대장암 환자의 임상양상에 따른 EGFR Mutation의 발생 빈도

오보영,이령아,정순섭,김광호 이화여자대학교 의과학연구소 2013 EMJ (Ewha medical journal) Vol.36 No.1

Objectives: The EGFR plays an important role in tumorigenesis and tumor progression of colorectal cancer, and leads to the activation of intracellular signaling pathways. The use of anti-EGFR-targeted therapy has increased for patients with colorectal cancer, but patients with EGFR mutations will be resistant to anti-EGFR-targeted therapy. The identification of gene mutations is critical in cancer treatment; therefore, the aim of this study is to investigate the incidences of EGFR mutations in colorectal cancer patients in Korea. Methods: We reviewed 58 colorectal cancer patients who underwent operations between 2003 and 2006, retrospectively. We analyzed their EGFR mutations in 4 loci by DNA sequencing. In addition, we analyzed the correlation between the presence of EGFR mutation and patients’ clinicopathologic features. Results: Of the 58 patients, 35 patients were male and 23 were female. Their mean age was 63.28±11.18 years. Two patients (3.45%) were diagnosed as stage Tis, 7 patients (12.07%) had stage I, 24 patients (41.38%) had stage II, 20 patients (34.48%) had stage III, and 5 patients (8.62%) had stage IV. As a result of mutational analysis, EGFR mutations on exon 20 were detected in 13 patients (22.41%, G→A transitions). EGFR mutations on exon 18, 19 and 21 were not detected. EGFR mutation increased in the earlier stage and the absence of lymph node metastasis (P=0.028). Conclusion: The incidence of EGFR mutation in Korean colorectal cancer patients is 22.41%. In addition, EGFR mutation significantly increased in the earlier stage and the absence of lymph node metastasis.

난소 기형종에 동반된 직장후방 기형종

오보영,이령아,구혜수,문혜성 이화여자대학교 의과학연구소 2012 EMJ (Ewha medical journal) Vol.35 No.2

저압 나노여과 공정에서의 유해성 유기물질의 거동

오정익,이석헌,이보영 대한상하수도학회 2004 상하수도학회지 Vol.18 No.2

Behavior of hazardous organic compounds including bisphenol A, phtalic acid, and phosphoric acid in low pressure nanofltration process were investigated. In the case of NTR729HF, rejection of all target organic compounds except 2-H-Benzothiazol and 2-isopropyl phenol was more than 90%. The lowest rejection for 2-H-Benzothiazol was observed in another membranes. The UTC60 and UTC20 showed similar rejection characteristics of hazardous organic compounds. Although the rejection of Bisphenol A, n-buthyl benzenesulfoneamide, N-ethyl-p-toluensulfonamide, 2-H-benzothiazol, p-t-butylphenol and 2-isopropyl phenol was less than 30%, the rejection of tribuiyl phosphate, triethyl phosphate, camphor, 2,2,4 trimethyl 1,3 pentandiol and diphenyl amine was more than 90% in the case of UTC60 and UTC20. The rejection characteristics of various hazardous organic compounds were converted into one parameter Ks, which was proposed in the diffusion-convection model. The Ks of hazardous organic compounds were discussed by comparing with their solute size represented by Stokes radius. The diffusion convection model considering Ks was successful to interpret rejection characteristics of hazardous organic compounds by low-pressure nanofiltration membranes.

소득작물 전후작지 적응 극단기성 벼 ‘중모 1032’

손영보,이종희,조준현,이지윤,오성환,송유천,박동수,박노봉,김상열,여운상,남민희,권영업 忠北大學校 農業科學硏究所 2015 農業科學硏究 Vol.31 No.2

암을 이기는 채식 밥상

오보영,노경태,이령아,김광호 이화여자대학교 의과학연구소 2012 EMJ (Ewha medical journal) Vol.35 No.1

Cancer prevention by vegetable diet has received considerable attention in recent years. In the past these attributes of vegetables were based more on beliefs than on scientific evidences. But over the past few decades many studies have been performed about that. Cancer preventive components of many vegetables have been studied in experimental carcinogenesis models. These studies have reported on these components influence carcinogenesis during initiation and promotion phases of cancer development. Also, epidemiological studies and clinical trials have reported cancer preventive effects of vegetables. However, there is no comprehensive summary of cancer preventive effects with the types of vegetables. In this review, we classified the vegetables and described the mechanism of action of active components of vegetables, experimental studies, and clinical trials. Results revealed a negative correlation between consumption of vegetables and cancer risk. But we can’t still conclude the effects of vegetables yet, so further studies would be necessary for final conclusion.

Inhibition of the Algal Growth using TiO₂-embedded Expanded Polystyrene (EPS) balls in Lab-scale Outdoor Experiment

Ga Young Kim,Jin Chul Joo,Bo Reum Ahn,Dae Hong Lee,Jae Roh Park,Chang Hyuk Ahn,Jong Min Oh 응용생태공학회 2018 Ecology and resilient infrastructure Vol.5 No.3

TiO₂-embedded expanded polystyrene (TiEPS) balls with powdered TiO₂ particles embedded on the surface of EPS were developed, and the growth inhibition of Chlorella ellipsoidea, a green algae, was evaluated. The experiment was conducted using four reactors with various conditions of (A) natural sunlight, (B) natural sunlight + TiEPS balls, (C) dark, and (D) dark + TiEPS balls on the roof of the building during five days. Based on the analysis of cell number, cell morphology, concentrations of chlorophyll-a and phaeopigments, both surface reactions in heterogeneous photocatalysis and light shielding could inhibit the growth of C. ellipsoidea. The highly reactive hydroxyl radicals (OH・) from TiEPS balls degraded the lipid cell membrane through the peroxidation reaction with the light shielding, eventually resulting in cell inactivation. Although dominant inhibitory effects on the growth of C. ellipsoidea were ambiguous, TiEPS balls were feasible to prevent and inhibit the excessive growth of algae in eutrophic water body.

외상성 뇌경막외 및 뇌경막하 혈종에서 혈종제거술 후 발생한 원발 병소 반대측 혈종에 대한 임상적 고찰

전은오,이상구,전영일,유찬종,김영보,박철완 최신의학사 2003 最新醫學 Vol.46 No.9-10

오스테나이트계 304 스테인레스강과 Nd-YAG 레이저빔과의 상호작용

유영태,오용석,노경보,임인호 조선대학교 에너지.자원신기술연구소 2002 에너지·자원신기술연구소 논문지 Vol.24 No.1

Laser beam welding is increasingly being used in welding of structural steels. The laser welding process is one of the most advanced manufacturing technologies owing to its high speed and penetration. The thermal cycles associated with laser welding are generally much faster than those involved in conventional arc welding processes, leading to a rather small weld zone. The experiments are performed for 304 stainless steel plate applying variation of : laser power(600~2000W), welding speed (3~10m/min), shielding gas flow rate, presence of surface pollution, with fixed or variable gap and misalignment between the similar and dissimilar and plates, etc. The variation of brightness temperature versus modification of operational parameters is found, certain typical welding defects can be detected.

Continuous Wave of Condensation Technique으로 근관충전시 치근면 온도상승 분석

김영주,황윤찬,김선호,황인남,최보영,정영진,정우남,오원만 전남대학교 치의학연구소 2003 구강과학 Vol.15 No.4

This study was conducted to evaluate safety to the supporting tissues of the root while the root canal is obturated using continuous wave of condensation technique. A extracted maxillary central incisor was prepared for repeated canal obturation. After conventional access opening, working length was then established to the point 1㎜ from anatomical root apex. The root canal was prepared with GT rotary Ni-Ti file (Dentsply Maillefer, Switzerland). Five thermocouples (Onega Engineering Inc., USA) were placed at 2㎜ increments on one side beginning 1㎜ from the anatomical root apex and the other five thermocouples at 2㎜ increments on the other side beginning 2㎜ from it. For obturation, a nonstandardized medium size gutta-percha cone and a ML Buchanan plugger (Analytic technologies, USA) were selected. After drying of root canal, AH 26 root canal sealer (Dentsply Detrey, Germany) was applied on the wall of the root canal. Baseline temperature was measured on the root surface. The ML size plugger was preheated for 2seconds and then the real temperature of it was recorded before insertion into the root canal. The root canal was obturated with continuous wave of condensation technique as described by Buchanan. The root surface temperature was recorded during obturation and it was performed ten times at each of the following temperature settings: 150℃, 200℃, 250℃ and 300℃. After completion of the temperature recording, the dentinal-cementum thickness at each sites where thermocouples were attached was measured. The data were analyzed using one-way ANOVA followed by Scheffe's test and linear regression test. The results were as follows. 1. When the temperature was set at 150℃, 200℃, 250℃ and 300℃ on the digital display of System B HeatSource, the real temperature of the plugger at the 1㎜ point from the tip revealed 130.82±2.96℃, 158.00±5.26℃, 215.92±6.91℃ and 249.88±3.65℃ respectively. 2. The position of 8 ㎜ from the anatomical apex showed the highest temperature increase at each temperature settings and it was significantly higher than those of other positions (p<0.01). The temperature rise was constantly increased toward coronal portion from apex of the root. 3. The maximum temperature increase on the root surface was 2.37±0.09℃ at 150℃ setting, 3.11±0.12℃ at 200℃ setting, 3.93± 0.09℃ at 250℃ setting and 5.69± 0.15℃ at 300℃ setting. These results suggest that it be relatively kind to the supporting tissues of the root that the root canal is obturated using continuous wave of condensation technique at 150℃, 200℃, 250℃ and 300℃ temperature settings on digital display of System B HeatSource.

직장인의 생활체육 참여가 삶의 질에 미치는 영향

이보선, 성영호, 오준석, 김종필 용인대학교 체육과학연구소 2000 體育科學硏究論叢 Vol.10 No.1

The purpose of this study is to identify the effects of participation in sport for all on quality of life among office workers. To achieve the aim, this study is to analyze firstly the difference of life quality depends on the Properties of office workers in terms of social demography, secondly the difference of and life quality depends on participation extent in practical sport, thirdly the effect of participation extent in practical sport on life quality, and fourthly casual relationship between participation in practical sports on life quality. Set up office workers who are working at company located in Kyounggi-do as population, and then analyzed 334 participants in sport and 383 non- Participants based on systematic cluster sampling. A tool to investigate, questionnaire was composed by total 40 questions such as 11 questions on demographic Properties, 24 Questions on leisure satisfaction, 5 questions on life satisfaction. Frequency Analysis, T-Test and One-Way ANOVA, ANCOVA and Multiple Regression Analysis were applied to analyze the collected data in accordance with the purpose of this study. Follows are results through data analysis in accordance with the above method and procedure. The first, showed a meaningful difference life duality are leisure satisfaction and life satisfaction, and leisure satisfaction showed a meaningful difference 5% in education level and family's income, and life satisfaction showed a meaningful difference 1% in education level and 0.1% in age, position and family's income. The second, life quality depends on the participation in practical sport showed a meaningful difference 0.1% in the only life satisfaction that is a sub-variable of life quality. Non-Participation group in Practical sport showed a low degree in leisure satisfaction and life satisfaction. The third, two elements influenced statically upon leisure satisfaction and life satisfaction as 1% respectively.