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일부 고지혈증 폐경 여성의 Isoflavone 공급에 따른 혈중지질 변화에 관한 연구
이다홍,승정자,이행신,김미현,서유리 대한지역사회영양학회 2001 대한지역사회영양학회지 Vol.6 No.1
Intake of soy protein may decrease the risk factors associated with cardiovascular disease in postmenopausal women. This study was designed to investigate the effects of isoflavone supplementation on serum lipids in 16 hyperlipidemic postmenopausal women. For this purpose, an intervention study was conducted for 12 weeks. Subjects were healthy, free-living women consuming habitual diets with 0.3 g/d of isoflavone. Food and nutrient intake was obtained by 24-hr recall method and anthropometric measurements were made. Systolic and diastolic blood pressure, total serum cholesterol, HDL-cholesterol and LDL-cholesterol were determined before and after the isoflavone supplementation. The results were summarized as follows. The average age, height, weight and BMI of the subjects were 65.3 years, 151.4 cm, 62.2 kg and 27.1, respectively. The systolic blood pressure and diastolic blood pressure were not reduced significantly with isoflavone supplementation. Total cholesterol (p < 0.001), HDL-C (p < 0.05), and LDL-C (p < 0.01) were significantly increased after isoflavone concentration. In conclusion, isoflavone supplementation was not effective to modify risk factors for cardiovascular disease.
Shin, Da Seul,Lee, Chi Hun,Kim, Suk Hyun,Park, Dong Yong,Oh, Joo Won,Gal, Chang Woo,Koo, Jin Mo,Park, Seong Jin,Lee, Seung Chul Elsevier Sequoia 2019 Powder technology Vol.353 No.-
<P><B>Abstract</B></P> <P>The constitutive relations for Fe-C and Fe-C-Cu powder compactions were investigated with the three consitituents: i) powder design parameters, ii) material related properties, and iii) final compaction properties. With the concept of materials informatics, this approach enables to predict the final compaction properties depending on the material conditions. The correlations between powder design parameters (particle size, graphite content, lubricant content, particle size distribution, copper content) and material related properties (<I>ρ</I> <SUB> <I>Tap</I> </SUB>, <I>γ</I>, <I>a</I>, <I>b</I>, <I>n</I>) in Shima-Oyane model were characterized by the compaction experiments and artificial neural network (ANN) model. The ANN model was developed to predict the effect of powder design parameters on the material related properties. The average mean absolute percentage error of predicted material related properties was 2.194%. The final properties (green density, density gradient, effective stress, hydrostatic stress, effective strain, volumetric strain) were calculated by the compaction simulation based on the experimental and predicted material related properties.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Compaction behaviors of Fe-C and Fe-C-Cu were characterized with Shima-Oyane model. </LI> <LI> A new artificial neural network model was developed for cold compaction. </LI> <LI> Leave one out cross validation and hyper parameter tuning approaches were applied. </LI> <LI> Sensitivities were calculated among powder design parameters and final properties. </LI> <LI> Integrated system was developed to predict the powder compaction behavior. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Lee, Da Eun,Shin, Gi Ru,Lee, Sunmin,Jang, Eun Seok,Shin, Hye Won,Moon, Byoung Seok,Lee, Choong Hwan Elsevier 2016 Food Research International Vol.87 No.-
<P><B>Abstract</B></P> <P>Metabolite profiling of <I>gochujangs</I> (Korean fermented red pepper paste) produced from different kinds of raw materials (WG, wheat <I>gochujang</I>; RG, rice <I>gochujang</I>) was performed using gas chromatography time-of-flight mass spectrometry (GC–TOF-MS) and ultra-performance liquid chromatography quadrupole time of flight mass spectrometry (UPLC-Q-TOF-MS). Using principal component analysis (PCA), <I>gochujang</I> samples were differentiated based on the differences in starchy source and secondary materials used in their production. The content of amino acids and sugars was higher in WG, whereas the content of flavonoids, soyasaponins, and γ-aminobutyric acid (GABA) was higher in RG. The content of flavonoids and soyasaponins was related to the higher soybean <I>koji</I> content of RG. The level of antioxidant activity in WG was higher than that in RG and showed a strong positive correlation with amino acid content and a negative correlation with flavonoid content. Although the Trolox equivalent antioxidant capacity of flavonoids was only 10-fold higher than that of amino acids in an antioxidant activity assay, the total amino acid content was as much as several hundred fold higher than total flavonoid content in <I>gochujang</I>. This result suggests that the amino acids could be a main contributor to the antioxidant capacity in <I>gochujang</I>.</P> <P><B>Highlights</B></P> <P> <UL> <LI> The starch <I>koji</I> used in the production of <I>gochujang</I> affected the metabolites produced. </LI> <LI> The wheat <I>gochujang</I> showed higher antioxidant activity than did rice <I>gochujang.</I> </LI> <LI> The amino acids in <I>gochujang</I> had a stronger correlation with antioxidant activity than did flavonoids. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Corni fructus ameliorates menopause symptom in 4-vinylcyclohexene diepoxide
Shin, Dasom,Koh, Myeong Shin,Lee, Sangchul,Lee, Da Hye,Kang, Geun-Hyung,Kim, Sejun,Jang, Dae Sik,Hwang, Deok-Sang,Kim, Youn-Sub,Bae, Hyunsu THE KOREAN SOCIETY OF TOXICOGENOMICS AND TOXICOPRP 2018 MOLECULAR AND CELLULAR TOXICOLOGY Vol. No.
Menopause is considered to mean falling levels of ovarian estradiol and progesterone. Menopause syndrome can lead to hot flashes, headaches, and depression etc. Corni Fructus (CF) was used as a therapeutic herbal medicine for treating various diseases such as pain, diabetic nephropathy and tuberculosis. This study was conducted to evaluate the protective effects of CF in follicle depletion of a mice model using the industrial chemical 4-vinylcyclohexene diepoxide (VCD). VCD directly targets prenatal follicles. Mice were injected with VCD (160 mg/kg) daily for 15 days and administered CF 18 times after VCD injection. CF treatment reduced body weight, tail skin temperature, and uterus weight. In addition, CF treatment significantly decreased total cholesterol, low-density lipoprotein, low-density lipoprotein/high-density lipoprotein ratio, and osteocalcin levels as well as correcting skin temperature. These results support the therapeutic potential of CF for those who suffer from menopause symptoms.
Lee, Su Jin,Nam, Min Jung,Lee, Da Eun,Park, Jeen-Woo,Kang, Beom Sik,Lee, Dong-Seok,Lee, Hyun-Shik,Kwon, Oh-Shin MDPI 2018 INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES Vol.19 No.8
<P>The mechanisms underlying the progression to non-alcoholic steatohepatitis (NASH) remain to be elucidated. In the present study, we aimed to identify the proteins involved in the pathogenesis of liver tissue inflammation and to investigate the effects of silibinin, a natural polyphenolic flavonoid, on steatohepatitis. We performed comparative proteomic analysis using methionine and choline-deficient (MCD) diet-induced NASH model mice. Eighteen proteins were identified from the two-dimensional proteomic analysis, which are not only differentially expressed, but also significantly improved, by silibinin treatment. Interestingly, seven of these proteins, including keratin cytoskeletal 8 and 18, peroxiredoxin-4, and protein disulfide isomerase, are known to undergo GlcNAcylation modification, most of which are related to structural and stress-related proteins in NASH model animals. Thus, we primarily focused on how the GlcNAc modification of these proteins is involved in the progression to NASH. Remarkably, silibinin treatment alleviates the severity of hepatic inflammation along with <I>O</I>-GlcNAcylation in steatohepatitis. In particular, the reduction of inflammation by silibinin is due to the inhibition of the <I>O</I>-GlcNAcylation-dependent NF-κB-signaling pathway. Therefore, silibinin is a promising therapeutic agent for hyper-<I>O</I>-GlcNAcylation as well as NASH.</P>
Impact of preoperative management in patients older than 80 years requiring cholecystectomy
Da-Kyum Shin,Seok-Hwan Kim,Deok-Bog Moon,Shin Hwang,Ki-Hum Kim,Chul-Soo Ahn,Tae-Yong Ha,Gi-Won Song,Dong-Hwan Jung,Ki-Byung Song,Dae-Wook Hwang,Song-Cheol Kim,Young-Joo Lee 한국간담췌외과학회 2018 Annals of hepato-biliary-pancreatic surgery Vol.22 No.4
Backgrounds/Aims: Elderly patients aged >80 yr have high morbidity and mortality rates after biliary surgery, especially in emergency operations. We conducted this study to determine the effect of preoperative management on the outcome of elderly patients undergoing cholecystectomy. Methods: The medical records of 452 elderly (≥80 yr old) patients who underwent cholecystectomy from January 1997 to December 2015 were reviewed retrospectively. We divided the patients into 2 groups: intervention (preoperative biliary drainage) and non-intervention groups. We evaluated the effects of preoperative management on the American Society of Anesthesiology (ASA) score and perioperative outcomes. Results: Among the preoperative biliary drainage intervention group (n=286), 48 patients (51.7%) were diagnosed as having gallbladder stone combined with common bile duct stone. On admission, the proportion of patients with ASA score ≥3 and WBC counts were significantly higher in the intervention group than in the non-intervention group (p <0.05). The preoperative hospital stay was longer in the intervention group; however, operation-related factors such as operation type, time, conversion rate, complications, and mortality showed no difference between groups. Conclusions: With proper preoperative evaluations and preoperative biliary drainage, cholecystectomy can be a safe treatment option for elderly patients with cholelithiasis.