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2급 치근 이개부 병소의 치료에 있어 치관 변위 판막술과 Gore-Tex membrane.을 이용한 조직유도 재생술의 치유효과에 관한 비교 연구
박주용,임성빈,정진형 단국대학교 치의학연구소 1993 논문집 Vol.5 No.-
The ultimate goal of periodontal therapy is regeneration and functional reconstruction the loss of periodontal structure. Used techniques for treatment of grade Ⅱ furcation involvement include periodontal surgery and coronally positioned flaps and Gore-Tex menbrane. To prevent the apical migration of epithelial cells and connective tissue cell the technique of guided tissue regeneration derived the periodontal ligament cell is used. The aim of this study is to histological comparative evaluate the effects of coronally positioned flaps and Gore-Tex membrane. Guided tissue regeneration used treatment of grade Ⅱ furcation involvement. Experimental periodontitis were created in maxillary, mandibulary, left. 3,4 premolar furcation area of healthy adult mongolian dogs with bone removal and ligation of orthodontic ligature wire for six weeks. The experiment was performed divided by 2 groups 1) flap operation ( control group ) 2) flap operation with Gore-Tex membrane ( experiment Ⅰ) 3) flap operation with coronally positioned flaps ( experiment Ⅱ ) Thereafter, dogs were serially sacrificed at the 1,2,4,8 and 16 weeks, and the specimens were prepared, and stained with hematoxylin-eosin stain for the light microscopic evaluation. The results of this study were as follows : 1. In all groups, the aspects of the inflammatory cell infiltration observed for 8 weeks. 2. In the control groups, bone and fibrotic attachment observed, especially new alveolar bone formation increased at 4 weeks. 3. Junctional epithelium of experimental group prevented the apical proliferation, but new alveolar bone formation is not clear. 4. In the coronally positioned flaps, apical migration of junctional epithelium did not found, but fibrotic attachment and new alveolar bone, new cementum formation. 5. Continued, the inflammatory cell infiltration for 8 weeks coronally positioned flaps is better results than Gore-Tex membrane.
Preparation of New Bioactive Hybrid Bone Cements Containing Bis-GMA Derivatives as a Prepolymer
Park, Bang-Ju,Park, Kwideok,Ahn, Kwang-Duk,Chin, Yong-Ok,Han, Dong Keun Wiley - VCHVerlag GmbH & Co. KGaA 2006 Macromolecular Materials & Engineering Vol.291 No.6
<P>Summary: Novel organic-inorganic hybrid bioactive bone cements containing bisphenol-A-glycidyl methacrylate (Bis-GMA) derivatives and a bioactive inorganic filler were prepared for orthopedic applications. The Bis-GMA derivatives, such as 3MA and a 3MA mixture (3MA mix), were synthesized by blocking one or two of the hydroxyl groups of the Bis-GMA so as to use it as a prepolymer. Four organic prepolymers, such as Bis-GMA, 3MA, 3MA 50 and 3MA mix, and an inorganic filler, AW-GC, were used for the preparation of the bioactive bone cements and their characteristics were evaluated. As compared with the Bis-GMA control, the new bioactive bone cements containing the Bis-GMA derivatives exhibited appropriate curing times, low polymerization shrinkage, low water absorption and solubility as well as high mechanical properties. In particular, the bioactive bone cement containing 3MA mix and AW-GC had higher bending and compressive strengths than the Bis-GMA one.</P><P> <img src='wiley_img/14387492-2006-291-6-MAME200500408-gra001.gif' alt='wiley_img/14387492-2006-291-6-MAME200500408-gra001'> Graphic Curing time and polymerization shrinkage on various prepolymers of bioactive bone cements. </P>
Park, Chin-Ju,Choi, Byong-Seok Blackwell Publishing Ltd 2006 FEBS JOURNAL Vol.273 No.8
<P>Xeroderma pigmentosum (XP) is an inherited disease in which cells from patients exhibit defects in nucleotide excision repair (NER). XP proteins A–G are crucial in the processes of DNA damage recognition and incision, and patients with XP can carry mutations in any of the genes that specify these proteins. In mammalian cells, NER is a dynamic process in which a variety of proteins interact with one another, via modular domains, to carry out their functions. XP proteins are key players in several steps of the NER process, including DNA strand discrimination (XPA, in complex with replication protein A), repair complex formation (XPC, in complex with hHR23B; XPF, in complex with ERCC1) and repair factor recruitment (transcription factor IIH, in complex with XPG). Through these protein–protein interactions, various types of bulky DNA adducts can be recognized and repaired. Communication between the NER system and other cellular pathways is also achieved by selected binding of the various structural domains. Here, we summarize recent studies on the domain structures of human NER components and the regulatory networks that utilize these proteins. Data provided by these studies have helped to illuminate the complex molecular interactions among NER factors in the context of DNA repair.</P>
Park, Chin-Ju,Lee, Joon-Hwa,Choi, Byong-Seok Oxford University Press 2005 Nucleic acids research Vol.33 No.13
<P>Replication protein A (RPA) is a three-subunit complex with multiple roles in DNA metabolism. DNA-binding domain A in the large subunit of human RPA (hRPA70A) binds to single-stranded DNA (ssDNA) and is responsible for the species-specific RPA–T antigen (T-ag) interaction required for Simian virus 40 replication. Although <I>Saccharomyces cerevisiae</I> RPA70A (scRPA70A) shares high sequence homology with hRPA70A, the two are not functionally equivalent. To elucidate the similarities and differences between these two homologous proteins, we determined the solution structure of scRPA70A, which closely resembled the structure of hRPA70A. The structure of ssDNA-bound scRPA70A, as simulated by residual dipolar coupling-based homology modeling, suggested that the positioning of the ssDNA is the same for scRPA70A and hRPA70A, although the conformational changes that occur in the two proteins upon ssDNA binding are not identical. NMR titrations of hRPA70A with T-ag showed that the T-ag binding surface is separate from the ssDNA-binding region and is more neutral than the corresponding part of scRPA70A. These differences might account for the species-specific nature of the hRPA70A–T-ag interaction. Our results provide insight into how these two homologous RPA proteins can exhibit functional differences, but still both retain their ability to bind ssDNA.</P>
진영기,이기주,문규,김현리,김태원,이만재,박유환,정춘해 朝鮮大學校 附設 醫學硏究所 1997 The Medical Journal of Chosun University Vol.22 No.1
Objective: Multiple myeloma is characterized by the neoplastic proliferation of a single clone of plasma cells engaged in the production of a monoclonal immunoglobulin. This clone of plasma cells proliferates in the bone marrow and frequently invades the adjacent bone. producing extensive skeletal destruction that results in bone pain and fractures. Anemia. hypercalcemia, and renal insufficiency are important features. We analyses clinical manifestation of multiple myeloma. Method: A clinical observation on 20 cases of myeloma which were diagnosed by criteria of the SW0G(Southwest Oncology Group) between March 1993 and December 1996 at Chosun University Hospital was done. Result: 1. The peak incidence was in 6th decade and male to female ratio was 0.8:1 2. The presenting symptoms at first diagnosis were bone pain(45%). and anemia(20%), but non specific symptoms were also noted. 3. Initial clinical stages were classified as stage in 20%, stage Ⅰ in 25%. and stage 11 in 55%. 40% of stage Ⅱ and 64% of stage Ⅲ patients showed renal impairment. 4. The distribution of immunoglobulin classes were IgG 61%, IgA 22% and light chain 5% 5. Complications of multiple myeloma, such as renal impairment, infections, compression fractures of spine and spinal cord compression were observed, Pneumonia was predominant in infections.
Pandemic Influenza (H1N1) and Mycobacterium tuberculosis Co-infection
Park, Yehyun,Chin, Bum Sik,Han, Sang Hoon,Yun, Yujung,Kim, Young Ju,Choi, Jun Yong,Kim, Chang Oh,Song, Young Goo,Kim, June Myung The Korean Academy of Tuberculosis and Respiratory 2014 Tuberculosis and Respiratory Diseases Vol.76 No.2
We hereby observe four co-infection cases of pandemic influenza H1N1 and Mycobacterium tuberculosis with various clinical presentations. It may be prudent to consider M. tuberculosis co-infections when patients with pandemic influenza reveal unusual clinical features that do not improve despite appropriate treatments against the influenza, especially in Korea, in the endemic areas of M. tuberculosis.
Antioxidant Compounds from Distylium racemosum Leaves
Park, Youngki,Lee, Wi Young,Ahn, Jin Kwon,Lee, Hak-Ju,Chin, Hwi Seung,Kwon, Young Jin 한국목재공학회 2003 목재공학 Vol.31 No.6
The leaves of D. racemosum showed strong DPPH (1,l-diphenyl-2-picrylhydrazyl) radical scavenging activity and the order of the radical scavenging activity against DPPH radical is ethyl acetate (EtOAc) fraction>crude extracts>residue fraction>hexane fraction>ether fraction, under the experimental conditions.Since EtOAc fraction has highest antioxidative activity among these fractions, the isolation was performed from the EtOAc fraction of the leaves of D. racemosum and four phenolic compounds were isolated and identified as follows: methyl gallate, kaempferol, quercetin and quercitrin. The free radical scavenging activities of these compounds were 79.9%, 9.31%, 93.6% and 66.7% at 10 ㎍/㎖, respectively. The IC_(50) of compound 1, compound 2, compound 3 and compound 4 were 6.1, 4.1, 3.6 and 6.5 ㎍/㎖, respectively.These compounds have higher antioxidative activity compared with reference compounds, ascorbic acid (IC_(50) = 9.6 ㎍/㎖).
( Ju Yup Lee ),( Nayoung Kim ),( Ji Hyun Park ),( Ryoung Hee Nam ),( Sun Min Lee ),( Chin-hee Song ),( Geun Kim ),( Hee Young Na ),( Yoon Jin Choi ),( Jin Joo Kim ),( Dong Ho Lee ) 대한소화기 기능성질환·운동학회 2020 Journal of Neurogastroenterology and Motility (JNM Vol.26 No.1
Background/Aims Emerging evidence shows that the mechanism of irritable bowel syndrome (IBS) is associated with neurotrophic factors and tight junction proteins (TJPs). It is known that there are sex differences in the pathophysiology of IBS. The aim of the present study is to determine expression levels of neurotrophic factors, TJPs, and cytokines according to IBS subtype and sex. Methods From 59 IBS (33 IBS-constipation, 21 IBS-diarrhea, and 5 IBS-mixed) and 36 control patients, colonic mucosa mRNA expression levels of transient receptor potential vanilloid-1 (TRPV1), nerve growth factor (NGF), glial cell-derived neurotrophic factor (GDNF), and various TJPs were assessed by real-time polymerase chain reaction. Western blot was performed to determine levels of zonular occludens-1 (ZO-1). Serum levels of cytokines were measured by enzyme-linked immunosorbent assay. Results TRPV1, GDNF, and NGF mRNA levels were significantly increased in those with IBS-constipation compared to those in controls (all P < 0.05). However, they showed no significant difference between those with IBS-diarrhea and controls. Expression level of TRPV1 correlated with that of GDNF (r = 0.741, P < 0.001) and NGF (r = 0.935, P < 0.001). ZO-1 RNA expression levels were lower (P = 0.021) in female IBS-diarrhea than those in controls, although they showed no significant differences between male IBS-diarrhea and controls. Serum IL-1β levels in female IBS were significantly higher than those of male IBS, especially in IBS-constipation (P < 0.001). Conclusion Our results suggest that neurotrophic factors and IL-1β are closely related to IBS-constipation and that decrease of ZO-1 is an important factor in female with IBS-diarrhea.