-level lesions, 70.8% below-the-knee lesions, and 77.1% total occlusions. Clinical success rate was 70.8% with a significant improvement in Rutherford classes (p<0.001) and significantly increased ABIs, from 0.62±0.05 to 0.85±0.04 (p<0.001). At 24 months, the rate of clinically driven TLR was 23.1%, and limb salvage rate was 87.2% with 5 major amputations. The rate of freedom free from unexpected amputations was 91.7% with 3 unexpected amputations. Continuing smoking after PTA was the only independent predictor of TLR (HR: 5.10; 95% CI: 1.08 to 24.04, p=0.039).?Conclusions: PTA was feasible and effective for the revascularization in Buerger's disease patients. Technical success was achieved in the majority of the patients and the freedom free from clinically driven TLR and amputation at 2-year follow-up were favorable.
Multiplexing enhancement for the detection of multiple pathogen DNA.
Han, Daehoon,Hong, Jinkee,Kim, Hyun Cheol,Sung, Jong Hwan,Lee, Jong Bum American Scientific Publishers 2013 Journal of Nanoscience and Nanotechnology Vol.13 No.11
<P>Various methods for the detection of pathogens have been researched and developed. However, most of detection methods are cost-ineffective and laborious. To minimize costs and labor, multi-detection of pathogen have been widely used. In this paper, we propose a novel multi-detection method, which can enhance multi-detection capability using fluorescent dye labeled DNA nanostructures that is named DNA nanobarcodes. By using three fluorescence colors, multi-detection capability is significantly increased because of the increased combination of three colors. Moreover, our approach uses a relatively simple DNA nanostructure to precisely control the fluorescence intensity ratio. Therefore, high multi-detection ability is achieved without constructing a complicated DNA nanostructure probe. Our novel detection method can overcome the obstacles of conventional methods and enhance multi-detection capability effectively. By using our new system, we were able to successfully detect nine different DNA pathogens simultaneously. Our system can easily increase the multiplexibility by using more fluosrescent colors on DNA nanobarcode.</P>
Terahertz lens made out of natural stone
Han, Daehoon,Lee, Kanghee,Lim, Jongseok,Hong, Sei Sun,Kim, Young Kie,Ahn, Jaewook The Optical Society 2013 Applied optics Vol.52 No.36
<P>Terahertz (THz) time-domain spectroscopy probes the optical properties of naturally occurring solid aggregates of minerals, or stones, in the THz frequency range. Refractive index and extinction coefficient measurement reveals that most natural stones, including mudstone, sandstone, granite, tuff, gneiss, diorite, slate, marble, and dolomite, are fairly transparent for THz frequency waves. Dolomite in particular exhibits a nearly uniform refractive index of 2.7 over the broad frequency range from 0.1 to 1?THz. The high index of refraction allows flexibility in lens designing with a shorter accessible focal length or a thinner lens with a given focal length. Good agreement between the experiment and calculation for the THz beam profile confirms that dolomite has high homogeneity as a lens material, suggesting the possibility of using natural stones for THz optical elements.</P>