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Underactive Bladder; Review of Progress and Impact From the International CURE-UAB Initiative
Michael B. Chancellor,Sarah N. Bartolone,Laura E. Lamb,Elijah Ward,Bernadette M.M. Zwaans,Ananias Diokno 대한배뇨장애요실금학회 2020 International Neurourology Journal Vol.24 No.1
There is a significant need for research and understanding of underactive bladder (UAB). The International Congress of Urologic Research and Education on Aging UnderActive Bladder (CURE-UAB) was organized by Doctors Michael Chancellor and Ananias Diokno in order to address these concerns. CURE-UAB was supported, in part, by the US National Institute of Aging and National Institute of Diabetes Digestive and Kidney. Since 2014, there have been 5 successful CURE-UAB congresses. They have brought together diverse stakeholders in the UAB field to identify areas of major scientific challenge and initiated a call to action among the medical community. In this review, we will highlight current and novel treatments under development for UAB and the progress and impact from the CURE-UAB initiative.
Economic and Fast-track Rehabilitation of Concrete Pavements and Bridge Decks
Ramseyer, Chris,Chancellor, Brent,Kang, Thomas H.K. Korea Concrete Institute 2008 International Journal of Concrete Structures and M Vol.2 No.2
The last 10 years have seen considerable growth in the use of proprietary and special repair cements for concrete pavements in the state of Oklahoma. Many of these products lend themselves to "fast track" construction techniques that allow reopening to traffic within 12 hours or less. These products achieve high early strengths by accelerating the Portland cement hydration process for both Type I and Type III cements. In this paper, the important features of a durable repair which include strength, compatibility and bond or adhesion are first discussed. Then the development, testing and field implementation of the aforementioned materials are discussed including the learning curve required to implement a repair system, not just install a new material. Some of the materials discussed, while expensive on a cost per unit basis, hold great promise for economical use on fast track project.
Chia-Pin (Simon) Yu,H. Charles Chancellor,Shu Tian Cole 한국관광학회 2011 International Journal of Tourism Sciences Vol.11 No.2
Tourism impacts studies have identified three major types of positive-negative tourism impacts that dynamically change residents’ life experiences and their evaluation of tourism development. This study examines three specific impacts, perceived social costs, environmental sustainability, and perceived economic benefit, to determine their effects on resident perceived quality of life. The results indicate that the social cost dimension has no significant effect on resident quality of life, however both environmental sustainability and perceived economic benefit dimensions significantly affect resident quality of life.
High Prevalence of Dysplastic Development of Sacral Vertebral Arches in Pediatric Enuresis
Hideo Ozawa,Takakuki Shibano,Isao Tanaka,Toshitaka Taniguchi,Michael B. Chancellor,Naoki Yoshimura 대한배뇨장애요실금학회 2023 International Neurourology Journal Vol.27 No.2
Purpose: This is the first report to compare 3-dimensional computed tomography (3D-CT) images between pediatric patients with enuresis and children without lower urinary tract symptoms who underwent pelvic CT for other reasons. Methods: Forty-seven children (33 boys and 14 girls) with primary enuresis underwent 3D-CT of sacrococcygeal bones. The control group consisted of 138 children (78 boys and 60 girls) who underwent pelvic CT for other reasons. First, we determined the presence or absence of unfused sacral arches at the L4-S3 levels in both cohorts. Subsequently, we compared the fusion of sacral arches in age- and sex-matched children from these 2 groups. Results: Dysplastic sacral arches, characterized by lack of fusion at 1 or more levels of the S1–3 arches, were observed in nearly all patients in the enuresis group. In the control group (n=138), 54 of 79 children over 10 years old (68%) exhibited fused sacral arches at 3 S1–3 levels. All 11 control children under 4 years old displayed at least 2 unfused sacral arches at the S1–3 levels. In a comparative study of age- and sex-matched patients with enuresis and control children aged 5 to 13 years (n=32 for each group, with 21 boys and 11 girls; mean age, 8.0±2.2 years [range, 5–13 years]), only 1 patient (3%) in the enuresis group exhibited fusion of all S1–3 arches. In contrast, 20 of 32 control group participants (63%) had 3 fused sacral arches (P<0.0001). Conclusions: Sacral vertebral arches typically fuse by the age of 10 years. However, in this study, children with enuresis exhibited a significantly elevated prevalence of unfused sacral arches, suggesting that dysplastic development of sacral vertebral arches may play a pathological role in enuresis.
Neural Mechanisms Underlying Lower Urinary Tract Dysfunction
Naoki Yoshimura,Teruyuki Ogawa,Minoru Miyazato,Takeya Kitta,Akira Furuta,Michael B. Chancellor,Pradeep Tyagi 대한비뇨의학회 2014 Investigative and Clinical Urology Vol.55 No.2
This article summarizes anatomical, neurophysiological, and pharmacological studiesin humans and animals to provide insights into the neural circuitry and neurotransmittermechanisms controlling the lower urinary tract and alterations in thesemechanisms in lower urinary tract dysfunction. The functions of the lower urinarytract, to store and periodically release urine, are dependent on the activity of smoothand striated muscles in the bladder, urethra, and external urethral sphincter. Duringurine storage, the outlet is closed and the bladder smooth muscle is quiescent. Whenbladder volume reaches the micturition threshold, activation of a micturition centerin the dorsolateral pons (the pontine micturition center) induces a bladder contractionand a reciprocal relaxation of the urethra, leading to bladder emptying. During voiding,sacral parasympathetic (pelvic) nerves provide an excitatory input (cholinergic and purinergic)to the bladder and inhibitory input (nitrergic) to the urethra. These peripheralsystems are integrated by excitatory and inhibitory regulation at the levels of the spinalcord and the brain. Therefore, injury or diseases of the nervous system, as well as disordersof the peripheral organs, can produce lower urinary tract dysfunction, leadingto lower urinary tract symptoms, including both storage and voiding symptoms, andpelvic pain. Neuroplasticity underlying pathological changes in lower urinary tractfunction is discussed.