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- 저자 : Bum Hoi Kim (검색결과 103 건)
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축압축을 받는 CFRP 적층부재의 에너지흡수특성과 파괴모드에 관한 연구
김정호,정회범,전형주 한국산업안전학회 2002 한국안전학회지 Vol.17 No.3
The object of this paper is to investigate collapse characteristics of CF/Epoxy(Carbon Fiber/Epoxy resin)composite tubes on the change of interlaminar number and fiber orientation angle of outer and to evaluate reappearance of collapse characteristics on the change of tension strength of fibers under static and impact axial compression loads. When a CF/Epoxy composite tube is crushed, static/impact energy is consumed by friction between the loading plate and the splayed fronds of the tube, by fracture of the fibers, matrix and their interface. In general, CF/Epoxy tube with 6 interlaminar number(C-type) absorbed more energy than other tubes(A, B, D-types). The maximum collapse load seemed to increase as the interlaminar number of such tubes increases. The collapse mode depended upon orientation angle of outer of CF/Epoxy tubes and loading status(static/impact). Typical collapse modes of CF/Epoxy tubes are wedge collapse mode, splaying collapse mode and fragmentation collapse mode. The wedge collapse mode was shown in case of CF/Epoxy tubes with 0˚ orientation angle of outer under static and impact loadings. The splaying collapse mode was shown in only case of CF/Epoxy tubes with 90˚ orientation angle of outer under static loadings, however in impact tests those were collapsed in fragmentation mode. So that, CF/Epoxy tube with 6 interlaminar number and 90˚ outer orientation angle presented to the optimal collapse characteristics.
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탄산가스 아크용접에서 보호가스량에 따른 용접부의 기계적 성질
정회범,김봉태 順天大學校 1998 論文集 Vol.17 No.1
The mechanical properties of a welding part have been examined by varying the shield gas flow rate from 0ℓ/min to 24ℓ/min when the CO₂ gas arc welding with solid wire is used for welding the SS41 steel. The welding parts have been investigated through X-ray film test, bending test and tensile test, which have shown following results ; 1) X-ray film tests show no pores for the shield gas flow rate from 6ℓ/min to 24ℓ/min. But some pores are existed at inner welding part for the flow rate 2ℓ/min and 4ℓ/min. When no gas is supplied, many pores are observed at the inner and the outer welding parts. 2) A bead configuration including a fusion depth and a bead's width and height is good for the shield gas flow rate more than 8ℓ/min. 3) Bending tests show that no cracks were developed for the shield gas flow rate 16ℓ/min to 24ℓ/min. But cracks are developed at the surface of a face side for the flow rate 4ℓ/min to 12ℓ/min. For the flow rate 0ℓ/min and 2ℓ/min, specimens break into pieces. 4) Tensile strength of the welding part increases as the shield gas flow rate increases. The tensile strength of the welding part is much higher than that of the base metal for the flow rate 4ℓ/min to 24ℓ/min. Considering the above results, the effective shield gas flow rate in the CO₂ gas arc welding is 16ℓ/min to 24ℓ/min.
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한영근,김성훈,이동녘,구범회,김연범 明知大學校 産業技術硏究所 2008 産業技術硏究所論文集 Vol.27 No.-
There are many potential dangers around our life, but we are laking in the consciousness of safety because accidents do no happen frequently. If an accidents occurs, an ability to deal with it is so weak that it can be enlarges to a disaster. Therefore it is important to accustom ourselves to manage dangers and this can be realized by traing. In this study, the traditional traing methodologies are compared and analyszed in order to find an efficient traing way for the public. Also, we propose a traing method by using UCC(User Created Contest) which is a growing communication and content tool in the Internet environment nowadays.
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Kim, Don-Kyu,Gang, Gil-Tae,Ryu, Dongryeol,Koh, Minseob,Kim, Yo-Na,Kim, Su Sung,Park, Jinyoung,Kim, Yong-Hoon,Sim, Taebo,Lee, In-Kyu,Choi, Cheol Soo,Park, Seung Bum,Lee, Chul-Ho,Koo, Seung-Hoi,Choi, Hu American Diabetes Association 2013 Diabetes Vol.62 No.9
<P>Type 2 diabetes mellitus (T2DM) is a progressive metabolic disorder with diverse pathological manifestations and is often associated with abnormal regulation of hepatic glucose production. Many nuclear receptors known to control the hepatic gluconeogenic program are potential targets for the treatment of T2DM and its complications. Nevertheless, the therapeutic potential of the estrogen-related receptor γ (ERRγ) in T2DM remains unknown. In this study, we show that the nuclear receptor ERRγ is a major contributor to hyperglycemia under diabetic conditions by controlling hepatic glucose production. Hepatic ERRγ expression induced by fasting and diabetic conditions resulted in elevated levels of gluconeogenic gene expression and blood glucose in wild-type mice. Conversely, ablation of hepatic ERRγ gene expression reduced the expression of gluconeogenic genes and normalized blood glucose levels in mouse models of T2DM: <I>db</I>/<I>db</I> and diet-induced obesity (DIO) mice. In addition, a hyperinsulinemic-euglycemic clamp study and long-term studies of the antidiabetic effects of GSK5182, the ERRγ-specific inverse agonist, in <I>db</I>/<I>db</I> and DIO mice demonstrated that GSK5182 normalizes hyperglycemia mainly through inhibition of hepatic glucose production. Our findings suggest that the ability of GSK5182 to control hepatic glucose production can be used as a novel therapeutic approach for the treatment of T2DM.</P>
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Kim, Don-Kyu,Kim, Yong-Hoon,Jang, Hyun-Hee,Park, Jinyoung,Kim, Jung Ran,Koh, Minseob,Jeong, Won-Il,Koo, Seung-Hoi,Park, Tae-Sik,Yun, Chul-Ho,Park, Seung Bum,Chiang, John Y L,Lee, Chul-Ho,Choi, Hueng-S BMJ Publishing Group Ltd 2013 Gut: journal of the British Society of Gastroenter Vol.62 No.7
<P>Background The hepatic endocannabinoid system and cytochrome P450 2E1 (CYP2E1), a key enzyme causing alcohol-induced reactive oxygen species (ROS) generation, are major contributors to the pathogenesis of alcoholic liver disease. The nuclear hormone receptor oestrogen-related receptor gamma (ERR gamma) is a constitutively active transcriptional activator regulating gene expression. Objective To investigate the role of ERR gamma in the alcohol-mediated regulation of CYP2E1 and to examine the possibility to control alcohol-mediated oxidative stress and liver injury through an ERR gamma inverse agonist. Design For chronic alcoholic hepatosteatosis study, C57BL/6J wild-type and CB1(-/-) mice were administered alcohol for 4 weeks. GSK5182 and chlormethiazole (CMZ) were given by oral gavage for the last 2 weeks of alcohol feeding. Gene expression profiles and biochemical assays were performed using the liver or blood of mice. Results Hepatic ERR gamma gene expression induced by alcohol-mediated activation of CB1 receptor results in induction of CYP2E1, while liver-specific ablation of ERR. gene expression blocks alcohol-induced expression of CYP2E1 in mouse liver. An ERR gamma inverse agonist significantly ameliorates chronic alcohol-induced liver injury in mice through inhibition of CYP2E1-mediated generation of ROS, while inhibition of CYP2E1 by CMZ abrogates the beneficial effects of the inverse agonist. Finally, chronic alcohol-mediated ERR gamma and CYP2E1 gene expression, ROS generation and liver injury in normal mice were nearly abolished in CB1(-/-) mice. Conclusions ERR gamma, as a previously unrecognised transcriptional regulator of hepatic CB1 receptor, controls alcohol-induced oxidative stress and liver injury through CYP2E1 induction, and its inverse agonist could ameliorate oxidative liver injury due to chronic alcohol exposure.</P>
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Effect of Chungpaesagan-tang on ischemic damage induced by MCAO in spontaneously hypertensive rats
Kim, Ko-Eun,Kim, Soo-Yong,Kim, Eun-Young,Kim, Bum-Hoi,Shin, Jung-Won,Lee, Hyun-Sam,Sohn, Young-Joo,Jung, Hyuk-Sang,Sohn, Nak-Won Kyung Hee Oriental Medicine Research Center 2008 Oriental pharmacy and experimental medicine Vol.8 No.4
Chungpaesagan-tang (CPSGT) is most frequently used to treat ischemic brain injury in tradition Korean medicine. Clinically, cerebral ischemia is likely to be accompanied by preexisting or complicating disease. However, animal models used to examine the effects of herbal medicines on cerebral ischemia have not given this issue sufficient consideration. The present study was undertaken to determine the effects of CPSGT on focal cerebral ischemia in normal and SHR rats subjected to transient middle cerebral artery occlusion (MCAO). Animals were divided into four groups: Normal (Sprague-Dawley) rats subjected to MACO (the NC+MCAO group), normal rats subjected to MCAO and then administered CPSGT (NC + MCAO + CP), SHR rats subjected to MCAO (SHR + MCAO), and SHR rats subjected to MCAO and then administered CPSGT (SHR + MCAO + CP). MCAO was performed using the intraluminal method. CPSGT was administrated orally twice (1 and 4 h) after MCAO. All animals were sacrificed at 24 h postoperatively. Brain tissues were stained with hematoxylin & eosin, to examine the effect of CPSGT on ischemic brain tissues. In addition, changes in TNF-$\alpha$ expression in ischemic areas were examined by immunostaining. CPSGT was found to significantly reduce infarction areas in normal and SHR rats and infarction volumes in SHR rats. Similarly, CPGST markedly increased neuron numbers and sizes in all treated groups, except cell sizes in SHRs. Furthermore, CPSGT reduced TNF-$\alpha$ expression in MCAO administered SHR rats. The findings of the present study suggest that CPSGT effectively ameliorates neuron damage caused by MACO-induced cerebral ischemia, and that it has a significant neuroprotective effect after cerebral ischemia in SHR.
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Kim, Soo-Man,Shim, Eun-Sheb,Kim, Bum-Hoi,Sohn, Young-Joo,Kim, Sung-Hoon,Jung, Hyuk-Sang,Sohn, Nak-Won The Society of Korean Medicine 2008 대한한의학회지 Vol.29 No.5
Objectives : It has been reported that Sophorae Subprostratae Radix (SSR) has a neuroprotective effect on cerebral ischemia in animals. In the present study, the authors investigated the neuroprotective effect of SSR on glutamate excitotoxicity. Glutamate excitotoxicity was induced by using NMDA, AMPA, and KA in PC12 cells and in organotypic hippocampal slice cultures. Methods :Methanolic extract of SSR was added at 0.5, 5, and 50 ${\mu}$g/ml to culture media for 24 hours. The effects of SSR were evaluated by measuring of cell viability, PI-stained neuronal cell death, TUNEL-positive cells, and MAP-2 immunoreactivity. Results : SSR increased PC12 cell viabilities significantly against AMPA-induced excitotoxicity, but not against NMDA-induced or KA-induced excitotoxicity. In organotypic hippocampal slice cultures damaged by NMDA-induced excitotoxicity, SSR attenuated neuronal cell death significantly in the CA1, CA3, and DG hippocampal regions and reduced TUNEL-positive cells significantly in CA1 and DG regions. In organotypic hippocampal slice cultures damaged by AMPA-induced excitotoxicity, SSR attenuated neuronal cell death and reduced TUNEL-positive cell numbers significantly in the CA1 and DG regions. In organotypic hippocampal slice cultures damaged by KA-induced excitotoxicity, SSR attenuated neuronal cell death significantly in CA3, but did not reduce TUNEL-positive cell numbers in CA1, CA3 or DG. In organotypic hippocampal slice cultures damaged by NMDA-induced excitotoxicity, SSR attenuated pyramidal neuron neurite retraction and degeneration in CA1. Conclusions : These results suggest that the neuroprotective effects of SSR are related to antagonistic effects on the NMDA and AMPA receptors of neuronal cells damaged by excitotoxicity and ischemia.
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Effects of Danggwieumja on the Healing of Full-Thickness Skin Injury in Rat
Kim, Bum-Hoi The Physiological Society of Korean Medicine and T 2011 동의생리병리학회지 Vol.25 No.5
The purpose of this study was to investigate the wound healing effects of Danggwieumja (DG), which is commonly used for skin inflammation, skin wound, skin pruritus, and chronic hives etc. The 1.5 cm ${\times}$ 1.5 cm full-thickness skin wound was induced to two groups, DG (n=16) and Saline (n=16) group. The DG extract and Saline were orally administrated daily for 15 days after skin wound induction. Then, the body weight of rats and the congestion indices were daily measured for 15 days after skin wound induction. The wound contractions and epithelizations were also measured. The wound contractions were daily measured for 15 days after wound induction and wound epithelizations were measured for 8 days from day 7 after wound induction. For evaluating angiogenesis, the immunoreactivities of vWF and VEGF protein were measured immunohistochemistrically on day 15. In results, although the percentage increases in mean body weight of rats in the DG and Saline groups hve no significant differences, DG extract decreased the time of wound healing and congestion around wound, and improved wound contraction and epithelization. The contraction percentage of DG group was significantly increased on day 5 (P<0.05) and day 7 (P<0.01) than that of Saline group. DG group showed significant increase of wound epithelization on day 7 (P<0.05) as compared to Saline group. Moreover, DG extract reduced the inflammation of skin dermis and promoted the growth of vascular vessels of dermis by accelerating vascular endothelial growth factor (VEGF) protein. These results suggest that DG has the beneficial effects on skin incision wound and can be the suitable wound healing agent for various surgical wounds.
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