Prevalence and Genotype Distribution of Human Papillomavirus among Women from Henan, China

Wang, Xiao-Chuan,Sun, Liang-Qi,Ma, Li,Li, Hua-Xin,Wang, Xiu-Li,Wang, Xin,Yun, Tian,Meng, Nian-Long,Lv, Da-Le Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.17

Human papillomavirus (HPV) infection has been implicated as a causative of cervical cancer. In the present study, a total of 578 samples from females attending the gynecological outpatient clinic in Henan province, China, were collected and the HPV genotypes were detected by gene chip and flow-through hybridization. Overall, 44.5% (257/578) females were found to be HPV DNA positive, and the high risk HPV (HR-HPV) rate was 35.1% (203/578). The first peak of HR-HPV infection appeared in the >60 year-old group (55.0%), and the second was within the 51-55 year-old group (50.0%) (${\chi}^2$=19.497, p<0.05). HPV 16 was the most prevalent genotype (9.2%), followed by HPV 52 (7.8%), HPV 6 (6.9%), HPV 11 (5.9%) and HPV 42 (5.0%). The single type HPV infection was 30.4%, with the five majority prevalent genotype HPV 16 (16.5%), HPV 52 (14.3%), HPV 6 (12.6%), HPV 42 (8.6%), HPV 31 (5.1%). The multiple-type HPV infections were 14.0%, and HPV 16 was the most prevalent type (29.6%), followed by HPV 52 (24.7%), HPV 6 (22.2%), HPV 11 (22.2%), HPV 42 (17.3%) and HPV 39 (17.3%).

Chloroquine and Valproic Acid Combined Treatment in Vitro has Enhanced Cytotoxicity in an Osteosarcoma Cell Line

Wang, Chuan-Kun,Yu, Xi-Dong,Li, Qiang,Xie, Gang,Teng, Yue Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.8

Choroquine (CQ) and valproic acid (VPA) have been extensively studied for biological effects. Here, we focused on efficacy of combined CQ and VPA on osteosarcoma cell lines. Viability of osteosarcoma cell lines (U20S and HOS) was analyzed by MTT assay. Apoptotic assays and colony formation assays were also applied. ROS generation and Western Blotting were performed to determine the mechanism of CQ and VPA combination in the process of apoptosis. The viability of different osteosarcoma cell lines significantly decreased after CQ and VPA combination treatment compared with either drug used alone, and apoptosis was increased significantly. ROS generation was triggered leading to expression of apoptosis related genes being increased and of antiapoptotic related genes being decreased. From our data shown here, CQ and VPA combination treatment in vitro enhanced cytotoxicy to osteosarcoma cells.

A SURVEY OF RECENT PATENTS OF FIN-AND-TUBE HEAT EXCHANGERS FROM 2001 TO 2009

Wang, Chi-Chuan The Society of Air-Conditioning and Refrigerating 2010 International Journal Of Air-Conditioning and Refr Vol.18 No.1

This study presents the updated information about patents of the fin-and-tube heat exchangers during 2001-2009. A total of 23 patents were examined and some explanations about how the work are provided. Fin patterns like convex-louver, enhanced wavy, enhanced slit, enhanced louver, vortex generators, and special fin pattern are reported in the present review paper. It is recommended that further detailed examinations via numerical simulation or experimental investigation be carried out in the future to gain further insight to these fin designs.

Detection of Low Frequency Signals using Interferometric Fiber Sensors based on Phase Generated Carrier Demodulation Technique

Wang Yong-jiao,Wang Chuan,Yuan Yin-quan,Liang Lei 보안공학연구지원센터 2015 International Journal of Signal Processing, Image Vol.8 No.2

A fiber-optic sensor is a sensor with high sensitivity, and signal detection technology is one of its key technologies. Phase generated carrier demodulation technology is a homodyne demodulation method widely used for interference fiber-optic sensors. Research reveals that the amplitude of the interference signal and the modulation depth will affect the result of demodulation. The distortion of the demodulated signal can be reduced by the elimination of the effects of the interference signal amplitude and modulation depth. A phase generated carrier demodulation method for interference fiber-optic sensors is proposed to detect weak ELF signals. Theoretical analysis and simulation have been implemented on the demodulation of weak ELF signals using low-level sub-mixer carrier. The results indicate that in the demodulation of weak ELF signals, DC drift occurs in the DCM approach, while the Arctangent approach does not have this problem. Then, an optical fiber sensing system for ELF signals is established based on optical fiber interferometer, indicating the Arctangent approach is able to demodulate the VLF signals accurately.

Using DEA Method to Measure and Evaluate Tourism Efficiency of Guangdong, Guangxi and Hainan Provinces in the South of China - A case of the Beibu Gulf Urban Agglomeration-

Wang, Xiao-Chuan,Kim, Hyung-Ho The Institute of Internet 2021 International journal of advanced smart convergenc Vol.10 No.1

China's "One Belt and One Road" initiative has brought multiple opportunities to the development of tourism in Guangdong, Guangxi and Hainan provinces and the implementation of the Beibu Gulf Urban Agglomeration Development Plan hasset clear goalsforfurther accelerating the coordinated development, in-depth cooperation of the three. This study takes the Beibu Gulf Urban Agglomeration as the research object and utilized the data envelopment analysis (DEA) procedure to estimate the technical efficiency, pure technical efficiency, and scale efficiency scores for each city and Malmquist index was subsequently used to analyze dynamically, then tries to offer an adequate inclusion of sustainable factors in overall tourism development efficiency results through the detection and estimation of potential sources of efficiency. In order to complete the task, data collection was focused on Guangdong, Guangxi and Hainan provinces of China over the period from 2016 to 2018. The results in the first phase show relatively high efficiency scores, particularly in the case of the Beibu Gulf Urban Agglomeration and with room for improvement in the case of other cities of Guangdong, Guangxi and Hainan provinces. The second stage results present several aspects that should be carefully considered in order to analysis tourism efficiency of the Beibu Gulf Urban Agglomerations vertically according to the changes of the frontier.

Extremely Bendable, High-PerformanceIntegrated CircuitsUsing Semiconducting Carbon Nanotube Networks for Digital, Analog,and Radio-Frequency Applications

Wang, Chuan,Chien, Jun-Chau,Takei, Kuniharu,Takahashi, Toshitake,Nah, Junghyo,Niknejad, Ali M.,Javey, Ali American ChemicalSociety 2012 Nano letters Vol.12 No.3

<P>Solution-processed thin-films of semiconducting carbonnanotubesas the channel material for flexible electronics simultaneously offershigh performance, low cost, and ambient stability, which significantlyoutruns the organic semiconductor materials. In this work, we reportthe use of semiconductor-enriched carbon nanotubes for high-performanceintegrated circuits on mechanically flexible substrates for digital,analog and radio frequency applications. The as-obtained thin-filmtransistors (TFTs) exhibit highly uniform device performance withon-current and transconductance up to 15 μA/μm and 4 μS/μm.By performing capacitance–voltage measurements, the gate capacitanceof the nanotube TFT is precisely extracted and the corresponding peakeffective device mobility is evaluated to be around 50 cm<SUP>2</SUP>V<SUP>–1</SUP>s<SUP>–1</SUP>. Using such devices, digitallogic gates including inverters, NAND, and NOR gates with superiorbending stability have been demonstrated. Moreover, radio frequencymeasurements show that cutoff frequency of 170 MHz can be achievedin devices with a relatively long channel length of 4 μm, whichis sufficient for certain wireless communication applications. Thisproof-of-concept demonstration indicates that our platform can serveas a foundation for scalable, low-cost, high-performance flexibleelectronics.</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/nalefd/2012/nalefd.2012.12.issue-3/nl2043375/production/images/medium/nl-2011-043375_0006.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nl2043375'>ACS Electronic Supporting Info</A></P>

Experimental investigation on the subsurface stress distributions in specimens with different strengths after ultrasonic impact treatment

Chuan Liu,Jia-bin Shen,Chang-hua Lin,Jian-fei Wang,Jian-xin Wang 대한기계학회 2021 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.35 No.5

Ultrasonic impact treatment (UIT) was carried out on three specimens with different strengths and, to measure the subsurface stress distribution of the specimens, the layer-by-layer removal x-ray diffraction method was applied. The stress redistribution due to material removal was corrected by finite element analysis. The effect of material strength on the after-UIT subsurface stress was investigated. The results show that the UIT can cause a compressive stress layer with a depth of over 2.5 mm for specimens with different strengths, while the material strength has no significant effect on the depth of UIT-induced stress. The UIT-induced peak compressive stresses in the three specimens exceed the material yield strength, appearing at the depth of 0.2 mm beneath the surface and increasing with the increase of material yield strength. The ratio of UIT-induced peak compressive stress magnitude to material yield strength decreases with the increase of material yield strength.

Epidemiology of Esophageal Cancer in Yanting - Regional Report of a National Screening Programme in China

Wang, Xiao,Fan, Jin-Chuan,Wang, An-Rong,Leng, Yue,Li, Jun,Bao, Yu,Wang, Ying,Yang, Qing-Feng,Ren, Yu Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.4

Background and Objectives: Yanting in Sichuan Province is one of the highest risk areas of esophageal cancer (EC) in the world. We here summarize the epidemiology of EC in Yanting using data from the national screening programme during 2006-2011. Methods: Random cluster sampling was used to select a proportion of natural villages from six towns in Yanting, and residents aged 40-69 years old were invited for screening. Participants were screened using endoscopy with iodine staining and then confirmed by histological examinations. Results: The overall detection rates of low-grade hyperplasia (LH), moderate hyperplasia (MH), high-grade hyperplasia (HH), carcinoma in situ (CIS), intramucosal carcinoma (IC) and invasive carcinoma (INC) were 5.33%, 1.28%, 0.68%, 0.15%, 0.06% and 0.29%, respectively. The detection rates of LH, MH, HH and INC increased with age, reaching the peak among those aged 60-65 years, and the prevalences of LH and MH were higher among men than among women. In addition, the detection rates of hyperplasia were much higher in mountainous than in hilly areas. Conclusions: Among the high risk population, there are a great number of people with early-stage EC or precancerous conditions who do not have presenting symptoms. In particular, the elderly, men, or those living in mountainous areas are the most vulnerable population. It is therefore important to reinforce health education and screening services among such high risk populations.

Inhibitory effects of piceatannol on human cytomegalovirus (hCMV) in vitro

Wang San-Ying,Zhang Jing,Xu Xiao-Gang,Su Hui-Li,Xing Wen-Min,Zhang Zhong-Shan,Jin Wei-Hua,Dai Ji-Huan,Wang Ya-Zhen,He Xin-Yue,Sun Chuan,Yan Jing,Mao Gen-Xiang 한국미생물학회 2020 The journal of microbiology Vol.58 No.8

Human cytomegalovirus (hCMV) is a ubiquitous herpesvirus, which results in the establishment of a latent infection that persists throughout the life of the host and can be reactivated when the immunity is low. Currently, there is no vaccine for hCMV infection, and the licensed antiviral drugs mainly target the viral enzymes and have obvious adverse reactions. Thus, it is important to search for compounds with antihCMV properties. The present study aimed to investigate the suppressive effects of piceatannol on hCMV Towne strain infection and the putative underlying mechanisms using human diploid fibroblast WI-38 cells. Piceatannol supplementation prevented the lytic changes induced by hCMV infection in WI-38 cells. Furthermore, piceatannol suppressed the expression of hCMV immediate-early (IE) and early (E) proteins as well as the replication of hCMV DNA in a dose-dependent manner. Moreover, hCMV-induced cellular senescence was suppressed by piceatannol, as shown by a decline in the senescence-associated β-galactosidase (SA-β-Gal) activity and decreased production of intracellular reactive oxygen species (ROS). p16INK4a, a major senescence-associated molecule, was dramatically elevated by current hCMV infection that was attenuated by pre-incubation with piceatannol in a dose-dependent manner. These results demonstrated that piceatannol suppressed the hCMV infection via inhibition of the activation of p16INK4a and cellular senescence induced by hCMV. Together, these findings indicate piceatannol as a novel and potent anti-hCMV agent with the potential to be developed as an effective treatment for chronic hCMV infection.

Prognostic Analysis of Schistosomal Rectal Cancer

Wang, Meng,Zhang, Yuan-Chuan,Yang, Xu-Yang,Wang, Zi-Qiang Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.21

Background: Schistosomiasis is an infectious disease that affects more than 230 million people worldwide, according to conservative estimates. Some studies published from China and Japan reported that schistosomiasis is a risk factor for colorectal cancer in Asia where the infective species is S. japonicum. Hoqwever, there have been only few reports of prognosis of patients with schistosomal rectal cancer SRC. Objectives: This study aimed to analyze differences in prognosis between SRC and non-schistosomal rectal cancer(NSRC) with current treatments. Materials and Methods: A retrospective review of 30 patients with schistosomal rectal cancer who underwent laparoscopic total mesorectal excision operation (TME) was performed. For each patient with schistosomal rectal cancer, a control group who underwent laparoscopic TME with non-schistosomal rectal cancer was matched for age, gender and tumor stage, resulting in 60 cases and controls. Results: Univariate analysis showed pathologic N stage (P=0.006) and pathologic TNM stage (P=0.047) statistically significantly correlated with disease-free survival (DFS). Pathologic N stage (P=0.014), pathologic TNM stage (P=0.002), and with/without schistosomiasis (P=0.026) were statistically significantly correlated with overall survival (OS). Schistosomiasis was the only independent prognostic factor for DFS and OS in multivariate analysis. Conclusions: The prognosis of patients with schistosomal rectal cancer is poorer than with non-schistosomal rectal cancer.