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- 저자 : Cuicui Liu (검색결과 3 건)
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Cuicui Chen,Xiaozhu Liu,Yinfeng Li,Huankun Liang,Kangyan Li,Jiali Li,Chengwu Cheng,Xianpan Liu,Shuhai Zhong,Laiqing Li,Yan Wang 사단법인약침학회 2017 Journal of Acupuncture & Meridian Studies Vol.10 No.4
Allergic contact dermatitis (ACD) is a chronic inflammatory skin disease. Topical corticosteroids are the first-line therapy for ACD despite their significant adverse effects. Acupuncture has been widely used in the treatment of various skin diseases, but its underlying mechanism remains unrevealed. In this study, we investigated the characteristics of acupuncture treatment based on effectiveness and mechanism. BALB/c mice received 1-chloro-2,4-dinitrobenzene (DNCB) application to build AD-like model. Results showed that acupuncture was an effective treatment method in inhibiting inflammatory conditions, serum IgE levels, and expression of proinflammatory cytokine Th2 (IL-4, IL-6), and Th2 (IL-1b, TNF-a) mRNA compared with DNCB treatment. Acupuncture treatment also inhibited nuclear factor-kB p65, phosphorylation of IkBa, and phosphorylation of occludin proteins expression. Furthermore, it could improve the expression of epidermal growth factor in both mRNA and protein levels. These results suggest that acupuncture, as an alternative therapy treatment for its no significant side effects, was effective in alleviating ACD by reducing proinflammatory cytokines and changing proteins’ expression.
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Accelerated Life Test Study on Thyristors of HVDC Converter Valve
Cuicui Liu,Ning Liang,Yating Gou,Jiachen Tian,Fang Zhuo,Feng Wang 전력전자학회 2019 ICPE(ISPE)논문집 Vol.2019 No.5
As the key component of HVDC converter valve system, thyristors have vital impact on the reliability of the entire HVDC transmission project. In order to effectively obtain the life model of thyristor, this paper uses the existing accelerated life test theory, combined with the operating conditions of the converter valve and the relevant characteristics of the thyristors, to deeply analyse the several stress levels that have the most serious impact on the life of the thyristors. An accelerated life test scheme that can effectively guide the life model of the thyristor, according to the test data collected by this test method, the thyristor junction temperature life model under the short-circuit current stress is established, and compared with the thyristor failure rate in the practical engineering, the results show the feasibility of the test scheme and the correctness of the life model.
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Chunyan Wei,Jingjing Wang,Cuicui Duan,Huimei Fan,Xiaoxiao Liu 한국식품영양과학회 2020 Journal of medicinal food Vol.23 No.2
Oxidative stress triggered by hyperglycemia is thought to be a major factor in the development of liver disease during diabetes mellitus (DM). The aim of this study was to determine the antioxidant capacity of aqueous extracts of selenium-enriched Auricularia auricular (AESA) and further investigate the hepatic protection and potential mechanism of AESA in a mouse model of diabetes. An in vitro antioxidant assay confirmed that AESA exhibited better antioxidant capacity characterized by increased reducing power and scavenging capacity of free radicals, such as diphenyl picrylhydrazyl radical, hydroxyl radical, and superoxide radical. The diabetic model was induced by high-fat diet combined with a single injection of streptozotocin in C57BL/6 mice. Our results showed that AESA treatment improved diabetes-induced disorders of lipid metabolisms and alleviated liver damage in diabetic mice. Furthermore, the antioxidant enzyme activities of glutathione peroxidase and catalase in liver were increased and malondialdehyde level was decreased with AESA treatment compared with those in the DM group. In parallel, AESA significantly reduced the contents of tumor necrosis factor-alpha and interleukin-1beta in liver in comparison with the DM group. In addition, western blot results showed that the expression of receptor for advanced glycation end products (RAGE), phospho-c-Jun NH2-terminal kinase, phospho-extracellular signal-regulated kinase, and phospho-p38 kinase were remarkably decreased in AESA treatment group compared with DM group. Taken together, supplementation of AESA may effectively attenuate diabetic hepatopathology by exerting antioxidant function through the RAGE/mitogen-activated protein kinase pathway.
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