Polarization Color Imaging System for On-Line Quantitative Evaluation of Facial Skin Lesions

KANG, HEESUNG,JUNG, BYUNGJO,NELSON, J. STUART Elsevier Science, Inc 2007 Dermatologic surgery Vol.33 No.11

<P>BACKGROUND</P><P>A number of studies have been performed for accurate evaluation of chromophores in skin lesions. Qualitative methods are subjective and cause user-dependent error in evaluation. Quantitative methods have limitations for widely distributed skin lesions due to poor spatial resolution, potential skin blanching, and difficulty in relocating identical sites for subsequent measurements and analysis.</P><P>OBJECTIVE</P><P>The objective was to develop a new imaging modality that provides both qualitative and quantitative methods to evaluate widely distributed skin lesions.</P><P>METHODS</P><P>We have developed a prototype polarization color imaging system named “DermaVision,” which provides quantitative on-line image analysis of polarization color images. Herein, we describe the hardware and software of DermaVision in terms of its performance and usefulness for dermatologic applications.</P><P>RESULTS</P><P>Polarization color images were successfully acquired from patients with vascular or pigmented skin lesions. The erythema and melanin index images were successfully computed and quantitatively confirmed the degree of erythema and pigmentation in the skin lesions.</P><P>CONCLUSION</P><P>We believe that DermaVision can be a useful auxiliary tool in dermatology because it simultaneously provides both qualitative and quantitative images of skin lesions.</P>

가변편광과 광학배율을 기반으로 한 피부 확대경을 이용한 피부주름 측정

배영우(Youngwoo Bae),정병조(Byungjo Jung) 대한전기학회 2006 대한전기학회 학술대회 논문집 Vol.2006 No.10

The clinical characteristics of photodamaged skin, such as coarse and fine wrinkle are not accurately evaluable with previous methods. Public awareness for wrinkle treatment and prevention which rely on proper assessment and evaluation of the underlying skin changes has been increased as the population ages. In this paper, we suggest an in-vivo method and instrument that allow us to acquire a wrinkle-enhanced image to improve the accuracy of Quantitative and Qualitative analysis for skin wrinkle. The method used involved white LED illumination and photography through polarizing filters. Finally, the polarized light photography yields an accurate and evaluable parameter of photodamaged skin, especially fine and coarse wrinkle.

다모드 디지털 사진 영상 시스템을 이용한 피부 손상의 진단적 분석에 대한 연구 : DermaVision-Pro

배영우(Youngwoo Bae),김은지(Eunji Kim),정병조(Byungjo Jung) 대한전기학회 2008 대한전기학회 학술대회 논문집 Vol.2008 No.10

Digital photographic analysis is currently considered as a routine procedure in clinic because periodic follow-up examinations can provide meaningful information for diagnosis. However, it is impractical to separately evaluate all suspicious lesions with conventional digital photographic systems, which have inconsistent characteristics of the environmental conditions. To address the issue, it is necessary for total diagnostic evaluation in clinic to integrate conventional systems. Previously, a multimodal digital photographic imaging system, which provides a conventional color image, parallel and cross polarization color images and a fluorescent color image, was developed for objective evaluation of facial skin lesions. Based on our previous study, we introduce a commercial product, "Derma Vision PRO," for routine use in clinical application in dermatology. We characterize the system and describe the image analysis methods for objective evaluation of skin lesions. In order to demonstrate the validity of the system in dermatology, sample images were obtained from subjects with various skin disorders, and image analysis methods were applied for objective evaluation of those lesions.

Investigation of Electrical Responses to Acupuncture Stimulation: The Effect of Electrical Grounding and Insulation Conditions

Yong-Heum Lee,Yeon-Hang Ryu,Byungjo Jung 사단법인약침학회 2009 Journal of Acupuncture & Meridian Studies Vol.2 No.1

Acupuncture in Oriental medicine has been widely used as a core therapeutic method due to its minimal side-effects and therapeutic efficacy. However, the electrical response to acupuncture stimulation (ERAS) has not been clearly studied under acupuncture conditions that might affect the efficacy of acupuncture therapy. In this study, the ERAS was objectively investigated by measuring meridian electric potentials (MEPs) when the electrical grounding conditions of the operator and subject were varied, and when the insulation conditions of acupuncture needle were varied. MEPs between Sang-geoheo (ST37) and Ha-geoheo (ST39) of the Stomach Meridian (ST) were measured by stimulating Jok-samni (ST36) with an acupuncture needle. For non-insulated acupuncture stimulation (NIAS), the average MEP peak was 148.6 ± 20.6 when neither the operator nor the subject were electrically grounded, 23.1 ± 8.8 when the subject only was electrically grounded, 348 ± 76.8 when the operator only was electrically grounded, and 19.9 ± 4.7 when both the operator and the subject were electrically grounded. The MEPs presented various magnitudes and patterns depending on the electrical grounding conditions. The MEP pattern was very similar to that of the charge and discharge of a capacitor. For insulated acupuncture stimulation (IAS), the average MEP peak was 20 ± 4 in all electrical grounding conditions, which is not a significant electric response for acupuncture stimulation. In terms of electricity, this study verified that acupuncture therapy might be affected by acupuncture conditions such as (1) the electrical grounding condition of the operator and the subject and (2) the insulation condition of the acupuncture needle. Acupuncture in Oriental medicine has been widely used as a core therapeutic method due to its minimal side-effects and therapeutic efficacy. However, the electrical response to acupuncture stimulation (ERAS) has not been clearly studied under acupuncture conditions that might affect the efficacy of acupuncture therapy. In this study, the ERAS was objectively investigated by measuring meridian electric potentials (MEPs) when the electrical grounding conditions of the operator and subject were varied, and when the insulation conditions of acupuncture needle were varied. MEPs between Sang-geoheo (ST37) and Ha-geoheo (ST39) of the Stomach Meridian (ST) were measured by stimulating Jok-samni (ST36) with an acupuncture needle. For non-insulated acupuncture stimulation (NIAS), the average MEP peak was 148.6 ± 20.6 when neither the operator nor the subject were electrically grounded, 23.1 ± 8.8 when the subject only was electrically grounded, 348 ± 76.8 when the operator only was electrically grounded, and 19.9 ± 4.7 when both the operator and the subject were electrically grounded. The MEPs presented various magnitudes and patterns depending on the electrical grounding conditions. The MEP pattern was very similar to that of the charge and discharge of a capacitor. For insulated acupuncture stimulation (IAS), the average MEP peak was 20 ± 4 in all electrical grounding conditions, which is not a significant electric response for acupuncture stimulation. In terms of electricity, this study verified that acupuncture therapy might be affected by acupuncture conditions such as (1) the electrical grounding condition of the operator and the subject and (2) the insulation condition of the acupuncture needle.

Fabrication of a thin-layer solid optical tissue phantom by a spin-coating method: pilot study.

Bae, Yunjin,Son, Taeyoon,Park, Jihoon,Jung, Byungjo SPIE--the International Society for Optical Engine 2013 Journal of biomedical optics Vol.18 No.2

<P>Solid optical tissue phantoms (OTPs) have been widely used for many purposes. This study introduces a spin-coating method (SCM) to fabricate a thin-layer solid OTP (TSOTP) with epidermal thickness. TSOTPs are fabricated by controlling the spin speed (250 to 2500 rpm), absorber concentration (0.2% to 1.0%), and the number of layers. The results show that the thicknesses of the TSOTPs are homogeneous in the region of interest. The one-layer TSOTP achieves maximum and minimum thicknesses of 650.28 μm (250 rpm) and 5.10.17 μm (2500 rpm), respectively, decreasing exponentially as a function of the spin speed. The thicknesses of the multilayer TSOTPs increases as a function of the number of layers and are correlated strongly with the spin speed (R20.95). The concentration of the OTP mixture does not directly affect the thickness of the TSOTP; however, the absorption coefficients exponentially increase as a function of absorber concentration (R20.98). These results suggest that the SCM can be used to fabricate homogeneous TSOTPs with various thicknesses by controlling the spin speed and number of layers. Finally, a double-layer OTP that combines epidermal TSOTP and dermal OTP is manufactured as a preliminary study to investigate the practical feasibility of TSOTPs.</P>

Enhancement of light propagation depth in skin: cross-validation of mathematical modeling methods

Kwon, Kiwoon,Son, Taeyoon,Lee, Kyoung-Joung,Jung, Byungjo Springer-Verlag 2009 Lasers in medical science Vol.24 No.4

압력을 이용한 광선 투과도 증가에 대한 연구

여창민(Changmin Yeo),손태윤(Taeyoon Son),정병조(Byungjo Jung) 대한전기학회 2008 대한전기학회 학술대회 논문집 Vol.2008 No.10

Laser has been applied in various diagnostic and therapeutic medical fields. For last few decades, medical low level laser devices have been introduced in market, but they have limitations which cannot convey enough energy to deep layer of tissues for diagnostic or therapeutic purposes. To address the issue, there have been many studies of using physical and chemical methods; it is one of ways to apply negative or positive pressure to tissue. However, it is hard to apply desired pressure on tissues continuously when practical laser devices are used. In this study, we introduce a low-level laser probe which allows maintain pressure on skin tissue. Consequently, we arc confident that the pressure probe for low-level laser treatment should be a useful tool in order to deliver sufficient energy for practical uses.

The effects of minimally invasive laser needle system on suppression of trabecular bone loss induced by skeletal unloading.

Ko, Chang-Yong,Kang, Heesung,Ryu, Yeonhang,Jung, Byungjo,Kim, Hyunsoo,Jeong, Daewon,Shin, Hong-In,Lim, Dohyung,Kim, Han Sung Baillière Tindall ; Springer London 2013 Lasers in medical science Vol.28 No.6

<P>This study was aimed to evaluate the effects of low-level laser therapy (LLLT) in the treatment of trabecular bone loss induced by skeletal unloading. Twelve mice have taken denervation operation. At 2 weeks after denervation, LLLT (wavelength, 660 nm; energy, 3 J) was applied to the right tibiae of 6 mice (LASER) for 5 days/week over 2 weeks by using a minimally invasive laser needle system (MILNS) which consists of a 100 μm optical fiber in a fine needle (diameter, 130 μm) [corrected]. Structural parameters and histograms of bone mineralization density distribution (BMDD) were obtained before LLLT and at 2 weeks after LLLT. In addition, osteocyte, osteoblast, and osteoclast populations were counted. Two weeks after LLLT, bone volume fraction, trabeculae number, and trabeculae thickness were significantly increased and trabecular separations, trabecular bone pattern factor, and structure model index were significantly decreased in LASER than SHAM (p?<?0.05). BMDD in LASER was maintained while that in SHAM was shifted to lower mineralization. Osteocyte and osteoblast populations were significantly increased but osteoclast population was significantly decreased in LASER when compared with those in SHAM (p?<?0.05). The results indicate that LLLT with the MILNS may enhance bone quality and bone homeostasis associated with enhancement of bone formation and suppression of bone resorption.</P>

색 공간 변환을 이용한 글리세린 도포 영역 검출 및 광 투과율 관찰

유현선(Hyunseon Yu),임진혁(Jinhyuck Im),정병조(Byungjo Jung) 대한전자공학회 2019 대한전자공학회 학술대회 Vol.2019 No.11

교차편광 촬영술(Cross Polarization Photographic Technique)를 이용한 부항요법의 배수혈 피부 색소 침착 변화 측정 평가

김수병 ( Soo Byeong Kim ),정병조 ( Byungjo Jung ),신태민 ( Tae Min Shin ),이용흠 ( Yong Heum Lee ) 경락경혈학회 2013 Korean Journal of Acupuncture Vol.30 No.4

Objectives: Skin color deformation by cupping has been widely used as a diagnostic parameter in Traditional Korean Medicine (TKM). Skin color deformation such as ecchymoses and purpura is induced by local vacuum in a suction cup. Since existing studies have relied on a visual diagnostic method, there is a need to use the quantitative measurement method. Methods: We conducted an analysis of cross-polarization photographic images to assess the changes in skin color deformation. The skin color variation was analyzed using L*a*b* space and the skin erythema index (E.I.). The meridian theory in TKM indicates that the condition of primary internal organs is closely related to the skin color deformation at special acupoints. Before conducting these studies, it is necessary to evaluate whether or not skin color deformation is influenced by muscle condition. Hence, we applied cupping at BL13, BL15, BL18, BL20 and BL23 at Bladder Meridian (BL) and measured blood lactate at every acupoint. Results: We confirmed the high system measurement accuracy, and observed the diverse skin color deformations. Moreover, we confirmed that the L*, a* and E.I. had not changed after 40 minutes(p>0.05). The distribution of blood lactate levels at each part was observed differently. Blood lactate level and skin color deformation at each part was independent of each other. Conclusions: The negative pressure produced by the suction cup induces a reduction in the volumetric fraction of melanosomes and subsequent reduction in epidermal thickness. The relationship between variations of tissue and skin properties and skin color deformation degree must be investigated prior to considering the relationship between internal organ dysfunction and skin color deformation.