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Lee, Hyun Ah,Song, Bo Ram,Kim, Hye Ryeong,Kim, Ji Eun,Yun, Woo Bin,Park, Jin Ju,Lee, Mi Lim,Choi, Jun Young,Lee, Hee Seob,Hwang, Dae Youn D.A. Spandidos 2017 Experimental and therapeutic medicine Vol.14 No.5
<P>Roots of <I>Asparagus cochinchinesis</I> have been widely used to treat fever, cough, kidney disease, breast cancer, inflammatory and brain disease, although the effects of their fermented products have not been assessed until now. To investigate the anti-inflammatory effects on macrophages of a butanol extract from <I>A. cochinchinensis</I> roots fermented with <I>Weissella cibaria</I> (BAW), alterations in the inducible nitric oxide synthase (iNOS)-mediated cyclooxygenase-2 (COX-2) induction pathway and inflammatory cytokine expression were measured in lipopolysaccharide (LPS)-activated RAW264.7 cells following pretreatment with BAW. Briefly, <I>W. cibaria</I> was selected from two bacterial strains for the fermentation of <I>A. cochinchinensis</I> roots based on its hyaluronidase inhibition and NO suppression rates. Following fermentation with <I>W. cibaria</I>, the level of various key components including total phenols and protodioscin were significantly enhanced in BAW. In addition, BAW exhibited high free radical scavenging activity (IC<SUB>50</SUB>=31.62 µg/ml) and induced a decrease of intracellular ROS production in RAW264.7 cells following DCFH-DA staining. Significant suppressions in the expression level of important members of the iNOS-mediated COX-2 induction pathway and the phosphorylation of mitogen-activated protein kinase members were detected. The expressions of pro-inflammatory and anti-inflammatory cytokines were recovered in BAW pretreated RAW264.7 cells. Overall, these results suggest that BAW may suppress inflammatory responses through differential regulation of the iNOS-mediated COX-2 induction pathway and inflammatory cytokine expressions in LPS-activated RAW264.7 cells.</P>
Lee, Bo Ryeong,Koo, Hyun Young Korean Academy of Child Health Nursing 2020 Child Health Nursing Research Vol.26 No.1
Purpose: This study was conducted to investigate the educational needs of parents of infants and toddlers with congenital heart disease (CHD) after hospital discharge. Methods: Qualitative content analysis was conducted of in-depth interviews of eight parents, and the results of an online survey of 171 parents were analyzed quantitatively. Results: Only 16.4% of parents reported that they had received education after hospital discharge on how to provide care for a child with CHD at home. The main reason why parents did not receive education on this topic was that they did not have sufficient opportunities or information (75.5%). In addition, 97.1% of parents stated that they needed educational programs that would be available at home after discharge. In terms of specific educational content, parents expressed the highest needs for education on the symptoms of CHD and ways to cope with them, the prognosis of CHD, and the growth and development of infants and toddlers with CHD. Conclusion: The study showed that parents' educational needs were high in many ways. However, the information and educational opportunities offered after discharge were insufficient compared to those needs. Further research is needed to develop post-hospital educational programs that meet their needs.
이세령 ( Se Ryeong Lee ),김아현 ( A Hyeon Kim ),김정현 ( Jung Hyeon Kim ),김보람 ( Bo Ram Kim ),김희진 ( Hee Jin Kim ),박지희 ( Ji Hee Park ),박찬울 ( Chan Ul Park ),이은서 ( Eun Ser Lee ) 한국정보처리학회 2016 한국정보처리학회 학술대회논문집 Vol.23 No.1
무선 네트워크가 설치되어있는 곳이면 언제 어디서나 네트워크로 정보를 이용할 수 있게 되었다. 사물들끼리 네트워크를 이용하여 정보를 주고받을 수 있는 사물인터넷을 기반으로 하는 수목원 관리 프로그램 설계하였다. 본 논문에서는 사물인터넷을 이용하여 수목원 관리자가 수목원관리를 하는 해결방안을 제시하였고, 해결방안으로 수목원 관리프로그램을 개발하기 전 단계인 설계 결과물을 볼 수 있다.
이세령 ( Se Ryeong Lee ),김아현 ( A Hyeon Kim ),김보람 ( Bo Ram Kim ),김희진 ( Hee Jin Kim ),박찬울 ( Chan Ul Park ),이은서 ( Eun Ser Lee ) 한국정보처리학회 2016 한국정보처리학회 학술대회논문집 Vol.23 No.2
네트워크를 이용하여 정보를 주고받을 수 있는 사물 인터넷과 메시지 전송 기능(GCM)을 기반으로 하는 화재 방지 프로그램을 설계하였다. 본 논문에서는 창고 관리자가 화재를 방지할 수 있는 해결 방안을 제시하였고, 해결방안인 화재 방지 프로그램의 설계 결과물과 구현 과정들을 볼 수 있다.
Bo-Kyung Yoo,Kisang Kwon,Eun Ryeong Lee,O-Yu Kwon 대한의생명과학회 2017 Biomedical Science Letters Vol.23 No.4
Endoplasmic reticulum (ER) stress induces unfolded protein response (UPR) via inositol-requiring enzyme 1 (IRE1) activation, which sends a molecular signal for X box-binding protein 1 (XBP1) mRNA splicing in the cytosol. IRE1 endoribonuclease activity induces cleavage of XBP1 mRNA. The XBP1 mRNA is then ligated by an uncharacterized RNA ligase and translated to produce spliced XBP1 by 23 nt removed in which contains the PstI restriction enzyme site. The splicing of XBP1 mRNA can be detected by semiquantitative RT-PCR, and then splicing of XBP1 is a useful tool to measure the genetic variability in ER stress. In this study, we have estimated IRE1-dependent splicing of XBP1 mRNA under conditions of various hypothermia. The results indicated that hypothermia regulated ER stress. This study demonstrated that hypothermia is closely related to ER stress and may be useful for early diagnosis of ER-associated disease.
Hypothermia Regulates Insulin-like Growth Factor 1 Gene Expression in PC12 Cells
Bo-Kyung Yoo,Kisang Kwon,Eun Ryeong Lee,Seung-Whan Kim,Kweon Yu,O-Yu Kwon 대한의생명과학회 2017 Biomedical Science Letters Vol.23 No.1
In this study, we evaluated the effects of various hypothermic conditions (32℃), including lithium chloride treatment, on insulin-like growth factor 1 (IGF-1) gene expression in PC12 cells. The results show that short-term hypothermic treatment (<1 day) resulted in relatively higher IGF-1 gene expression than did longer-term treatment (>1 day). Repeated switching between normal temperature and hypothermia every 2 h increased IGF-1 gene expression approximately 3-4-fold. These findings indicate that hypothermia dynamically regulates IGF-1 gene expression. This study could be helpful for the development of treatment and diagnostic strategies for ischemia.
장수풍뎅이(Allomyrina dichotoma)에 Oryctes rhinoceros nudivirus 감염에 의해서 유전자 발현이 조절되는 5개의 유전자
유보경(Bo-Kyung Yoo),권기상(Kisang Kwon),고영화(Young Hwa Ko),이은령(Eun Ryeong Lee),최지영(Ji-Young Choi),권오유(O-Yu Kwon) 한국생명과학회 2016 생명과학회지 Vol.26 No.11
최근에 장수풍뎅이(Allomyrina dichotoma)는 관상용으로 인기가 높으며, 애벌레는 건강보조식품으로 주목을 받고 있다. 장수풍뎅이의 대량사육 시 발생하는 질병의 원인이 Oryctes rhinoceros nudivirus (OrNV)인 것이 2015년에 처음 보고되었다. 그러나 아직 정확한 진단, 발병기전과 치료방법을 찾지 못하고 있으며 곤충 사육농가에 매년 심각한 경제적 손실을 입고 있다. 본 연구는 장수풍뎅이의 대량사육 시 발생하는 OrNV질병의 조기진단과 치료에 실마리를 제공하기 위하여 OrNV에 감염된 장수풍뎅이의 장(intestine)에서 유전자발현이 조절되는 Klf15, ERAP2, Snrnp200, mbnl2a, MIMI_L93를 보고한다. Korean rhinoceros beetles (Allomyrina dichotoma), which can be found in broad-leaved forests in mountainous habitats and lives for around one year in wild. This beetle is currently popular as a pet and traditionally regarded as a medicine for liver-related diseases in Korea. It is reported that the economic losses in the mass-rearing facilities by virus infection have been increased since the 2010s in Korea. The causing virus for the A. dichotoma was firstly reported as an Oryctes rhinoceros nudivirus (OrNV) in 2015. We, here, observes that serious morphological changes in the intestinal tube from the OrNV-infected beetles, and report five genes, which are regulated by OrNV infection in the intestine; Krueppel-like factor 15 (Klf15), Endoplasmic reticulum aminopeptidase 2 (ERAP2), U5 small nuclear ribonucleoprotein 200 kDa helicase (Snrnp200), Muscleblind-like protein 2a (mbnl2a), and MIMI_L93. The results may provide a clue to the early diagnosis and disease treatment during the mass-rearing facilities of the A. dichotoma.