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Design of Instrumentation and Control System for Research Reactors
Gee-Yong Park,Sang H. Bae,Dae I. Bang,Taek G. Kim,Jae K. Park,Young K. Kim 제어로봇시스템학회 2011 제어로봇시스템학회 국제학술대회 논문집 Vol.2011 No.10
New design is being carried out for the instrumentation and control (I&C) systems for a nuclear research reactor with intent to replace and improve the existing analog-based I&C systems. The I&C systems being designed are based on computer-based digital systems. Some systems that have not been designed in the exiting, old I&C systems are added into the I&C systems design in order to provide the diversity to improve the safety and availability of a reactor. The concept of the defense-in-depth implemented in the I&C system design is also described in this paper.
Lee, Ji H.,Park, Sunyoung,Cheon, Soyoung,Lee, Joo H.,Kim, Sunghan,Hur, Dae Y.,Kim, Tae S.,Yoon, Suk R.,Yang, Yoolhee,Bang, Sa I.,Park, Hyunjeong,Lee, Hoon T.,Cho, Daeho WILEY‐VCH Verlag 2011 European journal of immunology Vol.41 No.10
<P><B>Abstract</B></P><P>The active metabolite of vitamin D<SUB>3</SUB>, 1α,25(OH)<SUB>2</SUB>D<SUB>3</SUB>, displays anticancer effects by regulating cell cycle and apoptosis in many cancer cells. However, it has not been determined whether 1α,25(OH)<SUB>2</SUB>D<SUB>3</SUB> increases the susceptibility of cancer cells to NK cells. Here, we investigated the anticancer effect of 1α,25(OH)<SUB>2</SUB>D<SUB>3</SUB> in human melanoma cell lines by investigating enhancement of NK susceptibility and elucidating the mediator of NK cytotoxicity. 1α,25(OH)<SUB>2</SUB>D<SUB>3</SUB>‐resistant melanoma cells (G‐361 and SK‐MEL‐5) treated with 1α,25(OH)<SUB>2</SUB>D<SUB>3</SUB> showed higher susceptibility to NK cells with up‐regulation of Fas expression. Furthermore, G‐361 cells treated with 1α,25(OH)<SUB>2</SUB>D<SUB>3</SUB> showed significantly increased caspase activity. In addition to Fas up‐regulation, expression of heat shock protein 60 (Hsp60) was elevated by 1α,25(OH)<SUB>2</SUB>D<SUB>3</SUB>. Increased expression of Hsp60 by 1α,25(OH)<SUB>2</SUB>D<SUB>3</SUB> was related to not only up‐regulation of Fas expression but also to NK susceptibility of G‐361 cells. Taken together, our data suggest that 1α,25(OH)<SUB>2</SUB>D<SUB>3</SUB> acts as an anticancer agent by increasing expression of Fas on the surface of melanoma cells through Hsp60 induction and strengthens caspase sensitivity to Fas‐mediated apoptotic pathway by NK cells. 1α,25(OH)<SUB>2</SUB>D<SUB>3</SUB> treatment may therefore have a preventive role in melanoma occurrence or potentiate the anticancer effects of NK‐cell immune therapy.</P>