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Prognostic Factors in Adult Patients with Solid Cancers and Bone Marrow Metastases
Hung, Yu-Shin,Chou, Wen-Chi,Chen, Tai-Di,Chen, Tse-Ching,Wang, Po-Nan,Chang, Hung,Hsu, Hung-Chih,Shen, Wen-Chi,Cheng, Wei-Hong,Chen, Jen-Shi Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.1
Background: Solid cancers with bone marrow metastases are rare but lethal. This study aimed to identify clinical factors predictive of survival in adult patients with solid cancers and bone marrow metastases. Methods: A total of 83 patients were enrolled consecutively between January 1, 2000 and December 31, 2012. Bone marrow metastases were confirmed by biopsies. Patient clinical features and laboratory data were analyzed for associations. Results: The median age of the patients was 54 years (range, 23-88 years), and 58% were male. The 3 most common primary tumor locations were the stomach (32 patients, 39%), prostate (16 patients, 19%), and lungs (12 patients, 15%). The median overall survival was 49 days (range, 3-1423 days). Patients with Eastern Cooperative Oncology Group performance status 1, cancers of prostate origin, platelet counts over 50,000/ml, and undergoing antitumor therapies had a significantly better prognosis in the multivariate analysis. The median survival times were 173 and 33 days for patients with 2-3 more favorable parameters (n=24) and those with 0-1 (n=69), respectively (hazard ratio 0.30; 95% CI 0.17-0.52, p<0.001). Conclusions: Solid cancers with bone marrow metastases are dismal and incurable diseases. Understanding prognostic factors to these diseases helps medical personnel to provide appropriate treatments and better inform patients about outcomes. Antitumor therapies may improve outcomes in selected patient cohorts.
An Experimental Study to Improve Due-date Performance
Wang, Mei-Ting,Li, Rong-Kwei,Chen, Ching-Piao,Chen, Hsien-Ching,Tsai, Chih-Hung The Korean Society for Quality Management 2009 The Asian Journal on Quality Vol.10 No.3
Due-date performance (DDP) is a very important performance indicator for the companies. Thus, companies with a high hit rate would have greater competitive advantage; on the contrary, companies that delay customers' orders frequently would lose sales opportunities and reputations. Therefore, there were many academic studies and practical efforts to improve DDP in the past, but the problem of low hit rate still exists. In order to increase the hit rate, some companies have focused on reducing the variation, while others focus on production management, but is the real problem affecting the low rate variability or production management? This is indeed difficult to be validated through practice. Therefore, this study designed three scenarios, tested each scenario for 30 times, each test involved seven subjects. The tests were to provide counter-evidence in the Job Shop environment without variation. If the variation is the main factor of affecting hit rate, the rate at this time should be good; otherwise, the assumption that variation is the main cause is rebutted. The results demonstrated that production management planning is the main cause, and the method of enhancing the hit rate is obtained during the test.
8.01% CuInGaSe<sub>2</sub> solar cells fabricated by air-stable low-cost inks
Wang, Wei,Han, Seung-Yeol,Sung, Shi-Joon,Kim, Dae-Hwan,Chang, Chih-Hung The Royal Society of Chemistry 2012 Physical chemistry chemical physics Vol.14 No.31
<P>CuInGaSe<SUB>2</SUB> (CIGS), a promising thin film solar cell material, has gained lots of attention in decades due to its high energy conversion efficiency and potential lower manufacture cost over conventional Si solar cells. As a cheaper processing method compared to vacuum-based techniques, solution-based deposition has been successfully applied to fabricate electronic devices, such as transistors and solar cells. In this paper, we reported CIGS thin film solar cells with an energy conversion efficiency reaching up to 8.01% using air-stable, low-cost inks. The newly developed inks consist of commercially available, low-cost compounds and solvents and can be processed using a variety of printing and coating techniques. More importantly, the inks can produce CIGS films free of copper selenides and amorphous carbon, two common by-products from solution-based CIGS processes. The mechanism for the transformation from metal salt precursor films to CIGS absorber thin films and the influence of selenium vapour pressure on absorber film quality and photovoltaic device performance were investigated and discussed. High-quality CIGS films with micrometer-sized crystals were obtained by using higher selenization partial pressure.</P> <P>Graphic Abstract</P><P>8.01% CIGS solar cells were fabricated using air-stable low-cost inks without contamination of amorphous carbon and copper selenides. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=c2cp41969f'> </P>
Wang, Ming-Fu,Liao, Ya-Fan,Hung, Ying-Cheng,Lin, Chih-Li,Hour, Tzyh-Chyuan,Lue, Ko-Huang,Hung, Hui-Chih,Liu, Guang-Yaw Korean Society for Biochemistry and Molecular Bion 2011 Experimental and molecular medicine Vol.43 No.4
Ornithine decarboxylase (ODC) is the rate-limiting enzyme in polyamine biosynthesis and a target for chemoprevention. Hydroxydibenzoylmethane (HDB), a derivative of dibenzoylmethane of licorice, is a promising chemopreventive agent. In this paper, we investigated whether HDB would inhibit the ODC pathway to enhance apoptosis in human promyelocytic leukemia HL-60 cells. We found ODC enzyme activity was reduced during HDB treatment. Overexpression of ODC in HL-60 parental cells could reduce HDB-induced apoptosis, which leads to loss of mitochondrial membrane potential (${\Delta}{\psi}_m$), through lessening intracellular ROS. Furthermore, ODC overexpression protected cytochrome c release and the activation of caspase-3 following HDB treatment. The results demonstrated HDB-induced apoptosis was through a mechanism of down-regulation of ODC and occurred along a ROS-dependent mitochondria-mediated pathway.
On Establishing a New Fee Schedule for General Surgical Procedure Using Fuzzy MCDM
Hung, Chih-Young,Huang, Yuan-Huei,Chang, Pei-Yeh,Wang, Kuei-Ing,Chang, King-Jen,Liu, Yi-Hsin Korean Institute of Industrial Engineers 2005 Industrial Engineeering & Management Systems Vol.4 No.2
In this research a model for establishing a new, rational fee schedule for general surgical procedures in a national health insurance program is developed. A fuzzy multiple criteria decision-making (FMCDM) model is proposed. The relative values of eleven surgical procedures were obtained through an empirical study based on the FMCDM model. Consequently, a new fee schedule obtained from the FMCDM model. This new fee schedule is more convincing than previous schedule and more persuasive to the references for the policy setting.
Chih-Jen Yang,Yu-Jung Huang,Cheng-Yuan Wang,Chuan-Sheng Wang,Pei-Hui Wang,Jen-Yu Hung,Tung-Heng Wang,Hseng-Kuang Hsu,Hurng-Wern Huang,S.P. Anand Kumar,Ming-Shyan Huang,Ching-Feng Weng 한국식품영양과학회 2010 Journal of medicinal food Vol.13 No.1
Toona sinensis is a traditional Chinese herb, and the extracts of T. sinensis leaf possess a variety of biological functions. This study attempted to test the antiproliferative effect of TSL-1 (a bioactive fraction of T. sinensis) in H441 cells (lung adenocarcinoma). The data showed that the antiproliferative effect of TSL-1 on H441 cells is prominent using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. TSL-1-induced apoptosis was confirmed by cell morphology, sub-G1 peak accumulation, cleavage of poly(ADP)-ribose polymerase, and propidium iodide-annexin V double staining. Furthermore, decreased Bcl-2 accompanied by increased Bax (in western blotting) was found with TSL-1 treatment of H441 cells. TSL-1 treatment-induced G1 arrest was concurrent with the down-regulation of protein levels of cyclin D1 and cyclin-dependent kinase 4 in H441 cells. Peroral and intraperitoneal administrations of TSL-1 were performed to evaluate the therapeutic efficacy, and peroral administration of TSL-1 was also used to elucidate the therapeutic efficacy in the H441 cell xenograft model in vivo. The data revealed that TSL-1 treatment inhibited H441 tumor growth in both therapeutic and preventive experiments. Taken together, these results demonstrate that TSL-1 possesses the capability of preventing and alleviating lung cancer proliferation in vitro and in vivo with proven nephrological and hepatic safety and has the potential to be developed as an anti–lung cancer drug.
Michael, Chih-Hung Wang,Ya-Yun Tang 글로벌지식마케팅경영학회 2018 Global Marketing Conference Vol.2018 No.07
The flourishing trend of using multiple technology-based self-service channels (hereafter, SSCs) can be found across various service industries. So far, no studies have explored the effect of multichannel interaction on breadth consumer relationship breadth (i.e., cross-buying intention). Based on brand extension theory and the cross-buying literature, this study proposed a conceptual model for understanding the key determinants of consumer cross-buying intention in the context of multiple SSCs. A total of 262 respondents who had experience with using both online and mobile banking were collected. The result revealed that perceived online banking quality (i.e., original SSC), image congruity, and value congruity facilitate consumer trust and satisfaction toward a mobile banking service (i.e., extension SSC). In addition, the trust and satisfaction toward mobile banking have a positive influence on crossbuying intention. The result of this study not only provides an academic contribution to the multichannel service and SSC literature but also provides suggestions for service providers who wish to develop their multiple-SSC strategies.
EXPLORING THE EFFECTS OF SOCIAL MEDIA-BASED BRAND COMMUNITY ENVIRONMENT ON CONSUMER BRAND EVALUATION
Michael Chih-Hung Wang,Ya-Yun Tang 글로벌지식마케팅경영학회 2018 Global Marketing Conference Vol.2018 No.07
Social media-based brand community becomes an important information channel strategy for marketing firms. Despite the growing academic interest in the issue, little knowledge exists on how social media-based brand community (hereafter SMBBC) could influence consumer brand evaluation. Accordingly, this study attempts to remedy the literature gap by integrating the community integration model, engagement in the OBC or SMBBC, and consumer brand evaluation to propose a conceptual model for investigating the effect of SMBBC environment on consumer brand evaluation. This study collected data from 402 respondents experienced in using SMBBC. The result revealed that SMBBC identification and company identification have a positive impact on brand engagement; whereas brand identification has a positive effect on SMBBC engagement, peer identification has a positive influence on company identification. In addition, both brand engagement and SMBBC engagement are found to benefit corporate brand equity and corporate reputation, respectively.