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Aripiprazole-induced Hepatitis: A Case Report
Lígia Castanheira,Elsa Fernandes,Pedro Levy,Ricardo Coentre 대한정신약물학회 2019 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.17 No.4
Aripiprazole is an atypical antipsychotic that acts as a partial agonist of dopamine type 2 receptors as well as 5-HT1A receptors. It is used in the treatment of schizophrenia and in type 1 bipolar disorder for mania. Because aripiprazole is well tolerated with few side effects it is used off-label in other psychotic disorders. The prevalence of abnormal liver function tests with antipsychotic use is 32%, with clinically significant effects in 4% of cases. No cases of aripiprazole- induced liver injury have been published. We report a 28-year-old female who presented with non-affective first-episode psychosis and who was treated with aripiprazole. Initially she was medicated with 10 mg per day, with an increase to 20 mg per day on the 12th day of hospitalization. Nine days after she became icteric, with nausea and had a vomiting episode. Laboratory analysis revealed a very high level of alanine aminotransferase, and minor to moderately high levels of aspartate aminotransferase, alkaline phosphatase, gamma-glutamyl transferase, and bilirubin. Aripiprazole was tapered and paliperidone was started with the improvement of clinical and laboratory findings
Redaelli, M.,Kepler, S. O.,Costa, J. E. S.,Winget, D. E.,Handler, G.,Castanheira, B. G.,Kanaan, A.,Fraga, L.,Henrique, P.,Giovannini, O.,Provencal, J. L.,Shipman, H. L.,Dalessio, J.,Thompson, S. E.,Mu Blackwell Publishing Ltd 2011 Monthly notices of the Royal Astronomical Society Vol.415 No.2
<P><B>ABSTRACT</B></P><P>PG 1351+489 is one of the 20 DBVs – pulsating helium‐atmosphere white dwarf stars – known and has the simplest power spectrum for this class of star, making it a good candidate to study cooling rates. We report accurate period determinations for the main peak at 489.334 48 s and two other normal modes using data from the Whole Earth Telescope (WET) observations of 1995 and 2009. In 2009, we detected a new pulsation mode and the main pulsation mode exhibited substantial change in its amplitude compared to all previous observations. We were able to estimate the star's rotation period, of 8.9 h, and discuss a possible determination of the rate of period change of (2.0 ± 0.9) × 10<SUP>−13</SUP> s s <SUP>−1</SUP>, the first such estimate for a DBV.</P>