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석병석(Suk, Byong-suk),민승용(Min, Seung-yong),권재욱(Kwon, Jae-wook),김창균(Kim, Chang-kyoon),문상만(Moon, Sang-man),최수진(Choi, Su-jin),구철회(Koo, Cheol-hea),김인규(Kim, In-kyu),류동영(Ryu, Dong-young) 한국항공우주연구원 2015 항공우주산업기술동향 Vol.13 No.2
시험용 달 궤도선의 발사 요구조건 사전 분석 단계로 최근 외국에서 발사한 달 탐사선의 발사 요구조건을 분석하였다. 일반적으로 달 탐사선의 발사 요구조건은 달 임무 궤도를 결정하는 중요한 요소이며, 또한 지구, 달, 태양의 상대적인 운동으로 인해 임무궤도 요구조건을 만족하는 발사 가능 시간이 주기적으로 반복되는 경향이 있다. 분석 결과 설정된 발사 요구조건들로부터 달 궤도선의 주 임무가 달의 남/북극 지역의 광학 관측 임을 간접적으로 알 수 있었다. 향후 우리나라 달 궤도선 발사 요구 조건 설정에 본 논문이 도움이 되길 기대한다. In the preliminary study on launch window requirement for Korea Path-finder Lunar Orbiter(KPLO), the recent foreign lunar orbiter’s lauch window requirement was analyzed. Normally, the launch requirements depends on the mission orbit. Based on the relationship between Moon, Earth, and Sun, the launch time will be available periodically to meet requirements. In this paper, it is understood that the launch window requirements come from payload mission requirements to take picture each poles of Moon. This paper might be a practical example to derive KPLO launch requirements in the future.
卵巢 腫瘍組織의 植物凝集素 結合에 關한 免疫酵素組織化學的 硏究
文炳俊,崔宗相,白承龍 고려대학교 의과대학 1984 고려대 의대 잡지 Vol.21 No.3
Certain plant proteins called lectins are much more stable than globulin antibodies and are used to detect characteristics of carbobydrate on the cell membranes. To evaluate the changes in lectin bindings, the author had carried an experiment by applying wseveral kinds of lectins to each 3 cases of formalin-fixed and paraffin embedded mucinus cystadenoma, mucinous cystadenocarcinoma, serous cystadenoma, papillary serous cystadenocarcinoma, endometriod adenocarcinoma, granulosa cell tumor, Sertoli cell tumor, benign cystic teratoma, dysgerminoma and choriocarcinoma were selcted. Lectins used were concanavalin-A (Con-A), wheat grem agglutinin (WGA), peanut agglutinin (PNA), soybean agglutinin (SBA), Ricinus communis agglutinin I (RCA I), Ulex europaeus agglutinin I (UEA I), dolichos biflorus agglutinin (DBA) and Pinellia ternata agglutinin (PTA). And binding of lectins were evaluated by an immunohistochemistry based upon the avidinbiotin system. The results obtained are as follows; 1. On the neoplastic cells of mucinous cystadenoma, WGA, PNA SBA, RCA I, and DBA showed-positive reaction on the contrary WGA, SBA, RCA I and UEA I revealed positive reaction on those of mucinous cystadenocarcinoma. 2. On the serous neoplastic cells of serous cystadenoma, WGA, and RCA I showed positive reactions, on the contrary WGA, PNA, RCA I and PTA showed positive reactions on those of serous cystadenocarcinoma. 3. On the neoplastic cells of endomtrioid adenocarcinoma, WGA, PNA, RNA I, UEA I and PTA showed positive reactions. 4. On the neoplstic cells of granulosa-theca cell tumors, con-A, WGA and PTA showed positive reactions only on the theca cells. 5. On the neoplastic cells of Sertoli cells, Con-A and WGA showed psositive reactions. 6. On the neoplastic components of benign cystic teratomas, variable binding reactions were noted on the eqidermal, sebaceous and eccrine gland tissues. 7. On the neoplastic cells of dysgerminoumas, all the lectine showed negative reactions. 8. On the syncytiotrophoblasts of the chorcarcinomas, Con-A, WGA and PTA showed positive reactions, and only WGA showed positive reactions on the cytotropholbasts of the choriocarcinomas. Above findings suggest that the application of lectin pannel can be used for the purpose of differentiation between benign and malignant ovarian tumors.
In vitro and in vivo Activities of SM-101, a Micture of Metampicillin and Sulbactam
Choi, Keum-Hwa,Kim, Sook-Kyung,Baek, Moon-Chang,Kim, Byong-Kak,Lee, Dong-Young,Choi, Eung-Chil The Pharmaceutical Society of Korea 1995 Archives of Pharmacal Research Vol.18 No.6
SM-101 is a mixture of metampicillin and sulbactam(2:1). The antibacterial activities of SM-101 were compared with those of metampicillin, piperacillin and Augmentin. It showed powerful antibacterial activities against major strains. Except P. anruginosa and S. marcescens, the in vitro antibacterial activity of SM-101 was higher than those of metampicillin, piperacillin and Augmentin against Staphylococcus spp., Streptococcus spp., Moganella morganii, E. Coil, and Proteus spp. The $ED_{50}$ values of SM-101 were two-fold or greater than those of metampicillin, piperacillin and Augmentin against $\beta-lactamase$ producing strains, p. mirabilis GN79 and M. morganiii MB4-11. The in vivo efficacy of SM-101 was more active than metampicillin and pipeeracillin and similar to Augmentin against S. aureus Smith, E coli MB4-01 and K. pneumoniae MB4-02.
Resistance Mechanism of Acinetobacter spp. Strains Resistant to DW-116, a New Quinolone
Choi, Keum-Hwa,Baek, Moon-Chang,Kim, Byong-Kak,Choi, Eung-Chil The Pharmaceutical Society of Korea 1998 Archives of Pharmacal Research Vol.21 No.3
DW-116 is a new fluoroquinolone antimicrobial agent with a broad spectrum. In order to elucidate the resistance mechanism to DW-116 in Acinetobacter spp. bacteria, total chromosomal DNA was isolated from 10 strains of Acinetobacter spp. resistant to DW-116. Quinolone resistance determinant region (QRDR) of DNA gyrase gene was amplified by PCR. The 345 bp nucleotide fragment yielded was inserted into pKF 3 which was used as the vector. Comparisons of the DNA sequences of 8 strains with that of the wild type strain revealed a Ser-83 to Leu mutation in mutants and all ten strains contained one silent mutation$(T{\rightarrow}G)$in QRDR. From Acinetobacter MB4-8 strain, DNA gyrase was isolated and purified, through novobiocin-sepharose, heparin-sepharose affinity column chromatography. The enzyme was composed of two subunits and the molecular mass of subunits A and B were 75.6 and 51.9 kDa, respectively. The supercoiling activity of the reconstituted DNA gyrase composed of subunit A from Acinetobacter MB4-8 and subunit B from E. coli was not inhibited by $128{\mu}\textrm{g}$ml of ciprofloxacin. It might be said that one of the resistance mechanisms to DW-116 in Acinetohacter MB4-8 was subunit A alteration of DNA gyrase.
Byong-Kyu Kim,Deuk-Young Nah,Kang Un Choi,Jun-Ho Bae,Moo-Yong Rhee,Jae-Sik Jang,Keon-Woong Moon,Jun-Hee Lee,Hee-Yeol Kim,Seung-Ho Kang,Woo hyuk Song,Seung-Uk Lee,Byung-Ju Shim,Hangjae Chung,Min Su Hyo 대한심장학회 2020 Korean Circulation Journal Vol.50 No.11
Background and Objectives: The relationship between the hospital percutaneous coronary intervention (PCI) volumes and the in-hospital clinical outcomes of patients with acute myocardial infarction (AMI) remains the subject of debate. This study aimed to determine whether the in-hospital clinical outcomes of patients with AMI in Korea are significantly associated with hospital PCI volumes. Methods: We selected and analyzed 17,121 cases of AMI, that is, 8,839 cases of non-ST-segment elevation myocardial infarction and 8,282 cases of ST-segment elevation myocardial infarction, enrolled in the 2014 Korean percutaneous coronary intervention (K-PCI) registry. Patients were divided into 2 groups according to hospital annual PCI volume, that is, to a high-volume group (≥400/year) or a low-volume group (<400/year). Major adverse cardiovascular and cerebrovascular events (MACCEs) were defined as composites of death, cardiac death, non-fatal myocardial infarction (MI), stent thrombosis, stroke, and need for urgent PCI during index admission after PCI. Results: Rates of MACCE and non-fatal MI were higher in the low-volume group than in the high-volume group (MACCE: 10.9% vs. 8.6%, p=0.001; non-fatal MI: 4.8% vs. 2.6%, p=0.001, respectively). Multivariate regression analysis showed PCI volume did not independently predict MACCE. Conclusions: Hospital PCI volume was not found to be an independent predictor of in-hospital clinical outcomes in patients with AMI included in the 2014 K-PCI registry.
Variable Selection Based on Mutual Information
Huh, Moon-Y.,Choi, Byong-Su The Korean Statistical Society 2009 Communications for statistical applications and me Vol.16 No.1
Best subset selection procedure based on mutual information (MI) between a set of explanatory variables and a dependent class variable is suggested. Derivation of multivariate MI is based on normal mixtures. Several types of normal mixtures are proposed. Also a best subset selection algorithm is proposed. Four real data sets are employed to demonstrate the efficiency of the proposals.
In Vivo Kinetics and Biodistribution of a HIV-1 DNA Vaccine after Administration in Mice
Kim, Byong-Moon,Lee, Dong-Sop,Choi, Jae-Hoon,Kim, Chae-Young,Son, Mi-Won,Suh, You-Suk,Baek, Kwan-Hyuck,Park, Ki-Seok,Sung, Young-Chul,Kim, Won-Bae The Pharmaceutical Society of Korea 2003 Archives of Pharmacal Research Vol.26 No.6
In this study we have investigated the pharmacokinetics and tissue distribution of GX-12, a multiple plasmid DNA vaccine for the treatment of HIV-1 infection. Plasmid DNA was rapidly degraded in blood with a half-life of 1.34 min and was no longer detectable at 90 min after intravenous injection in mice. After intramuscular injection, plasmid DNA concentration in the injection site rapidly declined to less than 1 % of the initial concentration by 90 min post-injection. However, sub-picogram levels (per mg tissue) were occasionally detected for several days after injection. The relative proportions of the individual plasm ids of GX-12 remained relatively constant at the injection site until 90 min post-injection. The concentration of plasmid DNA in tissues other than the injection site peaked at 90 min post-injection and decreased to undetectable levels at 8 h post-injection. The rapid in vivo degradation of GX-12 and absence of persistence in non-target tissues suggest that the risk of potential gene-related toxicities by GX-12 administration, such as expression in non-target tissues, insertional mutagenesis and germline transmission, is minimal.