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RISS 인기검색어
- 검색키워드
- 저자 : Changchun Dong (검색결과 4 건)
- 무료
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- 유료
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A self-normalization test for a change-point in the shape parameter of a gamma distributed sequence
Changchun Tan,Yuehua Wu,Cuiling Dong,Baiqi Miao 한국통계학회 2013 Journal of the Korean Statistical Society Vol.42 No.3
In this paper, a parametric change-point problem encountered in analyzing a gamma distributed sequence is considered. We propose a self-normalization based CUSUM type test statistic to detect the presence of a change-point, and obtain its limiting null distribution. The CUSUM-based procedure for detecting the location of this change-point is also given. At the same time, simulation results are provided, which show that our procedures are effective.
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An Optimization of CORDIC Algorithm and FPGA Implementation
Rui Xu,Zhanpeng Jiang,Hai Huang,Changchun Dong 보안공학연구지원센터 2015 International Journal of Hybrid Information Techno Vol.8 No.6
ASIC and FPGA ASIC and FPGA are considered to be the ideal platform for special fast calculations because of the hardware structure, and how to achieve computational algorithm by is the hotpot of research. The CORDIC (Coordinate Rotational Digital Computer) can break the basis functions down to operations of shift and addition or subtraction, which can be used to lay the foundation for the realization of complex logic. But the functions selected by traditional CODIC for angle encoding are too complex, which will lead to some problems, such as too much of area consumption and large delay. In this paper, an optimization of CORDIC algorithm are proposed, which reduce the consumption of Adders and comparators, decrease the complexity and delay of the algorithm implement in hardware. The proposed algorithms are modeled in Verilog Hardware Description Language and implemented with FPGA. The simulation results show that the functions of sine and cosine are realized successfully, and the proposed algorithm not only improves the computation speed but also reduces the system hardware resources.
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Design of a ROM-Less Direct Digital Frequency Synthesizer on FPGA
Zhanpeng Jiang,Rui Xu,Hai Huang,Changchun Dong 보안공학연구지원센터 2015 International Journal of Signal Processing, Image Vol.8 No.5
DDFS (Direct Digital Frequency Synthesizer) is a new technique of frequency synthesizes which introduces the advanced digital processing theory into frequency synthesis. A direct digital frequency synthesizer is composed of a phase accumulator, an adder, an ROM for wave pattern saving, a D/A converter and a LPF (low pass filter). With the rapid development of VLSI, the speed of algorithm is required increasingly higher. This paper proposes a new frequency synthesizer by improving the structure of data storage which ensures the accuracy and speed. Rotation method was used to resolve the expected angle into many small rotation angles and sting wave symmetry principle was used to resolve the string wave. From point to area, the values in one quadrant were calculated and sampled and then the data was saved in ROM. Under the control of frequency, the data in ROM was read and then transferred to the D/A converter chip and the following low pass filter to achieve frequency synthesize. This algorithm could reduce the usage of ROM to increase the calculation efficiency.
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CHMP5 controls bone turnover rates by dampening NF-κB activity in osteoclasts
Greenblatt, Matthew B.,Park, Kwang Hwan,Oh, Hwanhee,Kim, Jung-Min,Shin, Dong Yeon,Lee, Jae Myun,Lee, Jin Woo,Singh, Anju,Lee, Ki-young,Hu, Dorothy,Xiao, Changchun,Charles, Julia F.,Penninger, Josef M. The Rockefeller University Press 2015 The Journal of experimental medicine Vol.212 No.8
<▼1><P>Greenblatt et al. show that deletion of CHMP5 in osteoclasts leads to increased bone resorption coupled with exuberant osteoblast activity, resembling an early onset form of human Paget’s Disease of Bone</P></▼1><▼2><P>Physiological bone remodeling requires that bone formation by osteoblasts be tightly coupled to bone resorption by osteoclasts. However, relatively little is understood about how this coupling is regulated. Here, we demonstrate that modulation of NF-κB signaling in osteoclasts via a novel activity of charged multivesicular body protein 5 (CHMP5) is a key determinant of systemic rates of bone turnover. A conditional deletion of CHMP5 in osteoclasts leads to increased bone resorption by osteoclasts coupled with exuberant bone formation by osteoblasts, resembling an early onset, polyostotic form of human Paget’s disease of bone (PDB). These phenotypes are reversed by haploinsufficiency for <I>Rank</I>, as well as by antiresorptive treatments, including alendronate, zolendronate, and OPG-Fc. Accordingly, CHMP5-deficient osteoclasts display increased RANKL-induced NF-κB activation and osteoclast differentiation. Biochemical analysis demonstrated that CHMP5 cooperates with the PDB genetic risk factor valosin-containing protein (VCP/p97) to stabilize the inhibitor of NF-κBα (IκBα), down-regulating ubiquitination of IκBα via the deubiquitinating enzyme USP15. Thus, CHMP5 tunes NF-κB signaling downstream of RANK in osteoclasts to dampen osteoclast differentiation, osteoblast coupling and bone turnover rates, and disruption of CHMP5 activity results in a PDB-like skeletal disorder.</P></▼2>
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