大羌活湯의 消炎 鎭痛作用에 관한 硏究

金度植,林起龍,李炳柱,엄기진,文永熙 조선대학교 약학연구소 1992 藥學硏究誌 Vol.14 No.1

Experimental studies were conducted to investigate for the effect of Daeganghwal-Tang(DHT) extract on the anti-inflammatory activity, analgesic activity, subacute toxicity and acute toxicity. The following results have been obtanied ; In the anti-inflammatory activity in rats, DHT extract (300,600㎎/㎏ p.o) was shown remarkable preventive effect in the edema induced by Freund's complete adjuvant and 5% acetic acid. In analgesic activity test in mouse, DHT extract(300,600㎎/㎏ p.o) was shown significant analgegic activity in mouse induced by 0.7% acetic acid. In acute toxicity test in mouse, DHT extract showed10% mortelity at DHT extract 1.200㎎/㎏ i.p. and 2,000㎎/㎏ p.o.. In subacute toxicity test in mouse. DHT extract was not showed toxicity for 19 day. Uric acid in the serum of the treated rats by Freund's complete adjuvant were slightly decreased by comparing with the control group. During the administration of DHT extract, The body weight increased, but the liver and spleen weight was not changed by comparing with the control group. .

말라리아의 임상적 고찰

최경숙,박무림,정병학 圓光大學校 醫科學硏究所 2001 圓光醫科學 Vol.16 No.1-2

연구배경: 국내의 말라리아는 1970년대 말부터 근절되었으나, 1993년을 기점으로 급증하는 추세이어서, 이에 대한 역학적, 임상증상이나 경과 및 치료결과에 대하여 분석하고, 서구문헌과 비교해보고자 하였다. 방 법: 1998년 10월부터 2001년 8월까지 고열과 오한을 주소로 원광대학병원에 입원하여 말라리아로 확진된 28례의 환자들에 대하여 후향적으로 의무기록을 조사하였다. 본 연구결과를 토대로 서구의 연구결과와 비교하였다. 통계학적인 분석은 SPSS 9.0 통계 프로그램의 Chi-square test를 이용하였다. 결 자: 총 28례에서 원인원충은 전 례 모두 P. vivax이었고, 27례에서 발병 1년 이내에 전역한 경력이 있었고, 여자1례는 경기도 북부지역이나 외국여행의 경력이 없는 상태에서 진단되었다. 토착형 말라리아는 6월부터 10월 사이에 집중적으로 발생하였고, 고열과 오한(100%), 설사(14%), 오심이나 구토(35%), 심박수 항진(28%), 간종대(21%), 비장종대(39%)의 소견이 관찰되었다. 혈액검사상 평균혈색소는 12.4±1.8 g/dl이었고, 평균혈소판 수는 99,860±64,740/u1이었으며, 간기능의 이상을 보인 경우는 11례(39%)이었다. 혈뇨는 5례(18%), 총빌리루빈치의 상승은 10예(36%)에서 관찰되었다. 전 예에서 chloroquine phosphate를 3일간 1500 ㎎을 투여하고, 이후 primaqulne 15 ㎎을 매일 14일간 투여하여 28례 전 예에서 발열과 오한이 사라지면서 이상소견을 보였던 검사들도 정상화되어 가는 양상을 보였고, 치료중 나타난 약제의 부작용은 없었다. 서구의 Stanley 등의 연구결과와 비교하였을 때 빈혈, 백혈구 감소의 빈도가 더 높았다. 결 론: 최근 국내 말라리아의 발생은 급증하고 있어 이에 대한 적극적인 관리가 필요하고, 발열을 주소로 내원한 환자에서 반드시 말라리아를 감별진단하여야 한다. 또한 국내 토착형 말라리아에 대한 유전적인 소인 등의 연구가 추가적으로 필요할 것으로 사료된다. Background: Vivax malaria, which was once thought to be eradicable since more than 20 years ago, has made a dramatic resurgence since 1993 in the northern parts of Kyeonggi-do. We analyzed the cases of malaria who were treated in Wonkwang University Hospital with regards to epidemiology, clinical manifestations, and treatment outcome. Method: We retrospectively analyzed, clinical data of 28 confirmed cases of malaria treated in the same hospital from October, 1998 to August, 2001. We also compared out data to meta-analysis reports from western contries. Results: Twenty-eight cases of malaria were enrolled. All cases were diagnosed as vivax malaria. All 28 patients had fever and chills. Hematologic abnormalities were the most common laboratory findings. Our patients showed anemia, thrombocytopenia, leukopenia and elevation of transaminase more frequently than western patients. Conclusion: The number of malaria cases has been increasing by year. Early diagnosis, treatment, and prevention of malaria are important. To prevent indigenous malaria, anyone who travels to endemic areas should receive proper education and chemoprophylaxis, considering the pattern of drug resistance. Further genetic studies are desired to determine the subspecies of plasmodium vivax.

3 차원 데이터획득 뇌 FDG-PET 의 정확도 평가

최창운,이경한,최용,임상무,김상은,이정림,홍성운,김병태 대한핵의학회 1999 핵의학 분자영상 Vol.33 No.3

Purpose: To assess the quantitative accuracy and the clinical utility of 3D volumetric PET imaging with FDG in brain studies, 24 patients with various neurological disorders were studied. Materials and Methods: Each patient was injected with 370 MBq of 2-[18F]fluoro-2-deoxy-D-glucose. After a 30 min uptake period, the patients were imaged for 30 min in 2 dimensional acquisition (2D) and subsequently for 10 min in 3 dimensional acquisition imaging (3D) using a GE AdvanceTM PET system. The scatter corrected 3D (3D SC) and non scatter-corrected 3D images were compared with 2D images by applying ROIs on gray and white matter, lesion and contralateral normal areas. Measured and calculated attenuation correction methods for emission images were compared to get the maximum advantage of high sensitivity of 3D acquisition. Results: When normalized to the contrast of 2D images, the contrasts of gray to white matter were 0.75±0.13 (3D) and 0.95±0.12 (3D SC). The contrasts of normal area to lesion were 0.83±0.05 (3D) 0.96±0.05 (3D SC). Three nuclear medicine physicians judged 3D SC images to be superior to the 2D with regards to resolution and noise. Regional counts of calculated attenuation correction was not significantly different to that of measured attenuation correction. Conclusion: 3D PET images with the scatter correction in FDG brain studies provide quantitatively and qualitatively similar images to 2D and can be utilized in a routine clinical setting to reduce scanning time and patient motion artifacts. (Korean J Nucl Med 1999;33:327-36)

Effects of Lonicera Japonica Extract as a Biological Response Modifier

Rim, Byung Moo,Rim, Chae Woong,Choi, Jin Young,Chung, Yun Shin,Jeong, Hyun Gook A.R. Liss 1992 ENVIRONMENTAL MUTAGENS AND CARCINOGENS Vol.12 No.1

The Protective Effect of Ginseng and Aloe Extract against Cigarette Smoke-induced Hepatotoxicity

Rim, Byung-Moo,Lim, Chae-Woong Korean Society of ToxicologyKorea Environmental Mu 1996 Toxicological Research Vol.12 No.2

The preventive effects of ginseng and aloe extract on cigarette smoke-induced hepatotoxicity to Spague-Dawley rats were investigated. The experimental rats were exposed smoke by inhalation for 5 weeks, 3 times per day, and 15 minutes each time. Also ginseng and aloe extract (Group G+A), aloe (Group A) or ginseng (Group G) were administered to each group, but the positive control rats (Group C) were exposed smoke without any other special treatments. Group C showed decreased food intake and increased water consumption. Also the reduction of body weight and the increase in serumAST, ALT, triglyceride and alkaline phosphatase were observed. The relative liver weights of group C were increased and the hepatic parenchyma revealed light brownish red grossly. On histopathologic observation, the hepatocytes of group C animals exhibited diffuse swelling which narrowed the, sinusoidal lumen and disarrayed the hepatic cord-like arrangement. Diffuse necrosis of the hepatocytes was also observed. However, degeneration and necrosis of the hepatocytes were milder in group G+A. In the case of group A, the damage was moderate, while the group G showed marginal improvement from group C. Electronmicroscopically, peroxisome increased and mitochodria decreased in group C. Various hepatic damages related to smoking in group C revealed recovering tendency in group G+A. This study indicated that daily administration of ginseng and aloe could decrease and even prevent cigarette smokeinduced hepatotoxicity.

Clinical and Hematologic Variables in Animals with Experimentally Induced Leptospirosis

Rim, Byung Moo,Rim, Chae Woong,Choi, Sam Im 한국수의공중보건학회 1992 예방수의학회지 Vol.16 No.1

Clinical and Hematologic Variables in animals with Experimentally Induced Leptospirosis

Rim, Byung Moo,Rim, Chae Woong,Choi, Sam Im 대한감염학회 1992 감염 Vol.24 No.2

동물이 렙토스피라균 감염시 나타내는 임상 및 혈액학적 변화상을 알아보기 위해서 강아지 20두와 햄스터 30두에 인공감염시켜 62일간 관찰하였다. 중요한 임상증세로는 강아지에서 초기에 39℃이상되는 체온상승과 전 실험기간에 걸쳐 맥박과 호흡수의 증가경향이었으며 양군 실험동물에서 접종후에 심한 원기쇠약 상태를 나타내었다. 햄스터에서 가장 특징적인 혈청검사소견은 접종 후 단기간 동안 ALT, AST, BUN 및 creatinine치의 증가였다. 한편 양군의 실험동물은 혈액검사 결과 적혈구수의 감소를 보였는데 총백혈구치는 초기에 증가 경향을 나타냈으며 백혈구 백분비에서는 좌방 이동을 동반하는 호증구의 증가와 임파구의 감소 및 단핵구와 호산구의 증가등 다양한 변화를 나타내었다. The clinical and hematologic variables of 20 puppies and 30 hamsters with experimentally induced leptospirosis were studied for a 62-day period. The earliest clinical sign indicative of leptospirosis was fever (rectal temperature exceeding 39℃) and increased pulse and respiration rates of the puppies. Both animals became depressed for a few days after inoculation. The most significant hematologic changes were increased ALT, AST, BUN and creatinine levels of the hamsters during early period. Red blood cell counts were decreased in both group, meanwhile white blood cell counts showed increasing tendency throughout early period. Differential WBC counts were highly variable including neutrophilic leucocytosis with left shift, lymphopenia, and increased monocytes and eosinophils.

PATHOLOGICAL STUDIES ON THE CHRONIC TOXICITY OF METHAMPHETAMINE ADMINISTRATION

Rim, Byung-Moo,Cho, Gye-Myung,Chang, Jae-Hong Korean Society of ToxicologyKorea Environmental Mu 1993 Toxicological Research Vol.9 No.2

Toxic effects of chronic adminstration of methamphetamine (MA) to SD rats were studied in respect to histopathological changes induced in each organ. In experimental groups liver weight decreased and brain weights increased markedly compared with controls in the 12th month after subcutaneous injection of 0.5 mg and 5mg/kg/BW MA. Serum alkaline phosphotase levels increased, but marked decrease of cholesterol, triglyceride, and BUN levels were checked depending on both the dose of MA and duration of treatment.

ACUTE MAMMALIAN TOXICITY OF O-CHLOROBENZYLIDENE MALONONITRILE(CS)

Rim, Byung-Moo,Rim, Chae-Woong The Korean Society of Toxicology Korea Environment 1989 Toxicological Research Vol.5 No.1

Acute inhalation intoxication of CS (O-chlorobenzylidene malononitrile) occurred among the 192 animals in confined animal cages of farm as the result of prolonged exposure. A total of 8 animals (3 silver foxes, 3 fitches and 2 minks) died in 15 hours after the exposure. Distinct evidences of pulmonary atelectasis were observed as with hepatorenal damages. The lethal toxicity of CS was considered to be due to early severelung damages leading to asphyxia, accompanying acute toxic hepatitis and nephritis.

Ultrastructural Studies on the Effects of Korean Panax Ginseng on the Theca Interna of Rat Ovary

Rim, Byung Moo 전북대학교 의과학연구소 1980 全北醫大論文集 Vol.4 No.1

휜쥐에 고려인삼 추출물을 60일간 투여하는 동안 steroid물질을 산생하는 난소내 난포막 내층 세포의 미세구조상의 변화를 구명하기 위해 본 연구를 실시하였던 바 다음과 같은 결과를 얻었다. 인삼 투여 동물의 난포막 내층 세포에 나타난 세포질성 변화로는 mitochondria의 수, 크기 및 그 치밀도가 증가되었으며, smooth surfaced endoplasmic reticulum, rough surfaced endoplasmic reticulum 및 Golgi체의 크기도 증가되었다. 역시 핵과 핵소체도 다소 증대되었으며, 한편 lipid과립의 수가 감소됨에 비해 dense body는 그 수가 증가되었다. 이상의 변화는 steroid산생세포의 기능한진상을 나타내는 결과로 결국 인삼 투여는 동물의 난포막 내층의 steroid산생세포에 대하여 자극의 효과가 있음을 형태학적으로 입증해 주었다.