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RISS 인기검색어
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- 저자 : Conghui Wang (검색결과 5 건)
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Analysis of the Residual Stress in Zirconium Subjected to Surface Severe Plastic Deformation
Yaomian Wang,Huanping Yang,Conghui Zhang,Fei Yu 대한금속·재료학회 2015 METALS AND MATERIALS International Vol.21 No.2
The residual stress of commercially pure zirconium specimens subjected to surface mechanical attritiontreatment (SMAT) for different durations is measured with X-ray diffraction (XRD). XRD peak broadeninganalysis is conducted to obtain the distributions of the crystallite size, microstrain and dislocation densityas functions of the depth from the processed surface. Finite element modeling is performed to revealthe characteristics of the residual stress distribution. Microstructure observation using optical and electronmicroscopy are also carried out in order to elucidate the residual stress development. The correlationsbetween the microstructure features and the residual stress distribution in zirconium are examined. Theresults indicate that a more pronounced compressive residual stress field can be generated by the SMATprocess compared to that obtained by conventional shot peening, and that the compressive residual stressdistributions exhibit nonlinear variation with the distributions of the full width at the half maximum of theXRD profiles and the dislocation densities.
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Zhang, Hui,Wang, Yuyuan,Zhang, Guowang,Tang, Conghui The Korean Institute of Power Electronics 2020 JOURNAL OF POWER ELECTRONICS Vol.20 No.4
A linear active disturbance rejection control (LADRC) strategy for permanent magnet synchronous motor (PMSM) for road-sensing based on the differential evolution (DE) algorithm is proposed in this paper, called DE-LADRC, to obtain the better dynamic and steady-state responses of the road-sensing simulation in electric vehicle (EV) steering-by-wire (SBW) systems. Since the novel control method ignores the time delay modules in digital motor control, the controlled object is regarded as a first-order inertial link to design a first-order LADRC controller. Then aiming to solve the problem where the values of the controller parameters are changed and difficult to tune due to ignoring the time delay modules in the first-order LADRC controller, the differential evolution (DE) algorithm is designed to find the optimal controller parameters by self-tuning. Experiment results indicate the effectiveness and convergence of the DE-LADRC, as well as the correctness of the road-sensing planning. In addition, the DE-LADRC can provide the smoother feel and real-time road-sensing for driver due to experiment of a Hardware in the Loop (HIL) platform under convergent iteration.
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SURF4 maintains stem-like properties via BIRC3 in ovarian cancer cells
Yongfang Yue,Lili Xia,Shanshan Xu,Conghui Wang,Xinyu Wang,Weiguo Lu,Xing Xie 대한부인종양학회 2020 Journal of Gynecologic Oncology Vol.31 No.4
Objective: As cancer stem cells (CSCs) are considered as the origin of tumor development,recurrence, and drug resistance, we aimed to explore the mechanism related to modulatingstemness in CSCs, thus facilitating to search for new therapeutic strategy for ovarian cancer. Methods: In this study, ovarian cancer stem cells (OCSCs) induced from cell line 3AOand A2780 were enriched in serum-free medium (SFM). The effect of SURF4 on CSC-likeproperties was evaluated by sphere-forming assays, re-differentiation assays, quantitativereal-time polymerase chain reaction, flow cytometry, Western blotting, cell viability assaysand in vivo xenograft experiments. The downstream molecule participating in SURF4maintaining stemness was screened by RNA-sequencing and identified by the experiments ofgene function. Results: SURF4 was upregulated expressed in OCSCs. Knockdown of SURF4 reduced theexpression of the related stem markers (SOX2 and c-MYC), inhibited self-renewal ability,and improved the sensitivity to chemotherapeutic drugs (paclitaxel and cisplatin) in OCSCs. SURF4 knockdown also inhibited tumorigenesis in nonobese diabetic/severe combinedimmunodeficiency mice. BIRC3 expression was controlled by SURF4, and BIRC3 showedthe similar effect as SURF4 did, and BIRC3 overexpression partially recovered stem-likeproperties abolished by SURF4 knockdown. Conclusion: Our findings suggest that SURF4 possesses the ability to maintain stemness ofOCSCs via BIRC3, and may serve as a potential target in stem cell-targeted therapy forovarian cancer.
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Yiting Xu,Jiamei Huang,Yuntong Li,Meijie Wang,Ying Cao,Conghui Yuan,Birong Zeng,Lizong Dai 한국고분자학회 2017 Macromolecular Research Vol.25 No.8
A novel zwitterionic hybrid amphiphilic copolymer containing polyhedral oligomericsilsesquioxane (POSS), and poly(methacrylate isobutyl POSS)-b-poly (3-dimethyl(methacryloyloxyethyl) ammonium propane sulfonaten-co-2-(diethylamino) ethyl methacrylate-co-styrene) (PMAiBuPOSS-b-P(DMAPS-co-DMAEMAco- St)), was prepared by the ring open reaction of 1, 3-propane sultone with tertiary amine on the precursor polymer. This hybrid copolymer could self-assemble into spherical micelle with a relatively narrow size distribution. The micelle size exhibited a great dependence on pH, as the size of the micelles was of evidently decreases with the increase of the pH value. Controllable release of pyrene from the micelles was investigated by fluorescent emission spectra. Micelles with more zwitterionic units would lead to less pyrene release and longer equilibrium time. The protein adsorption resistance of the micelles was tested by mixing them with fetal bovine serum. The antifouling ability was improved by increasing the number of zwitterionic units as well as decreasing the number of DMAEMA units. This novel hybrid amphiphilic random copolymer with the pH-responsive and anti-protein-fouling ability, can be potentially used for drug carriers for controlled release.
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Guojun Liu,Fang He,Yan Li,Xinbo Li,Hong Zhao,Conghui Wang,Conghong Zhan,Chunxiu Tang 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2019 NANO Vol.14 No.8
Based on the liquid-phase reduction mechanism, a controllable synthesis method, which uses piezoelectric-actuated high-frequency vibration self-circulating microfluidic reactor, to prepare silver nanoparticles is proposed. Firstly, the synthesis mechanism of silver nanoparticles and the working principle of the microfluidic reactor were analyzed. Then, in order to study and explore the influence of self-circulating and high frequency vibration on the synthesis of silver nanoparticles, a series of related synthesis experiments were carried out. The synthesized silver nanoparticles were characterized by UV-Visible spectroscopy and transmission electron microscopy. The effects of micropump driving voltage and high-frequency vibration on the synthesis of silver nanoparticles were analyzed. The experiment results show that when the silver nanoparticles were synthesized using piezoelectric-actuated high-frequency vibration self-circulating microfluidic reactor, the higher the driving voltage of the circulating reflux micropump, the faster the vortex rotation speed in the mixing pool and the more uniform the reagent reaction. Besides, high-frequency vibration can suppress the aggregation of silver nanoparticles, and balance the growth environment of particles, which is beneficial to the formation of silver nanoparticles with good monodispersity, high sphericity and small size deviation.
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