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Biagio Ricciuti,Giulia Costanza Leonardi,Noemi Ravaioli,Andrea De Giglio,Marta Brambilla,Enrico Prosperi,Franca Ribacchi,Marialuisa Meacci,Lucio Crinio,Daniele Maiettini,Rita Chiari,Giulio Metro 한국유방암학회 2016 Journal of breast cancer Vol.19 No.3
Breast cancer metastases to the gastrointestinal tract are very rare occurrences. Among the histological subtypes of breast cancer, invasive lobular carcinomas have a high capacity of metastasis to uncommon sites including the stomach. Conversely, there has not been sufficient evidence supporting the gastric metastasis of invasive ductal carcinoma. Herein, we report a unique case of metastatic ductal breast carcinoma mimicking primary linitis plastica in a male patient, particularly focusing on the clinical and pathological features of presentation. Moreover, we propose a immunohistochemical panel of selected antibodies including those for cytokeratin 20, cytokeratin 7, estrogen receptor, progesterone receptor, E-cadherin, gross cystic disease fluid protein 15, and GATA binding protein 3 for an accurate differential diagnosis.
Mohammad Najafzadeh,Daniele Biagio Laucelli,Abdolreza Zahiri 대한토목학회 2017 KSCE Journal of Civil Engineering Vol.21 No.5
Prediction of critical velocity for sediment deposition is a significant component in design of sewer pipes. Because of the abrupt changes in velocity and shear stress distributions, traditional equations based on regression analysis can fail in evaluating sediment transport efficiently. Therefore, different artificial intelligence approaches have been applied to investigate sediment transport in sewer pipes. This study proposes two different approaches to predict the critical velocity for sediment deposition in sewer networks: Model Tree (MT) and the Evolutionary Polynomial Regression (EPR), a hybrid data-driven technique that combines genetic algorithms with numerical regression. The hydraulic radius, average size of sediments, volumetric concentration, total friction factor, and non-dimensional sediment size were considered as input parameters to characterize sediment transport in clean sewer pipes. The present study implements data collected from different works in literature. The proposed modeling approaches are compared to some benchmark formulas from literature, and discussed from the accuracy and knowledge discovery points of view, highlighting the advantage of both proposed techniques. Results indicated that both techniques have similar accuracy in predictions, but EPR allows to physical validation of returned formulas, allowing identifying the most influent inputs on the phenomenon at stake.
Casimir scaling and Yang–Mills glueballs
Hong, Deog Ki,Lee, Jong-Wan,Lucini, Biagio,Piai, Maurizio,Vadacchino, Davide Elsevier 2017 Physics letters: B Vol.775 No.-
<P><B>Abstract</B></P> <P>We conjecture that in Yang–Mills theories the ratio between the ground-state glueball mass squared and the string tension is proportional to the ratio of the eigenvalues of quadratic Casimir operators in the adjoint and the fundamental representations. The proportionality constant depends on the dimension of the space-time only, and is henceforth universal. We argue that this universality, which is supported by available lattice results, is a direct consequence of area-law confinement. In order to explain this universal behavior, we provide three analytical arguments, based respectively on a Bethe–Salpeter analysis, on the saturation of the scale anomaly by the lightest scalar glueball and on QCD sum rules, commenting on the underlying assumptions that they entail and on their physical implications.</P>
Treatment modalities for recurrent high-grade vaginal intraepithelial neoplasia
Giorgio Bogani,Antonino Ditto,Stefano Ferla,Biagio Paolini,Claudia Lombardo,Domenica Lorusso,Francesco Raspagliesi 대한부인종양학회 2019 Journal of Gynecologic Oncology Vol.30 No.2
Objective: We have investigated outcomes of women presenting with recurrent high-grade vaginal intra-epithelial neoplasia. Methods: Data of consecutive women diagnosed with recurrent high-grade vaginal intraepithelial neoplasia after primary treatment(s) were retrieved. Risk of developing new recurrence over the time was assessed using Kaplan-Meier and Cox models. Results: Data of 117 women were available for the analysis. At primary diagnosis, 41 (35%), 4 (3.4%) and 72 (61.6%) patients had had laser, pure surgical and medical treatments, respectively. Secondary treatments included: laser ablation and medical treatment in 95 (81.2%) and 22 (18.8%) cases, respectively. After a mean (standard deviation) follow-up of 72.3 (±39.5) months, 37 (31.6%) out of the entire cohort of 117 patients developed a second recurrence. Median time to recurrence was 20 (range, 5–42) months. Patients with recurrent high-grade vaginal intra-epithelial neoplasia undergoing medical treatments were at higher risk of developing a second recurrence in comparison to women having laser treatment (p=0.013, log-rank test). After we corrected our results for type of treatment used for recurrent disease, we observed that the execution of primary laser treatment was independently associated with a lower risk of developing new recurrences (hazard ratio [HR]=0.46; 95% confidence interval [CI]=0.21–0.99; p=0.050). The other variable that is independently associated with a new recurrence is the persistent infection from HPV16 or 18 (HR=3.87; 95% CI=1.15–13.0; p=0.028). Conclusion: Patients with recurrent high-grade vaginal intra-epithelial neoplasia are at high risk of developing new recurrences. Our data underline that the choice of primary treatment might have an impact of further outcomes.
Giorgio Bogani,Umberto Leone Roberti Maggiore,Biagio Paolini,Antonino Diito,Fabio Martinelli,Domenica Lorusso,Francesco Raspagliesi 대한부인종양학회 2019 Journal of Gynecologic Oncology Vol.30 No.1
Objective: To examine outcomes of patients having treatments for newly diagnosed advanced stage low-grade serous ovarian cancer (LGSC). Methods: We conducted a retrospective case series of women affected by advanced stage (stage IIIB or more) LGSC undergoing surgery in a single oncologic center between January 2000 and December 2017. Survival outcomes were assessed using Kaplan-Meier and Cox models. Results: Data of 72 patients were retrieved. Primary cytoreductive surgery was attempted in 68 (94.4%) patients: 19 (27.9%) had residual disease (RD) >1 cm after primary surgery. Interval debulking surgery (IDS) was attempted in 15 of these 19 (78.9%) patients and the remaining 4 patients having not primary debulking surgery. Twelve out of 19 (63.1%) patients having IDS had RD. After a mean (±standard deviation) follow-up was 61.6 (±37.2) months, 50 (69.4%) and 22 (30.5%) patients recurred and died of disease, respectively. Via multivariate analysis, non-optimal cytoreduction (hazard ratio [HR]=2.79; 95% confidence interval [CI]=1.16–6.70; p=0.021) and International Federation of Obstetrics and Gynecologists (FIGO) stage IV (HR=3.15; 95% CI=1.29–7.66; p=0.011) were associated with worse disease-free survival. Via multivariate analysis, absence of significant comorbidities (HR=0.56; 95% CI=0.29–1.10; p=0.093) and primary instead of IDS (HR=2.95; 95% CI=1.12–7.74; p=0.027) were independently associated with an improved overall survival. Conclusion: LGSC is at high risk of early recurrence. However, owing to the indolent nature of the disease, the majority of patients are long-term survivors. Further prospective studies and innovative treatment modalities are warranted to improve patients care.