Research on the Characteristic of Diesel Elastic-plate Impingement Spray

( Chang Yuan Wang ),( Yong Shang ),( Xiang Rong Li ),( Fu Shui Liu ),( Cheng Hui Yu ) 한국액체미립화학회 2010 한국액체미립화학회 학술강연회 논문집 Vol.2010 No.-

A series of experimental research results on the characteristic of diesel elastic-plate impingement spray using High Speed Photography camera are presented in this paper. The experiments were carried out in a constant volume chamber specially designed, which can hold a high ambiance pressure. The special fixed device was designed so that the elastic-plate can be fixed on the spray path, meanwhile the spray incident angle and height can be changed. The free jet spray and elastic-plate impingement spray was compared under the same experimental condition including different injection pressure and different background pressure. Experimental research showed that impingement spray droplets diffuse more quickly than free jet spray.

Enhanced x-ray irradiation-induced cancer cell damage by gold nanoparticles treated by a new synthesis method of polyethylene glycol modification

Liu, Chi-Jen,Wang, Chang-Hai,Chien, Chia-Chi,Yang, Tsung-Yeh,Chen, Shin-Tai,Leng, Wei-Hua,Lee, Cheng-Feng,Lee, Kuen-Ho,Hwu, Y,Lee, Yao-Chang,Cheng, Chia-Liang,Yang, Chung-Shi,Chen, Y J,Je, J H,Margari IOP Pub 2008 Nanotechnology Vol.19 No.29

<P>We explored a very interesting gold nanoparticle system—pegylated gold in colloidal solution—and analyzed its uptake by mice colorectal adenocarcinoma CT26 tumor cells and the impact on the cell’s response to x-ray irradiation. We found that exposure to polyethylene glycol (PEG) modified (‘pegylated’) 4.7 ± 2.6 nm gold nanoparticles synthesized by a novel synchrotron-based method enhances the response of CT26 cells to x-ray irradiation. Transmission electron microscopy (TEM) and confocal microscopy revealed that substantial amounts of such nanoparticles are taken up and absorbed by the cells and this conclusion is supported by quantitative induced coupled plasma (ICP) results. Standard tests indicated that the internalized particles are highly biocompatible but strongly enhance the cell damage induced by x-ray irradiation. Synchrotron radiation Fourier transform infrared (SR-FTIR) spectromicroscopy analyzed the chemical aspects of this phenomenon: the appearance of C = O stretching bond spectral features could be used as a marker for cell damage and confirmed the enhancement of the radiation-induced toxicity for cells.</P>

Changes in prostate-specific antigen kinetics during androgen-deprivation therapy as a predictor of response to abiraterone in chemonaïve patients with metastatic castration-resistant prostate cancer

Chung-Lin Lee,Ying-Hsu Chang,Chung-Yi Liu,Ming-Li Hsieh,Liang-Kang Huang,Yuan-Cheng Chu,Hung-Cheng Kan,Po-Hung Lin,Kai-Jie Yu,Cheng-Keng Chuang,Chun-Te Wu,See-Tong Pang,I-Hung Shao 대한비뇨의학회 2022 Investigative and Clinical Urology Vol.63 No.5

Purpose: Metastatic castration-resistant prostate cancer (mCRPC) has a poor prognosis. Abiraterone acetate (AA), enzalutamide, and chemotherapy are first-line treatments for patients with mCRPC. This study examined prognostic factors for AA response in the form of prostate-specific antigen (PSA) kinetics throughout androgen-deprivation therapy (ADT) in chemonaïve patients with mCRPC. Materials and Methods: We retrospectively included data from 34 chemonaïve patients with mCRPC who had received AA at some point between January 2017 and December 2018. We separated patients into two study arms according to the decrease in PSA percentages after use of AA for 3 months. We correlated PSA kinetics parameters with response and compared the two study groups with respect to PSA kinetics. Results: The patients’ median age was 77 years. In the total group of patients, 64% had a response to AA, whereas 35% did not. The ratio of the PSA level at nadir to the level during ADT was significantly higher in the AA-sensitive group (19.78 vs. 1.03, p=0.019). Conclusions: Patients who experienced a dramatic change in PSA level during ADT were more likely to be resistant to AA after progression to mCRPC. Chemotherapy rather than AA might be more suitable as a first-line treatment for these patients.

Discrimination of neutrons and gamma-rays in plastic scintillator based on spiking cortical model

Liu Bing-Qi,Liu Hao-Ran,Chang Lan,Cheng Yu-Xin,Zuo Zhuo,Li Peng 한국원자력학회 2023 Nuclear Engineering and Technology Vol.55 No.9

In this study, a spiking cortical model (SCM) based n-g discrimination method is proposed. The SCMbased algorithm is compared with three other methods, namely: (i) the pulse-coupled neural network (PCNN), (ii) the charge comparison, and (iii) the zero-crossing. The objective evaluation criteria used for the comparison are the FoM-value and the time consumption of discrimination. Experimental results demonstrated that our proposed method outperforms the other methods significantly with the highest FoM-value. Specifically, the proposed method exhibits a 34.81% improvement compared with the PCNN, a 50.29% improvement compared with the charge comparison, and a 110.02% improvement compared with the zero-crossing. Additionally, the proposed method features the second-fastest discrimination time, where it is 75.67% faster than the PCNN, 70.65% faster than the charge comparison and 38.4% slower than the zero-crossing. Our study also discusses the role and change pattern of each parameter of the SCM to guide the selection process. It concludes that the SCM's outstanding ability to recognize the dynamic information in the pulse signal, improved accuracy when compared to the PCNN, and better computational complexity enables the SCM to exhibit excellent n-g discrimination performance while consuming less time.

Antitumor Activity of Histone Deacetylase Inhibitor Trichostatin A in Osteosarcoma Cells

Cheng, Dong-Dong,Yang, Qing-Cheng,Zhang, Zhi-Chang,Yang, Cui-Xia,Liu, Yi-Wen Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.4

Background: Histone deacetylase (HDAC) inhibitors have been reported to induce cell growth arrest, apoptosis and differentiation of tumor cells. The present study aimed to examine the effects of trichostatin A (TSA), one such inhibitor, on the cell cycle, apoptosis and invasiveness of osteosarcoma cells. Methods: MG-63 cells were treated with TSA at various concentrations. Then, cell growth and apoptosis were determined by 3-(4, 5-dimethyl-2-thiazolyl)-2H-tetrazolium bromide (MTT) and TUNEL assays, respectively; cell cycling was assessed by flow cytometry; invasion assays were performed with the transwell Boyden Chamber system. Results: MTT assays revealed that TSA significantly inhibited the growth of MG-63 cells in a concentration and time dependent manner. TSA treated cells demonstrated morphological changes indicative of apoptosis and TUNEL assays revealed increased apoptosis of MG-63 cells after TSA treatment. Flow cytometry showed that TSA arrested the cell cycle in G1/G2 phase and annexin V positive apoptotic cells increased markedly. In addition, the invasiveness of MG-63 cells was inhibited by TSA in a concentration dependent manner. Conclusion: Our findings demonstrate that TSA inhibits the proliferation, induces apoptosis and inhibits invasiveness of osteosarcoma cells in vitro. HDAC inhibitors may thus have promise to become new therapeutic agents against osteosarcoma.

Soil-atmosphere interaction as triggering factors of openings between embankment and pavement

Yongzhen Cheng,Xiaoming Huang,Chang Liu,Lianyou Li 대한토목학회 2018 KSCE JOURNAL OF CIVIL ENGINEERING Vol.22 No.5

The analysis of openings between embankment and pavement due to uneven deformations of the highway embankment isincapable of accurate prediction when the pattern of seasonal weather variation is considered. This realization was used for elaborateopenings analyses which include infiltration and evapotranspiration of the embankment soils to better predict atmosphere-inducedopenings between embankment and pavement at Nairobi where the longitudinal cracks of the pavement structure occurred during theperiod of the season alternation. The empirical equations were used to estimate evapotranspiration and the soil–water characteristiccurve was established for the embankment soils. The consolidation theory and the moisture swelling model were then used toestimate performances of the highway embankment under atmospheric influence. A field test was conducted to verify the simulatedmoisture change in soil and soil movement, and small difference between simulated and measured values was found. The resultsshowed that openings between embankment and pavement would occur when the highway embankment had undergone unevendeformations due to the rainfall and evapotranspiration, there were small openings during the dry season, but the maximum openingsreached 10.2 mm and 25.5 mm during the first rainy season and the most intense rainy season, respectively.

Hydrogen Bubbles and the Growth Morphology of Ramified Zinc by Electrodeposition

Hsu, Pei-Cheng,Seol, Seung-Kwon,Lo, Tsung-Nan,Liu, Chi-Jen,Wang, Chang-Liang,Lin, Chao-Sung,Hwu, Y.,Chen, C. H.,Chang, Liu-Wen,Je, J. H.,Margaritondo, G. The Electrochemical Society 2008 Journal of the Electrochemical Society Vol.155 No.5

노년 청각손상자와 청각장애의 삶의 질 관련성 연구

劉俊榮,張勝成 대구대학교 특수교육재활과학연구소 2006 再活科學硏究 Vol.24 No.2

The hearing impairment happened extensively in the elderly and often resulted in the hearing handicap. A lot of study confused the hearing impairment with the hearing handicap and replaced the score of quality of life by the hearing handicap score to calculate the quality adjusted life years and analyzed the cost-utility of aural rehabilitation. In this study, the confusion of hearing impairment and hearing handicap was clarified, and the relevance between hearing handicap and quality of life was explored in order to examine the fitness of replacing the score of quality of life by the hearing handicap score. The result of this study indicated that the correlation between the hearing handicap and the quality of life. The fitness of correlating model of the hearing handicap and the quality of life was not accepted. So, it was not suggested that replacing the score of quality of life by the hearing handicap score. The inventory of disease-specific quality of life should be developed. Secondly, the poor fitness of correlating model of the hearing handicap and the quality of life could be resulted from the other variables that shall be included in the model. It was proposed to include relevant variables into the model in the future. 청각손상은 노년기에 광범위하게 발생하는 문제이다. 심각한 청각장애를 자주 일으킨다. 많은 연구는 청각손상과 청각장애를 혼돈하는 것 뿐 만아니라 자주 청각장애 검목표의 득점으로 피실험자의 생활 품질을 대표한다. 심지어 청각장애 검목표의 득점으로 생활 품질 조정년을 계산한다. 이것으로 청각 재활의 성공 효과를 분석한다. 본 연구는 청각 손상과 청각장애의 다른 점을 밝히는 것 외에도 주요 목적은 청각장애와 생활 품질의 관련성을 이해하고자 하는 것이다. 이것으로 청각장애 검목표를 생활 품질을 삼는 정당성을 관찰한다. 연구결과에 나타나는 것은 청각 표현과 생활품질의 관련성은 높지 않은 결과를 얻었다. 이 두 가지의 관련 양식은 일반화 하기는 제한점을 갖는다. 그래서 이론적 개념에서 청각 표현과 생활품질은 각자 다른 내용을 갖추고 있다. 자료 통계의 분석 결과도 이 두 가지의 관련 양식에 대해서 유의한 결과를 얻지 못했다. 그래서 청각표현 능력으로 피실험자의 생활 품질을 대신할 수 없다. 마땅히 청각 손상자에게 맞는 적합한 생활 품질 설문지를 발행해야한다. 그 다음에 두 가지의 관련 양식의 관련도 적다. 아마도 청각 손상자의 청각 표현과 생활 품질 간에는 많은 변인의 영향이 존재하기 때문이다. 미래의 연구는 더 많은 상관 관련 인소를 귀납해서 이 이론구조를 검증해야한다는 것을 건의한다.

The in vivo photothermal treatment of gold nanorod in the mouse ear model

Liu, Bruce Yao Wen,Chen, Cheng-Lung,Lee, Shin-Yu,Chang, Fu-Hsiung,Lin, Win-Li,Chia, Chih-Ta,Chen, Yang-Yuan Techno-Press 2014 Biomaterials and biomedical engineering Vol.1 No.1

Gold nanorod's exceptional light to heat transduction is a robust phonomenon that has been extensively verified. The phenomenon is a trait from which many novel applications across disciplines have been proposed. In this investigation, the feasibility of utilizing heat harvested from such photothermal method to combat cancer is presented. Using non-invasive laser methods, an in vivo study is conducted on mouse ear tumors administered with gold nanorods (Au NRs). An emphasis is placed on monitoring the tumor developments after photothermal treatments, over time. The findings reveal significant tumor growth surpression at a threshold laser power of $0.6W/cm^2$ lasting 2 minutes; this energy also brought about dramatic size reduction in treated tumors. Furthermore, the apparent formation of an eschar over the laser treated region indicates extensive hemorrhagic necrosis of the tumor tissue; a phenomenon implicative to the inhibition of angiogenesis.

Numerical simulation of slit wall effect on the Taylor vortex flow with radial temperature gradient

Liu, Dong,Chao, Chang-qing,Zhu, Fang-neng,Han, Xi-qiang,Tang, Cheng Korean Society for Fluid machinery 2015 International journal of fluid machinery and syste Vol.8 No.4

Numerical simulation was applied to investigate the Taylor vortex flow inside the concentric cylinders with a constant radial temperature gradient. The reliability of numerical simulation method was verified by the experimental results of PIV. The radial velocity and temperature distribution in plain and 12-slit model at different axial locations were compared, and the heat flux distributions along the inner cylinder wall at different work conditions were obtained. In the plain model, the average surface heat flux of inner cylinder increased with the inner cylinder rotation speed. In slit model, the slit wall significantly changed the distribution of flow field and temperature in the annulus gap, and the radial flow was strengthen obviously, which promoted the heat transfer process at the same working condition.