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서브 - 링의 신드롬 분석을 이용한 하이퍼큐브 진단 알고리즘
김학원(Hak-Won Kim),김동군(Dong-Kun Kim),최문석(Moon-Seok Choi),이충세(Chung-Sei Rhee) 한국정보과학회 2001 한국정보과학회 학술발표논문집 Vol.28 No.2Ⅰ
하이퍼큐브의 정규직이며 계층적인 구조적 특성은 효율적인 진단 알고리즘 개발에 유리하게 적용될 수 있다. Feng et al.의 HADA/IHADA와 Choi와 Rhee의 적응적 큐브 분할 방법은 하이퍼큐브의 전체 노드를 하나의 링으로 임베딩하여 링의 진단 특성을 이용하여 위하여 분할 및 정복 방법을 이용하였다. 또한 Kranakis와 Pelc는 결함을 모두 포함하는 최소의 서브링을 하나의 노드로 하는 하이퍼큐브의 형태로 분할하는 HYP-DIAG 알고리즘을 제안하였다. 또한 최악의 경우에, 테스트 수만을 고려하여 2ⁿ+3n/2의 테스트 수를 갖는 FAST-HYP-DIAG 알고리즘과 병렬 시간만을 고려하여 많아야 11테스트 라운드 이내에 진단을 수행하는 EXPRESS-HYP-DIAG 알고리즘을 제안하였다. 본 논문에서는 HYP-DIAG의 첫 번째 단계에서 얻어진 서브링들의 신드롬을 분석하여 테스트의 수와 테스트 라운드를 모두 고려하는 알고리즘을 제안한다.
김경연 ( Kyung Yeon Kim ),백무열 ( Moo Yeol Baik ),박천석 ( Cheon Seok Park ),최성원 ( Sung Won Choi ),김창남 ( Chang Nam Kim ),김병용 ( Byung Yong Kim ) 한국식품영양학회 2013 韓國食品營養學會誌 Vol.26 No.1
죽의 기능성 향상을 위하여 2:1:1:1의 배합으로 혼합한 한약재료(가시오가피, 숙지황, 산약, 백복령)와 닭가슴살 등의 재료를 사용해 한방 영양죽을 제조하였다. 한방 닭죽의 DPPH radical 소거능, SOD 유사활성, 맛의 선호도, cost는 수학적인 canonical model과 trace plot을 이용하여 분석한 결과, SOD 유사활성 이외에는 각 성분들이 독립적으로 작용하여 상호작용이 없는 선형 모델을 보여주었다. DPPH radical 소거능, SOD 유사활성, 맛의 선호도를 최대로, cost를 최소로 목적 범위를 설정하고, 각각의 canonical 계수를 이용하여 수적 최적화를 통하여 최적 배합비를 구한 결과, 한약 혼합물 101g, 닭가슴살 38.66g, 찹쌀 비율 41.34g의 최적 배합비를 구하였으며, 이 배합비에 따른 맛의 선호도는 6.39, DPPH radical 소거능은 17.25㎎VCE/ℓ, SOD 유사활성은 2.25%, cost는 1,382.39 won으로 나타났으며, 여러 결과들 사이에 최적화된 한 값에 수렴하는 desirability는 0.714로 나타났다. 이는 한약혼합물이 많을수록 기능성 면에서는 높게 나타나지만 맛의 선호도면에서는 낮게 나타냈고, 닭가슴살의 경우에도 그 함량이 많을수록 맛의 선호도는 올라갔지만 그에 반해 cost가 높게 올라간 것을 반영한 결과로 사료된다. The objectives of this study were to develop porridge with medicinal herbs and chicken breast meat and to find out the optimum mixing ratio. Several herb extracts such as Acanthopanacis senticosus, Rehmannia glutinosa, Disocorea japonica, and Poria cocos Wolf were used in the ratio of 2, 1, 1, and 1, respectively. The optimum processing condition for herbal chicken porridge was determined by a design expert program. Seventeen experimental points were selected, and herb extracts (82∼101g), chicken breast meat (30∼50g), and glutinous rice (40∼60g) were chosen as the independent variables. The measured responses were preference of taste, DPPH radical scavenging, SOD-like activity, and cost. The optimum formulation of herbal chicken porridge using the numerical analysis was set at herbal extracts (101g), chicken breast meat (38.66g), and glutinous rice (41.34g) with a 0.714 desirability value. DPPH radical scavenging effect, preference of taste and the cost showed a linear model, whereas SOD-like activity showed a quadratic model indicating a higher interaction among the mixture. As a result of proximate composition of optimized herbal chicken porridge, the contents of moisture, carbohydrate, crude protein, crude lipid, and ash contents were 76.4, 9.0, 1.4, 0.5, and 1.6%, the calories of the porridge was 46.1kcal/100g.
Seok-Cheol Choi(최석철),Jai-Young Kim(김재영),Heun-Young Kwon(권헌영),Tae-Un Kim(김태운),Soo-Myung Hwang(황수명),Won-Jae Lee(이원재) 대한의생명과학회 2000 Biomedical Science Letters Vol.6 No.2
혈액 전해질 성분들에 대한 대장균 내독소의 영향을 조사하기 위해 토끼를 대상으로 한 동물실험을 실시하였다. 대장균 내독소 (혈청형 O55 : B5)를 토끼의 귀정맥을 통해 0.10 ㎎/㎏ 혹은 0.50 ㎎/㎏ 농도로 주입한 후 3, 6, 12, 24시간대에 채혈하여서 Ca??, Mg??, Na?, K?, Cl? 농도를 측정하였다. 대조군에 비해, 내독소투여 토끼의 Ca?? 농도는 6시간대에 증가하였고, Mg?? 농도는 3, 6, 12시간대에, Na?과 K?는 모든 채혈시간대에, 그리고 Cl? 농도는 3, 12, 24시간대에 각각 유의하게 높았다 (p<0.05). 흥미롭게도, 고 Mg? 혈증 (약 4.0 ㎎/dL)을 보인 내독소투여 토끼들은 심각한 임상징후들로 인식되는 분비불의 증가, 쇼크, 빈호흡, 경련, 혹은 설사와 같은 증세를 보였다. 본 연구의 결과들은 대장균 내독소가 혈액 전해질 농도의 항상성 혼란을 유도하며 이러한 생리적 불균형은 치명적 상황과 그로 인한 죽음을 야기할 수도 있음을 시사하고 있다. We studied the effects of Escherichia coli (E. coli) endotoxin on blood electrolytes levels in rabbits. Endotoxin (E. coli serotype O55 : B5) was injected via rabbits' ear vein : 0.10 ㎎/㎏ (Group A) or 0.50 ㎎/㎏ (Group B). Blood samples were taken at postendotoxemic 3, 6, 12 and 24 hrs and were analyzed for detections of the levels of blood electrolytes such as Ca??, Mg??, Na?, K? and Cl?. As compared to control group, in endotoxin-treated rabbits Ca?? levels elevated at 6 hrs but decreased at 24 hrs, Mg?? levels were high at 3, 6 and 12 hrs, Na? and K? levels increased at all sampling times and Cl? levels rose at 3, 12 and 24 hrs (p<0.05). Interestingly, endotoxic rabbits having hypermagnesemia (about 4.0 ㎎/dL) showed severe syndromes such as increased secretion, shock, tachypnea, seizure and/or diarrhea, suggesting that these may be clinical signs of imminent death in rabbits. These observations testify that bacterial endotoxin leads to dyshomeostasis of blood electrolytes and the physiological imbalances may cause fatal disorders and subsequent death.
Won-Suk Choi,Nam-Ju Park,Dong-Yun Lee,Dong-Seok Hyun 전력전자학회 2005 JOURNAL OF POWER ELECTRONICS Vol.5 No.4
In this paper, a simple power control scheme for a constant frequency Class-D inverter with a variable duty cycle is proposed. It is more suitable and acceptable for high- frequency induction heating (IH) jar applications. The proposed control scheme has the advantages of not only wide power regulation range but also ease of control output power. Also it can achieve a stable and efficient Zero-Voltage-Switching (ZVS) in a whole load range. The control principles of the proposed method are described in detail and its validity is verified through simulated and experimental results on 42.8㎑ IGBT for induction heating rated on 1.6kW with constant frequency variable power.
Choi, Jin-Ho,Choi, Jinoh,Lee, Wang-Soo,Rhee, Il,Lee, Sang-Chol,Gwon, Hyeon-Cheol,Lee, Sang Hoon,Choe, Yeon Hyeon,Kim, Dae Won,Suh, Wonhee,Kim, Duk-Kyung,Jeon, Eun-Seok Japanese Circulation Society. 2007 Circulation journal Vol.71 No.4
<P><B>Background</B> Recently the potential of myocardial repair by transplantation of autologous bone marrow stem cells has been suggested. Whether the additional intracoronary transplantation of autologous peripheral blood stem cells (PBSC), which were mobilized by granulocyte-colony-stimulating factor (G-CSF), could safely improve myocardial function in patients with acute myocardial infarction (AMI) was investigated. <B>Methods and Results</B> Seventy-three patients with AMI who had successfully undergone percutaneous coronary intervention (PCI) were enrolled in the present prospective nonrandomized open-labeled study. Ten patients with elective PCI received G-CSF for 4 days followed by intracoronary PBSC transplantation. Thirty-two patients with primary PCI and 31 patients with recent AMI and elective PCI served as controls. The left ventricular (LV) function was evaluated using echocardiography and magnetic resonance imaging. G-CSF and intracoronary transplantation of PBSC did not incur any periprocedural myocardial damage. After 6 months, the LV ejection fraction was significantly improved in the cell therapy group. For 2 years of the follow-up period, there was no adverse clinical events, except one asymptomatic in-stent restenosis. However, comparable improvement of the LV ejection fraction was also identified in the primary PCI and elective PCI control groups. <B>Conclusions</B> In the present study, additional intracoronary infusion of PBSC was safe and feasible for the patients with AMI who had undergone PCI, but did not lead to a significant improvement in LV function compared to standard reperfusion treatment. (<I>Circ J</I> 2007; <B>71:</B> 486 - 494)</P>
Seok Choi,Kyung Won Cho,Jong-Hyun Reu,Jun-Soo Kim,Hyun Sik Mun,Myung Young Kim,Kwang Chul Park,Gwang Sik Heo,Sung Jong Chang,Cheol Ho Yeum,Pyung Jin Yoon,Jae Yeoul Jun 대한생리학회-대한약리학회 2004 The Korean Journal of Physiology & Pharmacology Vol.13 No.1
The interstitial cells of Cajal (ICCs) are the pacemaker cells in gastrointestinal tract and generate electrical rhythmicity in gastrointestinal muscles. Therefore, ICC may be modulated by endogenous agents such as neurotransmitter, hormones, and prostaglandins (PGs). In the present study, we investigated the effects of prostaglandins, especially PGE<SUB>2</SUB>, on pacemaker currents in cultured ICCs from murine small intestine by using whole-cell patch clamp techniques. ICCs generated spontaneous slow waves under voltage-clamp conditions and showed a mean amplitude of 452⁑39 pA and frequency of 18⁑2 cycles/min (n=6). Treatments of the cells with PGE<SUB>2</SUB> (1μM) decreased both the frequency and amplitude of the pacemaker currents and increased the resting currents in the outward direction. PGE<SUB>2</SUB> had only inhibitory effects on pacemaker currents and this inhibitory effect was dose-dependent. For characterization of specific membrane EP receptor subtypes, involved in the effects of PGE<SUB>2</SUB> on pacemaker currents in ICCs, EP receptor agonists were used: Butaprost (1μM), EP<SUB>2</SUB> receptor agonist, reduced the spontaneous inward current frequency and amplitude in cultured ICCs (n=5). However sulprostone (1μM), a mixed EP<SUB>1</SUB> and EP<SUB>3</SUB> agonist, had no effects on the frequency, amplitude and resting currents of pacemaker currents (n=5). SQ-22536 (an inhibitor of adenylate cyclase; 100μM) and ODQ (an inhibitor of guanylate cyclase; 100μM) had no effects on PGE<SUB>2</SUB> actions of pacemaker currents. These observations indicate that PGE<SUB>2</SUB> alter directly the pacemaker currents in ICCs, and that the PGE<SUB>2</SUB> receptor subtypes involved are the EP<SUB>2</SUB> receptor, independent of cyclic AMP- and GMP-dependent pathway.
Case Reports : A Case of Necrotizing Keratoscleritis in Primary Sjogren`s Syndrome
( Won Choi ),( Shin Seok Lee ),( Yeong Geol Park ),( Kyung Chul Yoon ) 대한안과학회 2011 Korean Journal of Ophthalmology Vol.25 No.4
We report on a case of necrotizing keratoscleritis in primary Sjogren`s syndrome. A 66-year-old female patient who was complaining of ocular pain, tearing and decreased vision in her right eye for the previous two days was admitted to our hospital. Visual acuity in the right eye was hand movement, and initial examination showed a 3.0 × 1.8 mm uveal mass bulging through a corneoscleral melting site in the nasal region of the right eye. Positive anti-nuclear antibody was identified at a titer of 1:320 with a speckled pattern, and both Sjogren`s syndrome A and Sjogren`s syndrome B antibody tests were positive, with titers >200 U/mL. A technetium 99m pertechnetate salivary scan revealed chronic sialoadenitis in the submandibular glands. We diagnosed the lesion as necrotizing keratoscleritis due to primary Sjogren`s syndrome. A corneoscleral patch graft was performed, followed by immunosuppression including oral cyclosporin and topical prednisolone. During a follow-up period of 12 months, the corneoscleral graft was well maintained with no recurrence.