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- 저자 : Canyang Chen (검색결과 3 건)
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Xuejing Zhang,Junhu Yang,Wenkai Bei,Wei Han,Canyang Chen,Le Yang 한국유체기계학회 2021 International journal of fluid machinery and syste Vol.14 No.2
The efficiency of multiphase twin-screw pump decreases sharply under wet gas conditions (GVF>95%) with severe vibration and thermal problems. Based on the design characteristics of twin-screw pump and screw compressor, a design method of multigradient variable pitch decompression screw pump is to address these problems in this paper. This method keeps the cross section profiles of screw pump unchanged,only changes the pitch of screw. According to the design concept of decompression of screw compressor, the screw rotor is divided into three regions from the inlet to the outlet. The pitch of screw and thread width in these regions are designed separately to increase the volumetric efficiency of the screw pump and reduce the vibration. The effective clearance leakage model of twin-screw pump is simplified and modified. Considering two-phase back flow and combining mechanical model with thermodynamic model, the flow capacity, volumetric efficiency, pressure, and temperature distribution of new and conventional screw pumps are predicted by non-isothermal compression model. The calculations show that the design scheme of multi-gradient variable-pitch decompression screw pump can solve the volumetric efficiency and vibration problems under wet gas conditions fundamentally and can significantly reduce the power consumption of screw pump. However, the problem of temperature rise of screw pump still exists. Cooling system for the screw pump should be designed to continuously cool the screw pump.
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Ginsenosides Rc, as a novel SIRT6 activator, protects mice against high fat diet induced NAFLD
Zehong Yang,Yuanyuan Yu,Nannan Sun,Limian Zhou,Dong Zhang,HaiXin Chen,Wei Miao,Weihang Gao,Canyang Zhang,Changhui Liu,Xiaoying Yang,Xiaojie Wu,Yong Gao The Korean Society of Ginseng 2023 Journal of Ginseng Research Vol.47 No.3
Background: Hepatic lipid disorder impaired mitochondrial homeostasis and intracellular redox balance, triggering development of non-alcohol fatty liver disease (NAFLD), while effective therapeutic approach remains inadequate. Ginsenosides Rc has been reported to maintain glucose balance in adipose tissue, while its role in regulating lipid metabolism remain vacant. Thus, we investigated the function and mechanism of ginsenosides Rc in defending high fat diet (HFD)-induced NAFLD. Methods: Mice primary hepatocytes (MPHs) challenged with oleic acid & palmitic acid were used to test the effects of ginsenosides Rc on intracellular lipid metabolism. RNAseq and molecular docking study were performed to explore potential targets of ginsenosides Rc in defending lipid deposition. Wild type and liver specific sirtuin 6 (SIRT6, 50721) deficient mice on HFD for 12 weeks were subjected to different dose of ginsenosides Rc to determine the function and detailed mechanism in vivo. Results: We identified ginsenosides Rc as a novel SIRT6 activator via increasing its expression and deacetylase activity. Ginsenosides Rc defends OA&PA-induced lipid deposition in MPHs and protects mice against HFD-induced metabolic disorder in dosage dependent manner. Ginsenosides Rc (20mg/kg) injection improved glucose intolerance, insulin resistance, oxidative stress and inflammation response in HFD mice. Ginsenosides Rc treatment accelerates peroxisome proliferator activated receptor alpha (PPAR-α, 19013)-mediated fatty acid oxidation in vivo and in vitro. Hepatic specific SIRT6 deletion abolished ginsenoside Rc-derived protective effects against HFD-induced NAFLD. Conclusion: Ginsenosides Rc protects mice against HFD-induced hepatosteatosis by improving PPAR-α-mediated fatty acid oxidation and antioxidant capacity in a SIRT6 dependent manner, and providing a promising strategy for NAFLD.
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