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- 저자 : Carlos Gómez Alonso (검색결과 2 건)
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Anel Gómez García,Mireya Rivera Rodríguez,Carlos Gómez Alonso,Daysi Yazmin Rodríguez Ochoa,Cleto Alvarez Aguilar 대한당뇨병학회 2015 Diabetes and Metabolism Journal Vol.39 No.1
Background: Family history of type 2 diabetes mellitus (T2DM) is one of risk factors for that in future a subject can develop diabetes. Insulin resistance (IR) is important in the pathogenesis of T2DM. There is evidence that oxidative stress plays an important role in the etiology and/or progression of diabetes. Myeloperoxidase (MPO) participates in developing of inflammation. The objective was to investigate if MPO is associated with IR and inflammation in individuals with first-degree relatives of T2DM. Methods: Cross-sectional study in 84 overweight individuals with family history of T2DM divided in two groups according to IR, group with IR (homeostasis model assessment [HOMA] ≥2.5; n=43) and control group (CG; HOMA <2.5; n=41). Complete clinical history and a venous blood sample were collected for measuring glucose and lipids profile, insulin, interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), MPO, glutathione reductase (GRd), glutathione peroxidase, and superoxide dismutase. Results: MPO, TNF-α, and IL-6 were higher in patients with IR than in CG (MPO: 308.35 [190.85 to 445.42] vs. 177.35 [104.50 to 279.85], P=0.0001; TNF-α: 13.46 [10.58 to 18.88] vs. 9.39 [7.53 to 11.25], P=0.0001; IL-6: 32.93 [24.93 to 38.27] vs. 15.60 [12.93 to 26.27]; P=0.0001, respectively). MPO was associated with IR (rho de Spearman=0.362, P=0.001). In the analysis of lineal regression, MPO predicts IR (β, 0.263; t, 2.520; P=0.014). In the univariate analysis, MPO had an odds ratio of 9.880 for risk of IR (95% confidence interval, 2.647 to 36.879). Conclusion: MPO had relation with IR and inflammation parameters in overweight subjects with first-degree relatives of T2DM. We need studies on a casual relationship and molecular mechanisms among the increased serum MPO levels, inflammation markers, and IR.
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Susana Marcos Alonso,Nicole Almeida Ayerve,Chiara Monopoli Roca,Guillermo Coronel Touma,Juan Carlos del Pozo de Dios,Hortensia Sánchez Gómez,Santiago Santa Cruz Ruíz,Ángel Batuecas Caletrío 대한이비인후과학회 2023 Clinical and Experimental Otorhinolaryngology Vol.16 No.3
Objectives. Ménière disease (MD) is an idiopathic disorder that affects hearing and inner ear balance. Intratympanic genta-micin (ITG) is recognized as an effective treatment for uncontrolled MD characterized by persistent vertigo attacksdespite therapy. The video head impulse test (vHIT) and skull vibration-induced nystagmus (SVIN) are validated meth-ods for evaluating vestibular function. A progressive linear relationship has been identified between the slow-phasevelocity (SPV) of SVIN determined using a 100-Hz skull vibrator and the gain difference (healthy ear/affected ear)measured by vHIT. The aim of this study was to ascertain whether the SPV of SVIN was associated with the recoveryof vestibular function following ITG treatment. Consequently, we sought to determine whether SVIN could predictthe onset of new vertigo attacks in patients with MD who were treated with ITG. Methods. A prospective longitudinal case-control study was conducted. Several variables were recorded post-ITG and through-out the follow-up period, followed by statistical analyses. Two groups were compared: patients who experienced ver-tigo attacks 6 months after ITG and those who did not. Results. The sample comprised 88 patients diagnosed with MD who underwent ITG treatment. Of the 18 patients who ex-perienced recurring vertigo attacks, 15 demonstrated gain recovery in the affected ear. However, all 18 patients ex-hibited a decrease in the SPV of SVIN. Conclusion. The SPV of SVIN may be more sensitive than vHIT in identifying the recovery of vestibular function followingITG administration. To our knowledge, this is the first study to illustrate the link between a reduction in SPV and thelikelihood of vertigo episodes in patients with MD who have been treated with ITG.
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