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Highly Efficient and Facile Green Approach for One-Pot Fischer Indole Synthesis
Chaskar, Atul,Deokar, Hrushikesh,Padalkar, Vikas,Phatangare, Kiran,Patil, S.K. Korean Chemical Society 2010 대한화학회지 Vol.54 No.4
HPA-phosphomolybdic acid 촉매 하에서, 아릴히드라진과 알데히드/케톤을 반응시켜서 치환기를 가지고 있는 indole 화합물을 효율적으로 합성할 수 있는 친환경적인 합성 방법을 개발하였으며, 이때 촉매는 독성이 없으며, 회수하여 재 사용할 수 있다. A simple, efficient and an environmental friendly method have been developed for the synthesis of substituted indole from aryl hydrazines and aldehydes/ketones with HPA-phosphomolybdic acid as a heterogeneous catalyst. The catalyst is nontoxic and recyclable.
Practical and Green Approach for N-Boc Protection of Amines Catalyzed by Indion 190 Resin
Chaskar, Atul,Yewale, Sampat,Langi, Bhushan,Deokar, Hrushikesh Korean Chemical Society 2009 대한화학회지 Vol.53 No.4
An efficient, chemoselective and practical protocol for N-Boc protection of amines using di-tertbutoxypyrocarbonate $(Boc)_{2}O$ in presence of Indion 190 resin. Resin was easily separated from the reaction mixture by filtration and reused in subsequent reactions without any apparent loss of activity. Simple workup, mild condition, short reaction time and high yield are some of the striking features of the present process. Indion 190 수지의 존재하에서 di-tert-butoxypyrocarbonate $(Boc)_{2}O$를 이용한 아민의 N-Boc protection의 효과적인, 화학적 선택성적인, 실용적인 실험안. 수지는 반응혼합물로부터 쉽게 분리되었고 활성의 감소 없이 재사용되었다. 간단한 workup, 온화한 조건, 짧은 반응시간, 높은 수율은 이 방법의 두드러진 특색들이다.
Phosphomolybdic Acid-Catalyzed Highly Efficient and Simple One-Pot Synthesis of Quinoxaline
Chaskar, Atul,Padalkar, Vikas,Phatangare, Kiran,Langi, Bhushan,Naik, Pallavi Korean Chemical Society 2009 대한화학회지 Vol.53 No.6
촉매로서 인 몰립덴산을 이용하여 일련의 퀸옥살린의 유도체를 높은 수율로 합성하였다. 이 방법의 장점은 실내 온도에서 간단한 조작, HPA 촉매의 재사용, 반응단계의 친환경적인 면이다. A series of quinoxaline derivatives were efficiently synthesized in excellent yield using phosphomolybdic acid as a catalyst. The advantages of present methods are ambient reaction temperature, simplicity of operation, high atom economy, recyclability of HPA catalyst and ecofriendly nature of reaction medium.
Balasaheb Wakchaure Vrushali,Uttam Chaskar 대한전기학회 2022 Journal of Electrical Engineering & Technology Vol.17 No.1
In recent times, the intelligent biological control system in biomedical engineering has been utilized in various applications such as prosthesis control, drug delivery control, blood glucose control, and heart rate regulation. Moreover, the pancreas, gene regulatory network (GRN), and protein are the main sources in the human body system. However, the parameter regulations of these systems are crucial, because the conventional control methods lack the fnest performance, provoking a lot of errors. With an advanced control method, the parameters of the biological system can regulate as per the level to avoid serious conditions. Therefore, in this research, a novel self-constructing intelligent emperor penguin (SIEP) algorithm based fractional-order adaptive proportional integral derivative (FAPID) controller is proposed to regulate the parameters of the system. Here, the FAPID controller gain parameters are efectively tuned by the SIEP algorithm. This proposed SIEP-FAPID controller regulates the constraints of linear time-invariant (LTI) based biological systems such as the pancreas, GRN, and protein formation as per the required level. Moreover, the stability of the controller is studied using the discrete Lyapunov stability analysis function. The quality of the control function has been improved using this proposed approach thus the fnest gain and reduced error percentage was obtained. Furthermore, the proposed simulation outcomes are compared with various conventional control approaches which are validated for proving the enhanced controller function under external disturbances. The comparison shows that the proposed SIEP algorithm in the FAPID controller has attained 0.1% less error while comparing with the existing controllers.
R. Shashikant,Uttam Chaskar,Leena Phadke,Chetankumar Patil 대한의용생체공학회 2021 Biomedical Engineering Letters (BMEL) Vol.11 No.3
The main objective of the study was to develop a low-cost, non-invasive diagnostic model for the early prediction of T2DMrisk and validation of this model on patients. The model was designed based on the machine learning classifi cation techniqueusing non-linear Heart rate variability (HRV) features. The electrocardiogram of the healthy subjects (n = 35) and T2DMsubjects (n = 100) were recorded in the supine position for 15 min, and HRV features were extracted. The signifi cant nonlinearHRV features were identifi ed through statistical analysis. It was found that Poincare plot features (SD1 and SD2) candiff erentiate the T2DM subject data from healthy subject data. Several machine learning classifi ers, such as Linear DiscriminantAnalysis (LDA), Quadratic Discriminant Analysis, Naïve Bayes, and Gaussian Process Classifi er (GPC), have classifi edthe data based on the cross-validation approach. A GP classifi er was implemented using three kernels, namely radial basis,linear, and polynomial kernel, considering the ability to handle the non-linear data. The classifi er performance was evaluatedand compared using performance metrics such as accuracy(AC), sensitivity(SN), specifi city(SP), precision(PR), F1 score,and area under the receiver operating characteristic curve(AUC). Initially, all non-linear HRV features were selected forclassifi cation, but the specifi city of the model was the limitation. Thus, only two Poincare plot features were used to designthe diagnostic model. Our diagnostic model shows the performance using GPC based linear kernel as AC of 92.59%, SNof 96.07%, SP of 81.81%, PR of 94.23%, F1 score of 0.95, and AUC of 0.89, which are more extensive compared to otherclassifi cation models. Further, the diagnostic model was deployed on the hardware module. Its performance on unknown/testdata was validated on 65 subjects (healthy n = 15 and T2DM n = 50). Considering the desirable performance of the diagnosticmodel, it can be used as an initial screening test tool for a healthcare practitioner to predict T2DM risk.
Synthesis and Antibacterial Activity of New Tetrazole Derivatives
Mulwad, V.V.,Pawar, Rupesh B,Chaskar, Atul C Korean Chemical Society 2008 대한화학회지 Vol.52 No.3
3-Acetyl/Formyl 4-hydroxy-2H(1)-benzopyran-2-one를 malonitrile와 ethyl cyanoacetate로 처리하여 각각 1,1-dicyano-2-[4/-hydroxy-2/H(1)-benzopyran-2/-one-3/-yl] ethene/propene 2a-h와 ethyl-2-cyano-3-[4/-hydroxy-2/H (1)-benzopyran-2/-one-3/-yl] propenoate/butenoate 3a-h를 얻었다. NaN3와 2a-h의 1.3 dipolar 반응에서 4a-h인 tetrazole유도체를 얻었다. 3a-h는 PPA를 이용한 고리화 반응으로 3-cyano-2H,5H-pyrano [3, 2-c] benzopyran-2,5-diones 5a-h를 얻었다. 5a-h는 NaN3와1.3 dipolar 반응으로 -(1/H-tetrazol-5/-yl)-2H,5H-pyrano[3, 2-c] benzopyran-2,5-diones 6a-h얻었다. 화합물의 구조는 스펙트럼과 자료 분석을 기초로 입증했다.모든 화합물은 항균 활성을 검사하였고 의미있는 항균성을 가짐을 밝혔다. 2h화합물과 4h 화합물은 50 킽/mL에서 활성을 보였다 3-Acetyl/Formyl 4-hydroxy-2H(1)-benzopyran-2-one on treatment with malonitrile and ethyl cyanoacetate yielded 1,1-dicyano-2-[4/-hydroxy-2/H(1)-benzopyran-2/-one-3/-yl] ethene/propene 2a-h and ethyl-2-cyano-3-[4/-hydroxy-2/H (1)-benzopyran-2/-one-3/-yl] propenoate/butenoate 3a-h respectively. The 1,3 dipolar reaction of 2a-h with NaN3 gave the tetrazole derivative 4a-h. 3a-h on cyclization with PPA gave 3-cyano-2H,5H-pyrano [3, 2-c] benzopyran-2,5-diones 5a-h which on 1,3 dipolar reaction with NaN3 to gave 3-(1/H-tetrazol-5/-yl)-2H,5H-pyrano[3, 2-c] benzopyran-2,5-diones 6a-h. The structures of the compounds have been established on the basis of the spectral and analytical data. All the compounds were screened for their antimicrobial activities and have been found to exhibited significant antibacterial activities. Compounds 2h and 4h showed the activity 50g/mL.