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RISS 인기검색어
- 검색키워드
- 저자 : Boyman, Onur (검색결과 4 건)
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The role of interleukin-2 during homeostasis and activation of the immune system
Boyman, Onur,Sprent, Jonathan Nature Publishing Group, a division of Macmillan P 2012 Nature reviews. Immunology Vol.12 No.3
Interleukin-2 (IL-2) signals influence various lymphocyte subsets during differentiation, immune responses and homeostasis. As discussed in this Review, stimulation with IL-2 is crucial for the maintenance of regulatory T (T<SUB>Reg</SUB>) cells and for the differentiation of CD4<SUP>+</SUP> T cells into defined effector T cell subsets following antigen-mediated activation. For CD8<SUP>+</SUP> T cells, IL-2 signals optimize both effector T cell generation and differentiation into memory cells. IL-2 is presented in soluble form or bound to dendritic cells and the extracellular matrix. Use of IL-2 ?? either alone or in complex with particular neutralizing IL-2-specific antibodies ?? can amplify CD8<SUP>+</SUP> T cell responses or induce the expansion of the T<SUB>Reg</SUB> cell population, thus favouring either immune stimulation or suppression.
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Optimising IL-2 for Cancer Immunotherapy
Sprent Jonathan,Boyman Onur 대한면역학회 2024 Immune Network Vol.24 No.1
The key role of T cells in cancer immunotherapy is well established and is highlighted by the remarkable capacity of Ab-mediated checkpoint blockade to overcome T-cell exhaustion and amplify anti-tumor responses. However, total or partial tumor remission following checkpoint blockade is still limited to only a few types of tumors. Hence, concerted attempts are being made to devise new methods for improving tumor immunity. Currently, much attention is being focused on therapy with IL-2. This cytokine is a powerful growth factor for T cells and optimises their effector functions. When used at therapeutic doses for cancer treatment, however, IL-2 is highly toxic. Nevertheless, recent work has shown that modifying the structure or presentation of IL-2 can reduce toxicity and lead to effective anti-tumor responses in synergy with checkpoint blockade. Here, we review the complex interaction of IL-2 with T cells: first during normal homeostasis, then during responses to pathogens, and finally in anti-tumor responses.
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DOES POL ITICAL PARTICIPATION OF ORANG ASLI(ABORIGINAL PEOPLES) MEETING INTERNATIONAL LAW STANDARDS?
( Yahya ),( Rohaida Nordin ),( Siti Noranizahhafizah Boyman ),( Marshelayanti Mohamad Razali ),( Nafisah Ilham Hussin ),( Mohd Syafiq Zainal ) 한국정책학회 2016 한국정책학회 추계학술발표논문집 Vol.2016 No.-
Ploitical participation plays vital roles in translating the rights to self-determination of indigenous peoles into practice. Article 3 of the United Nations Declaration on the Rights of Indigenous Peoples (UNDRIP) recognized the rights to self-determination of indigenous peoples including the right to freely determine their political status. Irrespective of the current recognition, the rights of indigenous peoples including Orang Asli (Aboriginal Peoples) in the Peninsular of Malaysia are still at stake. The main objective of this study is to critically valuate the compatibility of the rights to political participation of Orang Asli by looking at the international law standards. To achieve the said objective, the discussion will be divided into four parts and conducted using the qualitative approach. In the first part, the study provides information background of Orang Asli includig their brief history and demographic. In the second part, the current study analyses the concept of political participation as part of the rights to self-determination of indigenous peoples under the international law. As the study focuses on the experience of Orang Asli in Malaysia, it will evaluate the political pariticipation of Orang Asli in pursuance to Malaysian law as compared to the international law standards. Ultimately, suitable recommendations and sustainable solutions to improve the political participation of Orang Asli will be presented. This is vital to ensure that the protection of the rights of Orang Asli is compatible with the international law standards. The solutions would also assist the Malaysian State to meet its international law duties and obligations.
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Lé,tourneau, Sven,van Leeuwen, Ester M. M.,Krieg, Carsten,Martin, Chris,Pantaleo, Giuseppe,Sprent, Jonathan,Surh, Charles D.,Boyman, Onur Proceedings of the National Academy of Sciences 2010 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF Vol.107 No.5
<P>IL-2 is crucial to T cell homeostasis, especially of CD4<SUP>+</SUP> T regulatory cells and memory CD8<SUP>+</SUP> cells, as evidenced by vigorous proliferation of these cells in vivo following injections of superagonist IL-2/anti-IL-2 antibody complexes. The mechanism of IL-2/anti-IL-2 antibody complexes is unknown owing to a lack of understanding of IL-2 homeostasis. We show that IL-2 receptor α (CD25) plays a crucial role in IL-2 homeostasis. Thus, prolongation of IL-2 half-life and blocking of CD25 using antibodies or CD25-deficient mice led in combination, but not alone, to vigorous IL-2-mediated T cell proliferation, similar to IL-2/anti-IL-2 antibody complexes. These data suggest an unpredicted role for CD25 in IL-2 homeostasis.</P>
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