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임태영,조영신,정춘해,박유환,하상호,유재원 조선대학교 부설 의학연구소 2002 The Medical Journal of Chosun University Vol.27 No.1
진행성 골화성 섬유 이형성증은 2 백만명 중에 1명 발생하는 매우 드문 유전질환이다. 저자들은 2차례의 외상후 심해진 진행성 섬유 이형성증환자에서 최근 다시 발생된 외상후 생긴 병변부위에 biphosphonate와 steroid 투여로 최근수상부위의 근육 골화와 경화를 현저한 호전을 보였으나, 기존의 골화가 이미 진행된 병변에서는 잘 반응하지 않음을 경험하였기에 문헌고찰과 함께 보고하는 바이다. Fibrodysplasia ossificans progressiva(FOP) is an extremely rare hereditary disorder characterised by progressive heterotopic ossification of the soft tissue. The resulting progressive immobilization of the limbs, jaw and chest wall generally leads to severe disability. We present an 20-rear-old man with advanced FOP. He had two operative interventions by prior traffic accident and recent biopsy. It resulted abnormal ossification. Treatment for this disorder is avoidance of exacerbating factors and medical strategies is biphosphonate and steroid. We observed the course of ossification and muscle atrophy during biphosphonate and steroid therapy in advanced FOP.
배승춘,김정환,김호운,박성근,김기완 경북대학교 센서기술연구소 1997 센서技術學術大會論文集 Vol.8 No.1
PLT and PLZT feroelectric thin films were fabricated on ITO substrate by rf magnetron sputtering. Pressure was 30mTorr, rf power was 180W and substrate temperature was varied from room temperature to 500℃. In this case, PLT had the highest dielectric constant of 120 at 500 ℃, oppositly PLZT had the highest dielectric constant of 312 at room temperature. I-V characteristics of PLZT film were shown that leakage current of PLZT film deposited at room temperature was below 3μA at 100V.
Agrobacterium tumefaciens를 이용한 bialaphos 저항성 형질전환 벼의 개발
이효연,이춘환,김호일,한원동,최지은,김진호,임용표 충남대학교 생물공학연구소 1999 생물공학연구지 Vol.7 No.-
비선택성 제초제인 bialaphos는 고등식물에 있어서 glutamine 합성을 억제하여 식물체를 고사시킨다. Acetyltransferase에 의해 encoding된 bialaphos 저항성 유전자는 세균 Streptomyces hygroscopicus SF1239로부터 cloning된 것을 사용하였다. Bialaphose 저항성 유전자를 Agrobacterium 감염법을 이용하여 국내에서 재배되는 벼(동진)에 도입한 결과 약 30%정도의 형질전환 식물체를 얻을 수 있었다. T_1세대의 17개체는 hygromycin과 bialaphos에 대한 저항성 유전형질이 3 : 1로 분리되었다. 또한 Southern 분석을 실시한 결과 wild type의 식물체에서는 Bar 유전자의 검출을 볼 수 없었으나 형질전환 식물체의 경우 Bar 유전자의 검출이 가능하였다. T_3 세대의 형질전환 식물체와 wild type의 식물체를 포장상태에서 비선택성 제초제인 바스타를 살포하고 3주 후에 관찰한 결과 형질전환 식물체는 외형적으로 아무런 피해를 받지 않고 정상적으로 생장하였으나, wild type의 식물체와 잡초는 모두 고사하였다. 이상의 결과를 종합해보면 hygromycin과 bialaphos 저항성 유전자는 Agrobacterium 감염법을 이용하여 단자엽 식물인 벼에 도입할 수 있다는 것을 보여준 것이며, 또한 bialaphos 저항성 유전자가 식물에 도입됨으로써 비선택성 제초제에 대한 저항성 식물을 개발 할 수 있다는 것을 보여 주었다. The bialaphos is a potent inhibitor of glutamine synthease in higher plants and is used as a non-selective herbicide. We have used the bialaphos resistant gene (Bar) encoding for an acetyltransferase isloated from Streptomyces hygroscopicus SF1293. Callus derived from mature seeds of rice (Oryza sativa L. cv. Dong Jin) were co-cultivated with Agrobacterium tumefacieus EHA101 carring a plasmid pGPTV-HB containing genes for hygromycin resistance (HygR) and Bar. Transgenic plants showing in vitro resistance to 50 mg/L hygromycin and 10 mg/L bialaphos were obtained by using a two-step selection/regeneration procedure. Transformation efficiency of rice was about 30% which was as high as reported in other dicotyledons. Progenies (T_1 generation) derived from primary transformant of 17 lines were segreagated with a 3 resistant:1 sensitive ratio in medium containing hygromycin and bialaphos. Stable integration of Bar gene into chromosomal DNA was proven by Southern blot analysis of genomic DNA isolated from T_2 progenies. Transgenic plants (T_3) grown in the field were resistant to bialaphos (Basta) at a dosage lethal to wild type plants.
나주오두제와 영암사자저수지의 바이오그라우팅에 대한 현장 적용성 평가
임춘호 ( Lim Choon-ho ) 조선대학교 공학기술연구원 2016 공학기술논문지 Vol.9 No.3
In this experiment, applicability of biogrouting method was evaluated at two construction sites. Comparison is made among the typical grouting, a patented grouting, and the biogrouting to evaluate the injection efficiency such as disparity effect and regenerating the functions of irrigations. Microorganism liquid and reaction liquid were separatly injected when implementaion of biogrout is difficult in actual sites. For ease of using biogrout, powdered products similar to cement were developed to use as injection material.
Characterization of CBF/DREB1 Gene Family in Brassica rapa
Sang-Choon Lee,Myung-Ho Lim,Jae-Gyeong Yu,Beom-Seok Park,Tae-Jin Yang 한국육종학회 2012 한국육종학회 심포지엄 Vol.2012 No.07
The C-repeat/dehydration-responsive element binding transcription factors (CBF/DREBs) are involved in an important pathway for abiotic stress-response in plants. We have identified CBF/DREB1 gene family from Brassica rapa whole genome sequence and designated them as BrDREB1s. They contain conserved nucleus localization signal, AP2/EREBP domain, and CBF/DREB1 signature, as other known plant CBF/DREB1s. By comparative genomics, we found that nine of ten BrDREB1 genes were present in seven macro-synteny blocks co-linear to four Arabidopsis counterpart blocks and also genomic organizations of their flanking regions were very similar to those for co-linear Arabidopsis CBF/DREB1 genes. In particular, three genes, BrDREB1A, BrDREB1B1, and BrDREB1C1, were closely located within a 59 kb genomic sequence, which was similar to that of their Arabidopsis counterpart genes. However, the genomic regions of those BrDREB1 genes contained additional sequences, compared to their co-linear regions in A. thaliana. The expression of BrDREB1 genes under abiotic stresses were examined by searching microarray database and by RT-PCR analysis. All of eight genes tested were highly up-regulated during cold treatment and some of them were also responsive to salt, drought, and ABA treatment. Taken together, these results indicate that CBF/DREB1-mediated stress signaling pathway is also functioning in B. rapa. On the other hand, differences in genomic organization and gene number for CBF/DREB1 are thought to cause different response to stress between B. rapa and A. thaliana. In this presentation, we will introduce more detailed results for CBF/DREB1 gene family in B. rapa.
Yun, Young Ho,Sim, Jin Ah,Lim, Ye Jin,Lim, Cheol Il,Kang, Sung-Choon,Kang, Joon-Ho,Park, Jun Dong,Noh, Dong Young Lippincott Williams & Wilkins 2016 Journal of Occupational and Environmental Medicine Vol.58 No.6
<P>Objectives: The objective of this study was to develop the Worksite Health Index (WHI) and validate its psychometric properties. Methods: The development of the WHI questionnaire included item generation, item construction, and field testing. To assess the instrument's reliability and validity, we recruited 30 different Korean worksites. Results: We developed the WHI questionnaire of 136 items categorized into five domains, namely Governance and Infrastructure, Need Assessment and Planning, Health Prevention and Promotion Program, Occupational Safety, and Monitoring and Feedback. All WHI domains demonstrated a high reliability with good internal consistency. The total WHI scores differentiated worksite groups effectively according to firm size. Each domain was associated significantly with employees' health status, absence, and financial outcome. Conclusions: The The WHI can assess comprehensive worksite health programs. This tool is publicly available for addressing the growing need for worksite health programs.</P>