MEMBRANE PROCESSES IN ENVIRONMENTAL TECHNOLOGY

Blume I.,Smolders C.A. 한국막학회 1992 멤브레인 Vol.2 No.1

Classical membrane processes like microfiltration (MF), ultrafiltration (UF) and reverse osmosis (RO) are being applied in the last years more frequently in environmental and effluent process problems. Newer technologies and developments like pervaporation (PV) and gas sepaxation (GS) recently found commercial applications in the treatment of waste waters and gas streams. The incentive here is either the clean-up from organic components to comply with federal emission regulations or the recovery of the organics for economical reasons. Processes still in their development stage are combinations of chemical reactions with membrane processes to separate and treat SOx and NOx laden waste gas streams in the clean-up of stack-gases. In this paper we will first give a short overview of the more recent developments in MF, UF and RO. This is followed by a closer look on newer technologies applied in environmental problems. The applications looked at are the recovery of organic components from solvent laden gas streams and the separation of organic volatiles from aqueous waste waters via pervaporation. Technical solutions, the advantages and disadvantages of the processes and. where possible, cost estimations will be presented.

The State of Research in Higher Education

Blume, Stuart 한국대학교육협의회 1983 大學敎育 Vol.4 No.-

AMP-activated Protein Kinase Impairs Endothelial Actin Cytoskeleton Assembly by Phosphorylating Vasodilator-stimulated Phosphoprotein

Blume, Constanze,Benz, Peter M.,Walter, Ulrich,Ha, Joohun,Kemp, Bruce E.,Renné,, Thomas American Society for Biochemistry and Molecular Bi 2007 The Journal of biological chemistry Vol.282 No.7

<P>Vasodilator-stimulated phosphoprotein (VASP) is an actin regulatory protein that links signaling pathways to remodeling of the cytoskeleton. VASP functions are modulated by protein kinases, which phosphorylate the sites Ser-157, Ser-239, and Thr-278. The kinase responsible for Thr-278 phosphorylation, biological functions of the phosphorylation, and association with disease states have remained enigmatic. Using VASP phosphorylation status-specific antibodies, we identified AMP-activated protein kinase (AMPK), a serine-threonine kinase and fundamental sensor of energy homeostasis, in a screen for kinases that phosphorylate the Thr-278 site of VASP in endothelial cells. Pharmacological AMPK inhibitors and activators and AMPK mutants revealed that the kinase specifically targets residue Thr-278 but not Ser-157 or Ser-239. Quantitative fluorescence-activated cell sorter analysis and serum response factor transcriptional reporter assays, which quantify the cellular F-/G-actin equilibrium, indicated that AMPK-mediated VASP phosphorylation impaired actin stress fiber formation and altered cell morphology. In the Zucker Diabetic Fatty (ZDF) rat model for type II diabetes, AMPK activity and Thr-278 phosphorylation were substantially reduced in arterial vessel walls. These findings suggest that VASP is a new AMPK substrate, that VASP Thr-278 phosphorylation translates metabolic signals into actin cytoskeleton rearrangements, and that this signaling system becomes down-regulated in diabetic vessels.</P>

Joseph Beuys: Schmerzraum. Hinter dem Knochen wird gezählt.

Eugene Blume 현대미술사학회 2008 현대미술사연구 Vol.24 No.-

Der Vortrag “Joseph Beuys: Schmerzraum. Hinter dem Knochen wird gezählt” geht von der These aus, dass das Leiden und der Schmerz im Werk von Joseph Beuys als Initialvorgang eine entscheidende Rolle spielt. Früh schon mit einem Sendungsbewusstsein ausgestattet, wollte Beuys als Künstler die Welt verändern. Seine Motivation, Kunst zu studieren, speiste sich aus dieser utopischen Rolle, die er der Kunst zugedacht hatte. Erst das etwa Mitte der 1950er Jahre sich einstellende Bewußstein, welchem politischen System er als junger Mann gedient hatte, stürzt ihn in eine tiefe Lebenskrise. Beuys begreift die menschenverachtende Rolle der Nationalsozialisten und wird erstmals mit dem Grauen von Auschwitz konfrontiert. In der Folge nimmt er an einen internationalen Wettbewerb teil, der die Aufstellung eines Mahnmals in Auschwitz-Birkenau zum Ziel hat. Es entstehen zahlreiche Zeichnungen zu Auschwitz und die Vitrine “Auschwitzdemonstration”. Seine existentielle Krise ist zugleich Untergang, wie Auferstehung. Von der Depression geheilt, stellt Beuys zunehmend den Schmerz, das Leiden, den Schmerz und den Tod ins Zentrum seiner künstlerischen Arbeit. Eine Durchsicht seines gesamten Werkes macht deutlich, dass diese Themen bis zu seinem Lebensende seine wichtigsten bleiben. Beuys formuliert, dass der Schmerz, das Leiden und der Tod das Bewußtsein fördert. Erst durch die Wahrnehmung des physischen Leidens wird sich der Mensch seiner selbst und seiner Kräfte bewusst. In Parallele dazu sieht er die Passion Christi als kulturbildende Kraft, die durch das Leiden ein neues Bewußtsein geschaffen hat. Der Vortrag erzählt in Parallele zu Beuys die Geschichte des romantischen Physikers Theodor Gustav Fechner, der durch eine schwere Krankheit hindurch sein Weltbild ändert und ähnlich wie Beuys, die inneren Seelenkräfte der Welt zu analysieren beginnt. Fechner tut es als Wissenschaftler, Beuys als Künstler. Beide nähern sich aber inhaltlich einander an, besonders in ihren Beschreibungen der Rolle übersinnlicher Kräfte. Der Vortrag “Joseph Beuys: Schmerzraum. Hinter dem Knochen wird gezählt” geht von der These aus, dass das Leiden und der Schmerz im Werk von Joseph Beuys als Initialvorgang eine entscheidende Rolle spielt. Früh schon mit einem Sendungsbewusstsein ausgestattet, wollte Beuys als Künstler die Welt verändern. Seine Motivation, Kunst zu studieren, speiste sich aus dieser utopischen Rolle, die er der Kunst zugedacht hatte. Erst das etwa Mitte der 1950er Jahre sich einstellende Bewußstein, welchem politischen System er als junger Mann gedient hatte, stürzt ihn in eine tiefe Lebenskrise. Beuys begreift die menschenverachtende Rolle der Nationalsozialisten und wird erstmals mit dem Grauen von Auschwitz konfrontiert. In der Folge nimmt er an einen internationalen Wettbewerb teil, der die Aufstellung eines Mahnmals in Auschwitz-Birkenau zum Ziel hat. Es entstehen zahlreiche Zeichnungen zu Auschwitz und die Vitrine “Auschwitzdemonstration”. Seine existentielle Krise ist zugleich Untergang, wie Auferstehung. Von der Depression geheilt, stellt Beuys zunehmend den Schmerz, das Leiden, den Schmerz und den Tod ins Zentrum seiner künstlerischen Arbeit. Eine Durchsicht seines gesamten Werkes macht deutlich, dass diese Themen bis zu seinem Lebensende seine wichtigsten bleiben. Beuys formuliert, dass der Schmerz, das Leiden und der Tod das Bewußtsein fördert. Erst durch die Wahrnehmung des physischen Leidens wird sich der Mensch seiner selbst und seiner Kräfte bewusst. In Parallele dazu sieht er die Passion Christi als kulturbildende Kraft, die durch das Leiden ein neues Bewußtsein geschaffen hat. Der Vortrag erzählt in Parallele zu Beuys die Geschichte des romantischen Physikers Theodor Gustav Fechner, der durch eine schwere Krankheit hindurch sein Weltbild ändert und ähnlich wie Beuys, die inneren Seelenkräfte der Welt zu analysieren beginnt. Fechner tut es als Wissenschaftler, Beuys als Künstler. Beide nähern sich aber inhaltlich einander an, besonders in ihren Beschreibungen der Rolle übersinnlicher Kräfte.

Suspected Perinatal Depression Revealed to be Hereditary Diffuse Leukoencephalopathy with Spheroids

Josefine Andrea Blume,Robert Weissert 대한파킨슨병및이상운동질환학회 2017 Journal Of Movement Disorders Vol.10 No.1

Early motor symptoms of neurodegenerative diseases often appear in combination with psychiatric symptoms, such as depression or personality changes, and are in danger of being misdiagnosed as psychogenic in young patients. We present the case of a 32-year-old woman who presented with rapid-onset depression, followed by a hypokinetic movement disorder and cognitive decline during pregnancy. Genetic testing revealed a mutation in the colony-stimulating factor 1 receptor gene, which led to the diagnosis of hereditary diffuse leukoencephalopathy with spheroids. Hereditary diffuse leukoencephalopathy with spheroids (HDLS) is probably an under-recognized disease. HDLS should be considered in patients with rapidly progressing parkinsonian symptoms and dementia accompanied by white matter lesions.

Handheld Echocardiography in a Clinical Practice Scenario: Concordances Compared to Standard Echocardiographic Reports

Gustavo Gavazzoni Blume,Luka David Lechinewski,Isabela Pedroza Vieira,Nadine Clausell,Giovana Paludo Bertinato,Paulo André Bispo Machado-Júnior,Pedro Goulart Berro,Lidia Ana Zytynski Moura,Teresa Tsan 한국심초음파학회 2022 Journal of Cardiovascular Imaging (J Cardiovasc Im Vol.30 No.1

BACKGROUND: The purpose of this study was to assess the utility of a handheld device (HH) used during common daily practice and its agreement with the results of a standard echocardiography study (STD) performed by experienced sonographers and echocardiographer. METHODS: A prospective follow-up was conducted in an adult outpatient echocardiography clinic. Experienced sonographers performed the STD and an experienced echocardiographer performed the HH. STD included 2-dimensional images, Doppler and hemodynamics analysis. Hemodynamic assessment was not performed with the HH device because the HH does not include such technology. The images were interpreted by blinded echocardiographers, and the agreement between the reports was analyzed. RESULTS: A total of 108 patients were included; and the concordance for left ventricle (LV) ejection fraction (EF), wall motion score index, LV and right ventricle (RV) function, RV size, and mitral and aortic stenosis was excellent with κ values greater than 0.80. Wall motion abnormalities had good concordance (κ value 0.78). The agreement for LV hypertrophy, mitral and aortic regurgitation was moderate, and tricuspid and pulmonary regurgitation agreements were low (κ values of 0.26 and 0.25, respectively). CONCLUSIONS: In a daily practice scenario with experienced hands, HH demonstrated good correlation for most echocardiography indications, such as ventricular size and function assessment and stenosis valve lesion analyses.

Neutrophil Gelatinase-Associated Lipocalin Cutoff Value Selection and Acute Kidney Injury Classification System Determine Phenotype Allocation and Associated Outcomes

Albert Annemarie,Radtke Sebastian,Blume Louisa,Bellomo Rinaldo,Haase Michael,Stieger Philipp,Hinkel Ulrich Paul,Braun-Dullaeus Rüdiger C.,Albert Christian 대한진단검사의학회 2023 Annals of Laboratory Medicine Vol.43 No.6

Background: We explored the extent to which neutrophil gelatinase-associated lipocalin (NGAL) cutoff value selection and the acute kidney injury (AKI) classification system determine clinical AKI-phenotype allocation and associated outcomes. Methods: Cutoff values from ROC curves of data from two independent prospective cardiac surgery study cohorts (Magdeburg and Berlin, Germany) were used to predict Kidney Disease: Improving Global Outcome (KDIGO)- or Risk, Injury, Failure, Loss of kidney function, End-stage (RIFLE)-defined AKI. Statistical methodologies (maximum Youden index, lowest distance to [0, 1] in ROC space, sensitivity≈specificity) and cutoff values from two NGAL meta-analyses were evaluated. Associated risks of adverse outcomes (acute dialysis initiation and in-hospital mortality) were compared. Results: NGAL cutoff concentrations calculated from ROC curves to predict AKI varied according to the statistical methodology and AKI classification system (10.6–159.1 and 16.85–149.3 ng/mL in the Magdeburg and Berlin cohorts, respectively). Proportions of attributed subclinical AKI ranged 2%–33.0% and 10.1%–33.1% in the Magdeburg and Berlin cohorts, respectively. The difference in calculated risk for adverse outcomes (fraction of odds ratios for AKI-phenotype group differences) varied considerably when changing the cutoff concentration within the RIFLE or KDIGO classification (up to 18.33- and 16.11-times risk difference, respectively) and was even greater when comparing cutoff methodologies between RIFLE and KDIGO classifications (up to 25.7-times risk difference). Conclusions: NGAL positivity adds prognostic information regardless of RIFLE or KDIGO classification or cutoff selection methodology. The risk of adverse events depends on the methodology of cutoff selection and AKI classification system.

RECEPTOR-MEDIATED PATHOGEN RECOGNITION AND SIGNAL TRANSDUCTION IN PLANT DEFENSE

Dierk Scheel,Beatrix Blume,Heribert Hirt,Thomas Kroj,Wilco Ligtering,Dirk Nennstie,Thorsten Nürnberger,Markus Tschöpe,Heidi Zinecker,Uta zur Nieden Plant molecular biology and biotechnology research 1998 Proceedings the 2nd Korean-Germany joint symposium Vol.1998 No.-

Sustainability in Manufacturing and Factories of the Future

Christoph Herrmann,Christopher Schmidt,Denis Kurle,Stefan Blume,Sebastian Thiede 한국정밀공학회 2014 International Journal of Precision Engineering and Vol.1 No.4

An increasing global demand for natural resources and the inherent challenges accompanying this demand pose a great task for manufacturing companies. Apart from this, new technologies and a demographic change of the workforce as well as the desire for new individualized products make manufacturing more challenging than ever. To succeed in this new setting manifold perspectives of a factory have been proposed in order to enhance the understanding of the complex interdependencies between the factory elements. Against this background, this paper starts with a short overview regarding the paradigm change in manufacturing including contemporary trends triggering the requirements for factories of the future. Subsequent to that, a selection of factory perspectives is revised indicating the demand for a new holistic perspective of a factory that is more suitable with respect to the new trends. For that reason a new holistic perspective on the factory of the future is presented.

Microwave-driven coherent operation of a semiconductor quantum dot charge qubit.

Kim, Dohun,Ward, D R,Simmons, C B,Gamble, John King,Blume-Kohout, Robin,Nielsen, Erik,Savage, D E,Lagally, M G,Friesen, Mark,Coppersmith, S N,Eriksson, M A Nature Pub. Group 2015 Nature nanotechnology Vol.10 No.3

<P>An intuitive realization of a qubit is an electron charge at two well-defined positions of a double quantum dot. This qubit is simple and has the potential for high-speed operation because of its strong coupling to electric fields. However, charge noise also couples strongly to this qubit, resulting in rapid dephasing at all but one special operating point called the 'sweet spot'. In previous studies d.c. voltage pulses have been used to manipulate semiconductor charge qubits but did not achieve high-fidelity control, because d.c. gating requires excursions away from the sweet spot. Here, by using resonant a.c. microwave driving we achieve fast (greater than gigahertz) and universal single qubit rotations of a semiconductor charge qubit. The Z-axis rotations of the qubit are well protected at the sweet spot, and we demonstrate the same protection for rotations about arbitrary axes in the X-Y plane of the qubit Bloch sphere. We characterize the qubit operation using two tomographic approaches: standard process tomography and gate set tomography. Both methods consistently yield process fidelities greater than 86% with respect to a universal set of unitary single-qubit operations.</P>