http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Da-Young Kim,Da-In Kim,Yeung-Jin Seo,Soon-Kun Choi,Kwon-Rae Kim,Kye-Hoon Kim,Oh-Kyung Kwon,Won-Il Kim 한국토양비료학회 2019 한국토양비료학회지 Vol.52 No.4
This study was conducted to identify transition characteristics of heavy metal(loid)s and to assess dietary risk in the Angelica gigas and Cnidium officinale grown at the major medicinal plant producing districts in Korea. Average bio-concentration factor (BCF) values and range were 0.056 (0.006-0.511) in arsenic (As), 2.030 (0.021-15.678) in cadmium (Cd), 0.179 (0.052-0.393) in mercury (Hg), and 0.061 (0.013-0.474) in lead (Pb) in Angelica gigas. Average BCF values and range were 0.044 (0.011-0.264) in As, 0.557 (0.052-4.255) in Cd, 0.174 (0.069-0.286) in Hg, and 0.024 (0.012-0.057) in Pb in Cnidium officinale. The BCF values by heavy metal(loid)s in Angelica gigas and Cnidium officinale were high in Cd, copper (Cu) and zinc (Zn), while As and Pb were found to be less transferable. The BCF values calculated in this study will be useful for predicting the uptake of heavy metal(loid)s. Human exposure to As, Cd, Hg, and Pb through dietary intake of Angelica gigas and Cnidium officinale might not cause adverse health effects although some Angelica gigas were higher than the allowable value for Cd. Further study on uptake and accumulation mechanism of Cd by Angelica gigas is required to assess the human health risk associated with soil contamination.
Blood flow-improving activity of methyl jasmonate-treated adventitious roots of mountain ginseng
Young-Hwan Ban,Yeseul Cha,Jieun Choi,Eun Suk An,Ji Young Lee,Nu Ry Han,Da Woom Seo,Gooyoung Jung,Da-Hye Jeong,Man Hee Rhee,Ehn-Kyoung Choi,Yun-Bae Kim 한국실험동물학회 2017 Laboratory Animal Research Vol.33 No.2
Ginsenosides from Panax ginseng are well known for their diverse pharmacological effects including antithrombotic activity. Since adventitious roots of mountain ginseng (ARMG) also contain various ginsenosides, blood flow-improving effects of the dried powder and extract of ARMG were investigated. Rats were orally administered with dried powder (PARMG) or ethanol extract (EARMG) of ARMG (125, 250 or 500 mg/kg) or aspirin (30 mg/kg, a reference control) for 3 weeks. Forty min after the final administration, carotid arterial thrombosis was induced by applying a 70% FeCl3-soaked filter paper outside the arterial wall for 5 min, and the blood flow was monitored with a laser Doppler probe. Both PARMG and EARMG delayed the FeCl3-induced arterial occlusion in a dose-dependent manner, doubling the occlusion time at high doses. In mechanism studies, a high concentration of EARMG inhibited platelet aggregation induced by collagen in vitro. In addition, EARMG improved the blood lipid profiles, decreasing triglyceride and cholesterol levels. Although additional action mechanisms remain to be clarified, it is suggested that ARMG containing high amount of ginsenosides such as Rg3 improves blood flow not only by inhibiting oxidative thrombosis, but also by modifying blood lipid profiles.
Seo, Da Young,Roh, Hwa Jung,Jo, Hwi Yul,Cho, Sung,Kim, Jae Nyoung Elsevier 2018 Tetrahedron letters: the international organ for t Vol.59 No.11
<P><B>Abstract</B></P> <P> <I>cis-N</I>,<I>N</I>′-Dialkylisoindigo derivatives were synthesized for the first time by the reaction of 3-indolyl-2-oxindoles with DDQ in aqueous 1,4-dioxane. <I>cis</I>-Isoindigo derivatives were completely isomerized to the corresponding <I>trans</I>-isomers by heating the solution in short time.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The first synthesis of <I>cis</I>-isoindigos. </LI> <LI> Isomerization of <I>cis</I>-isoindigos to <I>trans</I>-isoindigos. </LI> <LI> An efficient one-pot synthesis of isoindigos from 3-indolyl-2-oxindoles. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Lee Da Hyun,Park Ji Eun,Kim NakYoung,Park Seo Young,Kim Young-Hoon,Cho Young Hyun,Kim Jeong Hoon,Kim Ho Sung 대한영상의학회 2023 Korean Journal of Radiology Vol.24 No.3
Objective: It is difficult to predict the treatment response of tissue after stereotactic radiosurgery (SRS) because radiation necrosis (RN) and tumor recurrence can coexist. Our study aimed to predict tumor recurrence, including the recurrence site, after SRS of brain metastasis by performing a longitudinal tumor habitat analysis. Materials and Methods: Two consecutive multiparametric MRI examinations were performed for 83 adults (mean age, 59.0 years; range, 27–82 years; 44 male and 39 female) with 103 SRS-treated brain metastases. Tumor habitats based on contrastenhanced T1- and T2-weighted images (structural habitats) and those based on the apparent diffusion coefficient (ADC) and cerebral blood volume (CBV) images (physiological habitats) were defined using k-means voxel-wise clustering. The reference standard was based on the pathology or Response Assessment in Neuro-Oncologycriteria for brain metastases (RANO-BM). The association between parameters of single-time or longitudinal tumor habitat and the time to recurrence and the site of recurrence were evaluated using the Cox proportional hazards regression analysis and Dice similarity coefficient, respectively. Results: The mean interval between the two MRI examinations was 99 days. The longitudinal analysis showed that an increase in the hypovascular cellular habitat (low ADC and low CBV) was associated with the risk of recurrence (hazard ratio [HR], 2.68; 95% confidence interval [CI], 1.46–4.91; P = 0.001). During the single-time analysis, a solid low-enhancing habitat (low T2 and low contrast-enhanced T1 signal) was associated with the risk of recurrence (HR, 1.54; 95% CI, 1.01–2.35; P = 0.045). A hypovascular cellular habitat was indicative of the future recurrence site (Dice similarity coefficient = 0.423). Conclusion: After SRS of brain metastases, an increased hypovascular cellular habitat observed using a longitudinal MRI analysis was associated with the risk of recurrence (i.e., treatment resistance) and was indicative of recurrence site. A tumor habitat analysis may help guide future treatments for patients with brain metastases.
염료오염물질 제거를 위한 polyethylenimine가교 dialdehyde 나노셀룰로오스 에어로겔 제조
마서영 ( Seo-young Ma ),조승우 ( Seung-woo Cho ),이다영 ( Da-young Lee ),김정기 ( Jeong-gi Kim ),한송이 ( Song-yi Han ),권구중 ( Gu-joong Kwon ),반디라즈쿠마 ( Rajkumar Bandi ),다디갈라라마크리슈나 ( Ramakrishna Dadigala ),하이리반 ( Le V 한국목재공학회 2022 한국목재공학회 학술발표논문집 Vol.2022 No.2
공융용매 전처리 후 초음파 처리에 의해 제조된 셀룰로오스 나노섬유를 Dialdehyde 화 시킨 후 polyethylenimine(PEI)과 화학적 가교를 통하여 에어로겔을 제조하였다. FT-IR 분석으로 PEI 의 아민기와 aldehyde 와의 가교결합을 확인하였으며, 수계에서 안정적으로 겔구조를 유지하고 있는 것과 가교결합과정에서 에어로겔의 공극이 감소된것을 알수 있었다. 또한, PEI 의 풍부한 미반응 아미노기(-NH<sub>2</sub>)에 의하여, 염료물질 제거에 효과적인 것을 확인하였다.
Eum, Da-Young,Byun, Joo-Yun,Yoon, Chang-Hwan,Seo, Woo-Duck,Park, Ki-Hun,Lee, Jin-Hwan,Chung, Hee Young,An, Sungkwan,Suh, Yongjoon,Kim, Min-Jung,Lee, Su-Jae Lippincott Williams Wilkins, Inc. 2011 Anti-cancer drugs Vol.22 No.8
A combined treatment with conventional chemotherapies can enhance the effectiveness of chemotherapeutic agents against cancers. Here, we have shown that the naturally occurring triterpenoids synergistically enhance the response of cervical cancer cells to taxol. Of the triterpenoid compounds, pristimerin enhanced the anticancer effect of taxol with the highest efficiency by combination. Pristimerin synergizes with taxol to inhibit clonogenic survival and tumor growth in nude mice, and to enhance cell death in cervical cancer cells. A combined treatment with taxol and pristimerin induced cervical cancer cell death by increasing intracellular reactive oxygen species levels, upregulation of death receptor death receptor 5 (DR5), activation of Bax, and dissipation of mitochondrial membrane potential. Treatment with N-acetyl-L-cysteine, a thiol-containing antioxidant completely blocked combined treatment-induced Bax translocation as well as DR5 upregulation. Moreover, inhibition of Jun N-terminal kinase/c-Jun pathway attenuated cell death by blocking DR5 upregulation and Bax activation. These results indicate that the triterpenoid, pristimerin, synergistically enhances taxol response of cervical cancer cells through DR5 expression and Bax activation. Furthermore, the reactive oxygen species-dependent activation of the Jun N-terminal kinase/c-Jun pathway is required for the DR5 upregulation and Bax activation. The molecular mechanism revealed by this study may aid in the design of future combination cancer therapies against cells with intrinsically reduced sensitivity to taxol.
카라기난과 나노셀룰로오스를 이용한 습식방사 섬유의 특성
이다영 ( Da-young Lee ),조승우 ( Seung-woo Cho ),마서영 ( Seo-young Ma ),김정기 ( Jeong-gi Kim ),한송이 ( Song-yi Han ),권구중 ( Gu-joong Kwon ),반디라즈쿠마 ( Rajkumar Bandi ),다디갈라라마크리슈나 ( Ramakrishna Dadigala ),하이리반 ( Le V 한국목재공학회 2022 한국목재공학회 학술발표논문집 Vol.2022 No.2
TEMPO 산화 셀룰로오스와 carrageenan 을 혼합한 현탁액으로부터 습식방사 공정으로 섬유를 제조하였다. Carrageenan 습식방사 섬유는 carrageenan 농도가 증가함에 따라 원형에 가까운 형태를 보여주었고, 인장강도와 연신율은 증가하였다. Carrageenan/TOCNF 혼합 방사 현탁액으로부터 제조한 섬유의 직경은 TOCNF 첨가량이 1.0%까지 증가하다가 이후로 감소하였다. 인장강도는 TOCNF 첨가량 0.5%조건이 가장 높았고, 이후 TOCNF 첨가비율이 증가할수록 감소하였다. 세척용매에 따른 강도적 특성은 전체적으로 에탄올을 이용한 것이 높았지만, 연신율은 아세톤으로 이용한 것이 높게 나타났다.