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Sawair, F,Hassona, Y,Irwin, C,Stephenson, M,Hamilton, P,Maxwell, P,Gordon, D,Leonard, A,Napier, S Asian Pacific Journal of Cancer Prevention 2016 Asian Pacific journal of cancer prevention Vol.17 No.3
Background: Expression of p53, cyclin D1, p21 (WAF1) and Ki-67 (MIB1) was evaluated in oral squamous cell carcinoma (OSCC) to test whether levels of these markers at invasive tumour fronts (ITFs) could predict the development of local recurrence. Materials and Methods: Archived paraffin-embedded specimens from 51 patients with T1/T2 tumours were stained immunohistochemically and analysed quantitatively. Local recurrence-free survival was tested with Kaplan-Meier survival plots (log-rank test) using median values to define low and high expression groups and with a Cox's proportional hazards model in which the expression scores were entered as continuous variables. Results: The assessment of expression of all markers was highly reliable, univariate analysis showing that patients with clear surgical margins, with low cyclin D1 and high p21 expression at the ITF had the best local recurrence-free survival. Multivariate analysis showed that these three parameters were independent prognostic factors but that neither p53 nor MIB1 expression were of prognostic value. Conclusions: Assessment of p53, cyclin D1, p21 (WAF1), and Ki-67 (MIB1) at the ITF could help to predict local recurrence in early stage oral squamous cell carcinoma cases.
Antioxidant and antibacterial activity of Trametes polyzona (Pers.) Justo
Erute M. Adongbede,Yogini S. Jaiswal,Shurrita S. Davis,Priscilla D. Randolph,Li-Ni Huo,Leonard L. Williams 한국식품과학회 2020 Food Science and Biotechnology Vol.29 No.1
Polypores are cosmopolitan mushrooms, widely investigated for their beneficial properties in combatting multidrug resistant pathogens. The present study focuses on the need for new, naturally sourced antimicrobial and antioxidant compounds from mushrooms. The antioxidant and antibacterial activity of the phenolic extract of strains of Trametes polyzona (Pers.) Justo, were investigated. Strains of T. polyzona were analyzed for total phenolic content, Trolox antioxidant equivalent, DPPH radical scavenging and antibacterial activities. The amplification of the ribosomal DNA-ITS fragments from DNA of selected mushrooms was carried out using ITS1 and ITS4 primers. The antibacterial activity of phenolic extracts of T. polyzona was comparable to the antibiotics, ceftazidime and erythromycin. T. polyzona extracts inhibited the growth of the different strains of K. pneumoniae, E. coli, S. aureus, and S. enterica tested in this study. The results of the study demonstrate that, T. polyzona can be a potential source of antimicrobial and antioxidant compounds.
Trace radioactive impurities in final construction materials for EXO-200
Leonard, D.S.,Auty, D.J.,Didberidze, T.,Gornea, R.,Grinberg, P.,MacLellan, R.,Methven, B.,Piepke, A.,Vuilleumier, J.-L.,Albert, J.B.,Anton, G.,Badhrees, I.,Barbeau, P.S.,Bayerlein, R.,Beck, D.,Belov, Elsevier 2017 Nuclear instruments & methods in physics research. Vol.871 No.-
<P><B>Abstract</B></P> <P>We report results from a systematic measurement campaign conducted to identify low radioactivity materials for the construction of the EXO-200 double beta decay experiment. Partial results from this campaign have already been reported in a 2008 paper by the EXO collaboration. Here we release the remaining data, collected since 2007, to the public. The data reported were obtained using a variety of analytic techniques. The measurement sensitivities are among the best in the field. Construction of the EXO-200 detector has been concluded, and Phase-I data was taken from 2011 to 2014. The detector’s extremely low background implicitly verifies the measurements and the analysis assumptions made during construction and reported in this paper.</P>
Pulse-shape discrimination between electron and nuclear recoils in a NaI(Tl) crystal
Lee, H.S.,Adhikari, G.,Adhikari, P.,Choi, S.,Hahn, I.S.,Jeon, E.J.,Joo, H.W.,Kang, W.G.,Kim, G.B.,Kim, H.J.,Kim, H.O.,Kim, K.W.,Kim, N.Y.,Kim, S.K.,Kim, Y.D.,Kim, Y.H.,Lee, J.H.,Lee, M.H.,Leonard, D.S Institute of Physics Pub 2015 The journal of high energy physics Vol.2015 No.8
Simulation Study for the Half-Life Measurement of 180mTa Using HPGe Detectors
G. W. Kim,S. Y. Park,I. S. Hahn,Y. D. Kim,M. H. Lee,D. S. Leonard,E. K. Lee,W. G. Kang,E. Sala,V. Kazalov 한국물리학회 2019 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.75 No.1
$^{180m}$Ta, which is the second excited state of $^{180}$Ta at E$_x$ = 77 keV, is naturally occurring and is the only known stable isomer. The half-life of $^{180m}$Ta is considered to be an important parameter for nuclear synthesis models for heavy elements. However, the decay of $^{180m}$Ta has never been observed even though several groups tried to measure it. We will search for gamma transitions from $^{180m}$Ta decays in a tantalum sample by using an array of fourteen HPGe detectors recently installed in an underground laboratory at Yangyang, Korea. In preparation for the measurement, Monte-Carlo simulation studies were conducted to optimize the tantalum sample configuration. Based on the simulation study, we decided on a configuration composed of a 2 mm thick disk with diameter of 200 mm and six 2 mm thick rectangular plates with dimension of 158 $\times$ 195 mm$^2$. The finalized tantalum sample configuration gives 2.0 and 7.5 coincidence events per year for the EC and the $\beta$-decay of $^{180m}$Ta, respectively. In this study, we used T$_{1/2}$ = 2.0~$\times$~10$^{17}$ years and T$_{1/2}$ = 5.8~$\times$~10$^{16}$ years for the EC and $\beta$-decay which are the present best lower-limits as reported by B. Lehnert \textit{et al.}
Background study of NaI(Tl) crystals for the KIMS-NaI experiment
Adhikari, P,Adhikari, G,Choi, S,Ha, C,Hahn, I S,Jeon, EJ,Joo, H W,Kang, W G,Kim, H J,Kim, H O,Kim, K W,Kim, N Y,Kim, S K,Kim, Y D,Kim, Y H,Lee, H S,Lee, J H,Lee, M H,Leonard, D S,Li, J,Oh, S Y,Olsen, Institute of Physics Publishing Ltd 2016 Journal of Physics: Conference Series Vol.718 No.-
Kim, K. W.,Adhikari, G.,Adhikari, P.,Choi, S.,Ha, C.,Hahn, I. S.,Jeon, E. J.,Joo, H. W.,Kang, W. G.,Kim, H. J.,Kim, N. Y.,Kim, S. K.,Kim, Y. D.,Kim, Y. H.,Lee, H. S.,Lee, M. H.,Leonard, D. S.,Oh, S. Y IEEE 2016 IEEE transactions on nuclear science Vol.63 No.2
<P>In order to investigate discrimination between nuclear recoil and electron recoil events for the KIMS-NaI dark matter search experiment, we measured the pulse shapes produced by neutrons and gamma rays in a NaI(Tl) crystal. Relatively good pulse shape discrimination (PSD) power due to high light output of recently developed crystals makes it possible to test whether the annual modulation signal observed by the DAMA/LIBRA experiment is caused by nuclear recoil events. We applied the PSD to underground data taken with a 9.15 kg low-background and high-light-output NaI(Tl) crystal for 134 days. Good agreement between underground data and electron recoil events was observed.</P>