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Cheng Bin Cui,범현규 대한금속·재료학회 2018 METALS AND MATERIALS International Vol.24 No.1
The intergranular fracture toughness of Cu bicrystals with symmetric tilt grain boundaries was investigated usingatomistic simulations. Mode I fracture of Cu bicrystals with an intergranular crack was considered. The boundaryconditions were specified by the near-tip displacement fields obtained based on linear elastic fracture mechanics(LEFM). Based on the energy interpretation of the energy release rate, a two-specimen method was adopted todetermine the fracture toughness. The simulation results of the fracture toughness matched well with those determinedusing LEFM. In contrast to the toughness obtained using the Griffith energy criterion, the atomistic simulationresults for the same bicrystal were not constants, but dependent on the crack-tip circumstances. Thisbehavior was mainly associated with the different local stress conditions and fracture patterns observed for the differentmodels.
Optimization for Real-Time Object Tracking-by-Detection using Deep Neural Network on Embedded System
Cheng-Bin Jin,Mingjie Liu,Bin Yang,Xuenan Cui,Hakil Kim 한국자동차공학회 2018 한국자동차공학회 부문종합 학술대회 Vol.2018 No.6
This paper introduces a real-time object tracking-by-detection system on embedded boards. A backbone network of single-shot multi-box detectors is proposed using network optimizations for processing time and accuracy. In addition to processing time and accuracy, energy efficiency is an important issue in autonomous driving systems. Therefore, a sparse and independent local network architecture is further applied to train convolution filters of the backbone network. The object detector is followed by an online multiple-object tracker that uses multiple information points, including motion predicted by a Kalman filter, intersection over the union, and shape information. In addition, this paper trains the object detector on real and synthetic data generated using generative adversarial networks. This hybrid dataset minimizes the cost of manual annotation. The proposed tracking-by-detection algorithm demonstrates the best performance among real-time models on the KITTI test benchmark and has a reasonable processing time compared to the other models.
Fracture toughness of Cu and Ni single crystals with a nanocrack
Cui, Cheng Bin,Kim, Seon Do,Beom, Hyeon Gyu Published for the Materials Research Society by th 2015 Journal of materials research Vol.30 No.12
<▼1><B>Abstract</B><P/></▼1><▼2><P>The fracture toughness values of nanosized Cu and Ni single crystals with an edge nanocrack were determined under quasi-static loading conditions. Molecular statics (MS) simulations that can essentially capture the discreteness and the nonlinearity of materials were used in the present study. Different crack lengths were used to evaluate the effects of crack size on the fracture toughness. Based on MS simulations, the energy release rate was calculated using the energies obtained from two models with neighboring crack lengths under the same loading conditions. Furthermore, continuum counterparts of the atomistic models were used to calculate the toughness by the finite element method for linear elastic fracture mechanics (LEFM). The reasons behind the discrepancies between the toughness values obtained using different methods were discussed, and the applicable ranges of the toughness and the LEFM were indicated in terms of the lattice constants.</P></▼2>
CT-based MR Image Approximation using Cycle-Consistent Adversarial Networks
Cheng-Bin Jin(김성빈),Hakil Kim(김학일),Seongsu Joo(주성수),Eunsik Park(박은식),Young Saem Ahn(안영샘),In Ho Han(한인호),Jae Il Lee(이재일),Xuenan Cui(최학남) 대한전기학회 2019 대한전기학회 학술대회 논문집 Vol.2019 No.2
Computed tomography (CT) is widely used in various clinical applications. Magnetic resonance imaging (MRI) provides more anatomical details than CT for diagnostic purposes. However, the price of an MRI puts a heavy burden on low-income patients. This leads patients to undergo low-cost CT scans instead of MRIs, and this causes them to miss the opportunity for early diagnosis. To generate additional information and to increase the diagnostic value of CT, this paper proposes a method to approximate an MR image using a CT scan with the adversarial cycle-consistent networks. A novel objective function is introduced, consisting of adversarial loss, cycle-consistent loss, voxel-wise loss, gradient difference loss, and perceptual loss. Experimental results show that the proposed method significantly outperforms all baseline methods in all measurements, achieving the lowest mean absolute error and root mean square error and the highest peak-signal-to-noise-ratio, structural similarity, and Pearson correlation coefficient. This study can help the low-income patients, who cannot undergo MRI in clinical diagnosis, and patients in the developing countries where CT is the only diagnostic device.
Nan Wang,Cheng-Bin Cui,Chang-Wei Li 대한약학회 2016 Archives of Pharmacal Research Vol.39 No.6
A novel cyclic dipeptide, named penicimutide(1), and four known cyclic dipeptides, cyclo(L-Val-L-Pro)(2), cyclo(L-Ile-L-Pro) (3), cyclo(L-Leu-L-Pro) (4) andcyclo(L-Phe-L-Pro) (5), were isolated from a neomycinresistantmutant of the marine-derived fungus Penicilliumpurpurogenum G59. The structure of 1, including theabsolute configuration, was determined by spectroscopicand chemical methods, especially NMR and Marfey’sanalysis. An unusual amino acid in 1, 4,5-didehydro-Lleucine,was found for the first time occurring in nature. HPLC–ESI–MS analysis evidenced that 1–3 were producedonly in the mutant strain, but 4 and 5 were producedin both the mutant and parental strains, indicating that theintroduction of neomycin-resistance in the mutant activatedpathways of 1–3 biosynthesis that were silent in the parentalstrain. Compound 1 selectively inhibited HeLa cells(among five tested human cancer cell lines) with an inhibitionrate (IR %) of 39.4 % at 100 lg/mL, a similarinhibition intensity to that of the positive control 5-fluorouracil(IR % of 41.4 % at 100 lg/mL against HeLacells). The present work exemplifies the effectiveness ofour previous DMSO-mediated method for introducingdrug-resistance in fungi to activate silent biosyntheticpathways to obtain new bioactive compounds.
( Guang Yan Cheng ),( Li Ying He ),( Zhi Bin Sun ),( Zhong Li Cui ),( Ying Xiang Du ),( Yi Kong ) 한국미생물 · 생명공학회 2015 Journal of microbiology and biotechnology Vol.25 No.9
A novel proteolytic enzyme with fibrinolytic activity, FSP3, was purified from the recently isolated Streptomyces sp. P3, which is a novel bacterial strain isolated from soil. FSP3 was purified to electrophoretic homogeneity by ammonium sulfate precipitation, anion exchange, and gel filtration. FSP3 is considered to be a single peptide chain with a molecular mass of 44 kDa. The maximum activity of the enzyme was observed at 50°C and pH 6.5, and the enzyme was stable between pH 6 and 8 and below 40°C. In a fibrin plate assay, FSP3 showed more potent fibrinolytic activity than urokinase, which is a clinical thrombolytic agent acting as a plasminogen activitor. The activity was strongly inhibited by the serine protease inhibitor PMSF, indicating that it is a serine protease. Additionally, metal ions showed different effects on the activity. It was significantly suppressed by Mg2+ and Ca2+ and completely inhibited by Cu2+, but slightly enhanced by Fe2+. According to LC-MS/MS results, its partial amino acid sequences are significantly dissimilar from those of previously reported fibrinolytic enzymes. The sequence of a DNA fragment encoding FSP3 contained an open reading frame of 1287 base pairs encoding 428 amino acids. FSP3 is a bifunctional enzyme in nature. It hydrolyzes the fibrin directly and activates plasminogen, which may reduce the occurrence of side effects. These results suggest that FSP3 is a novel serine protease with potential applications in thrombolytic therapy.
Liu, Rui,Cui, Cheng-Bin,Duan, Lin,Gu, Qian-Qun,Zhu, Wei-Ming The Pharmaceutical Society of Korea 2005 Archives of Pharmacal Research Vol.28 No.12
Bioassay-guided fractionation of $CHCl_{3}$ extract from the fermentation broth of a sponge Mycale plumose-derived actinomycete Saccharopolyspora sp. nov., led to the isolation of two known prodigiosin analogs - metacycloprodigiosin (1) and undecylprodigiosin (2). These compounds exhibited significant cytotoxic activities against five cancer cell lines: P388, HL60, A-549, BEL7402, and SPCA4. This is the first report on the significant cytotoxicity of metacycloprodigiosin (1) against human cancer cell lines.