합병증이 동반된 Meckel씨 게실 2례 보고

정병욱,박동일,이준희,서정욱,원유홍,김웅,신현종,권영무 동국대학교 경주대학 1996 東國論集 Vol.15 No.-

합병증이 동반된 Meckel씨 게실을 가진 환자의 치료에 대한 필요성은 과정이 문제이다. 하지만 우연히 만나는 게실의 처치는 논란 중이다. 부수적인 게실 절제술(incidental diverticulectomy)의 제안자는 증상이 있는 게실의 외과적 처치는 중요한 이환 및 사망률은 지적한다. 이를 반대하는 사람들은 전 생애를 통해 합병증의 위험성이 낮게 나타나므로 필요가 없다고한다. 게실의 예방적 제거는 개복술시 우연히 발견 될 때 시행한다. 이는 남아있는 게실이 나중에 합병증을 일으키는 것보다 술후 합병증의 위험성이 매우 적음을 알 수 있다. 저자들은 합병증이 동반된 Meckel씨 게실 2예를 경험하였기에 문헌 고찰과 더불어 보고하는 바이다. The necessity for therapy with complicated Meckel's diverticular is a matter of course.However, management of the incidentally encountered diverticulum is controversial. Proponents of incidental diverticulectomy point to the significant morbidity and mortality rates of surgical treatment of symptomatic divenicular. Other authors base their opposition to incidental diveniculectomy on the low risk of complications developing during lifetime. Prophyillctic removal of the diveniculum is indicated when it is found incidentally at laparotomy, because there are few postoperative complications and the risk exists that the remaining diverticulum may be the cause of later complication. The 2 cases of complicated Meckel's diverticulum are reported with a brief review of literature.

인지과학적 시뮬레이션을 통한 朝鮮 性理學의 禮교육 心性모델 개발(1)

유권종,박충식,장숙필 고려대학교 민족문화연구원 2002 民族文化硏究 Vol.37 No.-

이 연구는 유교, 특히 조선 성리학의 도덕교육에 의한 인격변화의 과정과 그 결과를 컴퓨터로 모의 실험하기 위하여, 조선 성리학자들이 이해했던 心의 구조와 그 작동의 모형을 작성해보고자 하는 데 그 궁극적인 목적이 있다. 아울러 그것을 통해서 조선 성리학의 큰 줄기를 형성한 퇴계의 심학과 율곡의 심학을 연구대상으로 포용하고, 그 둘 사이에 나타나는 차이점과 공통점을 살피고, 그 결과를 근거로 일종의 성리학 통합심성모델을 작성해보고자 할 때 필요한 이론적 정지작업을 하는 것이 본 연구의 실제 내용이다. 그 작업을 위하여 먼저 통합심성모델 작성의 이론적 관점과 기반으로서 일종의 구성주의의 관점을 채택한 이유를 밝히고, 그것에 의하여 성리학의 심성론의 해석과 그에 따른 심성모델의 구성 방식을 제시하였다. 아울러 서구의 심리철학에서 이해되는 mind, 인지과학에서 연구되고 있는 인간의 마음, 인공지능에서 이해되는 마음을 분석하고 그것과 구성주의에 의하여 재해석된 성리학자들의 마음과의 비교를 행하였다. 중요한 것은 성리학의 역사로 볼 때 똑같이 주자학 계열의 성리학자이면서도 인간의 심성의 관념에 관해서 대립적인 견해를 지녔던 퇴계와 율곡의 관점을 하나로 묶어서 통합심성모델을 작성하는 작업이다. 이에 대해서 본 연구는 퇴계와 율곡이 근본적으로 禮실천에 의하여 인간의 심성의 순수함과 정직함을 기르고 회복하려는 점에서 동일한 입장이라는 점에 착안하여, 사단과 칠정, 인심과 도심 등에 관한 理氣論적 해석에 차이가 있다고 하더라도 그것을 통합해 볼 수 있는 이론적 체제를 확보하고자 하였다. 현대에 논의되는 서구철학적 관점의 윤리학과는 다소 다른 방향과 관점에서 진행되는 이 논의는 인지과학과 비트겐슈타인류의 언어철학 등의 관점과 상호 통하는 면이 있으며, 현대 서구철학의 윤리학이 해결하지 못하는 인간의 도덕적 앎과 행위와의 괴리를 넘어설 수 있는 이론적 가능성을 보여준다고 전망된다. 그 점을 인지과학자인 프란시스코 바레라, 언어철학자인 허버트 핑가레트 등의 이론을 근거로 추론하였다. 결론적으로 퇴계와 율곡의 성리학 심성모델은 현대 윤리교육에 대해서 인간의 심신관계 및 실천지향의 윤리교육의 기초를 제시할 수 있으며, 나아가서 그에 관한 실용성도 풍부하게 지니는 것으로 생각된다. This study has a purpose to make a structure of mind and its working principles, which had been thought and understood by confucians of Chosun Dynasty, for computer simulating processes of peronalyity changes through Chosun Dynasty's moral education. This study includes Simhak(心學) of famous Chosun confucians, Toegye and Yulgok, and compares commons and differences of two scholar's theory. The key of this study prepares a necessary theoretical foundation for making a Neo-confucian integrated mind model from such results. We explained why we adopt radical constructivism as a theoretical framework for the integrated mind model, and proposed an interpretation of Neo-confucian mind theory and a method of constructing mind model. Futhermore, we look around a mind of western psychological philosophy, a mind of cognitive science, and a mind of artificial intelligence, and we have compared the confucian mind which is re-interpreted as radical constructivism with such minds. An important work is to make an integrated mind model of Toegye and Yulgok because two scholars are same Neo-confucian, but assisted own theories about human mind. Although the interpretations of Sadan(四端) and Chiljung(七情), Insim(人心) and Dosim(道心) are different each other, encouraging and recovering purity and honesty human mind with the practice of rituals is very much alike. Therefore we want to prepare theoretical foundation for integrating both. This argument is different from ethics of modern western philosophy, but have something to do with cognitive science and Wittgenstein-like philosophy of language. We expect that this idea show a theoretical possibility beyond the dissociation between ethical thinking and behavior, which modern western ethics can't solve. Such a conclusion is inferred from the concepts of Francisco Valera, the cognitive scientist, and Herbert Figarette, the linguistic philosoper. Now to conclude, the confucian mind model of Toegye and Yulgok can provide the explainable mind-body relationship and the foundation of practical moral education for modern education. We believe that the model has much possibility for practical use.

폐쇄성 수면무호흡 환자의 상기도 형태의 특징과 압력강하에 관한 3차원 전산유체역학해석

모성서,안형택,이정선,정유삼,문윤식,배응권,성상진 대한치과교정학회 2010 대한치과교정학회지 Vol.40 No.2

폐쇄성 수면무호흡(obstructive sleep apnea, OSA)은 수면 중에 반복적으로 상기도의 완전폐쇄나 부분폐쇄가 일어나는 질환으로서 흡기된 공기는 반드시 상기도라는 연조직 관(tube) 구조를 통과해야 하므로 상기도의 폐쇄경향은 관의 형태 및 관을 통과하는 공기의 유체역학적 특성에 따라서도 큰 영향을 받을 수 있다. 본 연구에서는 OSA 환자 3인의 치료 전 상기도 CT 이미지를 이용하여 개별화된 3차원 유한요소모델 A, B, C를 제작하고, 비공 당 170, 200, 230 ml/s의 흡기유량에 대하여 3차원 전산유체역학 해석을 시행하였다. 상기도의 유속, 음압 그리고 압력강하를 측정한 결과 관찰된 3개의 모델에서 모두 단면적이 가장 작은 부위에서 유속이 증가하였고, 음압이 크게 나타났다. 기도의 형태는 구개인두와 구인두 부위에서 좁아지는 형태를 가지며, 최소 단면적 영역과 하인두 단면적의 차이가 클수록 유속과 음압의 변화가 크게 나타났다. 비강 부위의 최고 압력과 최소 단면적 영역의 최저 압력의 차이를 의미하는 압력강하는 상기도 저항을 종합적으로 판단할 수 있는 유용한 지표이며, 유량에 따라 증가하였다. Objective: Obstructive sleep apnea (OSA) is a common disorder which is characterized by a recurrence of entire or partial collapse of the pharyngeal airway during sleep. A given tidal volume must traverse the soft tissue tube structure of the upper airway, so the tendency for airway obstruction is influenced by the geometries of the duct and characteristics of the airflow in respect to fluid dynamics. Methods: Individualized 3D FEA models were reconstructed from pretreatment computerized tomogram images of three patients with obstructive sleep apnea. 3D computational fluid dynamics analysis was used to observe the effect of airway geometry on the flow velocity, negative pressure and pressure drop in the upper airway at an inspiration flow rate of 170, 200, and 230 ml/s per nostril. Results: In all 3 models, large airflow velocity and negative pressure were observed around the section of minimum area (SMA), the region which narrows around the velopharynx and oropharynx. The bigger the Out-A (outlet area)/ SMA-A (SMA area) ratio, the greater was the change in airflow velocity and negative pressure. Conclusions: Pressure drop meaning the difference between highest pressure at nostril and lowest pressure at SMA, is a good indicator for upper airway resistance which increased more as the airflow volume was increased.

Peripheral Anterior Synechiae and Ultrasound Biomicroscopic Parameters in Angle-Closure Glaucoma Suspects

( Chung Kwon Yoo ),( Jong Hyun Oh ),( Yong Yeon Kim ),( Hai Ryun Jung ) 대한안과학회 2007 Korean Journal of Ophthalmology Vol.21 No.2

Purpose: To investigate the correlation between peripheral anterior synechia (PAS) and the quantitative anterior chamber angle parameters measured by ultrasound microscopy (UBM) in angle-closure glaucoma suspect (ACGS) eyes. Methods: Eyes were defined ACGS as having occludable angles and intraocular pressure less than 21 mm Hg without glaucomatous optic nerve head. The gonioscopic criteria for ACGS were the trabecular meshwork invisible in 3 or more quadrants of the entire angle and the angular width less than 20 degrees by Shaffer classification. Twenty-seven eyes of 20 patients underwent anterior chamber angle and ciliary body imaging with UBM. Angle opening distance (AOD500), angle recess area (ARA), trabecular-ciliary process distance (TCPD) and trabecular-iris angle (TIA) were measured from the UBM images at each quadrant. Results: The AOD500, ARA, and TIA were not significantly different between the eyes with PAS (9 eyes) and without PAS (18 eyes) at each quadrant. However, the TCPD was significantly shorter in the superior quadrant when compared with the eyes without PAS (mean: 405.3±70.9 μm vs 536.4±140.5 μm) (p<0.05). Conclusions: The results suggest that the shorter distance from trabecular meshwork to ciliary body or the anterior placement of ciliary process may play a role in the development of PAS in ACGS eyes. Korean Journal of Ophthalmology 21(2):106-110, 2007

Pericardium Plug in the Repair of the Corneoscleral Fistula After Ahmed Glaucoma Valve Explantation

( Chung Kwon Yoo ),( Sung Wook Kwon ),( Yong Yeon Kim ) 대한안과학회 2008 Korean Journal of Ophthalmology Vol.22 No.4

We report four cases in which a pericardium (Tutoplast(R)) plug was used to repair a corneoscleral fistula after Ahmed Glaucoma Valve (AGV) explantation. In four cases in which the AGV tube had been exposed, AGV explantation was performed using a pericardium (Tutoplast(R)) plug to seal the defect previously occupied by the tube. After debridement of the fistula, a piece of processed pericardium (Tutoplast(R)), measured 1 mm in width, was plugged into the fistula and secured with two interrupted 10-0 nylon sutures. To control intraocular pressure, a new AGV was implanted elsewhere in case 1, phaco-trabeculectomy was performed concurrently in case 2, cyclophotocoagulation was performed postoperatively in case 3 and anti-glaucomatous medication was added in case 4. No complication related to the fistula developed at the latest follow-up (range: 12~26 months). The pericardium (Tutoplast(R)) plug seems to be an effective method in the repair of corneoscleral fistulas resulting from explantation of glaucoma drainage implants. Korean J Ophthalmol 2008;22:268-271

Highly Durable and Active PtFe Nanocatalyst for Electrochemical Oxygen Reduction Reaction

Chung, Dong Young,Jun, Samuel Woojoo,Yoon, Gabin,Kwon, Soon Gu,Shin, Dong Yun,Seo, Pilseon,Yoo, Ji Mun,Shin, Heejong,Chung, Young-Hoon,Kim, Hyunjoong,Mun, Bongjin Simon,Lee, Kug-Seung,Lee, Nam-Suk,Yoo American Chemical Society 2015 JOURNAL OF THE AMERICAN CHEMICAL SOCIETY - Vol.137 No.49

<P>Demand on the practical synthetic approach to the high performance electrocatalyst is rapidly increasing for fuel cell commercialization. Here we present a synthesis of highly durable and active intermetallic ordered face-centered tetragonal (fct)-PtFe nanoparticles (NPs) coated with a “dual purpose” N-doped carbon shell. Ordered fct-PtFe NPs with the size of only a few nanometers are obtained by thermal annealing of polydopamine-coated PtFe NPs, and the N-doped carbon shell that is <I>in situ</I> formed from dopamine coating could effectively prevent the coalescence of NPs. This carbon shell also protects the NPs from detachment and agglomeration as well as dissolution throughout the harsh fuel cell operating conditions. By controlling the thickness of the shell below 1 nm, we achieved excellent protection of the NPs as well as high catalytic activity, as the thin carbon shell is highly permeable for the reactant molecules. Our ordered fct-PtFe/C nanocatalyst coated with an N-doped carbon shell shows 11.4 times-higher mass activity and 10.5 times-higher specific activity than commercial Pt/C catalyst. Moreover, we accomplished the long-term stability in membrane electrode assembly (MEA) for 100 h without significant activity loss. From <I>in situ</I> XANES, EDS, and first-principles calculations, we confirmed that an ordered fct-PtFe structure is critical for the long-term stability of our nanocatalyst. This strategy utilizing an N-doped carbon shell for obtaining a small ordered-fct PtFe nanocatalyst as well as protecting the catalyst during fuel cell cycling is expected to open a new simple and effective route for the commercialization of fuel cells.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/jacsat/2015/jacsat.2015.137.issue-49/jacs.5b09653/production/images/medium/ja-2015-09653f_0006.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/ja5b09653'>ACS Electronic Supporting Info</A></P>

증식당뇨망막병증과 안축장

유정권(Chung Kwon Yoo),한헌승(Heon Seung Han),허걸(Kuhl Huh) 대한안과학회 2001 대한안과학회지 Vol.42 No.3

LaserScan LSX(R) 와 OmniMed 2(R) 를 이용하여 시행한 LASIK 의 임상성적 비교

유정권(Chung Kwon Yoo),이강석(Kang Seok Lee),김효명(Hyo Myung Kim) 대한안과학회 2001 대한안과학회지 Vol.42 No.5

Dietary fat-associated osteoarthritic chondrocytes gain resistance to lipotoxicity through PKCK2/STAMP2/FSP27

Lee, Sung Won,Rho, Jee Hyun,Lee, Sang Yeob,Chung, Won Tae,Oh, Yoo Jin,Kim, Jung Ha,Yoo, Seung Hee,Kwon, Woo Young,Bae, Ju Yong,Seo, Su Young,Sun, Hokeun,Kim, Hye Young,Yoo, Young Hyun Nature Publishing Group UK 2018 Bone research. Vol.6 No.-

<▼1><P>Free fatty acids (FFAs), which are elevated with metabolic syndrome, are considered the principal offender exerting lipotoxicity. Few previous studies have reported a causal relationship between FFAs and osteoarthritis pathogenesis. However, the molecular mechanism by which FFAs exert lipotoxicity and induce osteoarthritis remains largely unknown. We here observed that oleate at the usual clinical range does not exert lipotoxicity while oleate at high pathological ranges exerted lipotoxicity through apoptosis in articular chondrocytes. By investigating the differential effect of oleate at toxic and nontoxic concentrations, we revealed that lipid droplet (LD) accumulation confers articular chondrocytes, the resistance to lipotoxicity. Using high fat diet-induced osteoarthritis models and articular chondrocytes treated with oleate alone or oleate plus palmitate, we demonstrated that articular chondrocytes gain resistance to lipotoxicity through protein kinase casein kinase 2 (PKCK2)—six-transmembrane protein of prostate 2 (STAMP2)—and fat-specific protein 27 (FSP27)-mediated LD accumulation. We further observed that the exertion of FFAs-induced lipotoxicity was correlated with the increased concentration of cellular FFAs freed from LDs, whether FFAs are saturated or not. In conclusion, PKCK2/STAMP2/FSP27-mediated sequestration of FFAs in LD rescues osteoarthritic chondrocytes. PKCK2/STAMP2/FSP27 should be considered for interventions against metabolic OA.</P></▼1><▼2><P><B>Oil droplets protect cartilage from toxic fatty acids</B></P><P>Cartilage tissue deals with the stress of exposure to free fatty acids by sequestering the toxic molecules into sub-cellular oil droplets. Young Hyun Yoo from Dong-A University College of Medicine in Busan, South Korea, and coworkers exposed rat cartilage cells to increasing levels of a fatty acid called oleate, a by-product of fat metabolism, and observed that the accumulation of oil droplets conferred resistance to oleate-induced toxicity. In these rat cells and in experiments involving mouse models of osteoarthritis fed a high-fat diet, the researchers then identified three of the protective proteins needed for cartilage tissue to properly quarantine fatty acids into oil droplets. Those proteins — and their connected regulatory networks — could now serve as drug targets for treating metabolic syndrome-associated osteoarthritis.</P></▼2>

Pharmacokinetics of 11-Hydroxyaclacinomycin X (ID-6105), a Novel Anthracycline, after i.v. Bolus Multiple Administration in Rats

Yoo Bo-Im,Ahan Kwang Bok,Kang Min Hee,Kwon Oh-Seung,Hong Young-Soo,Lee Jung Joon,Lee Hong Sub,Ryu Jung Su,Kim Tae Yong,Moon Dong-Cheul,Song Sukgil,Chung Youn Bok The Pharmaceutical Society of Korea 2005 Archives of Pharmacal Research Vol.28 No.4

We investigated the pharmacokinetics of 11-hydroxyaclacinomycin X (ID-6105), a novel anthracycline, after intravenous (i.v.) bolus administration at a multiple dose every 24 h for 5 days in rats. To analyze ID-6105 levels in biological samples, we used an HPLC-based method which was validated in a pharmacokinetic study by suitable criteria. The concentrations of ID-6105 after the multiple administration for 5 days were not significantly different from the results after the single administration. The $t_{1/2\alpha}, t_{l/2\beta}, V_{dss}, and CL_{t}$ after the multiple administration were not significantly different from the values after the single administration. Moreover, the concentrations of ID-6105 1 min at day 1-5 after i.v. bolus multiple administration did not show the significant difference. Of the various tissues, ID-6105 mainly distributed to the kidney, lung, spleen, adrenal gland, and liver after i.v. bolus multiple administration. ID-6105 concentrations in the kidney or lung 2 h after i.v. bolus administration were comparable to the plasma concentration shortly after i.v. bolus administration. However, the ID-6105 concentrations in various tissues 48 h after i.v. bolus administration decreased to low levels. ID-6105 was excreted largely in the bile after i.v. bolus multiple administration at the dose of 3 mg/kg. The amounts of ID-6105 found in the bile by 12 h or in the urine by 48 h after the administration were calculated to be $14.1\% or 4.55\%$ of the initial dose, respectively, indicating that ID-6105 is mostly excreted in the bile. In conclusion, ID-6105 was rapidly cleared from the blood and transferred to tissues, suggesting that ID-6105 might not be accumulated in the blood following i.v. bolus multiple dosages of 3 mg/kg every 24 h for 5 days. By 48 h after i.v. bolus administration, ID-6105 concentrations in various tissues had decreased to very low levels. The majority of ID-6105 appears to be excreted in the bile.