조직기생 선충류 유충에서 분리한 단백 분해 효소의 특성 및 항원성 검토

임한종,주경환,최성아,이혜정,주종윤,정명숙 한국농촌보건회 1997 농촌의학·지역보건 Vol.22 No.1

선천성 피부 형성부전증 1례 보고

황성진,박혜림,김희석,김동철,김정헌 大韓成形外科學會 1994 Archives of Plastic Surgery Vol.21 No.2

Aplasia cutis congenita is a disorder of heterogeneous group characterized by isolate or multiple, localized or widespread areas of skin defect at birth. Since the first report by Cordon in 1767, it has been relatively rarely reported disorder abroad as well as domestically . It has several clinical subtypes classified by the location and pattern of skin absence, the presence of associated malformations and the mode of inheritance with unknown cause. We had a newborn male infant with this disorder clinically diagnosed, who showed wide full thickness skin defects on right knee and medial surface of ankle from birth, that covered with thin yellowish membrane and showed focal ulcerative area. On his familial history, there were four aplasia cutis congenita patients in the patient's mother in his maternal family side through four generations. Patient mother showed wide spread atrophic scarred looking appearance on her right lower leg. Chromosomal analysis revealed as normal male karyotype. The biopsy of lesions showed ulcerated surface and underlying chronic inflammation with total absence of epidermis. He had no associated congenital anomaly. The lesions healed rapidly for four weeks by conservative treatment as moist wound dressing and systemic antibiotic administrations. As a relatively uncommon skin anomaly, one case of aplasia cutis congenita is reported with review of references.

Adrenal and thyroid function in the fetus and preterm infant

Chung, Hye Rim The Korean Pediatric Society 2014 Clinical and Experimental Pediatrics (CEP) Vol.57 No.10

Adrenal and thyroid hormones are essential for the regulation of intrauterine homeostasis, and for the timely differentiation and maturation of fetal organs. These hormones play complex roles during fetal life, and are believed to underlie the cellular communication that coordinates maternal-fetal interactions. They serve to modulate the functional adaptation for extrauterine life during the perinatal period. The pathophysiology of systemic vasopressor-resistant hypotension is associated with low levels of circulating cortisol, a result of immaturity of hypothalamic-pituitary-adrenal axis in preterm infants under stress. Over the past few decades, studies in preterm infants have shown abnormal clinical findings that suggest adrenal or thyroid dysfunction, yet the criteria used to diagnose adrenal insufficiency in preterm infants continue to be arbitrary. In addition, although hypothyroidism is frequently observed in extremely low gestational age infants, the benefits of thyroid hormone replacement therapy remain controversial. Screening methods for congenital hypothyroidism or congenital adrenal hyperplasia in the preterm neonate are inconclusive. Thus, further understanding of fetal and perinatal adrenal and thyroid function will provide an insight into the management of adrenal and thyroid function in the preterm infant.

Adrenocortical Function in Preterm Infants

Hye Rim Chung 대한신생아학회 2015 Neonatal medicine Vol.22 No.3

Adrenal hormones are essential for the timely differentiation and maturation of fetal organs and the regulation of intrauterine homeostasis. These hormones play complex roles during fetal life, and they are believed to provide the cellular communication that coordinates maternal-fetal interactions. Cortisol serves to modulate functional adaptations for extrauterine life in the perinatal period. Serum cortisol levels of preterm infants are similar to basal levels reported for healthy full-term neonates. However, a rise of cortisol production is absent during illness. Compared with a fetus of a similar gestational age, premature maturation of the hypothalamic-pituitary- adrenal (HPA) axis is suggested in preterm infants; however, the inappropriate cortisol value observed in severe illness is due to immaturity of 11β-hydroxylase activity and an immature response of the brain to stress. Cardiovascular instability associated with adrenal insufficiency is more frequent than formerly reported, and replacing glucocorticoids in the treatment of refractory hypotension is effective without an increase in short term adverse consequences. However, the diagnostic criteria and optimal management have not yet been determined. Thus, further understanding of perinatal adrenal function will provide insight into the improved management of preterm infants.

Screening and management of thyroid dysfunction in preterm infants

Hye Rim Chung 대한소아내분비학회 2019 Annals of Pediatirc Endocrinology & Metabolism Vol.24 No.1

Preterm infants can suffer various thyroid dysfunctions associated with developmental immaturity of the hypothalamic-pituitary-thyroid axis, postnatal illness, medications, or iodine supply. The incidence of thyroid dysfunction among preterm infants is higher than that among term infants and has been increasing with improvement in the survival of preterm infants. Hypothyroxinemia is frequently observed during the first week of life in extreme preterm neonates, and the incidence of delayed thyrotropin elevation is high at the age of 2–6 weeks. Although the necessity of routine rescreening remains controversial, recent guidelines on screening for congenital hypothyroidism have recommended rescreening of all preterm neonates. Thyroid hormone replacement is recommended for persistent thyrotropin elevation with or without hypothyroxinemia. Hypothyroxinemia without thyrotropin elevation does not require treatment, and some potential risks of levothyroxine supplementation have been reported. Although most thyroid dysfunctions are transient, careful follow-up after discontinuation of levothyroxine is considered so as to avoid missing persistent hypothyroidism.

인간번역 자동평가에서 정답자와 평가자가 다르다면

정혜연 ( Chung¸ Hye-yeon ),명혜정 ( Myeong¸ Hye-jeong ),최혜림 ( Choi¸ Hye-rim ),허탁성 ( Heo¸ Tak-sung ) 한국독일언어문학회 2021 독일언어문학 Vol.- No.93

번거로운 번역평가를 보다 쉽게 하기 위해 최근 기계번역에서 사용하는 자동평가 시스템 BLEU, METEOR을 인간번역 평가에 활용하려는 연구가 이루어지고 있다. 본 연구의 목적은 이 자동평가 시스템이 어느 조건에서나 사용 가능한지를 알아보고자 하는 것이다. 자동평가를 위해서는 정답번역을 제공할 사람과 자동평가의 타당성을 판단할 사람이 필요한데, 본 연구는 정댭자-평가자가 반드시 일치해야 하는가(<일치> 조건), 그렇지 않을 경우(<불일치> 조건), 그 차이는 어느 정도인가라는 질문에 대한 답을 구하고자 한다. 이를 위해 번역사 3인이 12개 독일어 원문에 대한 정답을 제공하고 같은 원문을 번역한 120개의 번역문을 평가했다. 같은 번역을 BLEU, METEOR도 평가한 후, <일치>, <불일치> 조건에서 인간평가-자동평가를 비교했다. 그 결과, <일치>가 <불일치> 조건보다 평가의 타당도가 높은 것으로 나타났지만, 그 차이는 유의미하지 않았다. 이는 무엇보다 인간평가자가 정답에 대한 넓은 공통분모를 가지고 있었기 때문으로 보인다. 이 실험을 통해 본 연구는 자동평가라고 하더라도 인간의 영향이 크다는 결론을 얻었다. 정답자-평가자가 동일인일 필요는 없지만, 다를 경우, 이들은 번역사, 평가자로서의 비견할만한 자질을 갖추어야 한다. Im vorliegenden Beitrag geht es um die Rolle des Menschen bei der automatischen Bewertung von Humanübersetzungen. Die Kernfrage lautet dabei, ob BLEU und METEOR, die beiden weit verbreiteten automatischen Bewertungssysteme, noch anwendbar wären, auch wenn der Evaluator, der die Validität der automatischen Bewertung prüft, nicht dieselbe Person wäre wie der Referenzübersetzer, welcher für die Maschine die „Musterübersetzung“ liefert. 120 Übersetzungen (12 Sachtexte wurden von 10 Universitätsstudenten übersetzt) wurden von drei professionellen Übersetzern/Evaluatoren sowie den automatischen Systemen BLEU und METEOR bewertet. Drei Evaluatoren lieferten jeweils ihre eigenen Referenzübersetzungen. Die Validität der automatischen Bewertungen (Korrelation zwischen menschlichen Evaluatoren und automatischen Systemen) wurde unter zwei verschiedenen Bedingungen, Kongruenz- [Referenzübersetzer=Evaluator] und Inkongruenzbedingungen, gemessen und sowohl auf der Ebene der Einzeltexte als auch des gesamten Korpus analysiert (ANOVA). Die Ergebnisse zeigten, dass die Inkongruenzbedingung die Validität von BLEU und METEOR nicht wesentlich beeinträchtigt, was wiederum bedeutet, dass im Falle der Bewertung durch BLEU und METEOR Evaluatoren und Referenzübersetzer durchaus separat engagiert werden können, solange sie mit vergleichbaren Übersetzerkompetenzen ausgestattet sind.

정보전이지수를 이용한 원자재가격과 산업별 주식수익률의 연계성에 대한 Covid-19과 러우전쟁의 영향 분석

정정현(Chung-Hyun Chung),김나영(Na Yeong Kim),김하진(Ha Jin Kim),양혜림(Hye Rim Yang) 한국자료분석학회 2023 Journal of the Korean Data Analysis Society Vol.25 No.2

본 연구는 원자재가격 변화의 산업별 주식수익률에 대한 영항을 분석한다. Covid-19 및 러우전쟁을 전후하여 원유, 구리, 옥수수 등의 원자재가격 변화와 환율 변동이 Kospi 및 6개의 산업별 주식수익률에 미치는 영향을 분석하였다. 분석대상 기간은 2017년 9월 5일부터 2022년 12월 23일까지이며, Diebold, Yilmaz(2012)의 정보전이지수(spillover index)를 이용하여 분석하였다. 본 연구의 주요 분석결과는 다음과 같다. 첫째, 주식시장, 외환시장 및 다른 원자재시장에 대하여 가장 영향력이 큰 시장은 구리시장이며, 다음으로 영향을 주는 시장은 원유시장으로 나타났다. 다른 시장으로부터 가장 영향을 많이 받는 시장은 외환시장, 주식시장, 옥수수시장 등으로 나타났다. 둘째, Covid-19 이전에 정보의 공헌자(contributor)로서의 역할을 하던 주식시장이 Covid-19나 러우전쟁의 충격이 가해지는 기간에 정보의 수령자(recipient)로 역할이 바뀌는 것으로 나타났다. 셋째, Covid-19의 충격으로 인하여 Kospi 수익률에 대한 영향이 증가한 원자재는 원유와 옥수수이며, 러우전쟁의 충격으로 인하여 Kospi 수익률에 대한 영향이 증가한 원자재는 구리이다. 넷째, 산업별로 살펴보면, 전기전자, 화학, 철강업에서는 원자재시장과 연계성이 대체로 높은 편이며, 음식료품, 기계, 운송장비업에서는 비교적 낮은 편으로 나타났다. 다섯째, 모든 산업에서 Covid-19 기간이나 러우전쟁 기간에 총 정보전이지수가 높게 나타난다는 것을 확인하였다. This paper analyzes the effect of commodity prices on the industrial stock market. The commodities selected to represent raw materials are crude oil, copper, and corn. Kospi and six industrial stock price indices including foods, chemical, steel, machinery, electronic, and transport are analyzed. The exchange rate is also included in the model. Test period is 1,257 trading days from September 5, 2017 to December 23, 2022. Spillover effect is measured with Diebold and Yilmaz (2009, 2012)’s index. Major findings are as follows. First, the influential markets to stock and foreign exchange markets are copper and crude oil markets. Second, the stock market which was a contributor to information before Covid-19 changed role to the recipient of information during the Covid-19 and Russo-Ukraine war period. Third, the effect of crude oil and corn on Kospi returns caused by the Covid-19 is increased. And the effect of copper is increased during the Russo-Ukraine war period. Fourth, the stock returns of electronic, chemical and steel industries have high connectedness with the commodity market compared to that of foods, machinery and transport industries. Fifth, the total spillover index appears high in all industries during the Covid-19 and Russo-Ukraine war period compared to pre-Covid-19 period.

Retinoic Acid가 돼지 지방세포의 분화에 미치는 영향

김혜림 ( Hye Rim Kim ),정정수 ( Chung Soo Chung ) 한국동물자원과학회 2008 한국축산학회지 Vol.50 No.3

Molecular Biological Characterization of Bursaphelenchus xylophilus and Bursaphelenchus mucronatus in Korea

Hye Rim Han,Yeong Jin Chung,Sang Chul Shin 한국임학회 2008 Forest Science And Technology Vol.4 No.2

Case Reports : Recurrent Gastric Perforation in a Neonate Recovered after Primary Surgical Repair and Percutaneous Peritoneal Drainage

( Hye Rim Park ),( Ji Eun Ryu ),( Sung Hoon Chung ),( Yong Sung Choi ) 대한주산의학회 2015 大韓周産醫學會雜誌 Vol.26 No.4

Neonatal gastric perforation is a rare but fatal disease, occurred mainly in preterm infants. In general, primary surgical repair is the main treatment. To the best of our knowledge, there has been only one report of improvement of gastric perforation in neonates after percutaneous peritoneal drainage alone. We describe a case of gastric perforation in a premature extremely low-birth-weight infant girl of 25+4 weeks gestational age. We present this case to emphasize that gastric perforation may improve with percutaneous peritoneal drainage.