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Thomas, Ulrich,Kim, Eunjoon,Kuhlendahl, Sven,Koh, Young Ho,Gundelfinger, Eckart D.,Sheng, Morgan,Gamer, Craig C.,Budnik, Vivian 부산대학교 유전공학연구소 1997 분자생물학 연구보 Vol.13 No.-
The cells adhesion molecule FasciclinⅡ(FASⅡ)is invoved in synapse development and plasticity. Here we provide genetic and biochemical evidence that proper localization of FASⅡ at typeⅠglutamatergic aynapses of the Drosophila neuromuscular junction is mediated by binding between the intracellular tSXV bearing C-terminal tail of FASⅡ and the PDZ1-2 domains of Discs-Large (DLG). Moreover, mutations in fasⅡ and /or dlg have similar effects on presynaptic ultrastructure, suggesting their functional involvement in a common developmental pathway. DLG can directly mediate a biochemical complex and a macroscopic cluster of Ⅱ and Shaker K^+ channels in heterologous cells. These results indicate a central role for DLG in the structural organization and downstream signaling mechanisms of cell adhesion molecules and ion channels at synapses.
Park, Sang-Min,Kim, Sun-Young,Earle, Craig-C,Jeong, Seung-Yong,Yun, Young-Ho WJG Press 2009 World journal of gastroenterology Vol.15 No.25
<P>To identify a cost-effective strategy of second primary colorectal cancer (CRC) screening for cancer survivors in Korea using a decision-analytic model.</P>