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Diagnosis of Pulmonary Arterial Hypertension in Children by Using Cardiac Computed Tomography
Shyh-Jye Chen,Jou-Hsuan Huang,Wen-Jeng Lee,Ming-Tai Lin,Yih-Sharng Chen,Jou-Kou Wang 대한영상의학회 2019 Korean Journal of Radiology Vol.20 No.6
Objective: To establish diagnostic criteria for pulmonary arterial hypertension (PAH) in children by using parameters obtained through noninvasive cardiac computed tomography (CCT). Materials and Methods: We retrospectively measured parameters from CCT images of children from a single institution in a multiple stepwise process. A total of 208 children with mean age of 10.5 years (range: 4 days–18.9 years) were assessed. The variables were classified into three groups: the great arteries; the ventricular walls; and the bilateral ventricular cavities. The relationship between the parameters obtained from the CCT images and mean pulmonary arterial pressure (mPAP) was tested and adjusted by the children’s body size. Reference curves for the pulmonary trunk diameter (PTD) and ratio of diameter of pulmonary trunk to ascending aorta (rPTAo) of children with CCT images of normal hearts, adjusted for height, were plotted. Threshold lines were established on the reference curves. Results: PTD and rPTAo on the CCT images were significantly positively correlated with mPAP (r > 0.85, p < 0.01). Height was the body size parameter most correlated with PTD (r = 0.91, p < 0.01) and rPTAo (r = -0.69, p < 0.01). On the basis of the threshold lines on the reference curves, PTD and rPTAo both showed 88.9% sensitivity for PAH diagnosis, with negative predictive values of 93.3% and 92.9%, respectively. Conclusion: PTD and rPTAo measured from CCT images were significantly correlated with mPAP in children. Reference curves and the formula of PTD and rPTAo adjusted for height could be practical for diagnosing PAH in children.
Amal Mohamad Yanuar,Chen Shyh-Jye 아시아심장혈관영상의학회 2021 Cardiovascular Imaging Asia Vol.5 No.4
A partial pulmonary artery sling in bronchopulmonary situs inversus with association of congenital distal trachea stenosis is an extremely rare vascular developmental anomaly. Understanding of this unusual anomaly requires deep knowledge of pulmonary arterial embryogenesis. We present an asymptomatic pediatric female after a one-stage operation for Taussig- Bing anomaly and coarctation of the aorta. Contrast-enhanced cardiac CT examination clearly demonstrated partial sling of the pulmonary artery from the right hemithorax and running a course behind the carina and in front of the esophagus before heading to the left hemithorax. Congenital distal trachea stenosis should specifically be evaluated due to strong association with complete cartilaginous rings in majority cases.
History of the Asian Society of Cardiovascular Imaging
Lee Wen-Jeng,Chen Shyh-Jye,Wan Yung-Liang 대한영상의학회 2021 Korean Journal of Radiology Vol.22 No.4
The Asian Society of Cardiovascular Imaging (ASCI) was established in 2006 to improve the healthcare, education, training, quality control, and research in cardiovascular imaging in Asia. The ASCI is presently active, with more than 1400 members from 53 countries. Herein, the evolution and current development of the ASCI are described, including the early history, organization, annual congresses, collaboration with international sister societies, official journal, and the ASCI School. The ASCI has successfully led the development of cardiovascular imaging in Asia and will continue to grow.
History of the Asian Society of Cardiovascular Imaging
Lee Wen-Jeng,Chen Shyh-Jye,Wan Yung-Liang 아시아심장혈관영상의학회 2021 Cardiovascular Imaging Asia Vol.5 No.2
The Asian Society of Cardiovascular Imaging (ASCI) was established in 2006 to improve the healthcare, education, training, quality control, and research in cardiovascular imaging in Asia. The ASCI is presently active, with more than 1400 members from 53 countries. Herein, the evolution and current development of the ASCI are described, including the early history, organization, annual congresses, collaboration with international sister societies, official journal, and the ASCI School. The ASCI has successfully led the development of cardiovascular imaging in Asia and will continue to grow.
The Third Asian Radiology Forum: Screening Programs in Asia
Ning Chien,Jo-Yu Chen,Shyh-Jye Chen,Yeun-Chung Chang 대한영상의학회 2020 Korean Journal of Radiology Vol.21 No.2
According to reports presented at the Asian Radiology Forum 2017 in Taipei, the landscape of screening in Asia is growing, and the role of radiologists is also evolving. The Asian Radiology Forum was first held by the Korean Society of Radiology and the national delegates of Asian radiological partner societies, who attended this meeting with the aim of discussing selected subjects of global relevance in radiology. In 2017, current trends and policies concerning various cancer screening programs from each delegate country were discussed. Various screening programs were discussed, including liver screening in Thailand, thyroid cancer screening in Korea, and lung cancer screening data from the ongoing projects in Taiwan and Japan. The Asian Oceanian Society of Radiology could serve as a platform for international collaboration, and educational exchange between member societies was also highlighted in the forum. Most Asian radiology societies are looking forward to an expansion in the scale of international collaboration and for the provision of additional exchange programs in the future.
Goo Hyun Woo,Siripornpitak Suvipaporn,Chen Shyh-Jye,Lilyasari Oktavia,Zhong Yu-Min,Latiff Haifa Abdul,Maeda Eriko,Kim Young Jin,Tsai I-Chen,Seo Dong Man 대한영상의학회 2021 Korean Journal of Radiology Vol.22 No.8
The use of pediatric cardiothoracic CT for congenital heart disease (CHD) was traditionally limited to the morphologic evaluation of the extracardiac thoracic vessels, lungs, and airways. Currently, the applications of CT have increased, owing to technological advancements in hardware and software as well as several dose-reduction measures. In the previously published part 1 of the guideline by the Asian Society of Cardiovascular Imaging Congenital Heart Disease Study Group, we reviewed the prerequisite technical knowledge for clinical applications in a user-friendly and vendor-specific manner. Herein, we present the second part of our guideline on contemporary clinical applications of pediatric cardiothoracic CT for CHD based on the consensus of experts from the Asian Society of Cardiovascular Imaging CHD Study Group. This guideline describes up-to-date clinical applications effectively in a systematic fashion.
IgE-Binding Epitope Mapping and Tissue Localization of the Major American Cockroach Allergen Per a 2
Mey-Fann Lee,Chia-Wei Chang,Pei-Pong Song,Guang-Yuh Hwang,Shyh-Jye Lin,Yi-Hsing Chen 대한천식알레르기학회 2015 Allergy, Asthma & Immunology Research Vol.7 No.4
Purpose: Cockroaches are the second leading allergen in Taiwan. Sensitization to Per a 2, the major American cockroach allergen, correlates with clinical severity among patients with airway allergy, but there is limited information on IgE epitopes and tissue localization of Per a 2. This study aimed to identify Per a 2 linear IgE-binding epitopes and its distribution in the body of a cockroach. Methods: The cDNA of Per a 2 was used as a template and combined with oligonucleotide primers specific to the target areas with appropriate restriction enzyme sites. Eleven overlapping fragments of Per a 2 covering the whole allergen molecule, except 20 residues of signal peptide, were generated by PCR. Mature Per a 2 and overlapping deletion mutants were affinity-purified and assayed for IgE reactivity by immunoblotting. Three synthetic peptides comprising the B cell epitopes were evaluated by direct binding ELISA. Rabbit anti-Per a 2 antibody was used for immunohistochemistry. Results: Human linear IgE-binding epitopes of Per a 2 were located at the amino acid sequences 57-86, 200-211, and 299-309. There was positive IgE binding to 10 tested Per a 2-allergic sera in 3 synthetic peptides, but none in the controls. Immunostaining revealed that Per a 2 was localized partly in the mouth and midgut of the cockroach, with the most intense staining observed in the hindgut, suggesting that the Per a 2 allergen might be excreted through the feces. Conclusions: Information on the IgE-binding epitope of Per a 2 may be used for designing more specific diagnostic and therapeutic approaches to cockroach allergy.
Kao-Lang Liu,Yu-Feng Wang,Yeun-Chung Chang,Shu-Chien Huang,Shyh-Jye Chen,Yuk-Ming Tsang,Chin-Chen Chang 대한영상의학회 2014 Korean Journal of Radiology Vol.15 No.3
This pictorial review provides the principles of extracorporeal membrane oxygenation (ECMO) support and associated CT imaging features with emphasis on the hemodynamic changes and possible imaging pitfalls encountered. It is important that radiologists in ECMO centers apply well-designed imaging protocols and familiarize themselves with post-contrast CT imaging findings in patients on ECMO.