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Ok, Seong Ho,Bae, Sung Il,Kwon, Seong Chun,Park, Jung Chul,Kim, Woo Chan,Park, Kyeong Eon,Shin, Il Woo,Lee, Heon Keun,Chung, Young Kyun,Choi, Mun Jeoung,Sohn, Ju Tae The Korean Pain Society 2014 The Korean Journal of Pain Vol.27 No.3
Background: A toxic dose of bupivacaine produces vasodilation in isolated aortas. The goal of this in vitro study was to investigate the cellular mechanism associated with bupivacaine-induced vasodilation in isolated endothelium-denuded rat aortas precontracted with phenylephrine. Methods: Isolated endothelium-denuded rat aortas were suspended for isometric tension recordings. The effects of nifedipine, verapamil, iberiotoxin, 4-aminopyridine, barium chloride, and glibenclamide on bupivacaine concentration-response curves were assessed in endothelium-denuded aortas precontracted with phenylephrine. The effect of phenylephrine and KCl used for precontraction on bupivacaine-induced concentration-response curves was assessed. The effects of verapamil on phenylephrine concentration-response curves were assessed. The effects of bupivacaine on the intracellular calcium concentration ($[Ca^{2+}]_i$) and tension in aortas precontracted with phenylephrine were measured simultaneously with the acetoxymethyl ester of a fura-2-loaded aortic strip. Results: Pretreatment with potassium channel inhibitors had no effect on bupivacaine-induced relaxation in the endothelium-denuded aortas precontracted with phenylephrine, whereas verapamil or nifedipine attenuated bupivacaine-induced relaxation. The magnitude of the bupivacaine-induced relaxation was enhanced in the 100mM KCl-induced precontracted aortas compared with the phenylephrine-induced precontracted aortas. Verapamil attenuated the phenylephrine-induced contraction. The magnitude of the bupivacaine-induced relaxation was higher than that of the bupivacaine-induced $[Ca^{2+}]_i$ decrease in the aortas precontracted with phenylephrine. Conclusions: Taken together, these results suggest that toxic-dose bupivacaine-induced vasodilation appears to be mediated by decreased calcium sensitization in endothelium-denuded aortas precontracted with phenylephrine. In addition, potassium channel inhibitors had no effect on bupivacaine-induced relaxation. Toxic-dose bupivacaine-induced vasodilation may be partially associated with the inhibitory effect of voltage-operated calcium channels.
Case Reports : Radiological assessment of pectus excavatum in a Pekingese dog
( Sung Jin Cho ),( Sun Hwa Hong ),( Yung Ho Chung ),( Ok Jin Kim ) 한국가축위생학회 2012 韓國家畜衛生學會誌 Vol.35 No.3
Pectus excavatum (PE) is a ventral chest wall deformity, also known as funnel chest, sunken chest, chondrosternal depression or koilosternia. The 4 months old, 1.3 kg intact-female Pekingese dog was evaluated for acute semicoma and convulsion. The client reported that this patient have had chronic loss of appetite, intermittent dyspnea and palpable sunken breast. The other littermates did not show any abnormalities. On physical examination, cachexia (BCS 1/5), concave sternum, flatten thoracic cavity and cardiac murmur were observed. On radiographic study, the caudal sternum cave to vertebrae and narrowing thoracic cavity. The severities of thoracic deformity were evaluated by deformation indices such as-Frontosagittal index (FSI) and vertebral index (VI). Moderate to severe PE was founded by the radiological measurements.
Changes in Ginsenoside Composition of White Ginseng by Fermentation
Sung Kwon Ko,Ok Sun Cho,Hye Min Bae,Byung Wook Yang,Byung-Ok Im,Young Tae Hahm,Kyung Nam Kim,Soon Hyun Cho,Jae Young Kim,Sung Hyun Chung,Boo Yong Lee 한국식품과학회 2009 Food Science and Biotechnology Vol.18 No.1
The purpose of the study was to develop a new process to manufacture ginseng extract containing saponin aglycon of high concentration. The process to transform saponin glycosides to saponin aglycon was analyzed by high performance liquid chromatography (HPLC). GCK-1 (open cultured mixture for 1 day at 42℃) had the highest content of protopanaxadiol (0.662%). However, other mixtures (GCK-2, 3, 4, 5, and 6) had less than 0.152% in the content of protopanaxadiol. In case of fermentation by inoculation of Bacillus natto, BNG-5 (B. natto inoculated mixture for 5 days at 42℃) showed the highest content of protopanaxadiol (0.364%). Other mixtures (BNG-1, 2, 3, 4, and 6) also showed the high content of more than 0.2% in protopanaxadiol. B. natto inoculation or open culture fermentation with soybean transformed ginseng saponin glycosides into saponin aglycon.
( Sang-hee Jeong ),( Mi-young Lee ),( Ok-ju Kang ),( Rina Kim ),( Jin-hoon Chung ),( Hye-sung Won ),( Pil-ryang Lee ),( Euiseok Jung ),( Byong Sop Lee ),( Woo-jong Choi ),( Yoon Se Lee ) 대한산부인과학회 2021 Obstetrics & Gynecology Science Vol.64 No.1
Objective To report our experience with management of fetuses with congenital high airway obstruction syndrome (CHAOS). Methods We retrospectively reviewed the cases of fetuses who were prenatally diagnosed and postnatally confirmed with CHAOS between 2010 and 2019 at Asan Medical Center, Seoul, Korea. Results Of 13 fetuses prenatally diagnosed with CHAOS, 7 were lost to follow-up and 6 were postnatally confirmed as having CHAOS. All fetuses, except one were delivered via cesarean section with an ex utero intrapartum treatment (EXIT) procedure. Two patients had coexisting congenital heart diseases requiring several cardiac surgeries following birth. Both of these patients demonstrated developmental delay; however, the remaining 4 had a normal development except for expressive language. Two infants died of respiratory complications, and the remaining 4 were alive at the end of the follow-up period. All 4 live patients underwent tracheostomy with planned reconstruction surgery. Three children are now able to phonate, and 1 can maintain a conservation. Conclusion The proper management of CHAOS using the EXIT procedure results in high survival and low hypoxemia-induced complication rates. Therefore, an accurate prenatal diagnosis is necessary for an appropriate perinatal management.
Ginsenoside Composition Changes in Ginseng Extracts by Different Ascorbic Acid Treatments
Sung Kwon Ko,Ok Sun Cho,Hye Min Bae,Uy Dong Sohn,Byung Ok Im,Soon Hyun Cho,Byung Wook Yang,Sung Hyun Chung,Wang Soo Shin,Boo Yong Lee 한국식품과학회 2008 Food Science and Biotechnology Vol.17 No.4
The purpose of this study was to develop a new preparation process for chemical transformation of ginseng saponin glycosides to prosapogenins. Ginseng and ginseng extracts were processed under several treatment conditions using ascorbic acid solution. Treating with ascorbic acid at pH 2-3 and above 80℃ increased the ginsenoside Rg<sub>3</sub> content of samples to over 3% as compared to other pH levels and temperatures. In addition, ginseng and ginseng extracts that were processed under a high ascorbic acid solution treatment condition (pH 2.0, 5 hr) contained more ginsenoside Rg3 (approximately 16 times) than those processed under a low ascorbic acid solution treatment condition (pH 3.0, 5 hr). The highest quantity of ginsenoside Rg<sub>3</sub> (3.434%) occurred when a sample of fine ginseng root extract (AG2-9) was processed with the ascorbic acid solution at pH 2.0 for 9 hr. However, there was no change in the amount of ginsenoside Rg<sub>3</sub> when fine ginseng root extracts were processed with ascorbic acid solution at pH 2.0 for over 9 hr. In conclusion, the results indicated that ascorbic acid treatment of ginseng extracts can produce a level of ginsenoside Rg<sub>3<sub> that is over 90-fold the amount found in commercial red ginseng.
Chung, Dong Young,Kim, Min Jeong,Kang, Narae,Yoo, Ji Mun,Shin, Heejong,Kim, Ok-Hee,Sung, Yung-Eun American Chemical Society 2017 Chemistry of materials Vol.29 No.7
<P>The Fe-N-C-based carbon materials, which are generally formed by high-temperature annealing, have been highlighted as a promising alternative to expensive Pt electrocatalysts for oxygen reduction reaction. However, the delicate formation of active sites remains an issue because of decomposition and transformation of the macrocycle during heat treatment. Accordingly, we developed a low-temperature and gram-scale approach to synthesizing iron phthalocyanine (Pc)-embedded two-dimensional carbon sheets by annealing at 450 degrees C. The low temperature annealing process, which is motivated by the synthesis of carbon nanoribbons, is suitable for maintaining the Fe-N-C structure while enhancing coupling with carbon. Our two-dimensional carbon sheets show higher ORR activity than commercial Pt catalyst in alkaline media. Furthermore, the feasibility of real application to alkaline membrane electrolyte fuel cell is verified by superior volumetric current density. In durability point of view, the initial activity is retained up to 3000 potential cycles without appreciable activity loss; this excellent performance is attributed to the structural stabilization and electron donation from the carbon sheet, which occurs via strong electronic coupling. We believe that this low-temperature and large-scale synthesis of a carbon structure will provide new possibilities for the development of electrochemical energy applications.</P>
Analysis of Ginsenoside Composition of Ginseng Berry and Seed
Sung Kwon Ko,Hye Min Bae,Ok Sun Cho,Byung Ok Im,Sung Hyun Chung,Boo Yong Lee 한국식품과학회 2008 Food Science and Biotechnology Vol.17 No.6
This study was performed to provide basic information that can be used to differentiate Korean ginseng (Panax ginseng C.A. Meyer) berry and seed from American ginseng (Panax quinquefolium L.) seed. Total ginsenoside contents of Korean ginseng berry, Korean ginseng seed, and American ginseng seed were 9.09, 3.30, and 4.06%, respectively. Total ginsenoside content of Korean ginseng berry was about 2.2 to 2.7 times higher than those of Korean ginseng seed and American ginseng seed. Particularly ginsenoside Re content of 4-year cultivated Korean ginseng berry (5.99%) was about 3.6 to 5.4 times higher than that of 4-year cultivated Korean ginseng seed (1.65%) and 4-year cultivated American ginseng seed (1.10%). The contents of total ginsenoside and ginsenoside Re of Korean ginseng berry were about 4.8 and 28 times higher, respectively, than those of 4-year cultivated Korean ginseng root. In general the contents of total ginsenoside and ginsenoside Re of Korean ginseng berry were significantly higher than those of Korean ginseng seed and American ginseng seed.