청소년들의 최대 골량 향상을 위한 운동 가이드라인

민석기 ( Seok-ki Min ),오태웅 ( Taewoong Oh ),김상현 ( Sang Hyun Kim ),조진경 ( Jinkyung Cho ),정호연 ( Ho-yeon Chung ),박동호 ( Dong-ho Park ),김창선 ( Changsun Kim6 ) 한국운동생리학회(구 한국운동과학회) 2020 운동과학 Vol.29 No.1

PURPOSE: An increase in bone mineral density during adolescence increases resistance to fractures in older age. The Korean Society for Bone and Mineral Research and the Korean Society of Exercise Physiology developed exercise guidelines to increase the peak bone mass (PBM) in adolescents based on evidence through a systematic review of previous research. METHODS: Articles were selected using the systematic method, and the exercise guidelines were established by selecting key questions (KQs) and defining the effects of exercises based on evidence through a literature review for selecting the final exercise method. There were 9 KQs. An online search was conducted on articles published since 2000, and 93 articles were identified. RESULTS: An increase in PBM in adolescence was effective for preventing osteoporosis and fractures in older age. Exercise programs as part of vigorous physical activity (VPA) including resistance and impact exercise at least 5 to 6 months were effective for improving PBM in adolescents. It is recommended that resistance exercise is performed 10 to 12 rep·set^-1 1-2 set·region^-1 and 3 days·week^-1 using the large muscles. For impact exercises such as jumping, it is recommended that the exercise is performed at least 50 jumps·min^-1, 10 min·day^-1, and 2 days·week^-1. CONCLUSIONS: Exercise guidelines were successfully developed, and they recommend at least 5 to 6 months of VPA, which includes both resistance and impact exercises. With the development of exercise guidelines, the incidence of osteoporosis and fractures in the aging society can be reduced in the future, thus contributing to improved public health.

Apoptotic Effect of Quercetin on HT-29 Colon Cancer Cells via the AMPK Signaling Pathway

Hyeong-Jin Kim,Sang-Ki Kim,Byeong-Soo Kim,Seung-Ho Lee,Young-Seok Park,Byung-Kwon Park,So-Jung Kim,Jin Kim,Changsun Choi,Jong-Suk Kim,Sung-Dae Cho,Ji-Won Jung,Kyong-Hwan Roh,Kyung-Sun Kang,Ji-Youn Jun 한국실험동물학회 2010 한국실험동물학회 학술발표대회 논문집 Vol.2010 No.8

Apoptotic effect of tolfenamic acid on MDA-MB-231 breast cancer cells and xenograft tumors

Kim, Hyeong-Jin,Cho, Sung-Dae,Kim, Jin,Kim, So-Jung,Choi, Changsun,Kim, Jong-Suk,Nam, Jeong-Seok,Han Kwon, Ki,Kang, Kyung-Sun,Jung, Ji-Youn the Society for Free Radical Research Japan 2013 Journal of clinical biochemistry and nutrition Vol.53 No.1

<P>Recent studies have indicated that non-steroidal anti-inflammatory drug (NSAID), particularly tolfenamic acid, can inhibit proliferation and induce apoptosis invarious cancer cells. Breast cancer represents one-third of all cancers diagnosed in women and is the second leading cause of cancer death in Western European and North American women. In the present study, we investigated the apoptotic effect of tolfenamic acid in MDA-MB-231 estrogen receptor-negative human breast carcinoma cells and in a xenograft tumor model. Treatment of cells with tolfenamic acid significantly decreased cell viability in a concentration-dependent manner. Notably, tolfenamic acid increased apoptosis-related proteins, such as p53 and p21, within 48 h. Furthermore, <I>in vivo</I> experiments showed that tolfenamic acid treatment resulted in a significant reduction in tumor volume over 5 weeks. Immunohistochemistry results showed that apoptosis-related protein induction by tolfenamic acid was significantly higher in the 50 mg/kg-treated group compared to the control group. Together, these results indicate that tolfenamic acid induces apoptosis in MDA-MB-231 breast cancer cells and tumor xenograft model and it may be a potential chemotherapeutic agent against breast cancer.</P>

Biocompatible, drug-loaded anti-adhesion barrier using visible-light curable furfuryl gelatin derivative

Kim, Eun-Hye,Kim, Jae-Won,Han, Ga-Dug,Noh, Seung-Hyun,Choi, Jae-Hee,Choi, ChangSun,Kim, Mi-Kyung,Nah, Jae-Woon,Kim, Tae-Yeon,Ito, Yoshihiro,Son, Tae-Il Elsevier 2018 INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES Vol.120 No.1

<P><B>Abstract</B></P> <P>Recently, many of studies have been attempted to determine how to decrease adhesion. To effectively prevent adhesion, decrease in unnecessary surgical procedures, prevention of contact with other tissue, and drug treatment for inflammation are required. However, current anti-adhesion materials have disadvantages. To solve current problems, we prepared a biocompatible drug-loaded anti-adhesion barrier using a visible-light curable furfuryl gelatin derivative. We used riboflavin as a photo-initiator in the photo-curing process. The biocompatibility of riboflavin was estimated compared with that of Rose Bengal. In addition, the curing ratio was measured to determine whether riboflavin initiated photo-curing. We also evaluated the curing ratio of riboflavin according to the concentration of F-gelatin and the photo-irradiation time. A drug used to decrease inflammation that causes adhesion should not disappear from the surgical site and should also be released consistently. For this, we observed the release profiles of photo-immobilized ibuprofen with different concentrations of F-gelatin. Because an anti-adhesion barrier should protect from bacterial infection we evaluated the protective ability of a barrier formed by F-gelatin. In conclusion, a drug-loaded anti-adhesion barrier was prepared using a visible-light curable furfuryl gelatin derivative, with riboflavin as a photo-initiator. We expect that this drug-loaded anti-adhesion barrier effectively decrease adhesion formation.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Riboflavin showed the better photo-curable property and biocompatibility as photo-initiator than Rose Bengal. </LI> <LI> As concentration of furfuryl gelatin and photo-irradiation time increase, the photo-curing ratio increase. </LI> <LI> Release profile of photo-immobilized ibuprofen can be controlled by changing the concentration of furfuryl gelatin. </LI> <LI> Surgical site can be protected from bacterial infection by furfuryl gelatin barrier and adhesion also can be decreased. </LI> <LI> Drug-loaded anti-adhesion barrier can protect surgical site and prevent inflammation. </LI> </UL> </P>

국궁 활쏘기 동작 시 근활성 분석

김창선 ( Changsun Kim ),( Zhou Yuezhu ),박동호 ( Dong-ho Park ),김기훈 ( Kihoon Kim ),정왕수 ( Wangsoo Jeong ),김혜리 ( Hye-ree Kim ),이기광 ( Kikwang Lee ),민석기 ( Seok-ki Min ) 한국스포츠정책과학원(구 한국스포츠개발원) 2021 체육과학연구 Vol.32 No.1

〔목적〕 양궁종목에서 근전도를 이용한 운동학적 연구는 증가했지만, 우리나라 전통 활쏘기인 국궁 관련 연구는 전무한 실정이다. 본 연구의 목적은 국궁 궁사를 대상으로 활쏘기 동작중의 근전도를 평가하는 것이다. 〔방법〕 대상자는 국궁 궁사 10명으로 활쏘기 자세에 따라 마주 서기 그룹(PSG, n=5)과 사선 서기 그룹(OSG, n=5)의 두 집단으로 구분하였다. 근전도는 준비(Set), 거궁(Set up), 만작(Full draw), 발시(Release), 마치기(Ending) 등 5개 동작의 활쏘기 국면에서 12개의 근육에서 근전도를 측정했다. 〔결과〕 만작 및 발시 시의 뒤어 깨세모근, 등세모근, 큰마름근, 깍지팔의 넓은등근, 위팔두갈래근, 아래팔폄근무리, 위팔세갈래근, 어깨올림근의 근활성은 유의하게 증가하였다가, 마치기 국면에서는 다시 감소했다(p<.01, p<.001). 또한, 척주세움근의 근활성은 만작 및 발시 시 증가(p<.01, p<.001)한 반면, 배곧은근, 넓다리곧은근, 큰볼기근에 있어서는 유의한 변화는 없었다. 마주 서기 집단과 사선 서기 집단을 비교한 결과, 사선 서기 집단의 넓다리곧은근 근활성은 마주 서기 집단의 발시(p<.05) 국면 보다 높았고, 마치기 국면까지 유지되었다(p<.05). 한편, 활의 장력이 높아질수록 발시 시에 깍지 팔의 위팔두갈래근 근활성이 높아졌다(p<.05). 〔결론〕 국궁 활쏘기 시 복부, 다리, 엉덩이 근육보다 양팔과 등 근육이 더 활성화된다는 것이 시사되었다. 또한, 마주 서기 자세시에 상체를 비틀기 위해 하지의 근활성이 억제될 가능성이 있으며, 활의 장력이 높을수록 깍지 팔의 위팔두갈래근 근력 증가가 필요할 것으로 판단된다. [Abstract] The past few decades has seen increasing kinematic studies using surface electoromyography (EMG) in archery, however there has been no such specific study in Korean traditional archery. The purpose of this study was to evaluate EMGs during archery shooting motion in Korean traditional archers. Ten men Korean traditional archers were participated, and divided into two groups according to the shooting stance; parallel stance group(PSG, n=5) and oblique stance group(OSG, n=5). The surface EMGs were measured 12 muscles during shooting motion of five events including Junbi(Set), Geogung(Set up), Manjak(Full draw), Balsi(Release), Machigi(Ending). At the result, muscle activity of posterior deltoid, trapezius, rhomboid major, latissimus dorsi, biceps brachii, forearm extensor bundle, triceps brachii, levator scapulae significantly increased at event of full draw and release, then significantly decreased again at event of ending, respectively(p<.01, p<.001). The muscle activity of erector spinae(ES) was also significantly increased at event of full draw and release(p<.01, p<.001), while no significant changes in muscles of rectus abdominis, rectus femoris(RF), gluteus maximus. As a result of comparing PSG and OSG, muscle activity of RF in OSG was higher than PSG at event of release(p<.05), it remained until event of ending(p<.05). On the other hand, the higher the tension of the bow, the higher the muscle activity of the draw arm at event of release(p<.05). These results suggest that when Korean traditional archery shooting, both side arm and back muscles are more activated than the abdomen, leg and hip muscles. The parallel stance might suppress the muscle activity of the lower extremities to twist the upper body. And the higher bowstring tension needs to increase of muscle strength in BB of draw arm.

Amanita muscaria 경구투여 시 Sprague-Dawley Rat에서의 독성병리 연구

김진(Jin Kim),김형진(Hyeong-Jin Kim),김소정(So-Jung Kim),김병수(Byeong-Soo Kim),김상기(Sang-Ki Kim),박병권(Byung-Kwon Park),박영석(Young-Seok Park),조성대(Sung-Dae Cho),정지원(Ji-Won Jung),남정석(Jeong-Seok Nam),최창순(Changsun Choi 한국생명과학회 2009 생명과학회지 Vol.19 No.8

본 연구는 우리나라에 분포하는 광대버섯인 amanita muscaria로 단회투여독성시험과 반복투여독성시험을 하였을 때 SD 랫드의 독성병리학적 변화를 알아보고자 수행하였다. 단회투 여독성시험은 강경증, 경사판법, 정압자극법을 이용하여 측정하였다. 강경증은 33 ㎎/㎏의 농도에서 투여 2~3시간 후 강경증 시간이 감소하였다. 경사판법의 경우 33 ㎎/㎏의 농도에서 투여 2시간 후 대조군과 비교하였을 때 낮은 경사 각도에서도 쉽게 미끄러졌으며, 앞다리 보다는 뒷다리 쪽에서의 움직임 감소를 보였다. 정압자극법의 경우 대조군, 저용량군, 중간용량군에서 SD 랫드가 자극을 인지하는 시간이 1~2초 정도로 짧고 매우 공격적인 반응을 보였지만, 고용량군에서는 자극인지 시간이 대략 3~5초로 증가하였으며, 대부분 공격적인 반응을 보이지 않는 것이 관찰되었다. 강경증, 경사판법, 정압자극법 모두 투여 4시간 후 대조군과 비슷한 수치로 회복 되었으며 이것으로 보아 섭취 4시간 전후에는 amanita muscaria의 독성이 현저히 감소하는 것으로 확인되었다. 반복투여독성시험은 혈액, 혈청분석, 조직 병리학적 검사를 실시하였다. 혈청 분석에서 투여군과 대조군을 비교하였을 때 BUN과 creatinine의 변화는 없었지만 ALT와 LDH는 투여군에서 증가하였다. 이러한 결과를 바탕으로 표적장기인 간과 신장의 손상을 의심하였고 조직 병리학적 검사를 통해 간과 신장의 손상을 확인할 수 있었다. For the toxicological pathologic study of amanita muscaria, we have investigated single and repeated dose toxicity in Sprague-Dawley (SD) rats. Single dose toxicity study was identified as catalepsy, incline and tail pinch methods (control 0 ㎎/㎏, low 3.3 ㎎/㎏, middle 16.5 mg/kg, high 33.0 ㎎/㎏). Repeated dose toxicity study was carried out in blood tests, serum tests and histopathological methods. Neurotoxicity - muscle paralysis, and convulsion and loss of movement - was observed at 33.0 ㎎/㎏ group in the single dose toxicity study. Dysfunction of liver and kidney were shown in the repeated oral administration of the amanita muscaria at 3~4 weeks. Serum chemistry results revealed a marked increase of LDH [Lactate Dehydrogenase (3181.5 IU/ℓ; normal 230-460 IU/ℓ)], ALT [Alanine transaminase (124.0 IU/ℓ; normal <40 IU/ℓ)] but the kidney was normal. Histopathological results show interstitial edema and tubular epithelial necrosis in the kidney. These results suggest that amanita muscaria has a neurotoxic effect and causes dysfunction of liver and kidney in the SD rat.

전력 변환 시스템 상의 전도성 장해 전자파 해석 방법론

김홍근(Hongkeun Kim),김민성(Minsung Kim),임종엽(Jongyeob Lim),김창선(Changsun Kim),김주원(Joowon Kim) 한국자동차공학회 2017 한국자동차공학회 학술대회 및 전시회 Vol.2017 No.11

Anti-inflammatory Effect of Quercetin on Picryl Chloride-induced Contact Dermatitis in BALB/c Mice

Hyeong-Jin Kim,Jin Kim,So-Jung Kim,Seung-Ho Lee,Young-Seok Park,Byung-Kwon Park,Byeong-Soo Kim,Sang-Ki Kim,Sung-Dae Cho,Ji-Won Jung,Jeong-Seok Nam,Changsun Choi,Ji-Youn Jung 한국실험동물학회 2010 Laboratory Animal Research Vol.26 No.1

In this study, we investigated that anti-inflammatory effect of quercetin on picryl chloride(PCL)-induced contact dermatitis in BALB/c Mice. Experimental animals were divided into three groups and comprising five animals. All groups of oral administration was begun on the first day of PCL treatment and ceased on day 5. For the induction of contact dermatitis, BALB/c mice were sensitized with 40 ?L of 1.5% picryl choloride (PCL) to the left and right ear, respectively. Ear swelling responses were much weaker in highdose group (100 ㎎/㎏) than control group (0 ㎎/㎏). Total serum IgE levels and histamine levels were measured by sandwich ELISA method using mouse IgE, histamine measuring Kit. Both total serum IgE and histamine levels were significantly decreased in high-dose group (100 ㎎/㎏) than other groups. Degranulation of mast cells were also confirmed by Toluidine Blue (TB) staining method. In high-dose group (100 ㎎/㎏), the number of mast cells were significantly decreased and there are many mast cells were shown degranulation in control group (0 ㎎/㎏). All of these results demonstrate that the pharmacological actions of quercetin indicate their potential activity for allergic inflammatory diseases through the down-regulation of mast cell activation.

Effects of eight weeks mat pilates on core muscle function in female college students

Hyo-Jin Kim,Ji-Yeon Kim,Gi-Won Kim,Yue-Zhu Zhou,Seok-Ki Min,Changsun Kim 한국운동재활학회 2022 한국운동재활학회 학술대회 Vol.2022 No.06

Model-based approach to perform FMEA

Changsun Kim,Jieun Park,Seungyeon Jeong 한국자동차공학회 2018 한국자동차공학회 부문종합 학술대회 Vol.2018 No.6