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Brine Shrimp Bioassay를 이용한 해양생물의 세포독성검색
손병화,조용진,이대령,노연숙,이선미,최홍대 동의대학교 기초과학연구소 1994 基礎科學硏究論文集 Vol.4 No.1
As a part of chemical study on the bioactive metabolites from marine organisms, we have investigated cytotoxicity using brine shrimp bioassay for each solvent fractions of the marine algae(12 species), marine sponges(3 species), coelenterates(2 species), echinoderms(4 species), marine molluscs(17 species), and ascidians(2 species), respectively. As the results, chloroform extract of Stichopus japonicus (LC_50 : 274 ㎍/ml), ethyl acetate extract of Anthocidaris crassispina(LC_50 : 121 ㎍/ml), n-butanol extract of Undaria pinnatifida (LC_50 : 178 ㎍/ml), and water extract of Thais clavigera (LC_50 : 61 ㎍/ml), displayed the most significant cytotoxic activity against brine shrimp. Among the marine organisms tested, echinoderms and marine molluscs were thought to be the most active Phylums on screening of new bioactive compounds.
2-Chloro-2-(methylthio)acetophenone을 이용한 2-페닐벤조[b]퓨란 유도체의 합성
崔洪大,徐弼子,孫炳華 동의대학교 기초과학연구소 2000 基礎科學硏究論文集 Vol.10 No.1
It is well known that 2-arylbenzo[b]furan derivatives are occured in natural products such as Styrax obassia, Sophora tomentosa, and Krameria ramosissima. In the course of our search on the carbon-carbon bond formation utilizing 1-acyl-l-thiocarbocationic intermediates, we showed that the reaction of substituted phenols with α-chloro-α-(methylthio)acetone (1) in the presence of Lewis acid provided a convenient method for the 2-methylbenzo[b]furans (3) through the reductive desulfurization of the resulting products (2) (Scheme 1). The present paper describes the one-step synthesis for 2-phenylbenzo[b]furan derivatives from the reaction of phenol or cresol isomers with 2-chloro-2-(methylthio) acetophenone in the presence of zinc chloride. Many procedures have been reported for the preparation of 2-phenylbenzofuran ring. Among them, the most frequently employed method is based upon the cyclodehydration reaction of aryloxyacetone moiety with standard dehydrating reagents(H₂SO₄, ZnCl₂, POCl₃, KOH or PPA).
崔洪大,徐弼子,孫炳華 동의대학교 기초과학연구소 2000 基礎科學硏究論文集 Vol.10 No.1
황원자가 α-탄소상의 양이온을 안정화시키는 성질을 가짐은 널리 보고되어있다. 이 α-thiocarbocations를 이용한 탄소-탄소결합형성반응에 관한 연구의 일환으로서, 저자동은 Scheme 1처럼 Friedel-Crafts반응 또는 Pummerer반응조건하에서 발생되어지는 황원자와 acyl기(nitrile기를 포함)에 인접한 탄소양이온(1-acyⅠ-1-thiocarbocations)과 방향족 화합물로부터 arylacctic acid와 arylacetone 및 arylacetonitrile의 간편한 합성법을 개발하였다. 또한 1-acyⅠ-1-thiocarbocations를 적용하여 phenylacetic acid의 모핵구조를 포함하는 소염제인 aryalkanoic acid의 제법을 보고하였다.
α-클로로-α-(메틸티오)아세톤을 이용한 벤조푸란 유도체의 합성
崔洪大,徐弼子,孫炳華 동의대학교 기초과학연구소 1999 基礎科學硏究論文集 Vol.9 No.1
Benzofuran ring을 포함하는 다수의 화합물이 생리활성을 발현하는 의약품으로 개발되어있고 아울러 Benzofuran ring의 모핵 구조를 가진 천연물로서 천식, 위궤양 및 고혈압 등에 유용한 물질도 알려져 있다. Benzofuran ring의 합성법 중 대표적인 예로는 고온에서 arylalkyl ether의 cyclodehydration, aryloxyacetone의 탈수제에 의한 cyclization 및 o-allylphenol 류의 오존분해와 cyclization을 경유하는 방법과 (2-methoxyphenyl)ethynes을 2,4,6-trimethylpyrideine 중 lithium iodide로 처리하는 방법이 보고된바 잇다 .이들 제법은 출발물질의 합성이 용이하지 않고, 고온과 강산성의 격렬한 방응조건을 요구하고 있다.
Byeng Wha Son,Dahai Zhang,Dedi Noviendri,Muhammad Nursid,Xiudong Yang 한국생약학회 2007 Natural Product Sciences Vol.13 No.3
Dioxopiperazine alkaloids, 12R,13S 1), fumitremorgin C (2), andbrevianamide F (3), were isolated from the marine-derived fungus Pseudallescheria, and the absolutestereostructures of compounds 1 -3 were elucidated on the basis of chemical and physicochemical evidence.Compounds 1 -3 showed an antibacterial activity against Staphylococcus aureus, methicillin-resistant S. aureus,and multidrug-resistant . The MIC (minimum inhibitory concentration) values of compounds 1 -3 were125 g/mL for all strains. Keywords Marine-derived fungus, Pseudallescheria sp., 12,13-dihydroxyfumitremorgin C, fumitremorgin C,brevianamide F, antibacterial activity
Bioactive Marine Natural Products
Byeng Wha Son 한국생약학회 1990 생약학회지 Vol.21 No.1
Marine organisms have proven to be rich sources of interesting organic molecules. A great number of compounds with diverse structural features and interesting biological activities have been isolated. Recent studies on secondary metabolites of marine organisms are discussed with a focus on a variety of biological activities and marine natural product literatures are also reviewed.