Strong and biocompatible poly(lactic acid) membrane enhanced by Ti₃C₂T_z (MXene) nanosheets for Guided bone regeneration

Chen, Ke,Chen, Youhu,Deng, Qihuang,Jeong, Seol-Ha,Jang, Tae-Sik,Du, Shiyu,Kim, Hyoun-Ee,Huang, Qing,Han, Cheol-Min Elsevier 2018 Materials letters Vol.229 No.-

<P><B>Abstract</B></P> <P>Herein, strong and biocompatible Ti<SUB>3</SUB>C<SUB>2</SUB>T<SUB>z</SUB>-enhanced poly(lactic acid) (PLA) nanocomposite membranes were prepared. The interface of the Ti<SUB>3</SUB>C<SUB>2</SUB>T<SUB>z</SUB> nanosheets with the hydrophobic PLA matrix was mediated using n-octyltriethoxysilane (OTES). The optimized ultimate tensile strength of the OTES-Ti<SUB>3</SUB>C<SUB>2</SUB>T<SUB>z</SUB>/PLA nanocomposite membrane was 72 MPa (33% higher than that of a pure PLA membrane). The addition of Ti<SUB>3</SUB>C<SUB>2</SUB>T<SUB>z</SUB> enhanced the biological properties of the membrane, including the <I>in vitro</I> adhesion, proliferation, and osteogenic differentiation of MC3T3-E1 mouse preosteoblasts.</P> <P><B>Highlights</B></P> <P> <UL> <LI> First effort to introduce MXene into polymer matrix for tissue engineering. </LI> <LI> A robust strategy developed to prepare Ti<SUB>3</SUB>C<SUB>2</SUB>T<SUB>z</SUB>-enhanced PLA nanocomposite. </LI> <LI> Successful interfacial mediation between hydrophilic Ti<SUB>3</SUB>C<SUB>2</SUB>T<SUB>z</SUB> nanosheets and hydrophobic PLA. </LI> <LI> Intriguing future of this strong and biocompatible nanocomposite for GBR membrane. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

Early IL-17A Prevention Rather Than Late IL-17A Neutralization Attenuates Toluene Diisocyanate-Induced Mixed Granulocytic Asthma

Chen Shuyu,Yu Li,Deng Yao,Liu Yuanyuan,Wang Lingwei,Li Difei,Yang Kai,Liu Shengming,Tao Ailin,Chen Rongchang 대한천식알레르기학회 2022 Allergy, Asthma & Immunology Research Vol.14 No.5

Purpose: Interleukin (IL)-17A plays a critical role in the pathogenesis of allergic airway inflammation. Yet, the exact roles of IL-17A in asthma are still controversial. Thus, the aim of this study was to dissect the roles of IL-17A in toluene diisocyanate (TDI)-induced mixed granulocytic asthma and to assess the effects of neutralizing antibody in different effector phases on TDI-induced asthma. Methods: IL-17A functions in allergic airway inflammation were evaluated using mice deficient in IL-17A (Il17a−/−) or IL-17A monoclonal antibody (IL-17A mab, intraperitoneally, 50 μg per mouse, 100 μg per mouse). Moreover, the effects of exogenous recombinant IL (rIL)-17A in vivo (murine rIL-17A, intranasally, 1 μg per mouse) and in vitro (human rIL-17A, 100 ng/mL) were investigated. Results: TDI-induced mixed granulocytic airway inflammation was IL-17A-dependent because airway hyperreactivity, neutrophil and eosinophil infiltration, airway smooth muscle thickness, epithelium injury, dysfunctional T helper (Th) 2 and Th17 responses, granulocytic chemokine production and mucus overproduction were more markedly reduced in the Il17a−/− mice or by IL-17A neutralization during the sensitization phase of wild-type (WT) mice. By contrast, IL-17A neutralization during the antigen-challenge phase aggravated TDI-induced eosinophils recruitment, with markedly elevated Th2 response. In line with this, instillation of rIL-17 during antigen sensitization exacerbated airway inflammation by promoting neutrophils aggregation, while rIL-17A during the antigen-challenge phase protected the mice from TDI-induced airway eosinophilia. Moreover, rIL-17A exerted distinct effects on eosinophil- or neutrophil-related signatures in vitro. Conclusions: Our data demonstrated that IL-17A was required for the initiation of TDI-induced asthma, but functioned as a negative regulator of established allergic inflammation, suggesting that early abrogation of IL-17A signaling, but not late IL-17A neutralization, may prevent the progression of TDI-induced asthma and could be used as a therapeutic strategy for severe asthmatics in clinical settings.

Task Offloading Based on Edge Collaboration in MEC-Enabled IoV Networks

Deng, Tao Yu,Chen, Yueyun,Chen, Guang,Yang, Meijie,Du, Liping 한국통신학회 2023 Journal of communications and networks Vol.25 No.2

Benefiting from its abundant computing resourcesand low computing latency, mobile edge computing (MEC) isa promising approach for enhancing the computing capacity ofthe 5G Internet of vehicles (IoV). Because of the high mobility,handover is frequent and inevitable in IoV networks. In thispaper, we investigate an edge collaborative task offloading andsplitting strategy in MEC-enabled IoV networks, in which thetask is splitted on the edge and paralleling executed by eachpart of the task on several MEC servers when handover isoccured. Applications in IoV networks have flexible requirementson latency and energy consumption. To realize the tradeoffbetween latency and energy consumption, we formulate the taskoffloading and splitting as an optimization problem with the aimof minimizing the total cost of latency and energy consumptionby jointly optimizing the task splitting ratio and uplink transmitpower of vehicle terminal (VT). Because the proposed problemis non-smooth and non-convex, we divide the original probleminto two convex subproblems, and apply an alternate convexsearch (ACS) algorithm to obtain the optimized solution withlow computational complexity. Numerical simulation results showthat the proposed method can adjust the offloading strategyproperly according to task preference, and obtain a lower totalcost compared with the baseline algorithms.

Comparative Evaluation of Hepatoprotective Activities of Geniposide, Crocins and Crocetin by CCl₄-Induced liver Injury in Mice

Chen, Ping,Chen, Yang,Wang, Yarong,Cai, Shining,Deng, Liang,Liu, Jia,Zhang, Hao The Korean Society of Applied Pharmacology 2016 Biomolecules & Therapeutics(구 응용약물학회지) Vol.24 No.2

Iridoid glycosides (mainly geniposide) and crocetin derivatives (crocins) are the two major active constituents in Gardenia jasminoides Ellis. In the present study, geniposide, crocins, crocin-1 and crocetin were separated from gardenia chromatographically. Then, mice were orally administrated with geniposide (400 mg/kg b.w.), crocins (400 mg/kg b.w.), crocin-1 (400 mg/kg b.w.) and crocetin (140 mg/kg b.w.) once daily for 7 days with $CCl_4$. Hepatoprotective properties were evaluated by biochemical parameters: Administration of geniposide, crocins, crocin-1and crocetin significantly lowered serum alanine transaminase (ALT), aspartate transaminase (AST) and alkaline phosphatase (ALP) levels in $CCl_4$-treated mice. The reduced glutathione (GSH) levels and antioxidant enzymes (SOD and CAT) activities were also increased by geniposide, crocins, crocin-1 and crocetin. Histopathological examination of livers showed that these components reduced deformability, irregular arrangement and rupture of hepatocyte in $CCl_4$-treated mice. These biochemical results and liver histopathological assessment demonstrated that geniposide, crocetin derivatives and crocetin show comparative beneficial effects on $CCl_4$-induced liver damage via induction of antioxidant defense. Therefore, contents of geniposide and crocetin derivatives should be both considered for hepatoprotective efficacy of Gardenia jasminoides Ellis.

A Novel Molecular Grading Model: Combination of Ki67 and VEGF in Predicting Tumor Recurrence and Progression in Non-invasive Urothelial Bladder Cancer

Chen, Jun-Xing,Deng, Nan,Chen, Xu,Chen, Ling-Wu,Qiu, Shao-Peng,Li, Xiao-Fei,Li, Jia-Ping Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.5

Purpose: To assess efficacy of Ki67 combined with VEGF as a molecular grading model to predict outcomes with non-muscle invasive bladder cancer (NMIBC). Materials: 72 NMIBC patients who underwent transurethral resection (TUR) followed by routine intravesical instillations were retrospectively analyzed in this study. Univariate and multivariate analyses were performed to confirm the prognostic values of the Ki67 labeling index (LI) and VEGF scoring for tumor recurrence and progression. Results: The novel molecular grading model for NMIBC contained three molecular grades including mG1 (Ki67 $LI{\leq}25%$, VEGF $scoring{\leq}8$), mG2 (Ki67 LI>25%, VEGF $scoring{\leq}8$; or Ki67 $LI{\leq}25%$, VEGF scoring > 8), and mG3 (Ki67 LI > 25%, VEGF scoring > 8), which can indicate favorable, intermediate and poor prognosis, respectively. Conclusions: The described novel molecular grading model utilizing Ki67 LI and VEGF scoring is helpful to effectively and accurately predict outcomes and optimize personal therapy.

Structural features and thermoelectric performance of chalcopyrite Cu(In, Ga)Te2 system by isoelectronic substitution

Deng Shuping,Jiang Xianyan,Zhang Ziye,Liu Junjie,Chen Lili,Qi Ning,Tang Xinfeng,Wu Yichu,Chen Zhiquan 한국물리학회 2021 Current Applied Physics Vol.26 No.-

In this paper, a series of CuIn1-xGaxTe2 samples were prepared by vacuum melting combined with the spark plasma sintering process based on the initial stoichiometric ratios of 1: 1-x: x: 2 (x = 0, 0.1, 0.2, 0.3, 0.4, 0.5, 0.6, 0.7, 0.8, 0.9 and 1.0). Crystal results indicate that all Cu(In, Ga)Te2 system samples are the chalcopyrite structure with space group I42d. Thermal analysis results show that all the samples have excellent reproducibility and thermal stability. EPMA data indicates that Ga tended to replace In site instead of Cu or Te. Meanwhile, the roomtemperature carrier concentration of all p-type samples varies from 0.30 × 1019 to 1.25 × 1019cm 3, since carrier mobility changes from 15.16 to 69.27 cm2 V 1 s 1. Ultimately, the significantly reduced total thermal conductivity is observed in the Ga-doped samples, and the maximum ZT value of 0.80 is obtained at 773 K for the CuIn0.8Ga0.2Te2 sample due to the lower thermal conductivity

A New Interleaved Double-Input Three-Level Boost Converter

Chen, Jianfei,Hou, Shiying,Sun, Tao,Deng, Fujin,Chen, Zhe The Korean Institute of Power Electronics 2016 JOURNAL OF POWER ELECTRONICS Vol.16 No.3

This paper proposes a new interleaved double-input three-level Boost (DITLB) converter, which is composed of two boost converters indirectly in series. Thus, a high voltage gain, together with a low component stress and a small input current ripple due to the interleaved control scheme, is achieved. The operating principle of the DITLB converter under the individual supplying power (ISP) and simultaneous supplying power (SSP) mode is analyzed. In addition, closed-loop control strategies composed of a voltage-current loop and a voltage-balance loop, have been researched to make the converter operate steadily and to alleviate the neutral-point imbalance issue. Experimental results verify correctness and feasibility of the proposed topology and control strategies.

The Improved Algorithm of Edge Detection Based on Mathematics Morphology

Deng Caixia,Chen Yu,Bi Hui,Han Yao 보안공학연구지원센터 2014 International Journal of Signal Processing, Image Vol.7 No.5

Graphitization of graphene oxide films under pressure

Chen, Xianjue,Deng, Xiaomei,Kim, Na Yeon,Wang, Yu,Huang, Yuan,Peng, Li,Huang, Ming,Zhang, Xu,Chen, Xiong,Luo, Da,Wang, Bin,Wu, Xiaozhong,Ma, Yufei,Lee, Zonghoon,Ruoff, Rodney S. Elsevier 2018 Carbon Vol.132 No.-

<P><B>Abstract</B></P> <P>Lightweight, flexible graphite foils that are chemically inert, high-temperature resistant, and highly electrically and thermally conductive can be used as component materials in numerous applications. “Graphenic” foils can be prepared by thermally transforming graphene oxide films. For this transformation, it is desirable to maintain a densely packed film structure at high heating rates as well as to lower the graphitizing temperatures. In this work, we discuss the pressure-assisted thermal decomposition of graphene oxide films by hot pressing at different temperatures (<I>i.e.</I>, 300 °C, 1000 °C, or 2000 °C). The films pressed at 1000 °C or 2000 °C were subsequently heated at 2750 °C to achieve a higher degree of graphitization. The combination of heating and pressing promotes the simultaneous thermal decomposition and graphitic transformation of G-O films. Films pressed at 2000 °C as well as films further graphitized at 2750 °C show high chemical purity, uniformity, and retain their flexibility. For films pressed at 2000 °C and then further heated at 2750 °C, the mechanical performances outperform the reported values of the “graphite” foils prepared by calendering exfoliated graphite flakes; the electrical conductivity is ∼3.1 × 10<SUP>5</SUP> S/m and the in-plane thermal conductivity is ∼1.2 × 10<SUP>3</SUP> W/(m·K).</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

An Interleaved Five-level Boost Converter with Voltage-Balance Control

Chen, Jianfei,Hou, Shiying,Deng, Fujin,Chen, Zhe,Li, Jian The Korean Institute of Power Electronics 2016 JOURNAL OF POWER ELECTRONICS Vol.16 No.5

This paper proposes an interleaved five-level boost converter based on a switched-capacitor network. The operating principle of the converter under the CCM mode is analyzed. A high voltage gain, low component stress, small input current ripple, and self-balancing function for the capacitor voltages in the switched-capacitor networks are achieved. In addition, a three-loop control strategy including an outer voltage loop, an inner current loop and a voltage-balance loop has been researched to achieve good performances and voltage-balance effect. An experimental study has been done to verify the correctness and feasibility of the proposed converter and control strategy.