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RISS 인기검색어
- 검색키워드
- 저자 : Chih-Chieh Hsu (검색결과 4 건)
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Chih-Chieh Hsu,He-Ping Chen,Wei-Chieh Ting 한국물리학회 2015 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.67 No.2
was studied by using numerical simulations. The electrical characteristics of the triodes with V2O5 doping concentrations of 1016 − 1018 cm −3 and electrode work functions (WFs) of 4.4 − 5.1 eV were simulated. In addition, the corresponding physical mechanisms were investigated by quantitatively analyzing the energy band diagram, carrier distribution, injection and transports which were difficult to measure and obtain experimentally. The optimal triode performance was obtained for a doping concentration of V2O5 of 2 × 1017 cm −3 and WFs of the emitter and the collector electrodes of 5.1 eV and 4.8 eV, respectively. The simulation results were reasonable when compared with experimental data reported by other groups.
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Hsu Chiao-Lin,Wu Pin-Chieh,Yin Chun-Hao,Chen Chung-Hwan,Lee King-Teh,Lin Chih-Lung,Shi Hon-Yi 대한영상의학회 2023 Korean Journal of Radiology Vol.24 No.12
Objective: This study aimed to evaluate the clinical outcomes and cost-effectiveness of dual-energy X-ray absorptiometry (DXA) for osteoporosis screening. Materials and Methods: Eligible patients who had and had not undergone DXA screening were identified from among those aged 50 years or older at Kaohsiung Veterans General Hospital, Taiwan. Age, sex, screening year (index year), and Charlson comorbidity index of the DXA and non-DXA groups were matched using inverse probability of treatment weighting (IPTW) for propensity score analysis. For cost-effectiveness analysis, a societal perspective, 1-year cycle length, 20-year time horizon, and discount rate of 2% per year for both effectiveness and costs were adopted in the incremental cost-effectiveness (ICER) model. Results: The outcome analysis included 10337 patients (female:male, 63.8%:36.2%) who were screened for osteoporosis in southern Taiwan between January 1, 2012, and December 31, 2021. The DXA group had significantly better outcomes than the non-DXA group in terms of fragility fractures (7.6% vs. 12.5%, P < 0.001) and mortality (0.6% vs. 4.3%, P < 0.001). The DXA screening strategy gained an ICER of US$ -2794 per quality-adjusted life year (QALY) relative to the non-DXA at the willingness-to-pay threshold of US$ 33004 (Taiwan’s per capita gross domestic product). The ICER after stratifying by ages of 50–59, 60–69, 70–79, and ≥ 80 years were US$ -17815, US$ -26862, US$ -28981, and US$ -34816 per QALY, respectively. Conclusion: Using DXA to screen adults aged 50 years or older for osteoporosis resulted in a reduced incidence of fragility fractures, lower mortality rate, and reduced total costs. Screening for osteoporosis is a cost-saving strategy and its effectiveness increases with age. However, caution is needed when generalizing these cost-effectiveness results to all older populations because the study population consisted mainly of women.
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Yung-Chieh Tsai,Yen-Mei Lee,Sy-Ying Leu,Hsiao-Yen Chiang,Mao-Hsiung Yen,Pao-Yun Cheng,Chih-Hsiung Hsu 생화학분자생물학회 2015 Experimental and molecular medicine Vol.47 No.-
Leptin is a peptide hormone, which has a central role in the regulation of body weight; it also exerts many potentially atherogenic effects. Ferulic acid ethyl ester (FAEE) has been approved for antioxidant properties. The aim of this study was to investigate whether FAEE can inhibit the atherogenic effects of leptin and the possible molecular mechanism of its action. Both of cell proliferation and migration were measured when the aortic smooth muscle cell (A10 cell) treated with leptin and/or FAEE. Phosphorylated p44/42MAPK, cell cycle-regulatory protein (for example, cyclin D1, p21, p27), β-catenin and matrix metalloproteinase-9 (MMP-9) proteins levels were also measured. Results demonstrated that leptin (10, 100 ng ml−1) significantly increased the proliferation of cells and the phosphorylation of p44/42MAPK in A10 cells. The proliferative effect of leptin was significantly reduced by the pretreatment of U0126 (0.5 μM), a MEK inhibitor, in A10 cells. Meanwhile, leptin significantly increased the protein expression of cyclin D1, p21, β-catenin and decreased the expression of p27 in A10 cells. In addition, leptin (10 ng ml−1) significantly increased the migration of A10 cells and the expression of MMP-9 protein. Above effects of leptin were significantly reduced by the pretreatment of FAEE (1 and 10 μM) in A10 cells. In conclusion, FAEE exerts multiple effects on leptin-induced cell proliferation and migration, including the inhibition of p44/42MAPK phosphorylation, cell cycle-regulatory proteins and MMP-9, thereby suggesting that FAEE may be a possible therapeutic approach to the inhibition of obese vascular disease.
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Detecting multimuon jets from the Higgs boson exotic decays in the Higgs portal framework
Chang, Jung,Cheung, Kingman,Hsu, Shih-Chieh,Lu, Chih-Ting American Physical Society 2017 Physical review. D Vol.95 No.3
<P>A muon jet (mu-jet) is a very special feature that consists of a cluster of collimated muons from the decay of a fast-moving light particle of mass about O(1 GeV). We will use this feature to search for very light particles from rare decays of the Higgs boson. For such a small angular separation of muons which might come from a long-lived particle, both ATLAS and CMS could have the displaced-vertexing-reconstruction capability. We use two simple models of the Higgs portal type to explore the possibilities of event topologies with two 2 mu-jets, one 2 mu-jet and one 4 mu-jet, and two 4 mu-jets in the final state at LHC-14. We also summarize existing constraints on these models.</P>
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